iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID
Post-translational Modifications (PTMs)
CPLM	dbPTM
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/Alpha-Helix/CUE	CUE	17825049

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	0.001	19.8	335	373
UBD/Alpha-Helix/CUE	8.70e-13	48.2	432	473

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C +C+e + +  + lpC H+fh  Cl  w        +  +CP+Cr
   Q: 335  CVVCWELLGT-SRRLPCSHQFHDWCLMWW------LAQDSSCPTCR 373
           ********99.999***********9888......99999*****8 PP

UBD/Alpha-Helix/CUE

   S: 1    dletaleqLkeiFPnldysviqvvLeantgsleaavnnLLegs 43
           +l t+leq++e+FP++++++i+ +L  + gs +++++n+Leg 
   Q: 432  QLQTMLEQVREMFPQMSVDIIMTDL-RQSGSAQSTIENILEGR 473
           689**********************.***************95 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Proposed to have a role in neuroprotection.

Protein Sequence
(Fasta)

MGVVNLLSRS SFPSVDSYLA LSVLVAIVAS VTVFTTFRSQ PELQKLIEEE LRNNTRLSSA 60
YGLNIEALSG HTFFQIAHYI LSDTTLIWVA INSYFAILAV CTRLIIKLTF KELARQEENV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATACGG GGAACCCGGA TACCCGTCGT AACAATCAGG TACCCATGGG GGTTGTCAAT 60
CTACTATCCC GATCATCATT TCCATCTGTC GACTCATATC TGGCATTGTC AGTTCTTGTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003892--CUE
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51140--CUE
PS50089--ZF_RING_2

Pfam

PF02845--CUE
PF13639--zf-RING_2

SMART

SM00546--CUE
SM00184--RING

Gene Ontology

GO:0016021--C:integral component of membrane
GO:1904264--F:ubiquitin protein ligase activity involved in ERAD pathway
GO:1990381--F:ubiquitin-specific protease binding
GO:0008270--F:zinc ion binding
GO:0030968--P:endoplasmic reticulum unfolded protein response
GO:0035264--P:multicellular organism growth
GO:0000209--P:protein polyubiquitination
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:1901214--P:regulation of neuron death
GO:0030433--P:ubiquitin-dependent ERAD pathway

KEGG

cel:CELE_F26E4.11

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001300	Ailuropoda melanoleuca	24.76	2.00e-34	139.00
IUUC-Apl-003404	Anas platyrhynchos	24.88	1.00e-33	136.00
IUUC-Ago-007829	Ashbya gossypii	34.85	1.00e-06	45.80
IUUC-Ame-011640	Astyanax mexicanus	23.32	1.00e-41	163.00
IUUC-Bta-012980	Bos taurus	24.54	1.00e-34	139.00
IUUC-Cja-019577	Callithrix jacchus	25.00	3.00e-40	158.00
IUUC-Cfa-020793	Canis familiaris	24.41	4.00e-34	138.00
IUUC-Cpo-022387	Cavia porcellus	25.00	8.00e-41	160.00
IUUC-Csa-023168	Chlorocebus sabaeus	24.80	4.00e-41	161.00
IUUC-Cho-024433	Choloepus hoffmanni	24.62	2.00e-27	115.00
IUUC-Cin-025215	Ciona intestinalis	25.82	3.00e-39	154.00
IUUC-Csv-026133	Ciona savignyi	24.77	7.00e-36	144.00
IUUC-Dre-027594	Danio rerio	24.75	9.00e-38	150.00
IUUC-Dno-029407	Dasypus novemcinctus	24.64	3.00e-32	131.00
IUUC-Eca-033683	Equus caballus	22.51	2.00e-32	132.00
IUUC-Eeu-034515	Erinaceus europaeus	33.33	3.00e-13	68.90
IUUC-Fca-035398	Felis catus	23.70	4.00e-34	137.00
IUUC-Gmo-039014	Gadus morhua	23.56	3.00e-35	142.00
IUUC-Gga-040575	Gallus gallus	25.28	8.00e-38	150.00
IUUC-Gac-041414	Gasterosteus aculeatus	24.75	2.00e-38	152.00
IUUC-Hsa-046272	Homo sapiens	24.60	1.00e-39	156.00
IUUC-Itr-047956	Ictidomys tridecemlineatus	24.29	1.00e-33	136.00
IUUC-Lch-050491	Latimeria chalumnae	26.86	1.00e-37	150.00
IUUC-Loc-052758	Lepisosteus oculatus	23.41	1.00e-35	143.00
IUUC-Laf-053452	Loxodonta africana	24.53	4.00e-34	137.00
IUUC-Mcc-055820	Macaca mulatta	24.57	4.00e-32	131.00
IUUC-Mga-059937	Meleagris gallopavo	24.47	1.00e-32	133.00
IUUC-Mmr-060730	Microcebus murinus	25.00	4.00e-40	158.00
IUUC-Mdo-062771	Monodelphis domestica	25.00	4.00e-38	151.00
IUUC-Mmu-064219	Mus musculus	24.80	3.00e-40	158.00
IUUC-Mpu-066796	Mustela putorius furo	24.33	3.00e-32	132.00
IUUC-Mlu-068189	Myotis lucifugus	23.67	1.00e-36	146.00
IUUC-Nle-069239	Nomascus leucogenys	25.29	1.00e-38	153.00
IUUC-Ont-072033	Oreochromis niloticus	25.10	4.00e-40	158.00
IUUC-Oan-073717	Ornithorhynchus anatinus	24.82	4.00e-33	134.00
IUUC-Ocu-074145	Oryctolagus cuniculus	24.60	3.00e-40	158.00
IUUC-Ola-087152	Oryzias latipes	25.44	3.00e-39	155.00
IUUC-Oga-088486	Otolemur garnettii	24.65	5.00e-34	137.00
IUUC-Oar-089310	Ovis aries	24.53	5.00e-34	137.00
IUUC-Ptr-090649	Pan troglodytes	24.64	1.00e-33	136.00
IUUC-Pan-091692	Papio anubis	24.25	2.00e-38	152.00
IUUC-Pfo-096810	Poecilia formosa	24.05	5.00e-39	154.00
IUUC-Pab-097859	Pongo abelii	24.57	3.00e-32	131.00
IUUC-Pca-100344	Procavia capensis	24.21	3.00e-38	152.00
IUUC-Rno-105880	Rattus norvegicus	23.95	5.00e-37	147.00
IUUC-Sha-107015	Sarcophilus harrisii	25.23	1.00e-37	149.00
IUUC-Sar-113397	Sorex araneus	25.61	2.00e-31	129.00
IUUC-Ssc-115988	Sus scrofa	32.21	4.00e-12	63.90
IUUC-Tgu-116717	Taeniopygia guttata	25.40	9.00e-38	150.00
IUUC-Tru-117805	Takifugu rubripes	23.73	4.00e-37	148.00
IUUC-Tni-119777	Tetraodon nigroviridis	25.68	5.00e-31	127.00
IUUC-Ttr-128181	Tursiops truncatus	23.64	3.00e-34	138.00
IUUC-Xtr-132614	Xenopus tropicalis	31.97	7.00e-27	114.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence