iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMMUG00000008869.3	ENSMMUT00000012404.3	ENSMMUP00000011633.2
ENSMMUG00000008869.3	ENSMMUT00000071047.1	ENSMMUP00000046790.1
ENSMMUG00000008869.3	ENSMMUT00000072831.1	ENSMMUP00000049432.1
ENSMMUG00000008869.3	ENSMMUT00000066787.1	ENSMMUP00000042902.1
ENSMMUG00000008869.3	ENSMMUT00000065358.1	ENSMMUP00000050232.1
ENSMMUG00000008869.3	ENSMMUT00000072381.1	ENSMMUP00000046101.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.70e-40	139.8	93	262
UBD/ZnF/ZnF_A20	4.20e-25	88.5	756	790

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqsllgvfddds.lsdalveaLreltseyl....qkesdffsefieek........edekefcqklvepe... 74
           ++lkt+gDGnCL++A+sq+++gv+d+d+ l++al+++L+e+ ++++    q es + +ef+e++        +de++++ k+++++   
   Q: 93   VALKTNGDGNCLMHATSQYMWGVQDTDLvLRKALFSTLKETDTRNFkfrwQLESLKSQEFVETGlcydtrnwNDEWDNLIKMASTDtpm 181
           789**********************************************9**********************************99766 PP
   S: 75   ak.g......eeihifaLaqiLsrpiivvdvdsles..........kvggillpllfpeek.lkkpivLlYrsgHYdaLva 137
           a+ g      eeihif+L++iL+rpiiv+++++l+s          kvggi+lpl++p+++ +++pivL+Y+s+H+ +Lv+
   Q: 182  ARsGlqynslEEIHIFVLCNILRRPIIVISDKMLRSlesgsnfaplKVGGIYLPLHWPAQEcYRYPIVLGYDSHHFVPLVT 262
           6644999999*********************************************************************97 PP

UBD/ZnF/ZnF_A20

   S: 1    dpskllCkk.gCgfYGnpetngyCSkCyreelrrr 34
           dp+k++C++ +C+++Gn+++ngyC++C++++++++
   Q: 756  DPPKQRCRApACDHFGNAKCNGYCNECFQFKQMYG 790
           8********************************96 PP

Organism

Macaca mulatta

Protein Sequence
(Fasta)

MAEQVLPQAL YLSNMRKAVK IRERTPEDIF KPTNGIIHHF KTMHRYTLEM FRTCQFCPQF 60
REIIHKALID KNIQASLESQ KKLNWCREVR KLVALKTNGD GNCLMHATSQ YMWGVQDTDL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGTCCATGG AGCGTCGCCT CCGCCCGGTC CCGGCCCCGA CCTCCGCCTG CTGGGCGCTC 60
CTGCTTTGAC CCGGACTTGG GACTTTGCGA AAGGATCGCG GGGCCCGGAG AGGTAACCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR033478--A20
IPR003323--OTU_dom
IPR002653--Znf_A20

PROSITE

PS50802--OTU
PS51036--ZF_A20

Pfam

PF02338--OTU
PF01754--zf-A20

SMART

SM00259--ZnF_A20

Gene Ontology

GO:0005737--C:cytoplasm
GO:0070062--C:extracellular exosome
GO:0005634--C:nucleus
GO:0003677--F:DNA binding
GO:0070530--F:K63-linked polyubiquitin binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0001922--P:B-1 B cell homeostasis
GO:0070301--P:cellular response to hydrogen peroxide
GO:0072666--P:establishment of protein localization to vacuole
GO:0006955--P:immune response
GO:0050869--P:negative regulation of B cell activation
GO:2000349--P:negative regulation of CD40 signaling pathway
GO:0002677--P:negative regulation of chronic inflammatory response
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:2000352--P:negative regulation of endothelial cell apoptotic process
GO:1902042--P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:0043124--P:negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045824--P:negative regulation of innate immune response
GO:0032691--P:negative regulation of interleukin-1 beta production
GO:0032703--P:negative regulation of interleukin-2 production
GO:0032715--P:negative regulation of interleukin-6 production
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0070429--P:negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway
GO:0070433--P:negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0031397--P:negative regulation of protein ubiquitination
GO:0048662--P:negative regulation of smooth muscle cell proliferation
GO:0034140--P:negative regulation of toll-like receptor 3 signaling pathway
GO:0034148--P:negative regulation of toll-like receptor 5 signaling pathway
GO:0032720--P:negative regulation of tumor necrosis factor production
GO:1903364--P:positive regulation of cellular protein catabolic process
GO:2000347--P:positive regulation of hepatocyte proliferation
GO:0071947--P:protein deubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0002634--P:regulation of germinal center formation
GO:0050727--P:regulation of inflammatory response
GO:0045088--P:regulation of innate immune response
GO:0032495--P:response to muramyl dipeptide
GO:0072573--P:tolerance induction to lipopolysaccharide

KEGG

mcc:704130

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001825	Ailuropoda melanoleuca	91.01	0.00e+00	1501.00
IUUC-Apl-003501	Anas platyrhynchos	65.95	0.00e+00	1039.00
IUUC-Aca-004245	Anolis carolinensis	64.43	0.00e+00	1061.00
IUUC-Ame-011789	Astyanax mexicanus	45.62	0.00e+00	687.00
IUUC-Bta-012664	Bos taurus	86.08	0.00e+00	1373.00
IUUC-Cja-019895	Callithrix jacchus	96.84	0.00e+00	1572.00
IUUC-Cfa-020754	Canis familiaris	90.25	0.00e+00	1497.00
IUUC-Cpo-021780	Cavia porcellus	89.90	0.00e+00	1470.00
IUUC-Csa-023568	Chlorocebus sabaeus	99.49	0.00e+00	1625.00
IUUC-Cho-024300	Choloepus hoffmanni	90.09	0.00e+00	653.00
IUUC-Dre-028577	Danio rerio	48.01	0.00e+00	681.00
IUUC-Dno-029382	Dasypus novemcinctus	84.18	0.00e+00	1350.00
IUUC-Dor-030874	Dipodomys ordii	86.58	0.00e+00	1408.00
IUUC-Ete-032721	Echinops telfairi	91.39	0.00e+00	803.00
IUUC-Eca-033596	Equus caballus	87.59	0.00e+00	1411.00
IUUC-Eeu-035159	Erinaceus europaeus	88.38	0.00e+00	1141.00
IUUC-Fca-035847	Felis catus	91.27	0.00e+00	1502.00
IUUC-Fal-036681	Ficedula albicollis	65.26	0.00e+00	1053.00
IUUC-Gmo-038521	Gadus morhua	58.58	3.00e-146	512.00
IUUC-Gga-040975	Gallus gallus	65.06	0.00e+00	1057.00
IUUC-Gac-042216	Gasterosteus aculeatus	60.77	6.00e-153	534.00
IUUC-Ggo-045258	Gorilla gorilla	97.97	0.00e+00	1603.00
IUUC-Hsa-046071	Homo sapiens	98.23	0.00e+00	1605.00
IUUC-Itr-048386	Ictidomys tridecemlineatus	92.15	0.00e+00	1501.00
IUUC-Lch-050326	Latimeria chalumnae	56.84	0.00e+00	914.00
IUUC-Loc-051945	Lepisosteus oculatus	46.20	1.00e-176	613.00
IUUC-Laf-053722	Loxodonta africana	89.62	0.00e+00	1446.00
IUUC-Meu-056481	Macropus eugenii	76.09	0.00e+00	1196.00
IUUC-Mga-059690	Meleagris gallopavo	62.97	0.00e+00	972.00
IUUC-Mmr-061233	Microcebus murinus	91.79	0.00e+00	1471.00
IUUC-Mdo-062446	Monodelphis domestica	81.05	0.00e+00	1312.00
IUUC-Mmu-063436	Mus musculus	88.35	0.00e+00	1409.00
IUUC-Mpu-066808	Mustela putorius furo	90.89	0.00e+00	1496.00
IUUC-Mlu-067339	Myotis lucifugus	89.87	0.00e+00	1451.00
IUUC-Nle-069888	Nomascus leucogenys	98.10	0.00e+00	1603.00
IUUC-Opr-070303	Ochotona princeps	89.41	0.00e+00	1448.00
IUUC-Ont-072283	Oreochromis niloticus	58.70	3.00e-147	515.00
IUUC-Oan-072925	Ornithorhynchus anatinus	76.44	0.00e+00	1243.00
IUUC-Ocu-073889	Oryctolagus cuniculus	90.14	0.00e+00	1429.00
IUUC-Ola-087417	Oryzias latipes	58.94	3.00e-147	516.00
IUUC-Oga-088708	Otolemur garnettii	89.87	0.00e+00	1411.00
IUUC-Oar-089271	Ovis aries	86.33	0.00e+00	1385.00
IUUC-Ptr-091296	Pan troglodytes	98.23	0.00e+00	1604.00
IUUC-Pan-092474	Papio anubis	99.87	0.00e+00	1632.00
IUUC-Psi-093447	Pelodiscus sinensis	69.60	0.00e+00	1129.00
IUUC-Pfo-096511	Poecilia formosa	59.18	9.00e-149	521.00
IUUC-Pab-098700	Pongo abelii	97.97	0.00e+00	1599.00
IUUC-Pca-100246	Procavia capensis	76.08	0.00e+00	1195.00
IUUC-Pva-102606	Pteropus vampyrus	78.43	1.00e-179	623.00
IUUC-Rno-105818	Rattus norvegicus	88.24	0.00e+00	1445.00
IUUC-Sha-106559	Sarcophilus harrisii	79.67	0.00e+00	1289.00
IUUC-Sit-110516	Setaria italica	42.86	8.30e-02	33.10
IUUC-Sar-113454	Sorex araneus	94.21	0.00e+00	649.00
IUUC-Ssc-116064	Sus scrofa	88.73	0.00e+00	1418.00
IUUC-Tgu-117212	Taeniopygia guttata	64.94	0.00e+00	1041.00
IUUC-Tru-118230	Takifugu rubripes	59.66	2.00e-151	530.00
IUUC-Tsy-119066	Tarsius syrichta	89.75	0.00e+00	1476.00
IUUC-Tni-119825	Tetraodon nigroviridis	46.33	0.00e+00	678.00
IUUC-Tvi-122358	Trichoderma virens	45.95	1.60e-01	30.40
IUUC-Tur-126383	Triticum urartu	50.00	8.00e-03	31.60
IUUC-Tbe-127601	Tupaia belangeri	96.95	0.00e+00	676.00
IUUC-Ttr-128930	Tursiops truncatus	86.96	0.00e+00	1408.00
IUUC-Vpa-130450	Vicugna pacos	94.26	0.00e+00	796.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence