iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ont-072637

Ensembl Protein ID

ENSONIP00000012130.1

UniProt Accession

I3JTD5; I3JTD5_ORENI

Genbank Protein ID

ENSONIP00000012130

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AERX01046240

Gene Name

ARHGEF4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSONIG00000009654.1	ENSONIT00000012139.1	ENSONIP00000012130.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.90e-11	41.9	155	204

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 7    qvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
           + l+d    +d eL +k+Gdv++v+  + ++++W+ g       +G fP+ Fv+
   Q: 155  EGLWDHVTMDDQELGFKAGDVIEVV--DATNKEWWWG--RIMDSEGWFPASFVR 204
           669999*******************..9999******..8************97 PP

Organism

Oreochromis niloticus

Protein Sequence
(Fasta)

MRTQQGSEGG VPLPGGSCGS SGSGSSGLSP GSESDGGSPT GRGVDGMVDG GLGVGVCMGG 60
GGGGGGGGSL GGTLRGVLSR YWSLESLHST TDSATVAPDG TLEKSGFGDD LSSEEDLLYD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGCGGACTC AGCAGGGCTC GGAGGGGGGC GTGCCACTGC CAGGGGGCAG TTGTGGTAGT 60
AGCGGCAGTG GCAGCTCTGG GCTGTCACCG GGGTCTGAAT CAGACGGCGG GAGCCCAACA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0344--Guanine-nucleotide releasing factor
KW-1185--Reference proteome

Interpro

IPR000219--DH-domain
IPR001331--GDS_CDC24_CS
IPR011993--PH_dom-like
IPR001849--PH_domain
IPR001452--SH3_domain

PROSITE

PS00741--DH_1
PS50010--DH_2
PS50003--PH_DOMAIN
PS50002--SH3

Pfam

PF00169--PH
PF00621--RhoGEF
PF00018--SH3_1

SMART

SM00233--PH
SM00325--RhoGEF
SM00326--SH3

Gene Ontology

GO:0005622--C:intracellular
GO:0005089--F:Rho guanyl-nucleotide exchange factor activity
GO:0035556--P:intracellular signal transduction
GO:0035023--P:regulation of Rho protein signal transduction

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002073	Ailuropoda melanoleuca	64.32	0.00e+00	704.00
IUUC-Apl-004117	Anas platyrhynchos	65.32	0.00e+00	738.00
IUUC-Aca-004793	Anolis carolinensis	65.55	0.00e+00	714.00
IUUC-Ame-010682	Astyanax mexicanus	54.22	8.00e-172	598.00
IUUC-Bta-013253	Bos taurus	72.22	0.00e+00	832.00
IUUC-Cja-019555	Callithrix jacchus	63.99	0.00e+00	691.00
IUUC-Cfa-020578	Canis familiaris	64.67	0.00e+00	708.00
IUUC-Csa-023331	Chlorocebus sabaeus	71.89	0.00e+00	841.00
IUUC-Cho-025069	Choloepus hoffmanni	36.61	2.00e-55	212.00
IUUC-Cin-025453	Ciona intestinalis	46.86	1.00e-122	433.00
IUUC-Csv-025922	Ciona savignyi	47.04	9.00e-96	345.00
IUUC-Dre-028197	Danio rerio	85.94	0.00e+00	949.00
IUUC-Dno-029679	Dasypus novemcinctus	64.67	0.00e+00	682.00
IUUC-Dor-030739	Dipodomys ordii	71.45	0.00e+00	830.00
IUUC-Ete-032545	Echinops telfairi	38.67	7.00e-45	176.00
IUUC-Eca-034299	Equus caballus	63.20	0.00e+00	689.00
IUUC-Eeu-034720	Erinaceus europaeus	36.61	3.00e-56	214.00
IUUC-Fca-036416	Felis catus	65.18	0.00e+00	639.00
IUUC-Fal-037035	Ficedula albicollis	64.80	0.00e+00	727.00
IUUC-Gmo-039587	Gadus morhua	89.36	0.00e+00	988.00
IUUC-Gga-040841	Gallus gallus	80.43	0.00e+00	911.00
IUUC-Gac-042498	Gasterosteus aculeatus	89.10	0.00e+00	991.00
IUUC-Ggo-044700	Gorilla gorilla	36.89	1.00e-57	219.00
IUUC-Hsa-045681	Homo sapiens	64.85	0.00e+00	667.00
IUUC-Itr-048380	Ictidomys tridecemlineatus	64.32	0.00e+00	699.00
IUUC-Kpa-049278	Komagataella pastoris	31.28	6.00e-20	93.20
IUUC-Lch-049639	Latimeria chalumnae	75.59	0.00e+00	832.00
IUUC-Loc-051994	Lepisosteus oculatus	86.81	0.00e+00	985.00
IUUC-Laf-054307	Loxodonta africana	65.38	0.00e+00	731.00
IUUC-Mcc-055305	Macaca mulatta	64.75	2.00e-141	495.00
IUUC-Meu-056376	Macropus eugenii	79.30	0.00e+00	753.00
IUUC-Mga-059644	Meleagris gallopavo	64.27	0.00e+00	719.00
IUUC-Mvi-060486	Microbotryum violaceum	25.70	3.00e-23	103.00
IUUC-Mmr-061664	Microcebus murinus	63.64	0.00e+00	669.00
IUUC-Mdo-062404	Monodelphis domestica	36.61	5.00e-57	217.00
IUUC-Mmu-063143	Mus musculus	36.89	2.00e-57	218.00
IUUC-Mpu-066851	Mustela putorius furo	64.50	0.00e+00	666.00
IUUC-Mlu-066956	Myotis lucifugus	64.15	0.00e+00	684.00
IUUC-Nle-069174	Nomascus leucogenys	40.00	5.00e-40	158.00
IUUC-Opr-070209	Ochotona princeps	65.49	0.00e+00	694.00
IUUC-Oan-073722	Ornithorhynchus anatinus	60.66	0.00e+00	662.00
IUUC-Ocu-074885	Oryctolagus cuniculus	63.90	0.00e+00	667.00
IUUC-Ola-087155	Oryzias latipes	36.07	1.00e-52	202.00
IUUC-Oga-088758	Otolemur garnettii	67.56	0.00e+00	696.00
IUUC-Oar-089923	Ovis aries	72.40	0.00e+00	839.00
IUUC-Ptr-091555	Pan troglodytes	63.80	0.00e+00	715.00
IUUC-Pan-092037	Papio anubis	63.97	0.00e+00	725.00
IUUC-Psi-093865	Pelodiscus sinensis	65.32	0.00e+00	743.00
IUUC-Pfo-096918	Poecilia formosa	36.26	9.00e-54	206.00
IUUC-Pab-097910	Pongo abelii	63.97	0.00e+00	723.00
IUUC-Pca-100891	Procavia capensis	37.90	2.00e-52	202.00
IUUC-Pva-102967	Pteropus vampyrus	65.11	9.00e-150	523.00
IUUC-Rno-105479	Rattus norvegicus	36.10	4.00e-54	207.00
IUUC-Sha-107592	Sarcophilus harrisii	63.56	0.00e+00	702.00
IUUC-Sar-113369	Sorex araneus	67.53	1.00e-120	427.00
IUUC-Tgu-117088	Taeniopygia guttata	80.11	0.00e+00	911.00
IUUC-Tru-118716	Takifugu rubripes	36.05	5.00e-55	210.00
IUUC-Tsy-118846	Tarsius syrichta	64.77	4.00e-129	454.00
IUUC-Tni-120887	Tetraodon nigroviridis	37.32	1.00e-54	209.00
IUUC-Tbe-127248	Tupaia belangeri	38.78	6.00e-52	200.00
IUUC-Vda-129831	Verticillium dahliae	28.09	3.00e-11	64.30
IUUC-Vpa-130750	Vicugna pacos	38.51	2.00e-54	208.00
IUUC-Xtr-132676	Xenopus tropicalis	74.33	0.00e+00	845.00
IUUC-Xma-133871	Xiphophorus maculatus	36.26	1.00e-53	206.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence