iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aca-005160

Ensembl Protein ID

ENSACAP00000006363.2

UniProt Accession

G1KFF8; G1KFF8_ANOCA

Protein Name

Presenilin

Gene Name

PSEN2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000006455.3	ENSACAT00000006505.3	ENSACAP00000006363.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/CUE	6.10e-06	26.1	284	311

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/CUE

   S: 2    letaleqLkeiFPnldysviqvvLeant 29
           +eta+e++++iFP+l+ys+ + + + ++
   Q: 284  VETAQERNEPIFPALIYSSAMIWTVGMA 311
           89*********************98775 PP

Organism

Anolis carolinensis

Functional Description
(View)

Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.

Protein Sequence
(Fasta)

MITFMNNSDS EEESCNERTS LMSAESPLLP PYHDVSQAPA ATETQTHRKR RTGSSGSNKT 60
ADGNVPESDG ATRGSVALDN VEEELTLKYG AKHVIMLFVP VTLCMVVVVA TIKSVRFYTE 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGATCACCT TCATGAACAA CTCTGACAGC GAAGAGGAAT CCTGCAATGA AAGAACATCC 60
CTGATGTCAG CGGAGAGCCC CCTCCTGCCT CCTTACCATG ATGTCTCGCA AGCCCCTGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0333--Golgi apparatus
KW-0378--Hydrolase
KW-0472--Membrane
KW-0914--Notch signaling pathway
KW-0645--Protease
KW-1185--Reference proteome
KW-0812--Transmembrane
KW-1133--Transmembrane helix

Interpro

IPR001493--Pept_A22A_PS2
IPR001108--Peptidase_A22A
IPR006639--Preselin/SPP

Pfam

PF01080--Presenilin

PRINTS

PR01072--PRESENILIN

SMART

SM00730--PSN

Gene Ontology

GO:0005813--C:centrosome
GO:0005789--C:endoplasmic reticulum membrane
GO:0000139--C:Golgi membrane
GO:0005887--C:integral component of plasma membrane
GO:0000776--C:kinetochore
GO:0043025--C:neuronal cell body
GO:0005637--C:nuclear inner membrane
GO:0005634--C:nucleus
GO:0048471--C:perinuclear region of cytoplasm
GO:0030018--C:Z disc
GO:0004190--F:aspartic-type endopeptidase activity
GO:0004175--F:endopeptidase activity
GO:0042987--P:amyloid precursor protein catabolic process
GO:0050435--P:beta-amyloid metabolic process
GO:0006816--P:calcium ion transport
GO:0035556--P:intracellular signal transduction
GO:0006509--P:membrane protein ectodomain proteolysis
GO:0043066--P:negative regulation of apoptotic process
GO:0007220--P:Notch receptor processing
GO:0007219--P:Notch signaling pathway
GO:0043085--P:positive regulation of catalytic activity
GO:0016485--P:protein processing

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002356	Ailuropoda melanoleuca	69.26	6.00e-133	467.00
IUUC-Apl-003959	Anas platyrhynchos	82.40	0.00e+00	640.00
IUUC-Aly-005455	Arabidopsis lyrata	42.47	5.00e-19	88.60
IUUC-Ath-006730	Arabidopsis thaliana	41.78	9.00e-19	87.80
IUUC-Ame-010686	Astyanax mexicanus	73.91	4.00e-142	497.00
IUUC-Bta-013097	Bos taurus	75.44	4.00e-158	550.00
IUUC-Cja-018824	Callithrix jacchus	74.13	9.00e-155	539.00
IUUC-Cfa-020253	Canis familiaris	75.76	9.00e-160	556.00
IUUC-Cpo-021401	Cavia porcellus	75.66	5.00e-158	550.00
IUUC-Cre-022747	Chlamydomonas reinhardtii	34.10	5.00e-29	122.00
IUUC-Csa-023369	Chlorocebus sabaeus	75.65	1.00e-159	555.00
IUUC-Dre-028526	Danio rerio	70.99	7.00e-150	523.00
IUUC-Dor-031127	Dipodomys ordii	74.23	3.00e-158	551.00
IUUC-Ete-033081	Echinops telfairi	70.07	2.00e-72	266.00
IUUC-Eca-034387	Equus caballus	75.05	2.00e-152	531.00
IUUC-Eeu-034846	Erinaceus europaeus	59.54	1.00e-106	379.00
IUUC-Fca-035396	Felis catus	74.62	1.00e-162	565.00
IUUC-Fal-037457	Ficedula albicollis	82.79	1.00e-180	625.00
IUUC-Gmo-038550	Gadus morhua	80.24	2.00e-102	365.00
IUUC-Gga-040706	Gallus gallus	83.15	7.00e-180	622.00
IUUC-Gac-042511	Gasterosteus aculeatus	67.86	2.00e-139	488.00
IUUC-Gma-043822	Glycine max	37.02	9.00e-24	104.00
IUUC-Ggo-045338	Gorilla gorilla	75.65	1.00e-159	555.00
IUUC-Hsa-046455	Homo sapiens	75.65	1.00e-159	556.00
IUUC-Itr-048731	Ictidomys tridecemlineatus	75.71	5.00e-159	553.00
IUUC-Lch-049638	Latimeria chalumnae	67.80	3.00e-152	531.00
IUUC-Loc-052427	Lepisosteus oculatus	73.54	9.00e-166	576.00
IUUC-Laf-053758	Loxodonta africana	75.93	2.00e-170	592.00
IUUC-Mcc-054755	Macaca mulatta	75.65	1.00e-159	555.00
IUUC-Mmr-060890	Microcebus murinus	74.57	1.00e-157	549.00
IUUC-Mdo-062197	Monodelphis domestica	79.08	4.00e-174	603.00
IUUC-Mmu-063823	Mus musculus	75.44	5.00e-160	557.00
IUUC-Mac-064858	Musa acuminata	40.12	1.00e-21	96.70
IUUC-Mpu-066181	Mustela putorius furo	76.10	2.00e-160	558.00
IUUC-Nle-069596	Nomascus leucogenys	72.97	9.00e-146	509.00
IUUC-Opr-070344	Ochotona princeps	75.27	2.00e-162	565.00
IUUC-Ont-071867	Oreochromis niloticus	70.29	4.00e-139	487.00
IUUC-Oan-073378	Ornithorhynchus anatinus	73.85	4.00e-152	530.00
IUUC-Ocu-074652	Oryctolagus cuniculus	75.27	1.00e-157	549.00
IUUC-Obr-076302	Oryza brachyantha	60.49	8.00e-17	81.60
IUUC-Ola-086707	Oryzias latipes	70.00	3.00e-103	367.00
IUUC-Oga-088560	Otolemur garnettii	74.89	4.00e-155	540.00
IUUC-Oar-089200	Ovis aries	75.88	7.00e-159	553.00
IUUC-Ptr-090569	Pan troglodytes	75.43	7.00e-159	553.00
IUUC-Pan-091742	Papio anubis	75.65	1.00e-159	556.00
IUUC-Psi-093297	Pelodiscus sinensis	82.57	4.00e-153	533.00
IUUC-Pma-094612	Petromyzon marinus	75.13	2.00e-126	445.00
IUUC-Ppa-095431	Physcomitrella patens	31.45	5.00e-24	105.00
IUUC-Pab-098531	Pongo abelii	75.65	1.00e-159	555.00
IUUC-Pop-099661	Populus trichocarpa	31.31	4.00e-32	132.00
IUUC-Pca-101120	Procavia capensis	73.96	1.00e-151	529.00
IUUC-Pva-102934	Pteropus vampyrus	70.48	2.00e-155	541.00
IUUC-Rno-106052	Rattus norvegicus	74.35	2.00e-163	568.00
IUUC-Sha-106876	Sarcophilus harrisii	77.80	3.00e-168	584.00
IUUC-Sly-110865	Solanum lycopersicum	59.26	6.00e-09	52.00
IUUC-Ssc-115380	Sus scrofa	75.71	2.00e-159	555.00
IUUC-Tgu-117280	Taeniopygia guttata	83.22	1.00e-180	625.00
IUUC-Tbe-127632	Tupaia belangeri	72.91	1.00e-130	459.00
IUUC-Ttr-129008	Tursiops truncatus	74.84	2.00e-154	538.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence