iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Vda-129753

Ensembl Protein ID

EGY13391

UniProt Accession

G2WR90; G2WR90_VERDV

Genbank Protein ID

EGY13391.1

Protein Name

E3 ubiquitin-protein ligase

Genbank Nucleotide ID

DS572695

Gene Name

VDAG_00073

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
VDAG_00073	EGY13391	EGY13391

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.80e-122	408.0	473	805

Active Site

Position(s)	Description	Evidence
774	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlplsksfyklllg 102
           + dlkkrl+++f gE+gld+gG++ref++lls+e++np ++lf+ys+ d++tlq+np+sg+ npehl++F+f+Gr++g+a++++r+ld+++  ++yk++lg
   Q: 473  ATDLKKRLMIKFDGEDGLDYGGLSREFFFLLSHEMFNPFYCLFEYSAHDNYTLQINPHSGI-NPEHLNYFKFIGRVVGLAIFHRRFLDAFFIGALYKMILG 572
           579*********************************************************9.89************************************* PP
   S: 103  kklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyrlkegikeqveafreGfnevipl 203
           k++ l d+e vd+++++sl+++++n   di+   l+ tfs+++e +g + +e+Lkp+G+ni+V n+Nk+eYv+l+v++r++++i+eq++af+ Gf+e+ip+
   Q: 573  KSVVLADMEGVDADFHRSLQWMLDN---DISGGILEQTFSTEDERFGVICVEDLKPDGRNIDVDNDNKKEYVDLMVKWRIEKRIAEQFQAFQTGFHELIPQ 670
           ***********************99...9************************************************************************ PP
   S: 204  ellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk....prlfvirkdasddrlPs 300
           +l+++F+e+elelli G +eidv+d+kk+t y+g yte+++++q+Fw+++++++ e+++++LqF+Tg+sr+P++Gf++l+    pr+f+i+k+++ ++lP+
   Q: 671  DLINVFDERELELLIGGIAEIDVDDWKKHTDYRG-YTESDEVVQFFWQTIRSWDGEQKSRLLQFATGTSRIPVNGFKDLQgsdgPRRFTIEKAGEVNNLPK 770
           ********************************76.****************************************************************** PP
   S: 301  snTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           ++TCfn+L+LP+Y++ e l++kL++A+eet gF++
   Q: 771  AHTCFNRLDLPPYKNLEALQQKLTIAVEETMGFGQ 805
           *********************************96 PP

Organism

Verticillium dahliae

Protein Sequence
(Fasta)

MSNSRNAGGP AAGSPNLRVT SFPDPFAVIT ANGDQTKTTT AQKRTLNPYW NESYDLSVTE 60
DTILAVQVFD QKKFKKKDQG FLGVINVRIG DVIELAPDAD DQMLTRDLKK STDNLVVHGK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAGCAACT CGCGCAATGC TGGCGGTCCC GCTGCTGGGT GAGCTTCAAT CCAGCCCCCC 60
CCTCTCCCTT CTCGAAAGGC TGTCGACTGT CGTGTCCGGT GCCTGATGTC TTGGGCTCTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0436--Ligase
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR024928--E3_ub_ligase_SMURF1
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity

KEGG

vda:VDAG_00073

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001314	Ailuropoda melanoleuca	46.66	2.00e-152	531.00
IUUC-Apl-003752	Anas platyrhynchos	48.12	5.00e-158	549.00
IUUC-Aca-005338	Anolis carolinensis	46.74	5.00e-151	526.00
IUUC-Ago-007742	Ashbya gossypii	72.91	0.00e+00	905.00
IUUC-Acl-008273	Aspergillus clavatus	70.23	0.00e+00	1066.00
IUUC-Afl-008713	Aspergillus flavus	69.51	0.00e+00	1066.00
IUUC-Afu-009103	Aspergillus fumigatus	69.24	0.00e+00	1053.00
IUUC-Ani-009259	Aspergillus nidulans	68.92	0.00e+00	1077.00
IUUC-Ang-009738	Aspergillus niger	68.36	0.00e+00	1082.00
IUUC-Aor-010053	Aspergillus oryzae	76.67	6.00e-141	491.00
IUUC-Ate-010529	Aspergillus terreus	70.54	0.00e+00	1077.00
IUUC-Ame-011081	Astyanax mexicanus	46.50	7.00e-153	532.00
IUUC-Bgr-012148	Blumeria graminis	76.91	0.00e+00	1178.00
IUUC-Bta-012679	Bos taurus	46.66	6.00e-153	533.00
IUUC-Bci-013785	Botrytis cinerea	76.02	0.00e+00	1197.00
IUUC-Cel-018299	Caenorhabditis elegans	43.27	8.00e-141	492.00
IUUC-Cja-018732	Callithrix jacchus	44.33	3.00e-152	530.00
IUUC-Cfa-021226	Canis familiaris	44.93	6.00e-153	533.00
IUUC-Cpo-021671	Cavia porcellus	46.66	1.00e-152	532.00
IUUC-Csa-023252	Chlorocebus sabaeus	45.98	5.00e-153	533.00
IUUC-Cho-024695	Choloepus hoffmanni	47.96	3.00e-157	547.00
IUUC-Cin-025212	Ciona intestinalis	46.00	2.00e-146	511.00
IUUC-Csv-026256	Ciona savignyi	45.71	2.00e-145	507.00
IUUC-Cgl-026642	Colletotrichum gloeosporioides	87.47	0.00e+00	1360.00
IUUC-Cne-026849	Cryptococcus neoformans	60.17	0.00e+00	946.00
IUUC-Dre-027770	Danio rerio	51.44	7.00e-140	489.00
IUUC-Dno-029466	Dasypus novemcinctus	46.66	9.00e-153	532.00
IUUC-Dor-030138	Dipodomys ordii	45.99	1.00e-147	515.00
IUUC-Dse-031241	Dothistroma septosporum	70.43	0.00e+00	1110.00
IUUC-Dme-032041	Drosophila melanogaster	44.80	8.00e-139	486.00
IUUC-Ete-033145	Echinops telfairi	43.65	1.00e-138	485.00
IUUC-Eca-033445	Equus caballus	46.66	2.00e-152	531.00
IUUC-Eeu-035247	Erinaceus europaeus	45.99	1.00e-149	522.00
IUUC-Fca-035605	Felis catus	47.28	7.00e-156	542.00
IUUC-Fal-037126	Ficedula albicollis	47.87	1.00e-155	541.00
IUUC-Fox-037774	Fusarium oxysporum	83.52	0.00e+00	1293.00
IUUC-Fso-038393	Fusarium solani	83.69	0.00e+00	1266.00
IUUC-Gmo-039674	Gadus morhua	46.24	2.00e-143	501.00
IUUC-Ggr-040107	Gaeumannomyces graminis	82.00	0.00e+00	1317.00
IUUC-Gga-040703	Gallus gallus	46.82	5.00e-150	523.00
IUUC-Gac-042020	Gasterosteus aculeatus	46.32	3.00e-146	511.00
IUUC-Ggo-045332	Gorilla gorilla	46.66	1.00e-152	531.00
IUUC-Hsa-045968	Homo sapiens	46.66	1.00e-152	532.00
IUUC-Itr-048918	Ictidomys tridecemlineatus	45.98	4.00e-152	530.00
IUUC-Kpa-049273	Komagataella pastoris	66.71	0.00e+00	1008.00
IUUC-Lch-050443	Latimeria chalumnae	45.47	2.00e-151	528.00
IUUC-Loc-052645	Lepisosteus oculatus	46.43	2.00e-148	518.00
IUUC-Lma-052980	Leptosphaeria maculans	68.91	0.00e+00	671.00
IUUC-Laf-053850	Loxodonta africana	46.66	1.00e-152	531.00
IUUC-Mcc-055821	Macaca mulatta	46.66	1.00e-152	532.00
IUUC-Meu-056436	Macropus eugenii	45.32	3.00e-115	407.00
IUUC-Mor-057097	Magnaporthe oryzae	84.76	0.00e+00	1343.00
IUUC-Mpo-057442	Magnaporthe poae	78.52	0.00e+00	1215.00
IUUC-Mla-058996	Melampsora laricipopulina	60.82	0.00e+00	948.00
IUUC-Mga-059661	Meleagris gallopavo	48.04	4.00e-156	543.00
IUUC-Mvi-060395	Microbotryum violaceum	77.64	0.00e+00	809.00
IUUC-Mmr-061135	Microcebus murinus	38.62	2.00e-153	534.00
IUUC-Mdo-062505	Monodelphis domestica	46.94	5.00e-155	540.00
IUUC-Mmu-064136	Mus musculus	46.66	5.00e-153	533.00
IUUC-Mpu-066765	Mustela putorius furo	44.95	2.00e-152	531.00
IUUC-Mlu-067565	Myotis lucifugus	45.11	2.00e-152	531.00
IUUC-Nfi-068427	Neosartorya fischeri	70.61	0.00e+00	1069.00
IUUC-Ncr-068918	Neurospora crassa	79.18	0.00e+00	1205.00
IUUC-Nle-069244	Nomascus leucogenys	46.30	3.00e-153	534.00
IUUC-Opr-071044	Ochotona princeps	46.15	1.00e-149	521.00
IUUC-Ont-071664	Oreochromis niloticus	46.18	2.00e-142	498.00
IUUC-Oan-073019	Ornithorhynchus anatinus	44.88	3.00e-146	510.00
IUUC-Ocu-074160	Oryctolagus cuniculus	46.08	2.00e-149	521.00
IUUC-Ola-087467	Oryzias latipes	46.52	3.00e-147	514.00
IUUC-Oga-088460	Otolemur garnettii	46.66	2.00e-152	531.00
IUUC-Oar-090198	Ovis aries	44.87	1.00e-151	529.00
IUUC-Ptr-090939	Pan troglodytes	46.66	1.00e-152	532.00
IUUC-Pan-092284	Papio anubis	46.66	1.00e-152	532.00
IUUC-Psi-093645	Pelodiscus sinensis	44.33	5.00e-153	533.00
IUUC-Pma-094364	Petromyzon marinus	49.50	5.00e-138	482.00
IUUC-Pno-095118	Phaeosphaeria nodorum	70.43	0.00e+00	1107.00
IUUC-Pfo-096937	Poecilia formosa	47.28	4.00e-153	533.00
IUUC-Pab-098088	Pongo abelii	46.66	1.00e-152	531.00
IUUC-Pca-100568	Procavia capensis	43.34	3.00e-132	464.00
IUUC-Pva-102354	Pteropus vampyrus	46.66	2.00e-152	531.00
IUUC-Pgr-103620	Puccinia graminis	67.21	0.00e+00	842.00
IUUC-Ptt-103806	Puccinia triticina	76.09	0.00e+00	682.00
IUUC-Pte-104016	Pyrenophora teres	70.82	0.00e+00	1109.00
IUUC-Pyt-104550	Pyrenophora triticirepentis	70.82	0.00e+00	1109.00
IUUC-Rno-105318	Rattus norvegicus	46.66	6.00e-153	533.00
IUUC-Sce-106289	Saccharomyces cerevisiae	73.23	0.00e+00	907.00
IUUC-Sha-107482	Sarcophilus harrisii	45.59	7.00e-148	516.00
IUUC-Sja-107941	Schizosaccharomyces japonicus	63.71	0.00e+00	979.00
IUUC-Spo-108171	Schizosaccharomyces pombe	65.10	0.00e+00	994.00
IUUC-Ssl-108514	Sclerotinia sclerotiorum	75.64	0.00e+00	1184.00
IUUC-Sar-113761	Sorex araneus	47.28	6.00e-155	539.00
IUUC-Sre-114929	Sporisorium reilianum	71.40	0.00e+00	879.00
IUUC-Ssc-115368	Sus scrofa	43.48	2.00e-144	504.00
IUUC-Tgu-117130	Taeniopygia guttata	43.80	2.00e-149	521.00
IUUC-Tru-118442	Takifugu rubripes	46.76	2.00e-153	534.00
IUUC-Tsy-119492	Tarsius syrichta	46.66	2.00e-151	528.00
IUUC-Tni-120151	Tetraodon nigroviridis	45.83	3.00e-149	521.00
IUUC-Tre-122203	Trichoderma reesei	81.00	0.00e+00	1250.00
IUUC-Tvi-122595	Trichoderma virens	79.71	0.00e+00	1262.00
IUUC-Tme-126897	Tuber melanosporum	68.39	0.00e+00	1021.00
IUUC-Tbe-127793	Tupaia belangeri	46.09	6.00e-128	449.00
IUUC-Ttr-128275	Tursiops truncatus	45.03	6.00e-146	509.00
IUUC-Uma-129332	Ustilago maydis	71.07	0.00e+00	855.00
IUUC-Vpa-130503	Vicugna pacos	50.00	2.00e-134	471.00
IUUC-Xtr-132859	Xenopus tropicalis	47.67	3.00e-152	531.00
IUUC-Xma-133797	Xiphophorus maculatus	46.50	3.00e-148	517.00
IUUC-Yli-134668	Yarrowia lipolytica	73.68	0.00e+00	936.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence