iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012578

Ensembl Protein ID

ENSBTAP00000008030.4

UniProt Accession

A5D979; SPRTN_BOVIN

Genbank Protein ID

ABQ12938.1

Protein Name

SprT-like domain-containing protein Spartan; Protein with SprT-like domain at the N terminus

Genbank Nucleotide ID

BT030498

Gene Name

SPRTN

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000006112.4	ENSBTAT00000008030.4	ENSBTAP00000008030.4

Status

Reviewed

Details

Family	Domain	References (PMIDs)
UBD/ZnF/UBZ	UBZ	22681887

Classification

Family	E-value	Score	Start	End
UBD/ZnF/UBZ	3.20e-08	33.8	456	478

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/ZnF/UBZ

   S: 2    lvCPvCqkmvdqtdfeeHlDeCl 24
           ++CPvCq +v++t+++eHlD+Cl
   Q: 456  VHCPVCQDEVSETQINEHLDWCL 478
           79********************8 PP

Organism

Bos taurus

Functional Description
(View)

Regulator of UV-induced DNA damage response: acts as a 'reader' of ubiquitinated PCNA that enhances RAD18-mediated PCNA ubiquitination and translesion DNA synthesis (TLS). Recruited to sites of UV damage and interacts with ubiquitinated PCNA and RAD18, the E3 ubiquitin ligase that monoubiquitinates PCNA. Facilitates chromatin association of RAD18 and is required for efficient PCNA monoubiquitination, promoting a feed-forward loop to enhance PCNA ubiquitination and translesion DNA synthesis. Acts as a regulator of TLS by recruiting VCP/p97 to sites of DNA damage, possibly leading to extraction of DNA polymerase eta (POLH) by VCP/p97 to prevent excessive translesion DNA synthesis and limit the incidence of mutations induced by DNA damage (By similarity).

Protein Sequence
(Fasta)

MDEDLVLALQ LQEEWNLQVS EREPAQEPLS LVDASWELVD PTPDLQGLFV LFNDRFFWGQ 60
LEAVEVKWSV RMTLCAGICS YEGRGGMCSI RLSEPLLKLR PRKDLVETLL HEMIHAYLFV 120

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Nucleotide Sequence
(Fasta)

CGCGGGGCAG AGCGATGTAC GTACTACGAG GTGCTACGCA TGGGCCGAGT GTGTCGTTGG 60
TGTTTGACGT TATTCGTGAA CCGTGAGGAC GGTAACCAGG TATCTGAAAC CTTCAACCCT 120

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Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-1017--Isopeptide bond
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0832--Ubl conjugation
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR022636--S-AdoMet_synthetase_sfam
IPR006640--SprT-like_domain
IPR006642--Znf_Rad18_put

PROSITE

PS00142--ZINC_PROTEASE

Pfam

PF10263--SprT-like

SMART

SM00731--SprT
SM00734--ZnF_Rad18

Gene Ontology

GO:0005694--C:chromosome
GO:0016607--C:nuclear speck
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0046872--F:metal ion binding
GO:0004478--F:methionine adenosyltransferase activity
GO:0031593--F:polyubiquitin binding
GO:0043130--F:ubiquitin binding
GO:0006974--P:cellular response to DNA damage stimulus
GO:0031398--P:positive regulation of protein ubiquitination
GO:0009411--P:response to UV
GO:0006556--P:S-adenosylmethionine biosynthetic process
GO:0019985--P:translesion synthesis

KEGG

bta:534918

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-001028	Aegilops tauschii	32.34	4.00e-16	79.00
IUUC-Aml-001352	Ailuropoda melanoleuca	80.53	0.00e+00	780.00
IUUC-Atr-002445	Amborella trichopoda	44.44	1.00e-42	167.00
IUUC-Apl-003724	Anas platyrhynchos	47.55	1.00e-75	276.00
IUUC-Aca-005382	Anolis carolinensis	53.47	2.00e-138	485.00
IUUC-Ame-011053	Astyanax mexicanus	51.43	1.00e-102	367.00
IUUC-Bgr-012304	Blumeria graminis	23.85	6.90e-01	28.10
IUUC-Bci-013808	Botrytis cinerea	50.00	1.70e-02	33.50
IUUC-Bol-015928	Brassica oleracea	42.86	3.20e-01	30.80
IUUC-Cel-018317	Caenorhabditis elegans	63.68	4.00e-81	295.00
IUUC-Cja-019824	Callithrix jacchus	76.84	0.00e+00	709.00
IUUC-Cfa-020307	Canis familiaris	82.38	0.00e+00	800.00
IUUC-Cpo-022142	Cavia porcellus	71.52	3.00e-173	601.00
IUUC-Cre-022820	Chlamydomonas reinhardtii	39.15	2.00e-31	130.00
IUUC-Csa-024002	Chlorocebus sabaeus	77.66	0.00e+00	721.00
IUUC-Cho-024371	Choloepus hoffmanni	74.63	1.00e-134	472.00
IUUC-Cin-025503	Ciona intestinalis	60.16	5.00e-91	327.00
IUUC-Csv-025903	Ciona savignyi	64.68	4.00e-89	320.00
IUUC-Cgl-026737	Colletotrichum gloeosporioides	28.21	6.00e-05	42.40
IUUC-Dre-027871	Danio rerio	49.38	3.00e-108	385.00
IUUC-Dno-029800	Dasypus novemcinctus	70.67	0.00e+00	690.00
IUUC-Dor-030856	Dipodomys ordii	58.68	1.00e-129	456.00
IUUC-Dme-031958	Drosophila melanogaster	50.66	2.00e-67	250.00
IUUC-Ete-032321	Echinops telfairi	84.94	6.00e-126	444.00
IUUC-Eca-033610	Equus caballus	81.35	0.00e+00	811.00
IUUC-Eeu-034608	Erinaceus europaeus	65.65	4.00e-170	590.00
IUUC-Fca-035456	Felis catus	76.23	0.00e+00	732.00
IUUC-Fal-036725	Ficedula albicollis	47.17	3.00e-98	352.00
IUUC-Fox-037675	Fusarium oxysporum	40.62	1.30e-01	30.00
IUUC-Fso-038353	Fusarium solani	34.09	1.00e-04	41.20
IUUC-Gmo-039428	Gadus morhua	61.09	7.00e-91	327.00
IUUC-Ggr-039914	Gaeumannomyces graminis	30.77	5.00e-04	38.90
IUUC-Gga-041138	Gallus gallus	52.69	2.00e-129	456.00
IUUC-Gac-041946	Gasterosteus aculeatus	59.76	2.00e-90	325.00
IUUC-Ggo-044909	Gorilla gorilla	76.64	0.00e+00	720.00
IUUC-Hsa-046804	Homo sapiens	76.64	0.00e+00	714.00
IUUC-Hvu-047629	Hordeum vulgare	29.65	3.00e-17	83.20
IUUC-Itr-048136	Ictidomys tridecemlineatus	73.81	0.00e+00	631.00
IUUC-Lch-050399	Latimeria chalumnae	48.00	6.00e-107	381.00
IUUC-Lpe-050694	Leersia perrieri	33.19	6.00e-18	85.90
IUUC-Loc-052526	Lepisosteus oculatus	51.20	5.00e-105	375.00
IUUC-Lma-053205	Leptosphaeria maculans	43.29	1.00e-49	189.00
IUUC-Laf-054101	Loxodonta africana	80.53	0.00e+00	827.00
IUUC-Mcc-055889	Macaca mulatta	77.66	0.00e+00	721.00
IUUC-Meu-056236	Macropus eugenii	68.92	7.00e-25	108.00
IUUC-Mor-057257	Magnaporthe oryzae	28.48	2.00e-07	50.40
IUUC-Mpo-057531	Magnaporthe poae	30.77	6.00e-04	38.90
IUUC-Mla-058857	Melampsora laricipopulina	26.13	3.50e-02	33.10
IUUC-Mga-059774	Meleagris gallopavo	48.87	4.00e-111	394.00
IUUC-Mmr-061635	Microcebus murinus	77.76	0.00e+00	739.00
IUUC-Mdo-062699	Monodelphis domestica	67.43	1.00e-123	436.00
IUUC-Mmu-063270	Mus musculus	68.47	0.00e+00	664.00
IUUC-Mac-065121	Musa acuminata	31.90	3.00e-19	89.00
IUUC-Mpu-065833	Mustela putorius furo	80.33	0.00e+00	788.00
IUUC-Mlu-067479	Myotis lucifugus	71.08	1.00e-149	522.00
IUUC-Ncr-068774	Neurospora crassa	30.41	5.00e-06	45.40
IUUC-Nle-069224	Nomascus leucogenys	76.02	0.00e+00	729.00
IUUC-Opr-070699	Ochotona princeps	60.78	3.00e-152	531.00
IUUC-Ont-072423	Oreochromis niloticus	56.31	6.00e-104	371.00
IUUC-Oan-073554	Ornithorhynchus anatinus	70.13	3.00e-35	139.00
IUUC-Ocu-074946	Oryctolagus cuniculus	90.61	8.00e-138	482.00
IUUC-Oba-075090	Oryza barthii	33.65	2.00e-18	87.80
IUUC-Obr-076066	Oryza brachyantha	32.70	7.00e-17	82.40
IUUC-Ogl-077154	Oryza glaberrima	33.65	2.00e-18	87.80
IUUC-Ogu-077955	Oryza glumaepatula	33.65	1.00e-18	88.20
IUUC-Oin-079055	Oryza indica	33.65	2.00e-18	87.40
IUUC-Olo-080733	Oryza longistaminata	40.54	3.00e-14	73.60
IUUC-Ome-081338	Oryza meridionalis	33.49	2.00e-18	87.40
IUUC-Oni-082257	Oryza nivara	33.65	2.00e-18	87.40
IUUC-Opu-083290	Oryza punctata	33.17	3.00e-18	87.00
IUUC-Oru-084633	Oryza rufipogon	34.13	4.00e-18	86.70
IUUC-Osa-086222	Oryza sativa	33.65	2.00e-18	87.80
IUUC-Ola-087333	Oryzias latipes	44.82	4.00e-108	385.00
IUUC-Olu-087722	Ostreococcus lucimarinus	33.77	1.00e-04	42.40
IUUC-Oga-088956	Otolemur garnettii	77.85	0.00e+00	749.00
IUUC-Oar-090014	Ovis aries	94.05	0.00e+00	900.00
IUUC-Ptr-091565	Pan troglodytes	76.64	0.00e+00	714.00
IUUC-Pan-092756	Papio anubis	77.87	0.00e+00	729.00
IUUC-Psi-093051	Pelodiscus sinensis	53.56	5.00e-111	394.00
IUUC-Pma-094409	Petromyzon marinus	69.06	6.00e-57	212.00
IUUC-Pno-094926	Phaeosphaeria nodorum	45.27	2.00e-47	182.00
IUUC-Ppa-095219	Physcomitrella patens	44.44	2.90e-02	33.90
IUUC-Pfo-096555	Poecilia formosa	55.45	4.00e-101	362.00
IUUC-Pab-098754	Pongo abelii	71.80	7.00e-143	499.00
IUUC-Pop-099026	Populus trichocarpa	26.26	2.40e-01	29.60
IUUC-Pca-100166	Procavia capensis	73.47	0.00e+00	746.00
IUUC-Pva-102910	Pteropus vampyrus	67.21	1.00e-179	622.00
IUUC-Pte-104222	Pyrenophora teres	37.98	7.00e-50	191.00
IUUC-Pyt-104688	Pyrenophora triticirepentis	44.98	6.00e-48	184.00
IUUC-Rno-105616	Rattus norvegicus	60.04	3.00e-158	551.00
IUUC-Sha-106669	Sarcophilus harrisii	59.74	2.00e-132	465.00
IUUC-Smo-108867	Selaginella moellendorffii	47.83	1.00e-44	172.00
IUUC-Sit-110221	Setaria italica	27.14	8.00e-17	81.30
IUUC-Sar-113141	Sorex araneus	67.01	3.00e-178	617.00
IUUC-Sbi-114252	Sorghum bicolor	28.14	1.00e-16	80.90
IUUC-Ssc-115883	Sus scrofa	79.51	0.00e+00	768.00
IUUC-Tgu-116997	Taeniopygia guttata	47.34	9.00e-114	403.00
IUUC-Tru-117785	Takifugu rubripes	50.27	3.00e-100	358.00
IUUC-Tsy-119449	Tarsius syrichta	72.77	3.00e-153	534.00
IUUC-Tni-120379	Tetraodon nigroviridis	45.89	9.00e-113	400.00
IUUC-Tre-121886	Trichoderma reesei	41.94	3.00e-04	40.00
IUUC-Tvi-122337	Trichoderma virens	50.00	4.00e-03	35.80
IUUC-Tae-124356	Triticum aestivum	32.37	1.00e-18	88.60
IUUC-Tur-126257	Triticum urartu	29.65	1.00e-19	90.50
IUUC-Tbe-128156	Tupaia belangeri	70.15	0.00e+00	654.00
IUUC-Ttr-128748	Tursiops truncatus	80.00	0.00e+00	630.00
IUUC-Vda-129771	Verticillium dahliae	34.62	7.00e-05	42.00
IUUC-Vpa-130454	Vicugna pacos	67.25	4.00e-85	308.00
IUUC-Xtr-132163	Xenopus tropicalis	46.27	1.00e-111	396.00
IUUC-Xma-134184	Xiphophorus maculatus	52.63	2.00e-106	379.00
IUUC-Zma-134864	Zea mays	28.64	1.00e-17	84.30

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence