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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046792
UUCD1 version UUC-HoS-00344
Ensembl Protein ID ENSP00000429141.1
UniProt Accession Q9BYZ6; A8K9Z8; D3DSR8; E9PBU2; E9PEI7; O94825; Q8N4A8; Q9BZK6; RHBT2_HUMAN
Genbank Protein ID AAG61157.1; AAK07562.1; BAA34437.2; BAF85552.1; EAW63644.1; EAW63646.1; AAH34917.1
Protein Name Rho-related BTB domain-containing protein 2; Deleted in breast cancer 2 gene protein; p83
Genbank Nucleotide ID AY009093; AF315385; AB018260; AK292863; AC107959; CH471080; BC034917
Gene Name RHOBTB2; DBC2; KIAA0717
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000008853.16 ENST00000519685.5 ENSP00000427926.1
ENSG00000008853.16 ENST00000522948.5 ENSP00000429141.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
RepTarSomamiRmiRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
ClinVarGWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
MethyCancerTCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 adaptor/Cullin RING/BCR/BTB_Other BTB_Other 18374159; 18835386
Classification
Family E-value Score Start End
E3 adaptor/Cullin RING/BCR/BTB_Other: BTB 3.30e-42 144.4 273 449
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/BCR/BTB_Other: BTB
   S: 1    aDvilvvg.geeffahkivLaasSsvFyalflmelees...................................................... 37
           aDvilv++ ++++fahki+L++sSs+Fy+lflm+l+e+                                                      
   Q: 273  ADVILVLQeRVRIFAHKIYLSTSSSKFYDLFLMDLSEGelggpsepggthpedhqghsdqhhhhhhhhhgrdfllraasfdvcesvdeaggs 364
           7******************************************************************************************* PP
   S: 38   ..................................................ksklmveik.d..vqpevfrallkFlYtgkldene 69
                                                             ks+lmv++k d  +qp++fra+lk+lYtg+ldene
   Q: 365  gpaglrastsdgilrgngtgylpgrgrvlsswsrafvsiqeemaedpltyKSRLMVVVKmDssIQPGPFRAVLKYLYTGELDENE 449
           ***********************************************************989*********************97 PP
   
Organism Homo sapiens
Protein Sequence
(Fasta)
MKARSRLMDS DMDYERPNVE TIKCVVVGDN AVGKTRLICA RACNATLTQY QLLATHVPTV 60
WAIDQYRVCQ EVLERSRDVV DDVSVSLRLW DTFGDHHKDR RFAYGRSDVV VLCFSIANPN 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046792|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GTCCTTCACC TGCCTTCCCA TAAGCTGGAC TTTGGATCCC AGCCCTTAAA ACCCTTGTGT 60
TGTTTCTTCC TGCAGACCTG GTCGAGAACA CTACTTCAGG ACAGGGAATA GTGACAGGCC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046792|E3,BTB_Other|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0342--GTP-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0677--Repeat
Interpro

IPR000210--BTB/POZ_dom
IPR027417--P-loop_NTPase
IPR011333--SKP1/BTB/POZ
IPR001806--Small_GTPase
IPR003578--Small_GTPase_Rho
PROSITE

PS50097--BTB
PS51420--RHO
Pfam

PF00651--BTB
PF00071--Ras
SMART

SM00225--BTB
Gene Ontology

GO:0005829--C:cytosol
GO:0005886--C:plasma membrane
GO:0005525--F:GTP binding
GO:0051056--P:regulation of small GTPase mediated signal transduction
GO:0007264--P:small GTPase mediated signal transduction
KEGG hsa:23221
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002410 Ailuropoda melanoleuca 96.77 0.00e+00 1264.00
IUUC-Apl-003217 Anas platyrhynchos 89.19 0.00e+00 1189.00
IUUC-Aca-005325 Anolis carolinensis 88.73 0.00e+00 1186.00
IUUC-Ame-011099 Astyanax mexicanus 81.36 0.00e+00 1070.00
IUUC-Bta-012867 Bos taurus 93.33 0.00e+00 1191.00
IUUC-Cja-019189 Callithrix jacchus 99.29 0.00e+00 1282.00
IUUC-Cfa-020827 Canis familiaris 98.02 0.00e+00 1127.00
IUUC-Cpo-022064 Cavia porcellus 93.33 0.00e+00 1280.00
IUUC-Csa-023155 Chlorocebus sabaeus 99.15 0.00e+00 1306.00
IUUC-Cin-025684 Ciona intestinalis 50.52 5.00e-70 258.00
IUUC-Dre-028000 Danio rerio 75.89 0.00e+00 1005.00
IUUC-Dor-030606 Dipodomys ordii 90.78 0.00e+00 1139.00
IUUC-Dse-031542 Dothistroma septosporum 29.63 1.00e-07 48.10
IUUC-Ete-032270 Echinops telfairi 86.38 0.00e+00 1120.00
IUUC-Eca-034317 Equus caballus 98.16 0.00e+00 1270.00
IUUC-Eeu-034700 Erinaceus europaeus 94.76 0.00e+00 805.00
IUUC-Fca-036379 Felis catus 98.31 0.00e+00 1271.00
IUUC-Fal-037092 Ficedula albicollis 88.48 0.00e+00 1165.00
IUUC-Gmo-038991 Gadus morhua 81.02 0.00e+00 1071.00
IUUC-Gga-040643 Gallus gallus 89.68 0.00e+00 1213.00
IUUC-Gac-042348 Gasterosteus aculeatus 80.37 0.00e+00 1047.00
IUUC-Itr-048571 Ictidomys tridecemlineatus 98.86 0.00e+00 1302.00
IUUC-Lch-050574 Latimeria chalumnae 83.19 0.00e+00 1137.00
IUUC-Loc-052678 Lepisosteus oculatus 83.36 0.00e+00 1093.00
IUUC-Laf-054073 Loxodonta africana 97.60 0.00e+00 1316.00
IUUC-Mcc-055721 Macaca mulatta 99.14 0.00e+00 1276.00
IUUC-Mga-059438 Meleagris gallopavo 86.71 0.00e+00 1149.00
IUUC-Mmr-060772 Microcebus murinus 95.77 0.00e+00 1224.00
IUUC-Mdo-062724 Monodelphis domestica 96.74 0.00e+00 1266.00
IUUC-Mmu-064374 Mus musculus 98.16 0.00e+00 1297.00
IUUC-Mpu-066814 Mustela putorius furo 98.71 0.00e+00 1242.00
IUUC-Mlu-067678 Myotis lucifugus 96.21 0.00e+00 1097.00
IUUC-Nle-069747 Nomascus leucogenys 99.43 0.00e+00 1281.00
IUUC-Opr-070707 Ochotona princeps 97.30 0.00e+00 1266.00
IUUC-Ont-071486 Oreochromis niloticus 81.07 0.00e+00 1075.00
IUUC-Ocu-074035 Oryctolagus cuniculus 98.01 0.00e+00 1270.00
IUUC-Ola-086313 Oryzias latipes 80.23 0.00e+00 1034.00
IUUC-Oga-088127 Otolemur garnettii 98.02 0.00e+00 1273.00
IUUC-Ptr-090686 Pan troglodytes 99.72 0.00e+00 1293.00
IUUC-Pan-092489 Papio anubis 99.20 0.00e+00 1111.00
IUUC-Psi-093242 Pelodiscus sinensis 87.83 0.00e+00 1175.00
IUUC-Pma-094594 Petromyzon marinus 61.82 0.00e+00 636.00
IUUC-Pfo-096190 Poecilia formosa 80.79 0.00e+00 1054.00
IUUC-Pab-097796 Pongo abelii 99.02 0.00e+00 1298.00
IUUC-Pca-101016 Procavia capensis 93.14 0.00e+00 1133.00
IUUC-Rno-105601 Rattus norvegicus 98.01 0.00e+00 1295.00
IUUC-Sha-107317 Sarcophilus harrisii 95.18 0.00e+00 1114.00
IUUC-Ssc-116044 Sus scrofa 98.59 0.00e+00 1258.00
IUUC-Tgu-116664 Taeniopygia guttata 88.52 0.00e+00 1059.00
IUUC-Tru-118734 Takifugu rubripes 67.13 0.00e+00 875.00
IUUC-Tsy-119544 Tarsius syrichta 80.90 0.00e+00 856.00
IUUC-Tni-120718 Tetraodon nigroviridis 64.44 0.00e+00 817.00
IUUC-Ttr-128382 Tursiops truncatus 90.64 0.00e+00 1194.00
IUUC-Xtr-132039 Xenopus tropicalis 74.55 0.00e+00 973.00
Created Date 25-Jun-2017

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