iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

mRNA Expression
GEO	FFGED
Protein-protein Interaction
IID	iRefIndex	HINT	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	BioGRID
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
DUB/USP	USP	9615226

Classification

Family	E-value	Score	Start	End
DUB/USP	2.10e-116	387.3	134	666

Active Site

Position(s)	Description	Evidence
143	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
618	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenp............................................................ 42
           +G++N+gNtCY+NSvLQcL+nipe+r+++l+ ++e++++ n+                                                            
   Q: 134  FGYENFGNTCYCNSVLQCLYNIPEFRCNVLR-YPERVAAVNRirksdlkgskirvftnesfetstnsgnsntgyqsndnedahnhhhlqqsdqdnsssstqe 234
           6******************************.*******999************************************************************ PP
   S: 43   ...................................................................................................... 42
                                                                                                                 
   Q: 235  kqnnferkrnsfmgfgkdksnykdsakkddnnemerpqpvhtvvmasdtlteklhegckkiivgrpllkqsdslskasttdcqanshcqcdsqgsritsvdd 336
           ****************************************************************************************************** PP
   S: 43   ................................................kepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgyeqqDaqE 94
                                                           ++++++l++ l+++fe+++   s ++ vsp+e++k+lkke++ f++++qqDa+E
   Q: 337  dvlvnpescndavnnsnnnkentfptseqrkkaalirgpvlnvdhllyPTEEATLYNGLKDIFESITenLSLTGIVSPTEFVKILKKENVLFNTMMQQDAHE 438
           **********************************************9999999**************99999****************************** PP
   S: 95   flaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkkeslqdcLesftk 196
           fl+fll++++e++  ++n+p++++            ++k++++n+++i+dlF+g+l+++ikcl+cdn++sr+epfld++++v+g+eet   ++q++L+s+++
   Q: 439  FLNFLLNDFSEYI--QRNNPRMRF-----------GPQKTDNSNDNFITDLFKGTLTNRIKCLTCDNITSRDEPFLDFPIEVQGDEET---DIQKMLKSYHQ 524
           *************..668888777...........7889***********************************************99...*********** PP
   S: 197  eeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp.fctspeekqkekkkYeLiavvvHsG.slssGHYv 296
           +e+l+g nk+yc+kc+++qeae++++lk+lP++L+lhLkRf++seeqks++k+++k+ +pl+Ld+s+ f+ts      ++kkYeL++vv+H+G ++++GHYv
   Q: 525  REMLNGVNKFYCNKCYGLQEAERMVGLKQLPHILSLHLKRFKYSEEQKSNIKLFNKILYPLTLDVSStFNTS------VYKKYELSGVVIHMGsGPQHGHYV 620
           ******************************************************************956666......499********************* PP
   S: 297  ayvknekgkWllfdDskVtevkeeevleetg.....staYvlfYkr 337
           ++++nek++Wll+dD++V+++kee+vl++tg     +taYvlfYk+
   Q: 621  CICRNEKFGWLLYDDETVESIKEETVLQFTGhpgdqTTAYVLFYKE 666
           ********************************************97 PP

Organism

Saccharomyces cerevisiae

Protein Sequence
(Fasta)

MIKRWLSVNR KKSHPEKNTQ GNDEINRKAT SLKKTKGSGD PSIAKSPSAK SSTSSIPSNL 60
ASHERRSKFS SQTDNLAGNK HYHEHYHNMA STSDEREYDS STTYEDRAFD TESSILFTTI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATAAAAA GATGGTTATC TGTGAATAGG AAAAAGTCAC ACCCGGAGAA GAACACTCAA 60
GGTAATGACG AAATTAATCG GAAAGCAACT AGCCTGAAGA AAACGAAAGG TTCTGGAGAT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

sce:YER098W

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001964	Ailuropoda melanoleuca	38.38	5.00e-57	212.00
IUUC-Apl-003411	Anas platyrhynchos	38.59	2.00e-56	211.00
IUUC-Aca-005212	Anolis carolinensis	38.67	4.00e-57	213.00
IUUC-Ago-007871	Ashbya gossypii	44.39	3.00e-136	476.00
IUUC-Ame-011015	Astyanax mexicanus	37.87	6.00e-56	209.00
IUUC-Bta-012981	Bos taurus	38.46	1.00e-56	211.00
IUUC-Cfa-020534	Canis familiaris	38.38	5.00e-57	212.00
IUUC-Csa-023841	Chlorocebus sabaeus	37.41	3.00e-53	200.00
IUUC-Dre-027845	Danio rerio	38.21	1.00e-56	211.00
IUUC-Dno-029460	Dasypus novemcinctus	38.38	8.00e-57	212.00
IUUC-Dor-030972	Dipodomys ordii	39.22	3.00e-49	186.00
IUUC-Ete-032659	Echinops telfairi	39.01	1.00e-32	132.00
IUUC-Eca-033439	Equus caballus	38.38	5.00e-57	212.00
IUUC-Eeu-034916	Erinaceus europaeus	36.86	2.00e-39	154.00
IUUC-Fca-035524	Felis catus	38.05	2.00e-56	210.00
IUUC-Fal-036833	Ficedula albicollis	38.18	9.00e-57	211.00
IUUC-Gmo-038763	Gadus morhua	39.07	6.00e-58	215.00
IUUC-Gga-041151	Gallus gallus	38.59	2.00e-56	210.00
IUUC-Gac-041967	Gasterosteus aculeatus	38.74	1.00e-57	214.00
IUUC-Ggo-044659	Gorilla gorilla	37.41	3.00e-53	200.00
IUUC-Hsa-046156	Homo sapiens	37.41	3.00e-53	200.00
IUUC-Itr-049082	Ictidomys tridecemlineatus	38.38	6.00e-57	212.00
IUUC-Lch-050237	Latimeria chalumnae	36.79	1.00e-53	201.00
IUUC-Loc-052479	Lepisosteus oculatus	39.10	4.00e-57	213.00
IUUC-Laf-053887	Loxodonta africana	38.38	7.00e-57	212.00
IUUC-Mga-059195	Meleagris gallopavo	38.59	2.00e-56	211.00
IUUC-Mmr-060751	Microcebus murinus	38.38	7.00e-57	212.00
IUUC-Mdo-062735	Monodelphis domestica	38.38	7.00e-57	212.00
IUUC-Mmu-063263	Mus musculus	38.80	3.00e-57	213.00
IUUC-Mlu-068128	Myotis lucifugus	38.38	5.00e-57	212.00
IUUC-Nle-069330	Nomascus leucogenys	37.41	3.00e-53	200.00
IUUC-Ont-072658	Oreochromis niloticus	38.74	1.00e-57	214.00
IUUC-Oan-073372	Ornithorhynchus anatinus	38.38	7.00e-57	212.00
IUUC-Ocu-074322	Oryctolagus cuniculus	38.38	8.00e-57	211.00
IUUC-Ola-087418	Oryzias latipes	38.74	8.00e-58	215.00
IUUC-Oga-088298	Otolemur garnettii	38.38	1.00e-56	211.00
IUUC-Oar-090269	Ovis aries	38.46	2.00e-56	211.00
IUUC-Ptr-090814	Pan troglodytes	37.41	3.00e-53	200.00
IUUC-Pan-091753	Papio anubis	37.41	3.00e-53	200.00
IUUC-Psi-092993	Pelodiscus sinensis	39.13	5.00e-57	212.00
IUUC-Pma-094388	Petromyzon marinus	36.77	3.00e-55	206.00
IUUC-Pfo-097052	Poecilia formosa	38.74	9.00e-58	215.00
IUUC-Pca-100835	Procavia capensis	37.82	1.00e-42	164.00
IUUC-Pva-102878	Pteropus vampyrus	38.68	8.00e-56	208.00
IUUC-Rno-106060	Rattus norvegicus	38.38	7.00e-58	215.00
IUUC-Sha-107087	Sarcophilus harrisii	38.38	7.00e-57	212.00
IUUC-Sja-107684	Schizosaccharomyces japonicus	43.84	6.00e-60	223.00
IUUC-Sar-113216	Sorex araneus	38.38	3.00e-55	206.00
IUUC-Ssc-116321	Sus scrofa	38.38	4.00e-57	213.00
IUUC-Tgu-117482	Taeniopygia guttata	37.84	4.00e-55	206.00
IUUC-Tru-118613	Takifugu rubripes	38.74	1.00e-57	214.00
IUUC-Tsy-119520	Tarsius syrichta	40.00	8.00e-36	141.00
IUUC-Tni-120293	Tetraodon nigroviridis	38.74	1.00e-57	214.00
IUUC-Tbe-127783	Tupaia belangeri	38.38	5.00e-57	212.00
IUUC-Ttr-129083	Tursiops truncatus	38.38	4.00e-57	213.00
IUUC-Vpa-130391	Vicugna pacos	35.79	3.00e-49	186.00
IUUC-Xtr-132082	Xenopus tropicalis	37.12	2.00e-55	207.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence