iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
WBGene00003086	Y37A1B.2a	Y37A1B.2a
WBGene00003086	Y37A1B.2b	Y37A1B.2b
WBGene00003086	Y37A1B.2c	Y37A1B.2c
WBGene00003086	Y37A1B.2d	Y37A1B.2d
WBGene00003086	Y37A1B.2f	Y37A1B.2f

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
microRNA	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	Mentha
Post-translational Modifications (PTMs)
dbPAF	PHOSIDA
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	9.60e-13	48.2	2	58

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 4    ekvqvlydyeaq.nddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            +v++ yd+++q n++eL++ +G+v++vi  e+ d+gW++g ++ +g  GlfPe +v+ 
   Q: 2    AQVKAEYDFQSQpNTGELSISAGEVLTVI-RENIDGGWIEG-RNVRGSVGLFPESYVTP 58
           5899******98799**************.***********.5*************986 PP

Organism

Caenorhabditis elegans

Functional Description
(View)

Involved in the signaling of vulval development by acting as a negative regulator of epidermal growth factor receptor (EGFR) signaling. Aids in phagosomal membrane tubule formation which is required for phagosomal fusion with endosomes and lysosomes. Also recruits rab-7 to phagosomes by an intereaction with dyn-1. These are events leading to phagosome maturation which is a step in apoptotic cell corpse clearance. Binds phosphatidylinositol-3,4,5-trisphosphate.

Protein Sequence
(Fasta)

MAQVKAEYDF QSQPNTGELS ISAGEVLTVI RENIDGGWIE GRNVRGSVGL FPESYVTPYQ 60
ASRPPPVLPP PLPPTSSGPP AASSRPFDDW GGASEVAAPP SYGAQHHHQP TPSVPEVTRS 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGAAATGGCT CAGGTGAAAG CCGAGTATGA TTTTCAAAGT CAACCAAACA CAGGCGAACT 60
GTCAATCTCG GCTGGCGAAG TTTTGACGGT TATTCGAGAG GTAAGAGGCT TTTTGAGCAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0968--Cytoplasmic vesicle
KW-0446--Lipid-binding
KW-0472--Membrane
KW-1185--Reference proteome
KW-0728--SH3 domain

Interpro

IPR027267--AH/BAR-dom
IPR001683--Phox
IPR001452--SH3_domain
IPR014536--Snx9_subfam
IPR019497--Sorting_nexin_WASP-bd-dom

PROSITE

PS50195--PX
PS50002--SH3

Pfam

PF10456--BAR_3_WASP_bdg
PF00787--PX
PF14604--SH3_9

PRINTS

PR00452--SH3DOMAIN

SMART

SM00312--PX
SM00326--SH3

Gene Ontology

GO:0005737--C:cytoplasm
GO:0045335--C:phagocytic vesicle
GO:0030670--C:phagocytic vesicle membrane
GO:0051020--F:GTPase binding
GO:0019902--F:phosphatase binding
GO:0005547--F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0005546--F:phosphatidylinositol-4,5-bisphosphate binding
GO:0043621--F:protein self-association
GO:0007067--P:mitotic nuclear division
GO:0090386--P:phagosome maturation involved in apoptotic cell clearance
GO:0090389--P:phagosome-lysosome fusion involved in apoptotic cell clearance
GO:0015031--P:protein transport

KEGG

cel:CELE_Y37A1B.2

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001493	Ailuropoda melanoleuca	32.45	3.00e-68	251.00
IUUC-Apl-003889	Anas platyrhynchos	34.06	1.00e-71	263.00
IUUC-Ame-011163	Astyanax mexicanus	36.67	4.00e-70	258.00
IUUC-Bta-013027	Bos taurus	33.41	7.00e-70	257.00
IUUC-Cja-019428	Callithrix jacchus	33.09	1.00e-68	252.00
IUUC-Cfa-021208	Canis familiaris	32.93	4.00e-69	254.00
IUUC-Cpo-021353	Cavia porcellus	33.17	2.00e-69	254.00
IUUC-Cho-025020	Choloepus hoffmanni	30.15	8.00e-38	150.00
IUUC-Cin-025695	Ciona intestinalis	29.33	5.00e-82	297.00
IUUC-Csv-025870	Ciona savignyi	30.53	1.00e-82	299.00
IUUC-Dre-027983	Danio rerio	35.98	7.00e-69	253.00
IUUC-Dme-031845	Drosophila melanogaster	39.74	2.00e-79	288.00
IUUC-Fca-036506	Felis catus	33.09	6.00e-69	253.00
IUUC-Fal-037443	Ficedula albicollis	33.82	2.00e-70	258.00
IUUC-Gmo-039464	Gadus morhua	31.81	6.00e-56	210.00
IUUC-Gac-041835	Gasterosteus aculeatus	36.00	5.00e-66	243.00
IUUC-Ggo-045438	Gorilla gorilla	31.82	3.00e-60	224.00
IUUC-Hsa-046762	Homo sapiens	33.09	1.00e-68	252.00
IUUC-Itr-048294	Ictidomys tridecemlineatus	32.53	3.00e-68	251.00
IUUC-Lch-050438	Latimeria chalumnae	35.14	1.00e-98	352.00
IUUC-Loc-052748	Lepisosteus oculatus	36.88	4.00e-70	257.00
IUUC-Laf-053373	Loxodonta africana	32.45	2.00e-68	252.00
IUUC-Mcc-054953	Macaca mulatta	34.10	6.00e-68	250.00
IUUC-Mla-058814	Melampsora laricipopulina	43.33	5.00e-08	52.80
IUUC-Mga-059536	Meleagris gallopavo	34.10	5.00e-69	254.00
IUUC-Mmr-061000	Microcebus murinus	34.06	2.00e-70	258.00
IUUC-Mdo-061885	Monodelphis domestica	33.74	6.00e-70	257.00
IUUC-Mmu-063532	Mus musculus	32.93	4.00e-69	254.00
IUUC-Mlu-067314	Myotis lucifugus	38.31	5.00e-84	303.00
IUUC-Ont-072028	Oreochromis niloticus	35.66	2.00e-67	249.00
IUUC-Oan-073741	Ornithorhynchus anatinus	39.29	2.00e-11	60.50
IUUC-Ola-086919	Oryzias latipes	36.66	2.00e-70	258.00
IUUC-Oga-088465	Otolemur garnettii	33.82	2.00e-69	255.00
IUUC-Oar-089562	Ovis aries	33.49	1.00e-69	256.00
IUUC-Ptr-090632	Pan troglodytes	33.09	1.00e-68	252.00
IUUC-Pan-092192	Papio anubis	34.10	6.00e-68	250.00
IUUC-Psi-093346	Pelodiscus sinensis	34.55	3.00e-72	265.00
IUUC-Pma-094619	Petromyzon marinus	35.53	2.00e-72	265.00
IUUC-Pfo-096634	Poecilia formosa	36.25	6.00e-71	260.00
IUUC-Pab-097866	Pongo abelii	33.09	1.00e-68	252.00
IUUC-Pva-102273	Pteropus vampyrus	34.34	6.00e-68	250.00
IUUC-Rno-105513	Rattus norvegicus	33.76	1.00e-67	249.00
IUUC-Ssc-116184	Sus scrofa	33.41	1.00e-70	259.00
IUUC-Tgu-117370	Taeniopygia guttata	34.41	2.00e-70	258.00
IUUC-Tru-117764	Takifugu rubripes	37.08	2.00e-69	255.00
IUUC-Tni-119947	Tetraodon nigroviridis	37.05	6.00e-70	257.00
IUUC-Ttr-128700	Tursiops truncatus	31.23	3.00e-61	228.00
IUUC-Xtr-132466	Xenopus tropicalis	27.92	3.00e-62	231.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence