iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Mga-060100

UUCD1 version

UUC-MeG-00006

Ensembl Protein ID

ENSMGAP00000006984.1

UniProt Accession

H9H138; H9H138_MELGA

Protein Name

Uncharacterized protein

Gene Name

RNF41

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000006916.1	ENSMGAT00000007749.1	ENSMGAP00000006984.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	2.50e-06	27.6	18	57
E3 activity/RING/U-box	7.80e-07	28.8	12	69

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlp.CgHvfhadClqkwpglknssskefrCPlCr 46
           C+iC   +++ p+  p C H+f+  C+ +w       s++++CP++r
   Q: 18   CPICSGVLEE-PVQAPhCEHAFCNACITQW------FSQQQTCPVDR 57
           ****999999.777777*************......********987 PP

E3 activity/RING/U-box

   S: 2    vpeeflCpIslelMrdPvvlp.sGitydrssIekwlasggktcPvtrqplteedlvPnl 59
           v e+++CpI   + ++Pv +p + + +  ++I +w++++++ cPv+r+ +t   l P  
   Q: 12   VDEDLICPICSGVLEEPVQAPhCEHAFCNACITQWFSQQQT-CPVDRSVVTVAHLRPVP 69
           56899******************************998887.******99999887764 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

MGYDVARFQG DVDEDLICPI CSGVLEEPVQ APHCEHAFCN ACITQWFSQQ QTCPVDRSVV 60
TVAHLRPVPR IMRNMLSKLQ ITCDNAVFGC TAVVRLDNLM SHLNDCEHNP KRPVTCEQGC 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGGTTTCTGG CATTGGTGAT GAGCAATGGG GTATGATGTA GCACGCTTTC AGGGGGATGT 60
TGATGAAGAC CTCATATGCC CCATCTGCAG CGGGGTCCTG GAGGAGCCGG TTCAGGTAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008974--TRAF-like
IPR015036--USP8_interacting
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS
IPR013010--Znf_SIAH

PROSITE

PS00518--ZF_RING_1
PS50089--ZF_RING_2
PS51081--ZF_SIAH

Pfam

PF08941--USP8_interact

SMART

SM00184--RING

Gene Ontology

GO:0016881--F:acid-amino acid ligase activity
GO:0031386--F:protein tag
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0097191--P:extrinsic apoptotic signaling pathway
GO:0030336--P:negative regulation of cell migration
GO:0008285--P:negative regulation of cell proliferation
GO:1901525--P:negative regulation of macromitophagy
GO:2000379--P:positive regulation of reactive oxygen species metabolic process
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0010498--P:proteasomal protein catabolic process
GO:0051865--P:protein autoubiquitination
GO:0000209--P:protein polyubiquitination
GO:2000114--P:regulation of establishment of cell polarity
GO:0045619--P:regulation of lymphocyte differentiation
GO:0043408--P:regulation of MAPK cascade
GO:0045637--P:regulation of myeloid cell differentiation
GO:0051896--P:regulation of protein kinase B signaling

KEGG

mgp:100543651

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002398	Ailuropoda melanoleuca	96.85	0.00e+00	645.00
IUUC-Apl-003568	Anas platyrhynchos	99.06	0.00e+00	646.00
IUUC-Aca-005119	Anolis carolinensis	99.68	0.00e+00	659.00
IUUC-Ame-010708	Astyanax mexicanus	91.80	2.00e-180	624.00
IUUC-Bta-013428	Bos taurus	90.85	1.00e-174	604.00
IUUC-Cja-019844	Callithrix jacchus	96.86	0.00e+00	642.00
IUUC-Cfa-021124	Canis familiaris	97.16	0.00e+00	646.00
IUUC-Cpo-022325	Cavia porcellus	96.85	0.00e+00	645.00
IUUC-Csa-023113	Chlorocebus sabaeus	97.16	0.00e+00	646.00
IUUC-Cho-024991	Choloepus hoffmanni	97.42	9.00e-113	398.00
IUUC-Cne-026870	Cryptococcus neoformans	38.52	5.00e-20	92.40
IUUC-Dre-028730	Danio rerio	91.48	5.00e-180	622.00
IUUC-Dno-028908	Dasypus novemcinctus	96.86	2.00e-168	583.00
IUUC-Dor-030411	Dipodomys ordii	96.85	0.00e+00	646.00
IUUC-Dme-031868	Drosophila melanogaster	58.41	8.00e-113	399.00
IUUC-Ete-032896	Echinops telfairi	78.87	2.00e-122	431.00
IUUC-Eca-034135	Equus caballus	97.16	0.00e+00	646.00
IUUC-Eeu-034675	Erinaceus europaeus	96.85	0.00e+00	644.00
IUUC-Fca-035612	Felis catus	97.16	0.00e+00	646.00
IUUC-Fal-036922	Ficedula albicollis	98.77	9.00e-43	163.00
IUUC-Gmo-039648	Gadus morhua	88.33	5.00e-174	602.00
IUUC-Gga-040474	Gallus gallus	100.00	0.00e+00	660.00
IUUC-Gac-041951	Gasterosteus aculeatus	89.59	1.00e-176	611.00
IUUC-Ggo-045126	Gorilla gorilla	96.86	0.00e+00	642.00
IUUC-Hsa-046402	Homo sapiens	97.16	0.00e+00	646.00
IUUC-Itr-047895	Ictidomys tridecemlineatus	97.16	0.00e+00	646.00
IUUC-Lch-050266	Latimeria chalumnae	94.01	0.00e+00	634.00
IUUC-Loc-052547	Lepisosteus oculatus	92.74	0.00e+00	627.00
IUUC-Lma-053014	Leptosphaeria maculans	34.68	2.00e-12	66.60
IUUC-Laf-054332	Loxodonta africana	96.54	0.00e+00	641.00
IUUC-Mcc-055869	Macaca mulatta	97.16	0.00e+00	646.00
IUUC-Meu-056735	Macropus eugenii	97.21	9.00e-169	585.00
IUUC-Mmr-061382	Microcebus murinus	97.16	0.00e+00	646.00
IUUC-Mdo-062581	Monodelphis domestica	33.88	5.00e-23	103.00
IUUC-Mmu-064225	Mus musculus	96.85	0.00e+00	645.00
IUUC-Mpu-066709	Mustela putorius furo	97.16	0.00e+00	646.00
IUUC-Mlu-067168	Myotis lucifugus	96.21	0.00e+00	644.00
IUUC-Nle-070176	Nomascus leucogenys	97.16	0.00e+00	646.00
IUUC-Opr-070259	Ochotona princeps	96.85	0.00e+00	645.00
IUUC-Ont-071235	Oreochromis niloticus	90.85	7.00e-179	619.00
IUUC-Oan-072850	Ornithorhynchus anatinus	94.08	3.00e-82	297.00
IUUC-Ocu-074165	Oryctolagus cuniculus	96.85	0.00e+00	645.00
IUUC-Ola-086658	Oryzias latipes	89.27	4.00e-175	606.00
IUUC-Oga-088933	Otolemur garnettii	97.16	0.00e+00	646.00
IUUC-Oar-090089	Ovis aries	96.85	0.00e+00	646.00
IUUC-Ptr-091263	Pan troglodytes	97.16	0.00e+00	646.00
IUUC-Pan-092926	Papio anubis	97.16	0.00e+00	646.00
IUUC-Psi-093934	Pelodiscus sinensis	92.14	2.00e-172	597.00
IUUC-Pma-094578	Petromyzon marinus	68.34	1.00e-126	445.00
IUUC-Pno-094854	Phaeosphaeria nodorum	36.59	2.00e-13	70.10
IUUC-Pfo-097431	Poecilia formosa	90.85	2.00e-178	617.00
IUUC-Pab-097852	Pongo abelii	97.16	0.00e+00	646.00
IUUC-Pca-100496	Procavia capensis	88.99	2.00e-165	574.00
IUUC-Pva-103157	Pteropus vampyrus	97.00	5.00e-115	405.00
IUUC-Pgr-103416	Puccinia graminis	30.77	3.00e-13	69.70
IUUC-Rno-105928	Rattus norvegicus	96.85	0.00e+00	644.00
IUUC-Sha-107556	Sarcophilus harrisii	97.17	0.00e+00	644.00
IUUC-Sar-113208	Sorex araneus	97.16	0.00e+00	646.00
IUUC-Ssc-116011	Sus scrofa	96.85	0.00e+00	646.00
IUUC-Tgu-116882	Taeniopygia guttata	75.50	3.00e-74	270.00
IUUC-Tru-117987	Takifugu rubripes	90.54	5.00e-178	615.00
IUUC-Tsy-118785	Tarsius syrichta	96.85	0.00e+00	640.00
IUUC-Tni-120165	Tetraodon nigroviridis	90.22	1.00e-177	614.00
IUUC-Tbe-127920	Tupaia belangeri	97.50	6.00e-117	412.00
IUUC-Ttr-129160	Tursiops truncatus	96.53	0.00e+00	644.00
IUUC-Vpa-130629	Vicugna pacos	97.16	0.00e+00	646.00
IUUC-Xtr-131895	Xenopus tropicalis	95.90	0.00e+00	641.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence