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Basic Information Integrated Annotations
Tag Content
UUCD2 ID IUUC-Mmu-063698
UUCD1 version UUC-MuM-00316
Ensembl Protein ID ENSMUSP00000014499.3
UniProt Accession P53995; A2ATQ4; Q8BP33; Q8C772; APC1_MOUSE
Genbank Protein ID CAA56450.1; CAM25161.1; EDL28216.1; AAI39003.1; BAC34976.1; BAC37032.2
Protein Name Anaphase-promoting complex subunit 1; Cyclosome subunit 1; Mitotic checkpoint regulator; Testis-specific gene 24 protein
Genbank Nucleotide ID X80169; AL928910; CH466519; BC139002; AK052404; AK077847
Gene Name Anapc1; Mcpr; Tsg24
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000014355.10 ENSMUST00000014499.9 ENSMUSP00000014499.3
ENSMUSG00000014355.10 ENSMUST00000110332.1 ENSMUSP00000105961.1
ENSMUSG00000014355.10 ENSMUST00000110333.1 ENSMUSP00000105962.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitemiRTarBasemicroRNATRANSFAC
RepTarmiRNAMapRAID2
Protein-protein Interaction
IIDiRefIndexHINTMentha
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
UniProtPHOSIDAmUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Unreviewed
Classification
Family Identity E-Value Score Source Orthology
E3 adaptor/Cullin RING/APC_C/APC_C 92.39 0.00e+00 3598.00 IUUC-Hsa-045774
E3 adaptor/Cullin RING/APC_C/APC_C 26.03 2.00e-38 157.00 IUUC-Sce-106246
Active Site
Position(s) Description Evidence
N/A N/A N/A
Organism Mus musculus
Functional Description
(View)

Functional Description


     Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
 Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains (By similarity).
Protein Sequence
(Fasta)
MSNFSEERAT MIAAGDLQEF VPFGRDHCKH HPNALNLQLR QLQPASELWS SDGAAGLVGS 60
LQEVTIHEKQ KESWQLRKGV SEIGDAADYD EELYVAGNMV IWSKGSKSQA LAVYKAFTVD 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063698|E3,APC_C|Mus musculus
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Nucleotide Sequence
(Fasta)
TGGCGCGAGG CAGGTCGGGA AATCCAAGAT GGCTCCAGCC ATTTGAGTTG TTCGCAAGTC 60
TTTGGTGTCC CGCTGCCGCC CATTCTTCCT CCGGCATCCG GGAGGGAAAA GGGATGAGAA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063698|E3,APC_C|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0131--Cell cycle
KW-0132--Cell division
KW-0181--Complete proteome
KW-0498--Mitosis
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0677--Repeat
KW-0833--Ubl conjugation pathway
Interpro

IPR024990--Apc1
IPR002015--Proteasome/cyclosome_rpt
Pfam

PF12859--ANAPC1
PF01851--PC_rep
Gene Ontology

GO:0005680--C:anaphase-promoting complex
GO:0005634--C:nucleus
GO:0051301--P:cell division
GO:0007067--P:mitotic nuclear division
GO:0070979--P:protein K11-linked ubiquitination
KEGG mmu:17222
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Ata-000288 Aegilops tauschii 27.88 3.00e-09 56.20
IUUC-Aml-002294 Ailuropoda melanoleuca 90.58 0.00e+00 3464.00
IUUC-Atr-002881 Amborella trichopoda 31.69 6.00e-159 556.00
IUUC-Apl-003588 Anas platyrhynchos 82.66 0.00e+00 3017.00
IUUC-Aca-005361 Anolis carolinensis 81.33 0.00e+00 3135.00
IUUC-Aly-005680 Arabidopsis lyrata 29.74 1.00e-136 481.00
IUUC-Ath-007479 Arabidopsis thaliana 31.87 3.00e-175 610.00
IUUC-Ago-007943 Ashbya gossypii 25.81 2.00e-48 188.00
IUUC-Acl-008141 Aspergillus clavatus 36.49 4.00e-120 427.00
IUUC-Afl-008487 Aspergillus flavus 36.99 1.00e-115 412.00
IUUC-Afu-008897 Aspergillus fumigatus 31.66 2.00e-126 448.00
IUUC-Ani-009232 Aspergillus nidulans 36.59 7.00e-111 396.00
IUUC-Ang-009699 Aspergillus niger 37.28 8.00e-111 396.00
IUUC-Aor-009943 Aspergillus oryzae 36.99 9.00e-116 412.00
IUUC-Ate-010554 Aspergillus terreus 36.57 2.00e-120 428.00
IUUC-Ame-011373 Astyanax mexicanus 67.21 0.00e+00 2587.00
IUUC-Bgr-011994 Blumeria graminis 33.71 3.00e-121 430.00
IUUC-Bta-013227 Bos taurus 90.26 0.00e+00 3390.00
IUUC-Bci-013591 Botrytis cinerea 33.06 9.00e-134 472.00
IUUC-Bdi-015048 Brachypodium distachyon 34.97 4.00e-130 459.00
IUUC-Bol-016448 Brassica oleracea 33.39 2.00e-166 581.00
IUUC-Bra-017688 Brassica rapa 31.40 7.00e-146 512.00
IUUC-Cel-018707 Caenorhabditis elegans 27.26 8.00e-80 292.00
IUUC-Cja-019608 Callithrix jacchus 91.92 0.00e+00 3560.00
IUUC-Cfa-021133 Canis familiaris 91.82 0.00e+00 3520.00
IUUC-Cpo-022097 Cavia porcellus 90.97 0.00e+00 3518.00
IUUC-Cre-022722 Chlamydomonas reinhardtii 41.67 4.00e-16 80.50
IUUC-Csa-024077 Chlorocebus sabaeus 92.44 0.00e+00 3586.00
IUUC-Cho-024372 Choloepus hoffmanni 85.52 0.00e+00 666.00
IUUC-Cin-025169 Ciona intestinalis 47.20 3.00e-86 311.00
IUUC-Csv-026053 Ciona savignyi 33.78 1.00e-123 437.00
IUUC-Cgl-026415 Colletotrichum gloeosporioides 29.94 9.00e-107 382.00
IUUC-Cne-026772 Cryptococcus neoformans 28.37 4.00e-105 377.00
IUUC-Cme-027221 Cyanidioschyzon merolae 33.44 2.00e-16 83.20
IUUC-Dre-028168 Danio rerio 66.19 0.00e+00 2546.00
IUUC-Dno-029251 Dasypus novemcinctus 88.95 0.00e+00 2585.00
IUUC-Dor-031058 Dipodomys ordii 79.62 0.00e+00 1146.00
IUUC-Dse-031374 Dothistroma septosporum 35.64 4.00e-79 289.00
IUUC-Dme-031637 Drosophila melanogaster 36.44 0.00e+00 910.00
IUUC-Ete-032785 Echinops telfairi 89.35 0.00e+00 1413.00
IUUC-Eca-034301 Equus caballus 91.87 0.00e+00 3519.00
IUUC-Eeu-034448 Erinaceus europaeus 85.45 0.00e+00 1149.00
IUUC-Fca-036327 Felis catus 92.08 0.00e+00 3547.00
IUUC-Fal-037242 Ficedula albicollis 82.81 0.00e+00 2827.00
IUUC-Fox-037815 Fusarium oxysporum 37.67 4.00e-55 211.00
IUUC-Fso-038155 Fusarium solani 31.40 6.00e-117 416.00
IUUC-Gmo-039055 Gadus morhua 63.23 0.00e+00 1308.00
IUUC-Ggr-039950 Gaeumannomyces graminis 31.17 9.00e-120 426.00
IUUC-Gga-040699 Gallus gallus 78.96 0.00e+00 3047.00
IUUC-Gac-041384 Gasterosteus aculeatus 61.96 0.00e+00 2263.00
IUUC-Gma-043887 Glycine max 30.39 1.00e-169 591.00
IUUC-Hsa-045774 Homo sapiens 92.39 0.00e+00 3582.00
IUUC-Hvu-047197 Hordeum vulgare 38.08 6.00e-95 341.00
IUUC-Itr-048307 Ictidomys tridecemlineatus 89.40 0.00e+00 3204.00
IUUC-Kpa-049213 Komagataella pastoris 31.88 2.00e-108 387.00
IUUC-Lch-050625 Latimeria chalumnae 75.51 0.00e+00 2870.00
IUUC-Lpe-050901 Leersia perrieri 30.53 5.00e-139 489.00
IUUC-Loc-052539 Lepisosteus oculatus 79.72 0.00e+00 1493.00
IUUC-Lma-052970 Leptosphaeria maculans 31.83 1.00e-101 366.00
IUUC-Laf-054144 Loxodonta africana 90.48 0.00e+00 3518.00
IUUC-Mcc-054940 Macaca mulatta 92.44 0.00e+00 3586.00
IUUC-Meu-056069 Macropus eugenii 52.33 2.00e-68 252.00
IUUC-Mor-057218 Magnaporthe oryzae 31.24 6.00e-123 436.00
IUUC-Mtr-058775 Medicago truncatula 31.11 2.00e-176 614.00
IUUC-Mla-059122 Melampsora laricipopulina 33.37 1.00e-99 358.00
IUUC-Mga-059663 Meleagris gallopavo 79.27 0.00e+00 2943.00
IUUC-Mvi-060259 Microbotryum violaceum 32.09 1.00e-99 359.00
IUUC-Mmr-060620 Microcebus murinus 92.39 0.00e+00 3556.00
IUUC-Mdo-062149 Monodelphis domestica 85.97 0.00e+00 3323.00
IUUC-Mac-065285 Musa acuminata 38.24 1.00e-110 394.00
IUUC-Mpu-066489 Mustela putorius furo 91.72 0.00e+00 3557.00
IUUC-Mlu-067969 Myotis lucifugus 91.26 0.00e+00 3506.00
IUUC-Nfi-068325 Neosartorya fischeri 31.63 9.00e-124 439.00
IUUC-Ncr-068817 Neurospora crassa 35.38 2.00e-108 388.00
IUUC-Nle-069961 Nomascus leucogenys 92.62 0.00e+00 2983.00
IUUC-Opr-071086 Ochotona princeps 88.87 0.00e+00 813.00
IUUC-Ont-071831 Oreochromis niloticus 63.89 0.00e+00 2429.00
IUUC-Oan-073375 Ornithorhynchus anatinus 80.92 0.00e+00 706.00
IUUC-Ocu-073892 Oryctolagus cuniculus 92.64 0.00e+00 3593.00
IUUC-Oba-075880 Oryza barthii 34.67 1.00e-91 332.00
IUUC-Obr-076384 Oryza brachyantha 31.95 4.00e-152 533.00
IUUC-Ogl-077165 Oryza glaberrima 37.93 6.00e-134 472.00
IUUC-Ogu-078764 Oryza glumaepatula 31.57 3.00e-118 420.00
IUUC-Oin-079711 Oryza indica 33.93 2.00e-150 527.00
IUUC-Olo-080715 Oryza longistaminata 40.62 5.00e-91 330.00
IUUC-Ome-081131 Oryza meridionalis 32.59 3.00e-100 360.00
IUUC-Oni-082223 Oryza nivara 34.33 2.00e-102 368.00
IUUC-Opu-083985 Oryza punctata 39.32 1.00e-126 448.00
IUUC-Oru-085031 Oryza rufipogon 34.64 7.00e-99 356.00
IUUC-Osa-085599 Oryza sativa 39.80 7.00e-125 441.00
IUUC-Ola-087375 Oryzias latipes 63.46 0.00e+00 2379.00
IUUC-Olu-087875 Ostreococcus lucimarinus 28.94 2.00e-140 494.00
IUUC-Oga-088815 Otolemur garnettii 91.20 0.00e+00 3506.00
IUUC-Oar-090326 Ovis aries 90.28 0.00e+00 3364.00
IUUC-Ptr-091143 Pan troglodytes 92.53 0.00e+00 3193.00
IUUC-Pan-091945 Papio anubis 92.39 0.00e+00 3583.00
IUUC-Psi-092955 Pelodiscus sinensis 82.12 0.00e+00 2088.00
IUUC-Pma-094473 Petromyzon marinus 51.22 0.00e+00 1852.00
IUUC-Pno-094991 Phaeosphaeria nodorum 37.08 1.00e-97 350.00
IUUC-Ppa-095617 Physcomitrella patens 33.22 5.00e-165 576.00
IUUC-Pfo-096119 Poecilia formosa 63.34 0.00e+00 2413.00
IUUC-Pab-098265 Pongo abelii 92.38 0.00e+00 2316.00
IUUC-Pop-099429 Populus trichocarpa 32.79 4.00e-166 579.00
IUUC-Pca-100116 Procavia capensis 75.22 0.00e+00 940.00
IUUC-Ppe-102034 Prunus persica 34.97 3.00e-156 546.00
IUUC-Pva-102425 Pteropus vampyrus 87.88 0.00e+00 2710.00
IUUC-Pgr-103486 Puccinia graminis 31.97 7.00e-102 366.00
IUUC-Pte-104231 Pyrenophora teres 30.50 6.00e-100 360.00
IUUC-Pyt-104725 Pyrenophora triticirepentis 32.13 9.00e-111 395.00
IUUC-Rno-106106 Rattus norvegicus 98.10 0.00e+00 3765.00
IUUC-Sce-106246 Saccharomyces cerevisiae 25.67 5.00e-37 150.00
IUUC-Sha-107371 Sarcophilus harrisii 83.69 0.00e+00 3207.00
IUUC-Sja-107837 Schizosaccharomyces japonicus 29.18 3.00e-69 257.00
IUUC-Spo-108151 Schizosaccharomyces pombe 30.56 2.00e-96 347.00
IUUC-Smo-109131 Selaginella moellendorffii 32.49 3.00e-138 486.00
IUUC-Sit-109833 Setaria italica 38.55 9.00e-97 348.00
IUUC-Sly-111174 Solanum lycopersicum 38.79 3.00e-132 466.00
IUUC-Sar-113322 Sorex araneus 80.00 0.00e+00 859.00
IUUC-Sre-115207 Sporisorium reilianum 32.93 4.00e-94 340.00
IUUC-Ssc-115572 Sus scrofa 91.21 0.00e+00 3112.00
IUUC-Tgu-117040 Taeniopygia guttata 81.60 0.00e+00 3043.00
IUUC-Tru-118159 Takifugu rubripes 63.03 0.00e+00 2409.00
IUUC-Tsy-119288 Tarsius syrichta 80.10 0.00e+00 1176.00
IUUC-Tni-119889 Tetraodon nigroviridis 57.73 0.00e+00 1395.00
IUUC-Tca-120982 Theobroma cacao 32.89 9.00e-151 528.00
IUUC-Tre-122017 Trichoderma reesei 31.60 3.00e-121 431.00
IUUC-Tvi-122340 Trichoderma virens 32.17 2.00e-121 431.00
IUUC-Tae-122989 Triticum aestivum 31.79 3.00e-170 593.00
IUUC-Tur-126328 Triticum urartu 29.51 6.90e-01 29.60
IUUC-Tme-127169 Tuber melanosporum 33.80 3.00e-121 431.00
IUUC-Tbe-127596 Tupaia belangeri 81.58 0.00e+00 757.00
IUUC-Ttr-128376 Tursiops truncatus 89.25 0.00e+00 3391.00
IUUC-Uma-129513 Ustilago maydis 30.08 2.00e-86 315.00
IUUC-Vda-129898 Verticillium dahliae 29.62 4.00e-96 347.00
IUUC-Vpa-130495 Vicugna pacos 85.96 0.00e+00 3271.00
IUUC-Vvi-131656 Vitis vinifera 36.34 4.00e-135 476.00
IUUC-Xtr-132770 Xenopus tropicalis 76.13 0.00e+00 2905.00
IUUC-Xma-133490 Xiphophorus maculatus 71.21 0.00e+00 1133.00
IUUC-Yli-134525 Yarrowia lipolytica 31.85 3.00e-101 363.00
IUUC-Zma-134774 Zea mays 30.41 8.00e-108 385.00
Created Date 25-Jun-2017

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