iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Lch-050681

Ensembl Protein ID

ENSLACP00000019286.1

UniProt Accession

H3BBL5; H3BBL5_LATCH

Genbank Protein ID

ENSLACP00000019286

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AFYH01004277

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLACG00000016966.1	ENSLACT00000019420.1	ENSLACP00000019286.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	5.10e-87	292.4	693	1535

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle.kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsg 86
           tGl+NlgNtC+mNS +Qc sn++ l++++ + ++  +ln++np ++ g+++k++ +l++elw++++k+v+p +l   +kk++     
   Q: 693  TGLSNLGNTCFMNSSIQCVSNTQALTQYFISgRHLYELNRTNPIGMRGHMAKCYGDLVQELWSGTQKNVAPLKLRIEVKKVQF---- 775
           7******************************9******************************************999997764.... PP
   S: 87   yeqqDaqEfla.....flldqleeelkkeknkpkeeeeeedkselsde.........aeekkkkknkslisdlFqgqlksqikclec 159
            +q+D q ++      f+l++  +++           +    +  +           a+e++ ++nks+++dlF+gqlksq+kc++c
   Q: 776  -KQKDHQNLCGqgvqvFFLNKPYDSI-----------FVVCYKCIPTVlpvlsgqkeAWENHLRRNKSIVVDLFHGQLKSQVKCKTC 850
           .4666665554000014444444444...........222222222223333333349***************************** PP
   S: 160  dnvssreepfldlslpvpgkeetkke............................................................. 185
           +++s+r++pf+ lslp+p+++ ++ e                                                             
   Q: 851  GHISVRFDPFNFLSLPLPMDSYMHVEitvikldgstpvryglrlnmdekytglkkqlsdlcnlkpeqillaevhssniknfpqdnqk 937
           ***********************999************************************************************* PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 938  grlsvsgflcafeipvpgsptsassasspvqtdsstvplpngkhsltangsaseptlipnglpntmvpsgteknigngipnghiati 1024
           *************************************************************************************** PP
   S: 186  ....................................................................................... 185
                                                                                                  
   Q: 1025 lespfigyiiafhrkmmrtelyflssqknrpslfgmplivpctvhtrkkdlydaiwiqvsrlasplppqeasnhaqdcddsmgyqyp 1111
           *************************************************************************************** PP
   S: 186  ...............................................................................slqdcLes 193
                                                                                          +l++cL++
   Q: 1112 ftlrvvqkdgnacswcpwyrfcrgckidccderatvgnayiaidwdptalhlryqtsqeriveehesveqsrraqaepiNLDSCLRA 1198
           *************************************************************************************** PP
   S: 194  ftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefple.Ldlspfcts............ 267
           ft+eeel ++++yyc+kck ++ a+kkl+l++lP++Li+hLkRf+f +   + +k +k v+fp+e +d s f++             
   Q: 1199 FTSEEELGEDEMYYCSKCKTHCLATKKLDLWRLPPILIIHLKRFQFVNG--RWIKSQKIVKFPREkFDPSAFLVPrdpalcqqkgvt 1283
           ********************************************99775..5569*********99*****9999999999999999 PP
   S: 268  ....................................................................................... 267
                                                                                                  
   Q: 1284 srmddllephvlplqpkkpdvgnshptgngdtlsgvppvvstailnntkaspssarknsnnsssknnspsnsprtlgrskgrlrlpq 1370
           999999999999999999999999999999999999999999999999999888888877777666666666666666666666666 PP
   S: 268  ..................peekqke.............................................................. 274
                             +     +                                                              
   Q: 1371 lgnrnklsnskenldggkE-----Ngndqeqrlssdqsdangkacllggnhddslpegvpttqeteeilvnglihekeqngcsnvts 1452
           6666655555555555550.....055555666666666667777777777777777777777777788888888888888888899 PP
   S: 275  ......................kkkYeLiavvvHsGslssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlfYkrr 338
                                 k  Y+L+a+ +HsG l++GHYv+y+kn ++kW++++Ds+++ev+ ee+ +   ++aY+lfY+++
   Q: 1453 sgqiesymdedsaddqrdelclKPMYNLYAISCHSGILGGGHYVTYAKNPNNKWYYYNDSSCKEVPSEEIDT---DSAYILFYEQQ 1535
           9999999999999999999*99**************************************************...********985 PP

Organism

Latimeria chalumnae

Protein Sequence
(Fasta)

MNQQCFIKEV LGDGVPLKVA EVIYSSFGGT SKGLHFNNLI VGLVLLTRGR DEEKPKYIFS 60
LFANESGSYI VREEMESMLR AIDGEVPVSL KKCFSEGDKV NYDKFKNWLL QNKDAFTFSR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTGAGCAG CTCGGGTCAT GTGATTAAGC ATGGAGGCGT CGGCGAAGGG AAGCATCATC 60
AGTTGAGGAA GGAGAGGCGG CGGGGAAGAG TGAAAATAAA CAGAGGAAAA CAAACTGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0106--Calcium
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR011992--EF-hand-dom_pair
IPR018247--EF_Hand_1_Ca_BS
IPR002048--EF_hand_dom
IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR028135--Ub_USP-typ
IPR029071--Ubiquitin-rel_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00018--EF_HAND_1
PS50222--EF_HAND_2
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF13202--EF-hand_5
PF14836--Ubiquitin_3
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0005509--F:calcium ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001611	Ailuropoda melanoleuca	76.81	0.00e+00	2090.00
IUUC-Apl-003272	Anas platyrhynchos	76.73	0.00e+00	2417.00
IUUC-Aca-005057	Anolis carolinensis	77.67	0.00e+00	2052.00
IUUC-Ame-010781	Astyanax mexicanus	72.88	0.00e+00	2262.00
IUUC-Bta-013502	Bos taurus	75.02	0.00e+00	2268.00
IUUC-Cja-018754	Callithrix jacchus	78.29	0.00e+00	2420.00
IUUC-Cfa-020526	Canis familiaris	78.11	0.00e+00	2427.00
IUUC-Cpo-021568	Cavia porcellus	74.47	0.00e+00	2233.00
IUUC-Csa-023143	Chlorocebus sabaeus	77.91	0.00e+00	2397.00
IUUC-Cho-024603	Choloepus hoffmanni	50.17	7.00e-144	505.00
IUUC-Cin-025583	Ciona intestinalis	46.91	0.00e+00	1096.00
IUUC-Csv-026344	Ciona savignyi	42.21	0.00e+00	1002.00
IUUC-Dre-028121	Danio rerio	72.70	0.00e+00	2230.00
IUUC-Dno-029911	Dasypus novemcinctus	77.70	0.00e+00	2407.00
IUUC-Dor-030608	Dipodomys ordii	59.55	0.00e+00	833.00
IUUC-Dme-032094	Drosophila melanogaster	39.24	2.00e-94	341.00
IUUC-Ete-032639	Echinops telfairi	71.94	0.00e+00	1208.00
IUUC-Eca-034253	Equus caballus	78.24	0.00e+00	2449.00
IUUC-Eeu-035084	Erinaceus europaeus	70.37	0.00e+00	1273.00
IUUC-Fca-035474	Felis catus	75.91	0.00e+00	1990.00
IUUC-Fal-036985	Ficedula albicollis	76.32	0.00e+00	2380.00
IUUC-Gmo-039568	Gadus morhua	76.95	0.00e+00	1965.00
IUUC-Gga-040509	Gallus gallus	76.06	0.00e+00	2392.00
IUUC-Gac-041757	Gasterosteus aculeatus	77.77	0.00e+00	2033.00
IUUC-Ggo-044956	Gorilla gorilla	75.44	0.00e+00	1429.00
IUUC-Hsa-046107	Homo sapiens	78.16	0.00e+00	2423.00
IUUC-Itr-048865	Ictidomys tridecemlineatus	73.49	0.00e+00	929.00
IUUC-Loc-052474	Lepisosteus oculatus	76.55	0.00e+00	2352.00
IUUC-Laf-054273	Loxodonta africana	77.67	0.00e+00	2410.00
IUUC-Mcc-054718	Macaca mulatta	78.04	0.00e+00	2419.00
IUUC-Meu-056558	Macropus eugenii	61.18	0.00e+00	1105.00
IUUC-Mga-059892	Meleagris gallopavo	77.98	0.00e+00	2411.00
IUUC-Mmr-060866	Microcebus murinus	78.45	0.00e+00	2450.00
IUUC-Mdo-062607	Monodelphis domestica	78.93	0.00e+00	2484.00
IUUC-Mmu-063797	Mus musculus	77.75	0.00e+00	2444.00
IUUC-Mpu-066121	Mustela putorius furo	78.30	0.00e+00	2443.00
IUUC-Mlu-067581	Myotis lucifugus	77.17	0.00e+00	2442.00
IUUC-Nle-069916	Nomascus leucogenys	76.04	0.00e+00	2336.00
IUUC-Opr-071073	Ochotona princeps	73.54	0.00e+00	1008.00
IUUC-Ont-071310	Oreochromis niloticus	78.28	0.00e+00	1985.00
IUUC-Oan-073356	Ornithorhynchus anatinus	78.13	0.00e+00	2459.00
IUUC-Ocu-074216	Oryctolagus cuniculus	78.40	0.00e+00	2427.00
IUUC-Ola-087434	Oryzias latipes	71.50	0.00e+00	2139.00
IUUC-Oga-089034	Otolemur garnettii	78.09	0.00e+00	2429.00
IUUC-Oar-090369	Ovis aries	78.41	0.00e+00	2452.00
IUUC-Ptr-090605	Pan troglodytes	78.23	0.00e+00	2429.00
IUUC-Pan-092381	Papio anubis	77.99	0.00e+00	2422.00
IUUC-Psi-093819	Pelodiscus sinensis	79.61	0.00e+00	2493.00
IUUC-Pma-094480	Petromyzon marinus	59.70	0.00e+00	1318.00
IUUC-Pfo-096561	Poecilia formosa	76.88	0.00e+00	1951.00
IUUC-Pab-097643	Pongo abelii	78.00	0.00e+00	2382.00
IUUC-Pca-100944	Procavia capensis	73.00	0.00e+00	700.00
IUUC-Pva-102732	Pteropus vampyrus	69.29	0.00e+00	2071.00
IUUC-Rno-105113	Rattus norvegicus	77.85	0.00e+00	2414.00
IUUC-Sha-107608	Sarcophilus harrisii	71.46	7.00e-147	513.00
IUUC-Sar-113201	Sorex araneus	74.47	0.00e+00	1087.00
IUUC-Ssc-115469	Sus scrofa	69.40	4.00e-140	491.00
IUUC-Tgu-117322	Taeniopygia guttata	77.24	0.00e+00	2444.00
IUUC-Tru-118705	Takifugu rubripes	67.80	2.00e-159	556.00
IUUC-Tsy-119433	Tarsius syrichta	67.07	0.00e+00	1706.00
IUUC-Tni-120631	Tetraodon nigroviridis	76.88	0.00e+00	1995.00
IUUC-Tbe-127553	Tupaia belangeri	77.27	5.00e-163	568.00
IUUC-Ttr-128260	Tursiops truncatus	77.47	0.00e+00	2405.00
IUUC-Vpa-130479	Vicugna pacos	73.51	0.00e+00	2237.00
IUUC-Xtr-132686	Xenopus tropicalis	78.57	0.00e+00	2384.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence