iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ptr-091425

Ensembl Protein ID

ENSPTRP00000031907.2

UniProt Accession

H2QTW5; H2QTW5_PANTR

Genbank Protein ID

JAA06033.1; JAA16584.1; JAA27250.1; JAA34472.1

Protein Name

LATS, large tumor suppressor, homolog 1

Genbank Nucleotide ID

AACZ03045471; GABF01005561; GABD01005850; GABE01010267

Gene Name

LATS1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000018696.4	ENSPTRT00000034519.2	ENSPTRP00000031907.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/Alpha-Helix/UBA	6.60e-08	32.5	102	139

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/Alpha-Helix/UBA

   S: 3    dedkleqlveMGFdreealqaLraa.nnnleaAveyLl 39
           + ++l+ l++ GFd++ ++qaL+ + n ++eaA+e++ 
   Q: 102  NPQMLQDLQAAGFDEDMVIQALQKTnNRSIEAAIEFIS 139
           789*********************99*********975 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MKRSEKPEGY RQMRPKTFPA SNYTGSSRQM LQEIRESLRN LSKPSDAAKA EHNMSKMSTE 60
DPRQVRNPPK FGTHHKALQE IRNSLLPFAN ETNSSRSTSE VNPQMLQDLQ AAGFDEDMVI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGACGCTCA CGAACGATCA GAGCTGCGGG CGACGCAACG AAGCCCGGAG GCCGCAGGCT 60
GCGCGCTCCC TCGCAGCAGC CGGGCGGGCA AAAGCCCCCA GTTCTCGGCC CCCGCGCAAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0723--Serine/threonine-protein kinase
KW-0808--Transferase

Interpro

IPR000961--AGC-kinase_C
IPR011009--Kinase-like_dom
IPR028741--LATS1/Warts
IPR000719--Prot_kinase_dom
IPR008271--Ser/Thr_kinase_AS
IPR015940--UBA
IPR009060--UBA-like

PROSITE

PS51285--AGC_KINASE_CTER
PS50011--PROTEIN_KINASE_DOM
PS00108--PROTEIN_KINASE_ST
PS50030--UBA

Pfam

PF00069--Pkinase
PF00627--UBA

SMART

SM00220--S_TKc

Gene Ontology

GO:0005737--C:cytoplasm
GO:0000922--C:spindle pole
GO:0005524--F:ATP binding
GO:0000287--F:magnesium ion binding
GO:0004674--F:protein serine/threonine kinase activity
GO:0051220--P:cytoplasmic sequestering of protein
GO:0000082--P:G1/S transition of mitotic cell cycle
GO:0000086--P:G2/M transition of mitotic cell cycle
GO:0035329--P:hippo signaling
GO:0009755--P:hormone-mediated signaling pathway
GO:0001827--P:inner cell mass cell fate commitment
GO:0001828--P:inner cell mass cellular morphogenesis
GO:0030216--P:keratinocyte differentiation
GO:0060644--P:mammary gland epithelial cell differentiation
GO:0007067--P:mitotic nuclear division
GO:0090090--P:negative regulation of canonical Wnt signaling pathway
GO:0045736--P:negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0018105--P:peptidyl-serine phosphorylation
GO:0043065--P:positive regulation of apoptotic process
GO:0033138--P:positive regulation of peptidyl-serine phosphorylation
GO:0030833--P:regulation of actin filament polymerization
GO:0033146--P:regulation of intracellular estrogen receptor signaling pathway
GO:0046620--P:regulation of organ growth
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0000819--P:sister chromatid segregation

KEGG

ptr:748397

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001895	Ailuropoda melanoleuca	96.55	0.00e+00	2006.00
IUUC-Apl-003278	Anas platyrhynchos	84.20	0.00e+00	1817.00
IUUC-Aca-005319	Anolis carolinensis	82.22	0.00e+00	1744.00
IUUC-Ame-011324	Astyanax mexicanus	84.91	0.00e+00	942.00
IUUC-Bta-013438	Bos taurus	95.31	0.00e+00	1952.00
IUUC-Cel-018517	Caenorhabditis elegans	50.32	1.00e-129	457.00
IUUC-Cja-019072	Callithrix jacchus	98.23	0.00e+00	2083.00
IUUC-Cfa-021267	Canis familiaris	96.64	0.00e+00	2024.00
IUUC-Cpo-021496	Cavia porcellus	91.29	0.00e+00	1680.00
IUUC-Csa-023255	Chlorocebus sabaeus	98.85	0.00e+00	2082.00
IUUC-Cho-024461	Choloepus hoffmanni	98.67	0.00e+00	790.00
IUUC-Cin-025264	Ciona intestinalis	63.68	7.00e-141	493.00
IUUC-Dre-028034	Danio rerio	82.14	0.00e+00	928.00
IUUC-Dno-029888	Dasypus novemcinctus	93.10	0.00e+00	2006.00
IUUC-Dor-030144	Dipodomys ordii	85.94	0.00e+00	1699.00
IUUC-Dme-031656	Drosophila melanogaster	73.66	0.00e+00	659.00
IUUC-Ete-032813	Echinops telfairi	94.86	0.00e+00	1234.00
IUUC-Eca-033781	Equus caballus	96.37	0.00e+00	1983.00
IUUC-Eeu-035007	Erinaceus europaeus	92.84	0.00e+00	1992.00
IUUC-Fca-036142	Felis catus	92.12	0.00e+00	1903.00
IUUC-Fal-036626	Ficedula albicollis	83.58	0.00e+00	1815.00
IUUC-Gmo-038688	Gadus morhua	85.75	0.00e+00	781.00
IUUC-Gga-040553	Gallus gallus	84.53	0.00e+00	1821.00
IUUC-Gac-042031	Gasterosteus aculeatus	64.21	0.00e+00	1275.00
IUUC-Ggo-045242	Gorilla gorilla	99.73	0.00e+00	2097.00
IUUC-Hsa-046081	Homo sapiens	99.65	0.00e+00	2095.00
IUUC-Itr-048668	Ictidomys tridecemlineatus	96.28	0.00e+00	1733.00
IUUC-Lch-049425	Latimeria chalumnae	78.42	0.00e+00	1708.00
IUUC-Loc-052418	Lepisosteus oculatus	67.35	0.00e+00	1375.00
IUUC-Laf-053710	Loxodonta africana	94.26	0.00e+00	1978.00
IUUC-Mcc-055079	Macaca mulatta	99.03	0.00e+00	2083.00
IUUC-Mga-059713	Meleagris gallopavo	83.86	0.00e+00	1820.00
IUUC-Mmr-061728	Microcebus murinus	97.35	0.00e+00	2043.00
IUUC-Mdo-061942	Monodelphis domestica	87.61	0.00e+00	1838.00
IUUC-Mmu-063504	Mus musculus	93.27	0.00e+00	1919.00
IUUC-Mpu-066034	Mustela putorius furo	96.11	0.00e+00	2018.00
IUUC-Mlu-067986	Myotis lucifugus	94.69	0.00e+00	1985.00
IUUC-Nle-069202	Nomascus leucogenys	99.38	0.00e+00	2091.00
IUUC-Opr-070801	Ochotona princeps	95.50	0.00e+00	1293.00
IUUC-Ont-072487	Oreochromis niloticus	61.01	0.00e+00	1244.00
IUUC-Oan-073128	Ornithorhynchus anatinus	86.97	0.00e+00	1596.00
IUUC-Ocu-073998	Oryctolagus cuniculus	96.43	0.00e+00	1446.00
IUUC-Ola-086858	Oryzias latipes	60.23	0.00e+00	1196.00
IUUC-Oga-088874	Otolemur garnettii	94.97	0.00e+00	1956.00
IUUC-Oar-089236	Ovis aries	95.23	0.00e+00	1951.00
IUUC-Pan-091851	Papio anubis	99.12	0.00e+00	2085.00
IUUC-Psi-093825	Pelodiscus sinensis	85.38	0.00e+00	1517.00
IUUC-Pfo-096326	Poecilia formosa	61.61	0.00e+00	1195.00
IUUC-Pab-097815	Pongo abelii	99.73	0.00e+00	2098.00
IUUC-Pva-102836	Pteropus vampyrus	94.96	0.00e+00	1903.00
IUUC-Ptt-103762	Puccinia triticina	38.70	3.00e-93	336.00
IUUC-Rno-106053	Rattus norvegicus	93.72	0.00e+00	1976.00
IUUC-Sha-106843	Sarcophilus harrisii	88.72	0.00e+00	1875.00
IUUC-Sar-113649	Sorex araneus	93.65	0.00e+00	1565.00
IUUC-Ssc-115486	Sus scrofa	97.86	0.00e+00	865.00
IUUC-Tgu-116903	Taeniopygia guttata	83.58	0.00e+00	1795.00
IUUC-Tru-118760	Takifugu rubripes	64.42	0.00e+00	1297.00
IUUC-Tsy-119361	Tarsius syrichta	95.96	0.00e+00	1722.00
IUUC-Tni-120058	Tetraodon nigroviridis	58.98	0.00e+00	1160.00
IUUC-Tbe-127681	Tupaia belangeri	96.23	0.00e+00	1605.00
IUUC-Ttr-128652	Tursiops truncatus	95.94	0.00e+00	1694.00
IUUC-Vpa-130538	Vicugna pacos	95.22	0.00e+00	1983.00
IUUC-Xtr-132895	Xenopus tropicalis	72.06	0.00e+00	1256.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence