iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Pfo-096413

Ensembl Protein ID

ENSPFOP00000000458.2

UniProt Accession

A0A087X3V5; A0A087X3V5_POEFO

Genbank Protein ID

ENSPFOP00000000458

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AYCK01013502

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPFOG00000000468.2	ENSPFOT00000000459.2	ENSPFOP00000000458.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.30e-98	330.8	261	676

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenp........................................... 42
           tGl+NlgNtCYmNS+LQ+Ls+++++re++l+    +++e l+++n+                                           
   Q: 261  TGLRNLGNTCYMNSILQVLSHLQKFRECFLTldlcETEELLAKTNHsqgvkgvtgavvnsgttpplsenplgrmgkagcwnlpvgkkes 349
           7******************************999744444444444788999999********************************** PP
   S: 43   ...................kepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflaflldqleeelkkekn 112
                              + ++ +l+++l++lf+ +w+++++ vsp ++l++++++ + f+gy+qqDaqEfl+ lld++++el     
   Q: 350  vapspqaaelvqpkeprcsTRQQMSLCHELHTLFRVMWSGRWTLVSPFAMLHSVWNLIPAFRGYDQQDAQEFLCELLDKVQQEL----- 433
           999999999999999998888888************************************************************..... PP
   S: 113  kpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke...........slqdc 190
               ++e+++++    + ++k  k+  ++++++F+gql sq++cl+c+++s++ epf+dlsl++p++ ++ ++           sl ++
   Q: 434  ----DTEGSKRRIVIPITKRKLSKQVLKVLNTIFHGQLLSQVTCLSCKHKSNTVEPFWDLSLEFPERYHSRNKgpgatayqrscSLIEM 518
           ....7888999999999***************************************************98888**************** PP
   S: 191  Lesftkeeelegenkyycekckkkqe...........aekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfctsp 268
           L++ft+ e leg n y c++c+k+++           a+k+l + +lP+vL lhLkRf++s + ++reki  +v f + L+++p+c+++
   Q: 519  LSKFTEMEALEG-NIYACNHCNKRRRksshkplvlseARKQLLIYRLPQVLRLHLKRFRWSGR-NHREKIGVHVAFDQVLNIKPYCCTD 605
           ***********9.77*******999999999999999***********************997.8889*******************97 PP
   S: 269  eekqke..kkkYeLiavvvHsG.slssGHYvayvknekgk.WllfdDskVtevkeeevleetgstaYvlfYkrr 338
           +  + +   ++Y+L+avv+H+G +++sGHY+ay++n++g+ W++++Ds+ ++++ eev++   ++aY+lfY++r
   Q: 606  SGHSVHrgGYTYDLSAVVMHHGkGFGSGHYTAYCYNTEGGfWVHCNDSEMKVCSVEEVCN---TQAYILFYTQR 676
           766544779***************************9999********************...********985 PP

Organism

Poecilia formosa

Protein Sequence
(Fasta)

MDRCKHVVRL RLGQDHSILN PQKWHCVECS TTDSVWACLK CSHVACGRFI EEHFLKHFQE 60
SQHPLAMEVR ELDVFCFACG DYVLNDNAEG DLKLLRGALS TVRSPGRRSL RSSTGGDCGP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTTTAAAAT GTTCAAACTT TGTATTTTAT AACCTAAGAC CTGTATAGTT AACCTGTAAG 60
GCAGCTTTAT TTATACTAAG ATTAAATTAT AGCGTGACAA AAACTAAAAA ATATATTAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001220	Ailuropoda melanoleuca	54.60	0.00e+00	737.00
IUUC-Apl-003658	Anas platyrhynchos	64.39	0.00e+00	830.00
IUUC-Aca-005278	Anolis carolinensis	63.94	0.00e+00	829.00
IUUC-Ame-011403	Astyanax mexicanus	71.13	0.00e+00	843.00
IUUC-Bta-012911	Bos taurus	69.12	2.00e-168	585.00
IUUC-Cja-019171	Callithrix jacchus	62.27	0.00e+00	786.00
IUUC-Cfa-020408	Canis familiaris	69.76	9.00e-170	590.00
IUUC-Cpo-022233	Cavia porcellus	70.38	1.00e-171	597.00
IUUC-Csa-023177	Chlorocebus sabaeus	53.82	0.00e+00	723.00
IUUC-Cho-025051	Choloepus hoffmanni	62.84	2.00e-127	449.00
IUUC-Dre-027577	Danio rerio	70.26	0.00e+00	869.00
IUUC-Dno-029856	Dasypus novemcinctus	69.43	5.00e-171	594.00
IUUC-Ete-032627	Echinops telfairi	54.67	0.00e+00	729.00
IUUC-Eca-033851	Equus caballus	56.69	0.00e+00	702.00
IUUC-Eeu-035225	Erinaceus europaeus	51.34	0.00e+00	675.00
IUUC-Fca-036288	Felis catus	54.55	0.00e+00	724.00
IUUC-Fal-037290	Ficedula albicollis	64.49	0.00e+00	771.00
IUUC-Gmo-039249	Gadus morhua	89.97	4.00e-171	595.00
IUUC-Gga-040457	Gallus gallus	56.10	0.00e+00	733.00
IUUC-Gac-042595	Gasterosteus aculeatus	87.46	0.00e+00	1156.00
IUUC-Ggo-044979	Gorilla gorilla	62.52	0.00e+00	781.00
IUUC-Hsa-046743	Homo sapiens	62.57	0.00e+00	779.00
IUUC-Itr-048251	Ictidomys tridecemlineatus	59.94	0.00e+00	775.00
IUUC-Lch-050294	Latimeria chalumnae	63.78	0.00e+00	799.00
IUUC-Loc-051961	Lepisosteus oculatus	77.24	0.00e+00	713.00
IUUC-Laf-054491	Loxodonta africana	54.27	0.00e+00	720.00
IUUC-Mcc-055048	Macaca mulatta	62.23	0.00e+00	779.00
IUUC-Meu-055971	Macropus eugenii	53.44	1.00e-76	281.00
IUUC-Mga-059523	Meleagris gallopavo	55.37	0.00e+00	740.00
IUUC-Mmr-060885	Microcebus murinus	55.00	0.00e+00	733.00
IUUC-Mdo-062073	Monodelphis domestica	64.28	0.00e+00	829.00
IUUC-Mmu-064095	Mus musculus	60.86	0.00e+00	780.00
IUUC-Mpu-066207	Mustela putorius furo	54.46	0.00e+00	743.00
IUUC-Mlu-067090	Myotis lucifugus	69.34	3.00e-171	595.00
IUUC-Nle-069486	Nomascus leucogenys	62.80	0.00e+00	783.00
IUUC-Opr-070563	Ochotona princeps	59.71	0.00e+00	768.00
IUUC-Ont-072103	Oreochromis niloticus	90.15	0.00e+00	1187.00
IUUC-Oan-073030	Ornithorhynchus anatinus	53.47	1.00e-161	563.00
IUUC-Ocu-074836	Oryctolagus cuniculus	52.77	0.00e+00	731.00
IUUC-Ola-086413	Oryzias latipes	80.24	0.00e+00	1051.00
IUUC-Oga-088862	Otolemur garnettii	61.44	0.00e+00	776.00
IUUC-Oar-089953	Ovis aries	54.57	0.00e+00	743.00
IUUC-Ptr-091525	Pan troglodytes	61.56	0.00e+00	718.00
IUUC-Pan-092363	Papio anubis	62.23	0.00e+00	776.00
IUUC-Psi-093353	Pelodiscus sinensis	64.47	0.00e+00	838.00
IUUC-Pca-100449	Procavia capensis	59.37	0.00e+00	772.00
IUUC-Pva-102868	Pteropus vampyrus	70.21	2.00e-172	598.00
IUUC-Rno-105190	Rattus norvegicus	61.14	0.00e+00	787.00
IUUC-Sha-107337	Sarcophilus harrisii	64.05	0.00e+00	827.00
IUUC-Sar-113561	Sorex araneus	81.16	4.00e-67	248.00
IUUC-Ssc-115727	Sus scrofa	68.33	3.00e-166	578.00
IUUC-Tgu-117025	Taeniopygia guttata	59.80	0.00e+00	692.00
IUUC-Tru-117585	Takifugu rubripes	88.46	0.00e+00	1104.00
IUUC-Tsy-118814	Tarsius syrichta	60.11	0.00e+00	777.00
IUUC-Tni-120600	Tetraodon nigroviridis	85.59	0.00e+00	1020.00
IUUC-Ttr-128928	Tursiops truncatus	54.39	0.00e+00	741.00
IUUC-Vpa-130706	Vicugna pacos	53.44	0.00e+00	732.00
IUUC-Xtr-132090	Xenopus tropicalis	63.36	0.00e+00	811.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence