iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	CircNet	miRTarBase
microRNA	TRANSFAC	TargetScan	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	PINA	HINT	Mentha
InWeb_IM
Protein 3D Structure
PDB	MMDB
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
BioGRID	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	SOCS	12052866; 21030588

Classification

Family	E-value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	1.00e-16	62.1	488	535

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 2    sklwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedy 52
            ++ +++ ++rSLq+LCR++Ir++++++ +   +kLPLP+++kdYL++++y
   Q: 488  TNPVSRFMQVRSLQYLCRFVIRQYTRIDLI---QKLPLPNKMKDYLQEKHY 535
           5788999********************888...***************997 PP

Organism

Homo sapiens

Functional Description
(View)

SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (By similarity). Regulates KIT degradation by ubiquitination of the tyrosine-phosphorylated receptor.

Protein Sequence
(Fasta)

MKKISLKTLR KSFNLNKSKE ETDFMVVQQP SLASDFGKDD SLFGSCYGKD MASCDINGED 60
EKGGKNRSKS ESLMGTLKRR LSAKQKSKGK AGTPSGSSAD EDTFSSSSAP IVFKDVRAQR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGTAGTGGAC GGGGGGCGGC CCGCTCGGCT CCTCCGCACC CGCTCCCCGC TCGGGCCGAG 60
GCGCCGCGGC CGCGCGCCCC TCCTGGAGGA GGAGGAGGAA GGAGGCGGGA GGAGGAGTTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0181--Complete proteome
KW-0341--Growth regulation
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0734--Signal transduction inhibitor
KW-0833--Ubl conjugation pathway

Interpro

IPR000980--SH2
IPR028421--SOCS6
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0001772--C:immunological synapse
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0006952--P:defense response
GO:0007259--P:JAK-STAT cascade
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0050868--P:negative regulation of T cell activation
GO:0010498--P:proteasomal protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0040008--P:regulation of growth

KEGG

hsa:9306

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001911	Ailuropoda melanoleuca	95.51	0.00e+00	955.00
IUUC-Atr-002940	Amborella trichopoda	27.27	6.50e-02	32.00
IUUC-Apl-004035	Anas platyrhynchos	90.47	0.00e+00	897.00
IUUC-Aca-004782	Anolis carolinensis	88.62	0.00e+00	865.00
IUUC-Ani-009490	Aspergillus nidulans	31.88	7.90e-02	31.60
IUUC-Ame-011790	Astyanax mexicanus	69.41	0.00e+00	648.00
IUUC-Bta-012579	Bos taurus	94.74	1.00e-108	386.00
IUUC-Bol-015843	Brassica oleracea	28.77	3.30e-02	33.10
IUUC-Cel-018643	Caenorhabditis elegans	33.59	1.00e-11	62.80
IUUC-Cja-019528	Callithrix jacchus	97.94	0.00e+00	1028.00
IUUC-Cfa-020678	Canis familiaris	94.58	0.00e+00	968.00
IUUC-Cpo-021947	Cavia porcellus	95.33	0.00e+00	1004.00
IUUC-Csa-023935	Chlorocebus sabaeus	98.69	0.00e+00	1009.00
IUUC-Cho-024477	Choloepus hoffmanni	91.40	0.00e+00	960.00
IUUC-Cin-025413	Ciona intestinalis	68.24	3.00e-66	245.00
IUUC-Csv-026247	Ciona savignyi	67.47	5.00e-65	241.00
IUUC-Cne-026906	Cryptococcus neoformans	27.08	3.20e-02	33.90
IUUC-Dre-027636	Danio rerio	69.59	0.00e+00	643.00
IUUC-Dno-029048	Dasypus novemcinctus	94.02	0.00e+00	962.00
IUUC-Dor-030401	Dipodomys ordii	91.23	0.00e+00	922.00
IUUC-Ete-033116	Echinops telfairi	49.12	2.00e-58	219.00
IUUC-Eca-033825	Equus caballus	95.51	0.00e+00	934.00
IUUC-Fca-036253	Felis catus	93.27	0.00e+00	877.00
IUUC-Fal-037614	Ficedula albicollis	91.03	0.00e+00	902.00
IUUC-Fox-037898	Fusarium oxysporum	28.40	7.00e-03	34.30
IUUC-Gmo-038928	Gadus morhua	69.74	0.00e+00	681.00
IUUC-Gga-040177	Gallus gallus	90.28	0.00e+00	893.00
IUUC-Gac-042263	Gasterosteus aculeatus	71.09	0.00e+00	706.00
IUUC-Ggo-045288	Gorilla gorilla	99.25	0.00e+00	1018.00
IUUC-Itr-048996	Ictidomys tridecemlineatus	93.64	0.00e+00	931.00
IUUC-Lch-050354	Latimeria chalumnae	83.77	0.00e+00	871.00
IUUC-Loc-052319	Lepisosteus oculatus	81.53	0.00e+00	826.00
IUUC-Laf-054070	Loxodonta africana	92.15	0.00e+00	910.00
IUUC-Mcc-055045	Macaca mulatta	98.69	0.00e+00	1008.00
IUUC-Meu-055917	Macropus eugenii	90.47	0.00e+00	961.00
IUUC-Mga-059273	Meleagris gallopavo	90.65	0.00e+00	895.00
IUUC-Mmr-061597	Microcebus murinus	96.82	0.00e+00	989.00
IUUC-Mdo-062492	Monodelphis domestica	66.18	7.00e-114	403.00
IUUC-Mmu-063374	Mus musculus	84.20	0.00e+00	836.00
IUUC-Mpu-065967	Mustela putorius furo	89.72	0.00e+00	904.00
IUUC-Mlu-067532	Myotis lucifugus	93.08	0.00e+00	932.00
IUUC-Nle-069373	Nomascus leucogenys	99.25	0.00e+00	1015.00
IUUC-Opr-070873	Ochotona princeps	90.84	0.00e+00	963.00
IUUC-Ont-072498	Oreochromis niloticus	71.40	0.00e+00	736.00
IUUC-Oan-072943	Ornithorhynchus anatinus	71.59	4.00e-98	351.00
IUUC-Ocu-073870	Oryctolagus cuniculus	94.21	0.00e+00	961.00
IUUC-Ola-086866	Oryzias latipes	89.40	3.00e-105	374.00
IUUC-Oga-089057	Otolemur garnettii	93.08	0.00e+00	929.00
IUUC-Oar-089841	Ovis aries	61.75	5.00e-168	584.00
IUUC-Ptr-091054	Pan troglodytes	99.63	0.00e+00	1018.00
IUUC-Pma-094253	Petromyzon marinus	44.17	5.00e-101	361.00
IUUC-Pfo-097179	Poecilia formosa	65.25	1.00e-177	616.00
IUUC-Pab-097702	Pongo abelii	99.25	0.00e+00	1015.00
IUUC-Pca-100671	Procavia capensis	85.62	4.00e-128	451.00
IUUC-Rno-106044	Rattus norvegicus	81.52	0.00e+00	825.00
IUUC-Sha-107139	Sarcophilus harrisii	89.56	0.00e+00	879.00
IUUC-Smo-108823	Selaginella moellendorffii	33.96	4.10e-02	32.00
IUUC-Sly-111748	Solanum lycopersicum	46.15	2.70e-01	30.00
IUUC-Ssc-115343	Sus scrofa	92.34	0.00e+00	951.00
IUUC-Tgu-117061	Taeniopygia guttata	90.84	0.00e+00	902.00
IUUC-Tni-119829	Tetraodon nigroviridis	67.47	0.00e+00	650.00
IUUC-Tae-123723	Triticum aestivum	27.50	1.40e-02	35.40
IUUC-Ttr-129148	Tursiops truncatus	91.40	0.00e+00	896.00
IUUC-Vpa-130780	Vicugna pacos	89.53	0.00e+00	865.00
IUUC-Vvi-130966	Vitis vinifera	32.69	6.70e-02	31.20
IUUC-Xtr-132513	Xenopus tropicalis	82.62	0.00e+00	857.00
IUUC-Xma-133904	Xiphophorus maculatus	69.32	0.00e+00	676.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence