iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000003608.3	ENSCJAT00000007012.2	ENSCJAP00000006641.2
ENSCJAG00000003608.3	ENSCJAT00000007026.1	ENSCJAP00000006655.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.90e-121	406.5	1171	1503

Active Site

Position(s)	Description	Evidence
1471	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 3    sdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlld 89
           + ++++l+v+fvgEegld++G++ref++l+s+el+np++glf+ys+nd++t+q++p s +   +h ++F+f Gr+lg+al ++ lld
   Q: 1171 DLQRNKLYVTFVGEEGLDYSGPSREFFFLVSRELFNPYYGLFEYSANDTYTVQISPMSAFV-DNHHEWFRFSGRILGLALIHQYLLD 1256
           456689****************************************************985.5************************ PP
   S: 90   lplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvkl 176
           ++++++fyk ll+  ++l+dle +d+e+++sl+++k+n   di+++ ldltf+v+ee++g+++e+eLkpgG+nipVt++Nk+eY+++
   Q: 1257 AFFTRPFYKALLRILCDLSDLEYLDEEFHQSLQWMKDN---DIHDI-LDLTFTVNEEVFGQITERELKPGGANIPVTEKNKKEYIER 1339
           ************************************99...9***9.**************************************** PP
   S: 177  vveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerka 263
           +v++r+++g+ +q+e++ +Gf+ev++ +l+s+F+++elel+i G++eid++d++++t+y+ggy++++ +i+wFw ++e+f++e+r +
   Q: 1340 MVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELELVIAGTAEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLR 1426
           *************************************************************************************** PP
   S: 264  fLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFels 336
           +LqFvTg+s++P +Gfa+l+    pr+f+++k+++ + lP+++TCfn+L+LP+Y+s + l+ekLl+A+eet+ F+l+
   Q: 1427 LLQFVTGTSSIPYEGFASLRgsngPRRFCVEKWGKITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEETSTFGLE 1503
           **************************************************************************985 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MYEYTLGQAQ NLIIFWDIKE EVDPSDWIGL YHIDENSPAN FWDSKNRGVT GTQKGQIVWR 60
IEPGPYFMEP EIKICFKYYH GISGALRATT PCITVKNPAV MMGAEGMEGG ASGNLHSRKL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATTTGAGCAT CACTTGAGGG AGAGGACGCT TCATTTCCTA TTCGGTTGGG AATGTGCCGC 60
GAACATCCTC TGCTGGAGCT TGGGGCCTGG AGGAAACCGG GGCTGCAGAT TTAGACGTCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR032348--HECW_N
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF16562--HECW_N
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0072686--C:mitotic spindle
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030071--P:regulation of mitotic metaphase/anaphase transition

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001271	Ailuropoda melanoleuca	95.03	0.00e+00	2798.00
IUUC-Apl-003935	Anas platyrhynchos	84.76	0.00e+00	2556.00
IUUC-Aca-004558	Anolis carolinensis	82.71	0.00e+00	2499.00
IUUC-Ame-010893	Astyanax mexicanus	88.58	0.00e+00	1300.00
IUUC-Bta-013093	Bos taurus	96.08	0.00e+00	1564.00
IUUC-Cfa-021232	Canis familiaris	98.73	0.00e+00	1604.00
IUUC-Cpo-021770	Cavia porcellus	88.74	0.00e+00	2678.00
IUUC-Csa-023970	Chlorocebus sabaeus	97.35	0.00e+00	2805.00
IUUC-Cho-024512	Choloepus hoffmanni	87.40	0.00e+00	2474.00
IUUC-Csv-026127	Ciona savignyi	72.27	1.00e-154	539.00
IUUC-Dre-028275	Danio rerio	84.79	0.00e+00	1469.00
IUUC-Dno-029963	Dasypus novemcinctus	93.91	0.00e+00	2744.00
IUUC-Dor-030282	Dipodomys ordii	88.75	0.00e+00	1843.00
IUUC-Dme-032217	Drosophila melanogaster	71.91	0.00e+00	658.00
IUUC-Ete-033132	Echinops telfairi	82.67	0.00e+00	1241.00
IUUC-Eca-033978	Equus caballus	94.36	0.00e+00	2763.00
IUUC-Eeu-035278	Erinaceus europaeus	60.44	0.00e+00	1051.00
IUUC-Fca-036157	Felis catus	94.89	0.00e+00	2768.00
IUUC-Fal-037110	Ficedula albicollis	96.42	0.00e+00	1617.00
IUUC-Gmo-039291	Gadus morhua	80.16	0.00e+00	1015.00
IUUC-Gga-040821	Gallus gallus	85.33	0.00e+00	2568.00
IUUC-Gac-042456	Gasterosteus aculeatus	64.62	0.00e+00	1818.00
IUUC-Ggo-044862	Gorilla gorilla	97.55	0.00e+00	2843.00
IUUC-Hsa-046219	Homo sapiens	97.55	0.00e+00	2876.00
IUUC-Lch-050526	Latimeria chalumnae	77.19	0.00e+00	2284.00
IUUC-Loc-052648	Lepisosteus oculatus	79.22	0.00e+00	1518.00
IUUC-Laf-054005	Loxodonta africana	95.03	0.00e+00	2816.00
IUUC-Mcc-055314	Macaca mulatta	97.41	0.00e+00	2796.00
IUUC-Meu-056356	Macropus eugenii	67.05	0.00e+00	1003.00
IUUC-Mga-060074	Meleagris gallopavo	85.29	0.00e+00	2457.00
IUUC-Mmr-061526	Microcebus murinus	95.16	0.00e+00	2749.00
IUUC-Mdo-063017	Monodelphis domestica	91.13	0.00e+00	2674.00
IUUC-Mmu-064165	Mus musculus	92.74	0.00e+00	2719.00
IUUC-Mpu-065835	Mustela putorius furo	82.11	0.00e+00	1537.00
IUUC-Mlu-067709	Myotis lucifugus	89.39	0.00e+00	2603.00
IUUC-Nle-069308	Nomascus leucogenys	97.35	0.00e+00	2841.00
IUUC-Opr-070330	Ochotona princeps	80.97	0.00e+00	2241.00
IUUC-Ont-071345	Oreochromis niloticus	80.76	0.00e+00	1444.00
IUUC-Ocu-074775	Oryctolagus cuniculus	94.10	0.00e+00	2595.00
IUUC-Ola-087225	Oryzias latipes	64.56	0.00e+00	1796.00
IUUC-Oga-088177	Otolemur garnettii	91.73	0.00e+00	2660.00
IUUC-Oar-089452	Ovis aries	95.16	0.00e+00	2773.00
IUUC-Ptr-090806	Pan troglodytes	97.61	0.00e+00	2876.00
IUUC-Pan-091838	Papio anubis	97.42	0.00e+00	2807.00
IUUC-Psi-094090	Pelodiscus sinensis	85.39	0.00e+00	2558.00
IUUC-Pfo-096520	Poecilia formosa	68.86	0.00e+00	1520.00
IUUC-Pab-098405	Pongo abelii	97.41	0.00e+00	2840.00
IUUC-Pca-100441	Procavia capensis	88.39	0.00e+00	2106.00
IUUC-Pva-102324	Pteropus vampyrus	98.35	0.00e+00	1599.00
IUUC-Rno-105943	Rattus norvegicus	92.67	0.00e+00	2811.00
IUUC-Sha-106985	Sarcophilus harrisii	86.54	0.00e+00	2311.00
IUUC-Sar-113505	Sorex araneus	94.92	0.00e+00	1514.00
IUUC-Ssc-115439	Sus scrofa	93.15	0.00e+00	1779.00
IUUC-Tgu-117078	Taeniopygia guttata	89.80	0.00e+00	1735.00
IUUC-Tru-118671	Takifugu rubripes	80.95	0.00e+00	1444.00
IUUC-Tni-120619	Tetraodon nigroviridis	86.62	0.00e+00	1422.00
IUUC-Tbe-127975	Tupaia belangeri	92.19	0.00e+00	2283.00
IUUC-Ttr-128469	Tursiops truncatus	89.26	0.00e+00	2496.00
IUUC-Vpa-130498	Vicugna pacos	83.59	0.00e+00	2302.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence