iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Mmu-064235

UUCD1 version

UUC-MuM-00062

Ensembl Protein ID

ENSMUSP00000108649.1

UniProt Accession

Q9D304; Q3UJY0; Q9CVG1; Q9DBN3; Q9JJF8; RN128_MOUSE

Genbank Protein ID

AAM51876.1; AAL34514.1; BAA95033.1; BAB23613.1; BAB25595.3; BAB31291.1; BAE27025.1; BAE39203.1; AAH10477.1

Protein Name

E3 ubiquitin-protein ligase RNF128; Gene related to anergy in lymphocytes protein; Goliath-related E3 ubiquitin-protein ligase 1; RING finger protein 128; RING-type E3 ubiquitin transferase RNF128

Genbank Nucleotide ID

AY112656; AF426411; AB041548; AK004847; AK008312; AK018582; AK146266; AK167031; BC010477

Gene Name

Rnf128; Grail; Greul1; MNCb-3816

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMUSG00000031438.11	ENSMUST00000113027.7	ENSMUSP00000108650.1
ENSMUSG00000031438.11	ENSMUST00000113026.1	ENSMUSP00000108649.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	GXD
DNA & RNA Element
AREsite	miRTarBase	microRNA	TRANSFAC
RepTar	RAID2
Protein-protein Interaction
IID	iRefIndex	Mentha
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus
Protein Expression/Proteomics
GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	18574499

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.60e-05	26.4	277	318

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledf..kdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           Ca+C e +   d +++l C+H+fh++C+  w         + +CP C+
   Q: 277  CAVCIELYkpNDLVRILTCNHIFHKTCVDPW------LLEHRTCPMCK 318
           *****9985545499****************......9999******6 PP

Organism

Mus musculus

Functional Description
(View)

E3 ubiquitin-protein ligase that catalyzes 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains formation. Functions as an inhibitor of cytokine gene transcription. Inhibits IL2 and IL4 transcription, thereby playing an important role in the induction of the anergic phenotype, a long-term stable state of T-lymphocyte unresponsiveness to antigenic stimulation associated with the blockade of interleukin production. Ubiquitinates ARPC5 with 'Lys-48' linkages and COR1A with 'Lys-63' linkages leading to their degradation, down-regulation of these cytosleletal components results in impaired lamellipodium formation and reduced accumulation of F-actin at the immunological synapse. Functions in the patterning of the dorsal ectoderm; sensitizes ectoderm to respond to neural-inducing signals (By similarity).

Protein Sequence
(Fasta)

MGPPPGIGVY CRGGCGAARL LAWCFLLALS PHAPGSRGAE AVWTAYLNVS WRVPHTGVNR 60
TVWELSEEGV YGQDSPLEPV SGVLVPPDGP GALNACNPHT NFTVPTVWGS TVQVSWLALI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GAGCCGGTGT ATTCAGAGCT TATGTTGCTA GAGGTGAGAT CAGTTACCTG CCTGCAACTG 60
AAATTTCAAA CTTCTGTTTA GAAGGGACAT GAGTGGACAA TGGTGACTGA TAGTTGGAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS50089--ZF_RING_2

Pfam

PF02225--PA
PF13639--zf-RING_2

SMART

SM00184--RING

Gene Ontology

GO:0005856--C:cytoskeleton
GO:0005783--C:endoplasmic reticulum
GO:0005794--C:Golgi apparatus
GO:0016021--C:integral component of membrane
GO:0005770--C:late endosome
GO:0048471--C:perinuclear region of cytoplasm
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0042036--P:negative regulation of cytokine biosynthetic process
GO:0031647--P:regulation of protein stability

KEGG

mmu:66889

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000714	Aegilops tauschii	36.70	8.00e-13	66.60
IUUC-Aml-001674	Ailuropoda melanoleuca	95.82	0.00e+00	827.00
IUUC-Apl-003776	Anas platyrhynchos	67.22	2.00e-108	384.00
IUUC-Aca-004318	Anolis carolinensis	69.37	6.00e-119	421.00
IUUC-Ame-011286	Astyanax mexicanus	46.74	5.00e-85	308.00
IUUC-Bta-013454	Bos taurus	93.97	0.00e+00	812.00
IUUC-Cja-019864	Callithrix jacchus	96.26	0.00e+00	829.00
IUUC-Cfa-020185	Canis familiaris	95.13	0.00e+00	816.00
IUUC-Csa-023224	Chlorocebus sabaeus	95.79	0.00e+00	799.00
IUUC-Cho-024710	Choloepus hoffmanni	79.25	2.00e-145	508.00
IUUC-Dre-028249	Danio rerio	53.02	2.00e-89	322.00
IUUC-Dno-029216	Dasypus novemcinctus	94.46	1.00e-135	475.00
IUUC-Dor-030487	Dipodomys ordii	83.01	0.00e+00	667.00
IUUC-Dse-031357	Dothistroma septosporum	45.21	2.00e-12	67.40
IUUC-Ete-032376	Echinops telfairi	95.31	5.00e-137	479.00
IUUC-Eca-034264	Equus caballus	95.82	0.00e+00	827.00
IUUC-Eeu-034606	Erinaceus europaeus	91.34	4.00e-127	447.00
IUUC-Fca-036503	Felis catus	95.36	0.00e+00	820.00
IUUC-Fal-036671	Ficedula albicollis	60.59	1.00e-112	399.00
IUUC-Gmo-039483	Gadus morhua	47.65	4.00e-81	294.00
IUUC-Gga-040248	Gallus gallus	67.96	2.00e-134	471.00
IUUC-Hsa-046745	Homo sapiens	95.33	0.00e+00	821.00
IUUC-Itr-048362	Ictidomys tridecemlineatus	96.50	0.00e+00	836.00
IUUC-Kpa-049143	Komagataella pastoris	49.02	4.00e-11	63.20
IUUC-Lch-050549	Latimeria chalumnae	57.96	2.00e-122	432.00
IUUC-Loc-051929	Lepisosteus oculatus	56.51	4.00e-97	348.00
IUUC-Laf-054197	Loxodonta africana	94.20	0.00e+00	788.00
IUUC-Mcc-055146	Macaca mulatta	96.26	0.00e+00	803.00
IUUC-Meu-056649	Macropus eugenii	77.21	9.00e-165	573.00
IUUC-Mtr-057787	Medicago truncatula	47.17	3.00e-11	62.00
IUUC-Mga-059520	Meleagris gallopavo	67.03	1.00e-134	472.00
IUUC-Mmr-061502	Microcebus murinus	95.09	0.00e+00	795.00
IUUC-Mdo-062875	Monodelphis domestica	67.01	7.00e-127	447.00
IUUC-Mpu-066452	Mustela putorius furo	91.21	3.00e-170	590.00
IUUC-Mlu-067189	Myotis lucifugus	93.74	0.00e+00	794.00
IUUC-Nle-070026	Nomascus leucogenys	96.03	0.00e+00	803.00
IUUC-Opr-070435	Ochotona princeps	72.18	2.00e-96	345.00
IUUC-Oan-073238	Ornithorhynchus anatinus	77.00	1.00e-117	416.00
IUUC-Ocu-074960	Oryctolagus cuniculus	95.33	0.00e+00	790.00
IUUC-Ola-086348	Oryzias latipes	47.04	1.00e-77	282.00
IUUC-Oga-088543	Otolemur garnettii	93.46	0.00e+00	806.00
IUUC-Oar-089599	Ovis aries	93.97	0.00e+00	811.00
IUUC-Ptr-091576	Pan troglodytes	91.85	3.00e-167	580.00
IUUC-Pan-091690	Papio anubis	96.04	0.00e+00	799.00
IUUC-Psi-093642	Pelodiscus sinensis	77.44	1.00e-105	375.00
IUUC-Pfo-096270	Poecilia formosa	45.61	1.00e-76	280.00
IUUC-Pab-097965	Pongo abelii	95.56	0.00e+00	798.00
IUUC-Pva-102991	Pteropus vampyrus	84.24	4.00e-175	607.00
IUUC-Rno-105667	Rattus norvegicus	98.36	0.00e+00	846.00
IUUC-Sha-107293	Sarcophilus harrisii	78.55	2.00e-157	548.00
IUUC-Sar-113682	Sorex araneus	95.11	3.00e-143	500.00
IUUC-Ssc-115583	Sus scrofa	94.90	0.00e+00	814.00
IUUC-Tgu-117406	Taeniopygia guttata	58.33	4.00e-82	297.00
IUUC-Tru-118147	Takifugu rubripes	46.08	8.00e-74	270.00
IUUC-Tsy-118918	Tarsius syrichta	94.63	0.00e+00	769.00
IUUC-Tni-120865	Tetraodon nigroviridis	46.15	3.00e-69	255.00
IUUC-Ttr-128640	Tursiops truncatus	95.36	0.00e+00	790.00
IUUC-Vpa-130536	Vicugna pacos	87.27	0.00e+00	729.00
IUUC-Xma-133114	Xiphophorus maculatus	48.14	5.00e-78	284.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence