iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aca-004782

UUCD1 version

UUC-AnC-00716

Ensembl Protein ID

ENSACAP00000011306.1

UniProt Accession

G1KL86; G1KL86_ANOCA

Protein Name

Uncharacterized protein

Gene Name

SOCS6

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSACAG00000011568.1	ENSACAT00000011543.1	ENSACAP00000011306.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	3.00e-17	62.2	486	533

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
            ++ +++ ++rSLq+LCR++Ir++++++ +   +kLPLP+++kdYL++++y
   Q: 486  TNPVSRFMQVRSLQYLCRFVIRQYTRIDLI---QKLPLPNKMKDYLQEKHY 533
           5788999********************888...***************997 PP

Organism

Anolis carolinensis

Protein Sequence
(Fasta)

MKKISLKTIR KSFNLNKSKD ESDFVVVTQP SLNDFGKDDS LFGGCYGKDL ASCDINSEDE 60
KSGKNRSKSE SLMGTLKRRL SAKQKQKGSK GSTPSVSSAD DDTFSSSSAP ITFKDARTQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAAGAAAA TTAGTCTCAA GACTATTCGT AAGTCTTTTA ATTTAAATAA GAGCAAAGAT 60
GAAAGTGACT TTGTTGTAGT CACACAGCCA TCATTGAATG ATTTTGGAAA AGATGACTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028421--SOCS6
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0001772--C:immunological synapse
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0050868--P:negative regulation of T cell activation
GO:0010498--P:proteasomal protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

KEGG

acs:100557492

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001911	Ailuropoda melanoleuca	87.87	0.00e+00	873.00
IUUC-Apl-004035	Anas platyrhynchos	94.39	0.00e+00	923.00
IUUC-Ame-011790	Astyanax mexicanus	69.72	0.00e+00	635.00
IUUC-Bta-012579	Bos taurus	93.72	6.00e-107	380.00
IUUC-Cja-019528	Callithrix jacchus	88.62	0.00e+00	922.00
IUUC-Cfa-020678	Canis familiaris	88.25	0.00e+00	898.00
IUUC-Cpo-021947	Cavia porcellus	88.62	0.00e+00	926.00
IUUC-Csa-023935	Chlorocebus sabaeus	88.25	0.00e+00	892.00
IUUC-Cho-024477	Choloepus hoffmanni	86.19	0.00e+00	897.00
IUUC-Cin-025413	Ciona intestinalis	68.82	8.00e-67	247.00
IUUC-Csv-026247	Ciona savignyi	68.07	2.00e-65	242.00
IUUC-Dre-027636	Danio rerio	69.96	0.00e+00	639.00
IUUC-Dno-029048	Dasypus novemcinctus	88.81	0.00e+00	900.00
IUUC-Dor-030401	Dipodomys ordii	85.26	0.00e+00	849.00
IUUC-Ete-033116	Echinops telfairi	50.19	4.00e-53	201.00
IUUC-Eca-033825	Equus caballus	88.25	0.00e+00	852.00
IUUC-Fca-036253	Felis catus	86.01	0.00e+00	795.00
IUUC-Fal-037614	Ficedula albicollis	93.46	0.00e+00	913.00
IUUC-Fox-037898	Fusarium oxysporum	28.05	7.00e-03	34.30
IUUC-Gmo-038928	Gadus morhua	68.20	0.00e+00	658.00
IUUC-Gga-040177	Gallus gallus	93.83	0.00e+00	918.00
IUUC-Gac-042263	Gasterosteus aculeatus	70.17	0.00e+00	691.00
IUUC-Ggo-045288	Gorilla gorilla	88.62	0.00e+00	900.00
IUUC-Hsa-046409	Homo sapiens	88.62	0.00e+00	899.00
IUUC-Itr-048996	Ictidomys tridecemlineatus	85.45	0.00e+00	851.00
IUUC-Lch-050354	Latimeria chalumnae	85.29	0.00e+00	866.00
IUUC-Loc-052319	Lepisosteus oculatus	81.19	0.00e+00	815.00
IUUC-Laf-054070	Loxodonta africana	86.94	0.00e+00	861.00
IUUC-Mcc-055045	Macaca mulatta	88.43	0.00e+00	892.00
IUUC-Meu-055917	Macropus eugenii	91.23	0.00e+00	957.00
IUUC-Mga-059273	Meleagris gallopavo	94.02	0.00e+00	917.00
IUUC-Mmr-061597	Microcebus murinus	88.62	0.00e+00	894.00
IUUC-Mdo-062492	Monodelphis domestica	67.73	2.00e-112	398.00
IUUC-Mmu-063374	Mus musculus	78.85	0.00e+00	788.00
IUUC-Mpu-065967	Mustela putorius furo	83.96	0.00e+00	835.00
IUUC-Mlu-067532	Myotis lucifugus	86.38	0.00e+00	858.00
IUUC-Nle-069373	Nomascus leucogenys	88.43	0.00e+00	896.00
IUUC-Opr-070873	Ochotona princeps	84.70	0.00e+00	895.00
IUUC-Ont-072498	Oreochromis niloticus	71.09	0.00e+00	723.00
IUUC-Oan-072943	Ornithorhynchus anatinus	70.37	2.00e-99	354.00
IUUC-Ocu-073870	Oryctolagus cuniculus	87.31	0.00e+00	878.00
IUUC-Oru-084874	Oryza rufipogon	41.38	2.10e+00	27.70
IUUC-Ola-086866	Oryzias latipes	88.48	1.00e-103	368.00
IUUC-Oga-089057	Otolemur garnettii	86.01	0.00e+00	849.00
IUUC-Oar-089841	Ovis aries	57.38	3.00e-155	541.00
IUUC-Ptr-091054	Pan troglodytes	88.62	0.00e+00	897.00
IUUC-Pma-094253	Petromyzon marinus	82.11	7.00e-93	334.00
IUUC-Pfo-097179	Poecilia formosa	65.68	7.00e-175	606.00
IUUC-Pab-097702	Pongo abelii	88.43	0.00e+00	897.00
IUUC-Pca-100671	Procavia capensis	78.16	1.00e-115	410.00
IUUC-Rno-106044	Rattus norvegicus	76.67	0.00e+00	780.00
IUUC-Sha-107139	Sarcophilus harrisii	90.38	0.00e+00	874.00
IUUC-Smo-108823	Selaginella moellendorffii	33.96	4.80e-02	31.20
IUUC-Sly-111748	Solanum lycopersicum	42.31	7.60e-01	28.50
IUUC-Ssc-115343	Sus scrofa	86.19	0.00e+00	879.00
IUUC-Tgu-117061	Taeniopygia guttata	93.83	0.00e+00	917.00
IUUC-Tni-119829	Tetraodon nigroviridis	68.39	0.00e+00	651.00
IUUC-Tae-123723	Triticum aestivum	34.15	5.70e-01	29.60
IUUC-Ttr-129148	Tursiops truncatus	85.26	0.00e+00	832.00
IUUC-Vpa-130780	Vicugna pacos	83.02	0.00e+00	813.00
IUUC-Vvi-130966	Vitis vinifera	32.69	7.00e-02	30.80
IUUC-Xtr-132513	Xenopus tropicalis	83.40	0.00e+00	855.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence