iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mcc-054776

Ensembl Protein ID

ENSMMUP00000053308.1

UniProt Accession

I0FRT6; I0FRT6_MACMU

Genbank Protein ID

AFI34718.1; AFI37162.1

Protein Name

Mitogen-activated protein kinase kinase kinase 5

Genbank Nucleotide ID

JSUE03032149; JV047091

Gene Name

MAP3K5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000016376.3	ENSMMUT00000057151.1	ENSMMUP00000053308.1
ENSMMUG00000016376.3	ENSMMUT00000022996.3	ENSMMUP00000021508.3
ENSMMUG00000016376.3	ENSMMUT00000022994.3	ENSMMUP00000021506.3

Status

Unreviewed

Classification

Family	Identity	E-Value	Score	Source Orthology
ULD/UDP/UBQ/UBQ_Other	99.27	0.00e+00	2617.00	IUUC-Hsa-046906

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MSTEAGEGIT FSVPPFAPSG FCTIPEGGIC RRGGAAAVGE SEEHQLPPPP PGSFWNVESA 60
AAPGIGCPAA TSASSATRGR GSSVGGGSRR TTVAYVINEA SQGQLVVAES EALQSLREAC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCTGGCCAGG CGGTGCGGCT GGGCGGGGGA CGCCGCCGCC GTTGCTGCCC GGCCCGGAGA 60
GATGAGCACG GAGGCGGGCG AGGGCATCAC TTTCTCCGTG CCACCCTTCG CCCCCTCGGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0808--Transferase

Interpro

IPR025136--DUF4071
IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR013761--SAM/pointed
IPR008271--Ser/Thr_kinase_AS

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST

Pfam

PF13281--DUF4071
PF00069--Pkinase

SMART

SM00220--S_TKc

Gene Ontology

GO:1990604--C:IRE1-TRAF2-ASK1 complex
GO:1902911--C:protein kinase complex
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004709--F:MAP kinase kinase kinase activity
GO:0000187--P:activation of MAPK activity
GO:0070301--P:cellular response to hydrogen peroxide
GO:1902170--P:cellular response to reactive nitrogen species
GO:0070059--P:intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
GO:0008631--P:intrinsic apoptotic signaling pathway in response to oxidative stress
GO:0007254--P:JNK cascade
GO:0038066--P:p38MAPK cascade
GO:0043280--P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0043507--P:positive regulation of JUN kinase activity
GO:0045663--P:positive regulation of myoblast differentiation
GO:1901216--P:positive regulation of neuron death
GO:0097300--P:programmed necrotic cell death

KEGG

mcc:711382

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002318	Ailuropoda melanoleuca	96.96	0.00e+00	2362.00
IUUC-Apl-003713	Anas platyrhynchos	89.16	0.00e+00	2076.00
IUUC-Aca-005331	Anolis carolinensis	87.87	0.00e+00	2092.00
IUUC-Ame-011158	Astyanax mexicanus	74.14	0.00e+00	1854.00
IUUC-Bta-012770	Bos taurus	95.12	0.00e+00	2468.00
IUUC-Cja-019656	Callithrix jacchus	98.54	0.00e+00	2569.00
IUUC-Cfa-020488	Canis familiaris	96.14	0.00e+00	2462.00
IUUC-Cpo-022516	Cavia porcellus	94.72	0.00e+00	2334.00
IUUC-Csa-023104	Chlorocebus sabaeus	99.92	0.00e+00	2365.00
IUUC-Cho-024379	Choloepus hoffmanni	90.25	0.00e+00	1236.00
IUUC-Dre-028836	Danio rerio	75.50	0.00e+00	1888.00
IUUC-Dno-029842	Dasypus novemcinctus	94.46	0.00e+00	2212.00
IUUC-Dor-030990	Dipodomys ordii	95.50	0.00e+00	1939.00
IUUC-Ete-032693	Echinops telfairi	85.19	0.00e+00	1999.00
IUUC-Eca-033337	Equus caballus	95.77	0.00e+00	2325.00
IUUC-Eeu-034602	Erinaceus europaeus	80.35	0.00e+00	2063.00
IUUC-Fca-035954	Felis catus	96.38	0.00e+00	1937.00
IUUC-Fal-037358	Ficedula albicollis	88.65	0.00e+00	2106.00
IUUC-Gmo-038836	Gadus morhua	78.62	0.00e+00	1766.00
IUUC-Gga-040443	Gallus gallus	86.65	0.00e+00	2237.00
IUUC-Gac-041634	Gasterosteus aculeatus	75.13	0.00e+00	1942.00
IUUC-Ggo-045263	Gorilla gorilla	97.31	0.00e+00	2511.00
IUUC-Hsa-046906	Homo sapiens	99.27	0.00e+00	2592.00
IUUC-Itr-048449	Ictidomys tridecemlineatus	95.66	0.00e+00	1105.00
IUUC-Lch-050213	Latimeria chalumnae	78.61	0.00e+00	1808.00
IUUC-Loc-051829	Lepisosteus oculatus	72.01	0.00e+00	1879.00
IUUC-Laf-053538	Loxodonta africana	95.34	0.00e+00	2499.00
IUUC-Mga-059636	Meleagris gallopavo	88.61	0.00e+00	2135.00
IUUC-Mmr-061323	Microcebus murinus	96.95	0.00e+00	2492.00
IUUC-Mdo-062146	Monodelphis domestica	91.01	0.00e+00	2338.00
IUUC-Mmu-064022	Mus musculus	94.27	0.00e+00	2437.00
IUUC-Mpu-066531	Mustela putorius furo	93.18	0.00e+00	2476.00
IUUC-Mlu-068181	Myotis lucifugus	90.90	0.00e+00	2401.00
IUUC-Nle-069758	Nomascus leucogenys	99.43	0.00e+00	2357.00
IUUC-Opr-070531	Ochotona princeps	88.25	0.00e+00	1472.00
IUUC-Ont-072014	Oreochromis niloticus	77.57	0.00e+00	1913.00
IUUC-Oan-073169	Ornithorhynchus anatinus	93.40	0.00e+00	2245.00
IUUC-Ocu-074050	Oryctolagus cuniculus	92.57	0.00e+00	2172.00
IUUC-Ola-086941	Oryzias latipes	80.34	0.00e+00	1555.00
IUUC-Oga-088796	Otolemur garnettii	96.00	0.00e+00	2477.00
IUUC-Oar-090445	Ovis aries	96.81	0.00e+00	2302.00
IUUC-Ptr-090846	Pan troglodytes	98.98	0.00e+00	2607.00
IUUC-Pan-091986	Papio anubis	99.93	0.00e+00	2633.00
IUUC-Psi-093805	Pelodiscus sinensis	89.01	0.00e+00	2237.00
IUUC-Pfo-097301	Poecilia formosa	73.99	0.00e+00	1932.00
IUUC-Pab-097662	Pongo abelii	99.25	0.00e+00	2511.00
IUUC-Pca-100755	Procavia capensis	95.16	0.00e+00	728.00
IUUC-Pva-102280	Pteropus vampyrus	86.67	0.00e+00	2266.00
IUUC-Rno-105547	Rattus norvegicus	93.26	0.00e+00	2427.00
IUUC-Sha-106859	Sarcophilus harrisii	90.90	0.00e+00	2288.00
IUUC-Sar-113714	Sorex araneus	84.22	0.00e+00	1946.00
IUUC-Tgu-117116	Taeniopygia guttata	87.39	0.00e+00	2176.00
IUUC-Tru-118088	Takifugu rubripes	74.96	0.00e+00	1953.00
IUUC-Tsy-119616	Tarsius syrichta	91.79	0.00e+00	2013.00
IUUC-Tni-120284	Tetraodon nigroviridis	75.54	0.00e+00	1904.00
IUUC-Tbe-127900	Tupaia belangeri	95.12	0.00e+00	852.00
IUUC-Ttr-128294	Tursiops truncatus	85.31	0.00e+00	2147.00
IUUC-Vpa-130470	Vicugna pacos	87.52	0.00e+00	2068.00
IUUC-Xtr-132396	Xenopus tropicalis	75.67	0.00e+00	1979.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence