iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Tru-118284

Ensembl Protein ID

ENSTRUP00000004702.1

UniProt Accession

H2RX32; H2RX32_TAKRU

Protein Name

Tyrosine-protein kinase

Gene Name

lyn; LOC101072875

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSTRUG00000002047.1	ENSTRUT00000004730.1	ENSTRUP00000004702.1
ENSTRUG00000002047.1	ENSTRUT00000004731.1	ENSTRUP00000004703.1
ENSTRUG00000002047.1	ENSTRUT00000004732.1	ENSTRUP00000004704.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	2.00e-14	54.5	69	123

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +  ly+yea + d+L +kkG+ ++++   e+ ++W+k+++ +++++G++P+n+v +++
   Q: 69   MVGLYPYEALHADDLGFKKGERMKIL---EEHGEWWKAKSLTTNREGFIPSNYVGQAD 123
           5669**********************...999**********************8875 PP

Organism

Takifugu rubripes

Protein Sequence
(Fasta)

MGCMKSTLCE SLGSGLERKN SPQTVGAEQR HYVRDPTFEA KHNFLSQNSS LLPGQRFQTM 60
EDKVVGKIMV GLYPYEALHA DDLGFKKGER MKILEEHGEW WKAKSLTTNR EGFIPSNYVG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGGCTGCA TGAAGTCCAC ACTTTGTGAA AGTCTGGGCA GTGGTTTGGA GAGAAAGAAC 60
AGCCCGCAGA CTGTTGGTGC TGAGCAAAGG CATTATGTCA GAGACCCCAC CTTCGAGGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0016477--P:cell migration
GO:0006974--P:cellular response to DNA damage stimulus
GO:0007417--P:central nervous system development
GO:0006935--P:chemotaxis
GO:0097028--P:dendritic cell differentiation
GO:0002431--P:Fc receptor mediated stimulatory signaling pathway
GO:0006954--P:inflammatory response
GO:0045087--P:innate immune response
GO:0030889--P:negative regulation of B cell proliferation
GO:0070667--P:negative regulation of mast cell proliferation
GO:0031175--P:neuron projection development
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0002576--P:platelet degranulation
GO:2000670--P:positive regulation of dendritic cell apoptotic process
GO:0002902--P:regulation of B cell apoptotic process
GO:0050855--P:regulation of B cell receptor signaling pathway
GO:0043304--P:regulation of mast cell degranulation
GO:0090022--P:regulation of neutrophil chemotaxis
GO:0090330--P:regulation of platelet aggregation
GO:0009611--P:response to wounding
GO:0002513--P:tolerance induction to self antigen
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001812	Ailuropoda melanoleuca	71.40	0.00e+00	779.00
IUUC-Apl-004139	Anas platyrhynchos	71.43	0.00e+00	776.00
IUUC-Aca-004333	Anolis carolinensis	72.62	0.00e+00	780.00
IUUC-Ame-011257	Astyanax mexicanus	77.99	0.00e+00	845.00
IUUC-Bta-013257	Bos taurus	71.40	0.00e+00	783.00
IUUC-Cja-018827	Callithrix jacchus	72.37	0.00e+00	787.00
IUUC-Cfa-020816	Canis familiaris	71.79	0.00e+00	783.00
IUUC-Cpo-021423	Cavia porcellus	72.37	0.00e+00	786.00
IUUC-Csa-024244	Chlorocebus sabaeus	71.98	0.00e+00	783.00
IUUC-Dre-028518	Danio rerio	79.57	0.00e+00	851.00
IUUC-Dno-029322	Dasypus novemcinctus	71.98	0.00e+00	780.00
IUUC-Dor-030706	Dipodomys ordii	66.15	0.00e+00	709.00
IUUC-Eca-034193	Equus caballus	72.37	0.00e+00	793.00
IUUC-Fal-037273	Ficedula albicollis	71.60	0.00e+00	786.00
IUUC-Gmo-039677	Gadus morhua	79.19	0.00e+00	754.00
IUUC-Gga-040417	Gallus gallus	70.82	0.00e+00	769.00
IUUC-Gac-042490	Gasterosteus aculeatus	79.96	0.00e+00	867.00
IUUC-Ggo-045096	Gorilla gorilla	72.37	0.00e+00	787.00
IUUC-Hsa-046214	Homo sapiens	72.37	0.00e+00	787.00
IUUC-Itr-048354	Ictidomys tridecemlineatus	71.98	0.00e+00	786.00
IUUC-Lch-049991	Latimeria chalumnae	72.87	0.00e+00	769.00
IUUC-Loc-052309	Lepisosteus oculatus	79.11	0.00e+00	858.00
IUUC-Laf-053568	Loxodonta africana	72.43	0.00e+00	786.00
IUUC-Mcc-054849	Macaca mulatta	71.98	0.00e+00	783.00
IUUC-Mmr-061519	Microcebus murinus	71.79	0.00e+00	785.00
IUUC-Mdo-062090	Monodelphis domestica	68.62	0.00e+00	746.00
IUUC-Mmu-063760	Mus musculus	71.93	0.00e+00	785.00
IUUC-Mpu-065677	Mustela putorius furo	71.60	0.00e+00	785.00
IUUC-Mlu-067386	Myotis lucifugus	71.79	0.00e+00	784.00
IUUC-Nle-069742	Nomascus leucogenys	72.18	0.00e+00	786.00
IUUC-Ont-071537	Oreochromis niloticus	83.07	0.00e+00	903.00
IUUC-Oan-073193	Ornithorhynchus anatinus	72.23	0.00e+00	791.00
IUUC-Ocu-074501	Oryctolagus cuniculus	72.18	0.00e+00	786.00
IUUC-Ola-086726	Oryzias latipes	79.38	0.00e+00	868.00
IUUC-Oga-088069	Otolemur garnettii	71.32	0.00e+00	778.00
IUUC-Oar-090091	Ovis aries	71.40	0.00e+00	782.00
IUUC-Ptr-091409	Pan troglodytes	72.37	0.00e+00	787.00
IUUC-Pan-092268	Papio anubis	71.98	0.00e+00	783.00
IUUC-Psi-093685	Pelodiscus sinensis	72.06	0.00e+00	783.00
IUUC-Pma-094100	Petromyzon marinus	65.92	0.00e+00	658.00
IUUC-Pfo-096217	Poecilia formosa	80.93	0.00e+00	884.00
IUUC-Pab-098601	Pongo abelii	72.37	0.00e+00	787.00
IUUC-Rno-105557	Rattus norvegicus	71.79	0.00e+00	783.00
IUUC-Sha-106643	Sarcophilus harrisii	70.87	0.00e+00	773.00
IUUC-Sbi-114452	Sorghum bicolor	27.21	1.00e-19	91.70
IUUC-Ssc-116317	Sus scrofa	67.57	0.00e+00	721.00
IUUC-Tgu-116865	Taeniopygia guttata	71.60	0.00e+00	788.00
IUUC-Tsy-119440	Tarsius syrichta	75.70	0.00e+00	759.00
IUUC-Tni-120005	Tetraodon nigroviridis	84.99	0.00e+00	923.00
IUUC-Ttr-128481	Tursiops truncatus	63.04	0.00e+00	652.00
IUUC-Xtr-131907	Xenopus tropicalis	64.11	0.00e+00	683.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence