iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Gga-040725

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AADN04000379

Gene Name

SOCS4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGALG00000012179.5	ENSGALT00000019886.3	ENSGALP00000019859.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.50e-15	57.2	374	421

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l r+ p+SLqh+CR +I++c++++++   d+LP+P+s k YL++++y+
   Q: 374  STPLNRTFPFSLQHICRTVICNCTTYDGI---DALPIPPSVKLYLKEYHYK 421
           5678899**********************...****************985 PP

Organism

Gallus gallus

Protein Sequence
(Fasta)

MAENKDSNTK NTDVRPKSSR SRSADRKDGY VWSGKKLSWS KKTERCSDAE TANAAGRSGP 60
NLRSQERKYS CSSIELDLDR SCGHRFLGRS LKQKLQDAVG QCFPIKNCTS RHASGLQSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGGCGGGCG CGGCTGGGGC CGCTCGGCGG TGGCTGAGCT CCGGCAGGTG ACGGGGCCGG 60
GCCGGGGCTG CCTCCTCACG GCTGCCGGGC GGCAGCGGCA GGTGAGCCCT AAGAGGGGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028416--SOCS4
IPR022252--SOCS4/SOCS5_dom
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

KEGG

gga:423557

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001789	Ailuropoda melanoleuca	79.91	0.00e+00	667.00
IUUC-Apl-003839	Anas platyrhynchos	92.43	0.00e+00	747.00
IUUC-Aca-004840	Anolis carolinensis	80.00	0.00e+00	706.00
IUUC-Bta-012503	Bos taurus	79.04	0.00e+00	663.00
IUUC-Bol-016597	Brassica oleracea	30.38	2.00e-02	33.90
IUUC-Cja-019284	Callithrix jacchus	79.04	0.00e+00	667.00
IUUC-Cfa-020890	Canis familiaris	80.41	0.00e+00	672.00
IUUC-Cpo-022081	Cavia porcellus	72.27	0.00e+00	627.00
IUUC-Csa-023076	Chlorocebus sabaeus	79.04	0.00e+00	671.00
IUUC-Cho-024700	Choloepus hoffmanni	78.86	0.00e+00	694.00
IUUC-Dno-029961	Dasypus novemcinctus	77.73	0.00e+00	693.00
IUUC-Dor-030273	Dipodomys ordii	78.86	0.00e+00	664.00
IUUC-Ete-032972	Echinops telfairi	77.81	2.00e-138	484.00
IUUC-Eca-034289	Equus caballus	79.32	0.00e+00	666.00
IUUC-Eeu-035208	Erinaceus europaeus	78.36	0.00e+00	649.00
IUUC-Fal-036829	Ficedula albicollis	90.14	0.00e+00	714.00
IUUC-Ggo-044886	Gorilla gorilla	78.82	0.00e+00	667.00
IUUC-Hsa-046322	Homo sapiens	78.59	0.00e+00	665.00
IUUC-Itr-048585	Ictidomys tridecemlineatus	78.29	0.00e+00	647.00
IUUC-Lch-049459	Latimeria chalumnae	57.70	1.00e-136	479.00
IUUC-Laf-053484	Loxodonta africana	79.08	0.00e+00	659.00
IUUC-Mcc-054890	Macaca mulatta	78.82	0.00e+00	669.00
IUUC-Meu-056532	Macropus eugenii	75.70	4.00e-167	580.00
IUUC-Mtr-057670	Medicago truncatula	37.04	5.70e+00	25.00
IUUC-Mvi-060418	Microbotryum violaceum	32.10	6.30e-02	30.80
IUUC-Mmr-061714	Microcebus murinus	79.27	0.00e+00	662.00
IUUC-Mmu-063161	Mus musculus	75.45	3.00e-180	624.00
IUUC-Mpu-066499	Mustela putorius furo	79.09	0.00e+00	689.00
IUUC-Mlu-066945	Myotis lucifugus	77.95	0.00e+00	645.00
IUUC-Nle-069976	Nomascus leucogenys	78.59	0.00e+00	664.00
IUUC-Opr-070255	Ochotona princeps	77.22	0.00e+00	650.00
IUUC-Ocu-074764	Oryctolagus cuniculus	78.64	0.00e+00	660.00
IUUC-Oga-088910	Otolemur garnettii	76.19	0.00e+00	665.00
IUUC-Oar-090330	Ovis aries	79.27	0.00e+00	665.00
IUUC-Ptr-090709	Pan troglodytes	78.82	0.00e+00	667.00
IUUC-Pan-092540	Papio anubis	79.04	0.00e+00	671.00
IUUC-Psi-093678	Pelodiscus sinensis	84.63	0.00e+00	747.00
IUUC-Pfo-097139	Poecilia formosa	80.92	1.00e-87	316.00
IUUC-Pab-097970	Pongo abelii	75.87	3.00e-153	534.00
IUUC-Pca-100211	Procavia capensis	68.64	8.00e-156	543.00
IUUC-Rno-106014	Rattus norvegicus	73.12	9.00e-180	622.00
IUUC-Sha-106822	Sarcophilus harrisii	77.22	0.00e+00	661.00
IUUC-Ssc-115821	Sus scrofa	79.09	0.00e+00	661.00
IUUC-Tgu-117117	Taeniopygia guttata	90.83	0.00e+00	719.00
IUUC-Tsy-118979	Tarsius syrichta	95.10	1.00e-118	418.00
IUUC-Tca-121131	Theobroma cacao	30.77	6.00e-03	35.00
IUUC-Vpa-130626	Vicugna pacos	79.32	0.00e+00	672.00
IUUC-Xtr-132138	Xenopus tropicalis	72.67	5.00e-174	603.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence