iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-059886

Ensembl Protein ID

ENSMGAP00000010603.1

UniProt Accession

G1NCU1; G1NCU1_MELGA

Protein Name

Protein kinase C

Gene Name

PRKCI

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000010216.2	ENSMGAT00000011464.1	ENSMGAP00000010603.1
ENSMGAG00000010216.2	ENSMGAT00000020701.1	ENSMGAP00000017704.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
ULD/UDP/UFD/PB1	3.90e-16	58.8	3	72

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

ULD/UDP/UFD/PB1

   S: 15   faldlekpgkfedLlkavrtltelkn.sevalkYeDedGDlvtlksDedldkavslla.skksllrlliq 82
           + + +e++++fe L+++vr++++++n + +++k+ De+GD +t++s+ +l++a++l++ +k+s l ++++
   Q: 3    MITYFEPSISFEGLCSEVRDMCSFDNeQLFTMKWIDEEGDPCTVSSQLELEEAFRLYElNKDSELLIHVF 72
           5567999*************************************************************98 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

DIMITYFEPS ISFEGLCSEV RDMCSFDNEQ LFTMKWIDEE GDPCTVSSQL ELEEAFRLYE 60
LNKDSELLIH VFPCVPERPG MPCPGEDKSI YRRGARRWRK LYCANGHTFQ AKRFNRRAHC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GACATCATGA TAACGTATTT TGAACCTTCC ATCTCGTTTG AGGGACTGTG CAGTGAAGTT 60
CGAGACATGT GCTCCTTTGA CAACGAGCAG CTTTTCACCA TGAAATGGAT TGATGAAGAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0479--Metal-binding
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR000961--AGC-kinase_C
IPR034661--aPKC_iota
IPR020454--DAG/PE-bd
IPR011009--Kinase-like_dom
IPR000270--PB1_dom
IPR002219--PE/DAG-bd
IPR012233--PKC
IPR017892--Pkinase_C
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS51285--AGC_KINASE_CTER
PS51745--PB1
PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS00479--ZF_DAG_PE_1
PS50081--ZF_DAG_PE_2

Pfam

PF00130--C1_1
PF00564--PB1
PF00069--Pkinase
PF00433--Pkinase_C

PRINTS

PR00008--DAGPEDOMAIN

SMART

SM00109--C1
SM00666--PB1
SM00133--S_TK_X
SM00220--S_TKc

Gene Ontology

GO:0016324--C:apical plasma membrane
GO:0005829--C:cytosol
GO:0070062--C:extracellular exosome
GO:0045171--C:intercellular bridge
GO:0015630--C:microtubule cytoskeleton
GO:0005634--C:nucleus
GO:0043220--C:Schmidt-Lanterman incisure
GO:0005524--F:ATP binding
GO:0046872--F:metal ion binding
GO:0005543--F:phospholipid binding
GO:0004697--F:protein kinase C activity
GO:0007015--P:actin filament organization
GO:0045216--P:cell-cell junction organization
GO:0032869--P:cellular response to insulin stimulus
GO:0035089--P:establishment of apical/basal cell polarity
GO:0042462--P:eye photoreceptor cell development
GO:0035556--P:intracellular signal transduction
GO:0034351--P:negative regulation of glial cell apoptotic process
GO:0043524--P:negative regulation of neuron apoptotic process
GO:0018105--P:peptidyl-serine phosphorylation
GO:2000353--P:positive regulation of endothelial cell apoptotic process
GO:0090004--P:positive regulation of establishment of protein localization to plasma membrane
GO:0060252--P:positive regulation of glial cell proliferation
GO:0046326--P:positive regulation of glucose import
GO:0010976--P:positive regulation of neuron projection development
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001764	Ailuropoda melanoleuca	95.25	0.00e+00	985.00
IUUC-Apl-003711	Anas platyrhynchos	99.47	0.00e+00	1109.00
IUUC-Aca-005142	Anolis carolinensis	96.10	0.00e+00	1067.00
IUUC-Ame-010977	Astyanax mexicanus	88.83	0.00e+00	956.00
IUUC-Bta-013414	Bos taurus	95.74	0.00e+00	1074.00
IUUC-Bol-015169	Brassica oleracea	35.29	1.00e-50	194.00
IUUC-Cel-018340	Caenorhabditis elegans	59.97	0.00e+00	693.00
IUUC-Cja-019802	Callithrix jacchus	95.58	0.00e+00	1070.00
IUUC-Cfa-021236	Canis familiaris	95.39	0.00e+00	1042.00
IUUC-Cpo-022127	Cavia porcellus	94.16	0.00e+00	1025.00
IUUC-Csa-023332	Chlorocebus sabaeus	95.45	0.00e+00	914.00
IUUC-Cho-025054	Choloepus hoffmanni	62.33	6.00e-107	380.00
IUUC-Cin-025740	Ciona intestinalis	60.63	0.00e+00	676.00
IUUC-Csv-026145	Ciona savignyi	79.49	4.00e-171	593.00
IUUC-Dre-028444	Danio rerio	90.07	0.00e+00	979.00
IUUC-Dno-029228	Dasypus novemcinctus	99.03	0.00e+00	642.00
IUUC-Dme-031630	Drosophila melanogaster	69.07	0.00e+00	776.00
IUUC-Ete-032633	Echinops telfairi	70.18	4.00e-173	600.00
IUUC-Eca-033572	Equus caballus	95.92	0.00e+00	1076.00
IUUC-Eeu-035110	Erinaceus europaeus	95.21	0.00e+00	1068.00
IUUC-Fca-035559	Felis catus	95.74	0.00e+00	1077.00
IUUC-Fal-036953	Ficedula albicollis	98.76	0.00e+00	1099.00
IUUC-Gmo-039334	Gadus morhua	88.65	0.00e+00	985.00
IUUC-Gga-040223	Gallus gallus	99.29	0.00e+00	1106.00
IUUC-Gac-042113	Gasterosteus aculeatus	89.36	0.00e+00	990.00
IUUC-Ggo-044520	Gorilla gorilla	88.69	0.00e+00	969.00
IUUC-Hsa-046991	Homo sapiens	95.57	0.00e+00	1074.00
IUUC-Lch-050263	Latimeria chalumnae	90.07	0.00e+00	1007.00
IUUC-Loc-052221	Lepisosteus oculatus	91.13	0.00e+00	986.00
IUUC-Laf-053591	Loxodonta africana	96.10	0.00e+00	1079.00
IUUC-Mcc-055118	Macaca mulatta	93.79	0.00e+00	1044.00
IUUC-Mmr-060926	Microcebus murinus	95.92	0.00e+00	1077.00
IUUC-Mdo-062698	Monodelphis domestica	94.86	0.00e+00	1051.00
IUUC-Mmu-063689	Mus musculus	95.57	0.00e+00	1070.00
IUUC-Mpu-066630	Mustela putorius furo	95.74	0.00e+00	1074.00
IUUC-Mlu-067416	Myotis lucifugus	92.57	0.00e+00	995.00
IUUC-Nle-069811	Nomascus leucogenys	95.57	0.00e+00	1072.00
IUUC-Opr-070466	Ochotona princeps	83.71	0.00e+00	710.00
IUUC-Ont-072278	Oreochromis niloticus	87.09	0.00e+00	956.00
IUUC-Oan-073651	Ornithorhynchus anatinus	98.90	0.00e+00	743.00
IUUC-Ocu-074383	Oryctolagus cuniculus	95.74	0.00e+00	1075.00
IUUC-Ola-087283	Oryzias latipes	82.90	0.00e+00	766.00
IUUC-Oga-088337	Otolemur garnettii	88.03	0.00e+00	969.00
IUUC-Oar-089954	Ovis aries	95.74	0.00e+00	1077.00
IUUC-Ptr-091673	Pan troglodytes	95.57	0.00e+00	1074.00
IUUC-Pan-092494	Papio anubis	95.74	0.00e+00	1075.00
IUUC-Psi-094044	Pelodiscus sinensis	97.16	0.00e+00	1077.00
IUUC-Pfo-096661	Poecilia formosa	87.50	0.00e+00	948.00
IUUC-Pab-097659	Pongo abelii	95.39	0.00e+00	1070.00
IUUC-Pca-101107	Procavia capensis	95.26	0.00e+00	759.00
IUUC-Rno-105790	Rattus norvegicus	95.92	0.00e+00	1076.00
IUUC-Sha-106895	Sarcophilus harrisii	96.28	0.00e+00	1051.00
IUUC-Sar-113513	Sorex araneus	93.19	3.00e-172	597.00
IUUC-Ssc-115835	Sus scrofa	95.23	0.00e+00	987.00
IUUC-Tgu-116874	Taeniopygia guttata	98.40	0.00e+00	1098.00
IUUC-Tru-117823	Takifugu rubripes	88.44	0.00e+00	960.00
IUUC-Tsy-119154	Tarsius syrichta	95.74	0.00e+00	1075.00
IUUC-Tni-119968	Tetraodon nigroviridis	87.41	0.00e+00	942.00
IUUC-Tbe-127238	Tupaia belangeri	75.65	0.00e+00	718.00
IUUC-Ttr-129208	Tursiops truncatus	95.57	0.00e+00	1073.00
IUUC-Vpa-130363	Vicugna pacos	85.46	0.00e+00	918.00
IUUC-Xtr-132652	Xenopus tropicalis	87.96	0.00e+00	986.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence