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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Rno-105515
Ensembl Protein ID ENSRNOP00000057895.2
UniProt Accession A0JN27; TF2H2_RAT
Genbank Protein ID AAI26098.1
Protein Name General transcription factor IIH subunit 2; Basic transcription factor 2 44 kDa subunit; General transcription factor IIH polypeptide 2; TFIIH basal transcription factor complex p44 subunit
Genbank Nucleotide ID BC126097
Gene Name Gtf2h2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSRNOG00000018230.7 ENSRNOT00000061183.3 ENSRNOP00000057895.2
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpress
DNA & RNA Element
TRANSFACRAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 activity/RING/RING 39.49 2.00e-74 273.00 IUUC-Sce-106434
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Rattus norvegicus
Functional Description
(View)

Functional Description


     Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.
 Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. The N-terminus interacts with and regulates XPD whereas an intact C-terminus is required for a successful escape of RNAP II form the promoter.
Protein Sequence
(Fasta)
MDEEPERTKR WEGGYERTWE ILKEDESGSL KATIEDILFK AKRKRVFEHH GQVRLGMMRH 60
LYVVVDGSRT MEDQDLKPNR LTCTLKLLEY FVEEYFDQNP ISQIGIIVTK SKRAEKLTEL 120
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Protein Fasta Sequence


>IUUC-Rno-105515|E3,RING|Rattus norvegicus
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Nucleotide Sequence
(Fasta)
CTCCTACTGA CGACACTTCC GGTGAGGGTC TTCTAGTCGA GGCCGGTGAG TCTACTTGTG 60
GAGACCCGCG GGGTGCTGAG GCTGTGGAGG CTGACTAGAG GGACCTGGAG CTGAGGACCG 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Rno-105515|E3,RING|Rattus norvegicus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0804--Transcription
KW-0805--Transcription regulation
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR007198--Ssl1-like
IPR004595--TFIIH_C1-like_dom
IPR012170--TFIIH_SSL1/p44
IPR002035--VWF_A
IPR013087--Znf_C2H2_type
PROSITE

PS50234--VWFA
Pfam

PF07975--C1_4
PF04056--Ssl1
SMART

SM01047--C1_4
SM00327--VWA
Gene Ontology

GO:0000438--C:core TFIIH complex portion of holo TFIIH complex
GO:0005675--C:holo TFIIH complex
GO:0005634--C:nucleus
GO:0003676--F:nucleic acid binding
GO:0008270--F:zinc ion binding
GO:0006289--P:nucleotide-excision repair
GO:0006468--P:protein phosphorylation
GO:0006357--P:regulation of transcription from RNA polymerase II promoter
GO:0006366--P:transcription from RNA polymerase II promoter
KEGG rno:294693
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000536 Aegilops tauschii 35.03 2.00e-46 179.00
IUUC-Aml-002041 Ailuropoda melanoleuca 95.45 0.00e+00 744.00
IUUC-Atr-003056 Amborella trichopoda 43.96 5.00e-74 271.00
IUUC-Apl-003464 Anas platyrhynchos 86.98 0.00e+00 634.00
IUUC-Aca-004745 Anolis carolinensis 89.11 0.00e+00 673.00
IUUC-Aly-005559 Arabidopsis lyrata 41.28 2.00e-81 295.00
IUUC-Ath-007556 Arabidopsis thaliana 41.28 2.00e-81 295.00
IUUC-Ago-007851 Ashbya gossypii 39.24 2.00e-81 296.00
IUUC-Acl-008100 Aspergillus clavatus 39.66 4.00e-81 295.00
IUUC-Afl-008649 Aspergillus flavus 40.91 7.00e-12 61.20
IUUC-Afu-009066 Aspergillus fumigatus 38.72 7.00e-82 297.00
IUUC-Ani-009372 Aspergillus nidulans 39.33 3.00e-78 285.00
IUUC-Ang-009726 Aspergillus niger 39.26 3.00e-84 305.00
IUUC-Aor-010135 Aspergillus oryzae 38.86 5.00e-79 288.00
IUUC-Ate-010399 Aspergillus terreus 37.66 2.00e-24 105.00
IUUC-Ame-011618 Astyanax mexicanus 81.19 0.00e+00 686.00
IUUC-Bgr-012154 Blumeria graminis 37.19 1.00e-77 283.00
IUUC-Bta-012353 Bos taurus 95.20 0.00e+00 763.00
IUUC-Bci-013932 Botrytis cinerea 38.75 3.00e-82 298.00
IUUC-Bdi-014391 Brachypodium distachyon 40.41 2.00e-77 282.00
IUUC-Bol-015128 Brassica oleracea 41.71 3.00e-82 298.00
IUUC-Bra-017932 Brassica rapa 41.71 4.00e-82 298.00
IUUC-Cel-018649 Caenorhabditis elegans 42.56 3.00e-86 311.00
IUUC-Cja-018776 Callithrix jacchus 95.71 0.00e+00 741.00
IUUC-Cfa-020584 Canis familiaris 96.21 0.00e+00 748.00
IUUC-Cpo-021300 Cavia porcellus 95.45 0.00e+00 746.00
IUUC-Cre-022657 Chlamydomonas reinhardtii 41.84 8.00e-74 270.00
IUUC-Csa-024092 Chlorocebus sabaeus 96.46 0.00e+00 748.00
IUUC-Cho-024919 Choloepus hoffmanni 87.78 6.00e-102 362.00
IUUC-Cin-025386 Ciona intestinalis 53.15 9.00e-112 396.00
IUUC-Csv-026295 Ciona savignyi 50.00 3.00e-106 378.00
IUUC-Cgl-026612 Colletotrichum gloeosporioides 35.78 2.00e-69 256.00
IUUC-Cne-026956 Cryptococcus neoformans 34.88 4.00e-79 288.00
IUUC-Cme-027150 Cyanidioschyzon merolae 32.34 1.00e-47 184.00
IUUC-Dre-027962 Danio rerio 82.22 0.00e+00 691.00
IUUC-Dno-029979 Dasypus novemcinctus 93.85 0.00e+00 631.00
IUUC-Dse-031405 Dothistroma septosporum 36.10 5.00e-68 251.00
IUUC-Dme-031710 Drosophila melanogaster 50.49 2.00e-113 402.00
IUUC-Ete-032631 Echinops telfairi 88.64 0.00e+00 693.00
IUUC-Eca-034054 Equus caballus 94.19 0.00e+00 737.00
IUUC-Fca-035724 Felis catus 91.16 0.00e+00 720.00
IUUC-Fal-036987 Ficedula albicollis 88.78 0.00e+00 742.00
IUUC-Fox-037692 Fusarium oxysporum 36.80 2.00e-72 266.00
IUUC-Fso-038442 Fusarium solani 38.44 6.00e-74 271.00
IUUC-Gmo-039273 Gadus morhua 76.84 0.00e+00 655.00
IUUC-Ggr-040009 Gaeumannomyces graminis 34.84 3.00e-57 216.00
IUUC-Gga-041089 Gallus gallus 87.63 0.00e+00 737.00
IUUC-Gac-041978 Gasterosteus aculeatus 77.38 4.00e-180 624.00
IUUC-Gma-043371 Glycine max 42.39 2.00e-89 323.00
IUUC-Hsa-046001 Homo sapiens 96.21 0.00e+00 746.00
IUUC-Itr-048355 Ictidomys tridecemlineatus 96.46 0.00e+00 778.00
IUUC-Kpa-049235 Komagataella pastoris 40.25 4.00e-75 275.00
IUUC-Lch-049926 Latimeria chalumnae 84.69 0.00e+00 685.00
IUUC-Lpe-051352 Leersia perrieri 39.90 1.00e-73 270.00
IUUC-Loc-051987 Lepisosteus oculatus 84.28 0.00e+00 699.00
IUUC-Lma-053171 Leptosphaeria maculans 32.97 9.00e-61 228.00
IUUC-Laf-054372 Loxodonta africana 96.19 0.00e+00 766.00
IUUC-Mcc-055108 Macaca mulatta 96.72 0.00e+00 749.00
IUUC-Mor-056990 Magnaporthe oryzae 35.14 2.00e-73 270.00
IUUC-Mtr-058401 Medicago truncatula 41.10 4.00e-87 315.00
IUUC-Mla-059186 Melampsora laricipopulina 40.44 1.00e-86 313.00
IUUC-Mvi-060262 Microbotryum violaceum 37.78 2.00e-83 303.00
IUUC-Mmr-061688 Microcebus murinus 88.41 0.00e+00 686.00
IUUC-Mdo-062154 Monodelphis domestica 92.17 0.00e+00 747.00
IUUC-Mmu-064232 Mus musculus 98.23 0.00e+00 762.00
IUUC-Mac-065091 Musa acuminata 41.98 4.00e-81 295.00
IUUC-Mpu-066747 Mustela putorius furo 89.14 0.00e+00 676.00
IUUC-Mlu-067799 Myotis lucifugus 87.91 0.00e+00 668.00
IUUC-Nfi-068371 Neosartorya fischeri 32.69 4.00e-18 83.60
IUUC-Ncr-068704 Neurospora crassa 38.74 1.00e-70 260.00
IUUC-Nle-069054 Nomascus leucogenys 95.96 0.00e+00 742.00
IUUC-Ont-071624 Oreochromis niloticus 77.63 0.00e+00 639.00
IUUC-Oan-072898 Ornithorhynchus anatinus 91.92 0.00e+00 738.00
IUUC-Ocu-074289 Oryctolagus cuniculus 97.43 9.00e-175 605.00
IUUC-Oba-075985 Oryza barthii 39.14 2.00e-72 266.00
IUUC-Obr-076887 Oryza brachyantha 40.25 3.00e-76 279.00
IUUC-Ogl-077823 Oryza glaberrima 39.14 2.00e-72 266.00
IUUC-Ogu-078412 Oryza glumaepatula 41.02 2.00e-66 246.00
IUUC-Oin-079569 Oryza indica 36.51 6.00e-49 188.00
IUUC-Olo-080249 Oryza longistaminata 36.63 7.00e-48 185.00
IUUC-Ome-081240 Oryza meridionalis 41.02 5.00e-67 248.00
IUUC-Oni-082152 Oryza nivara 41.02 2.00e-66 246.00
IUUC-Opu-084011 Oryza punctata 38.89 4.00e-72 265.00
IUUC-Oru-084719 Oryza rufipogon 40.68 5.00e-68 251.00
IUUC-Osa-085286 Oryza sativa 39.39 1.00e-73 270.00
IUUC-Ola-086525 Oryzias latipes 68.21 1.00e-152 532.00
IUUC-Olu-087876 Ostreococcus lucimarinus 41.54 4.00e-69 254.00
IUUC-Oga-088125 Otolemur garnettii 93.94 0.00e+00 751.00
IUUC-Oar-089701 Ovis aries 95.45 0.00e+00 763.00
IUUC-Ptr-091218 Pan troglodytes 96.46 0.00e+00 749.00
IUUC-Pan-091755 Papio anubis 96.72 0.00e+00 749.00
IUUC-Psi-094061 Pelodiscus sinensis 92.60 0.00e+00 746.00
IUUC-Pma-094430 Petromyzon marinus 75.89 4.00e-118 417.00
IUUC-Pno-094900 Phaeosphaeria nodorum 31.36 2.00e-24 107.00
IUUC-Ppa-095895 Physcomitrella patens 42.71 1.00e-84 306.00
IUUC-Pfo-096297 Poecilia formosa 81.03 7.00e-125 439.00
IUUC-Pab-097717 Pongo abelii 96.72 0.00e+00 749.00
IUUC-Pop-098938 Populus trichocarpa 41.49 2.00e-83 302.00
IUUC-Pca-100389 Procavia capensis 84.90 8.00e-169 586.00
IUUC-Ppe-102045 Prunus persica 41.18 8.00e-82 297.00
IUUC-Pva-102357 Pteropus vampyrus 90.91 7.00e-99 352.00
IUUC-Pgr-103399 Puccinia graminis 42.79 3.00e-93 335.00
IUUC-Ptt-103872 Puccinia triticina 43.77 7.00e-94 337.00
IUUC-Pte-104092 Pyrenophora teres 33.96 2.00e-53 203.00
IUUC-Pyt-104669 Pyrenophora triticirepentis 34.50 7.00e-54 204.00
IUUC-Sce-106434 Saccharomyces cerevisiae 39.49 1.00e-81 296.00
IUUC-Sha-106808 Sarcophilus harrisii 92.93 0.00e+00 749.00
IUUC-Sja-107995 Schizosaccharomyces japonicus 41.98 1.00e-80 293.00
IUUC-Spo-108044 Schizosaccharomyces pombe 39.95 5.00e-82 298.00
IUUC-Smo-109581 Selaginella moellendorffii 42.42 7.00e-84 303.00
IUUC-Sit-110704 Setaria italica 40.10 2.00e-77 283.00
IUUC-Sly-110990 Solanum lycopersicum 44.66 1.00e-70 259.00
IUUC-Stu-112542 Solanum tuberosum 41.26 1.00e-45 176.00
IUUC-Sar-113766 Sorex araneus 94.44 3.00e-174 603.00
IUUC-Sbi-114016 Sorghum bicolor 40.36 2.00e-75 276.00
IUUC-Sre-115099 Sporisorium reilianum 38.00 5.00e-82 298.00
IUUC-Ssc-115277 Sus scrofa 95.20 0.00e+00 728.00
IUUC-Tgu-117343 Taeniopygia guttata 87.34 0.00e+00 734.00
IUUC-Tru-118397 Takifugu rubripes 76.61 4.00e-179 620.00
IUUC-Tni-120272 Tetraodon nigroviridis 75.64 8.00e-178 615.00
IUUC-Tca-121514 Theobroma cacao 42.78 1.00e-90 326.00
IUUC-Tre-121990 Trichoderma reesei 37.62 1.00e-69 256.00
IUUC-Tvi-122504 Trichoderma virens 39.07 2.00e-69 256.00
IUUC-Tae-123153 Triticum aestivum 40.00 6.00e-77 281.00
IUUC-Tur-126693 Triticum urartu 43.51 7.00e-61 227.00
IUUC-Tme-127011 Tuber melanosporum 39.56 5.00e-78 285.00
IUUC-Tbe-127939 Tupaia belangeri 95.71 0.00e+00 743.00
IUUC-Ttr-128889 Tursiops truncatus 86.87 0.00e+00 685.00
IUUC-Uma-129450 Ustilago maydis 37.21 4.00e-81 295.00
IUUC-Vda-129919 Verticillium dahliae 36.56 8.00e-66 244.00
IUUC-Vvi-130928 Vitis vinifera 42.78 7.00e-86 310.00
IUUC-Xtr-131891 Xenopus tropicalis 72.61 9.00e-175 606.00
IUUC-Xma-133260 Xiphophorus maculatus 80.24 4.00e-124 436.00
IUUC-Yli-134578 Yarrowia lipolytica 37.69 6.00e-76 278.00
IUUC-Zma-135427 Zea mays 40.46 3.00e-76 279.00
Created Date 25-Jun-2017

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