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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046141
Ensembl Protein ID ENSP00000468312.1
UniProt Accession O95834; B7Z3I2; B7Z3Q9; K7ERL7; Q59EN8; Q8N5A2; Q9UG50; EMAL2_HUMAN
Genbank Protein ID AAD19904.1; CAB46373.2; BAH12218.1; BAH12295.1; AAH32630.1; BAD93010.1
Protein Name Echinoderm microtubule-associated protein-like 2
Genbank Nucleotide ID AF103939; AL096717; AK295905; AK296258; AC006132; AB209773
Gene Name EML2; EMAP2; EMAPL2
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000125746.15 ENST00000589876.5 ENSP00000464789.1
ENSG00000125746.15 ENST00000588308.5 ENSP00000468329.1
ENSG00000125746.15 ENST00000586195.5 ENSP00000465339.1
ENSG00000125746.15 ENST00000245925.7 ENSP00000245925.2
ENSG00000125746.15 ENST00000536630.5 ENSP00000442365.1
ENSG00000125746.15 ENST00000587152.5 ENSP00000468312.1
ENSG00000125746.15 ENST00000586405.1 ENSP00000465885.1
ENSG00000125746.15 ENST00000587484.5 ENSP00000465994.1
ENSG00000125746.15 ENST00000590819.5 ENSP00000464950.1
ENSG00000125746.15 ENST00000399594.7 ENSP00000382503.3
ENSG00000125746.15 ENST00000590575.5 ENSP00000464764.1
ENSG00000125746.15 ENST00000588272.1 ENSP00000466100.1
ENSG00000125746.15 ENST00000588496.5 ENSP00000465607.1
ENSG00000125746.15 ENST00000592853.5 ENSP00000468383.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBasecircRNADb
CircNetTRANSFACRepTarSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdb
Post-translational Modifications (PTMs)
CPLMdbPAFPhosphositePlusdbPTM
mUbiSiDa
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
E3 adaptor/Cullin RING/DCX/DWD 1.10e-15 58.8 494 523
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 adaptor/Cullin RING/DCX/DWD
   S: 2    Htdsvtcla.fsd.tllvsGsdDgtikvWD 29
           H ++v++l+ + d tl++ G++D  + +W 
   Q: 494  HDGGVFGLCaLRDgTLVSGGGRDRRVVLWG 523
           999****97367746655588********6 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.
 Tubulin binding protein that inhibits microtubule nucleation and growth, resulting in shorter microtubules.
Protein Sequence
(Fasta)
MLERRALLWQ REAGPGWGDR ARAGTGGAGG GCGGAMAERG PAFCGLYDTS SLLRYCNDDN 60
LSGTSGMEVD DRVSALEQRL QLQEDELAVL KAALADALRR LRACEEQGAA LRARGTPKGR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046141|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATACTCCGGT TGTGGGCGGG ACCAGACGGT ACCTAGGGGG ATCCGGGCGC AGCCAATCCT 60
GGCCCTAGGA TTGTGTTGGG GGGCTTGGCA GGCGGTGTCC CGACCCCCCT TTCTGGGCAT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046141|E3,WD_repeat|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0493--Microtubule
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat
Interpro

IPR005108--HELP
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR017986--WD40_repeat_dom
PROSITE

PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION
Pfam

PF03451--HELP
PF00400--WD40
SMART

SM00320--WD40
Gene Ontology

GO:0005737--C:cytoplasm
GO:0005874--C:microtubule
GO:0005875--C:microtubule associated complex
GO:0005819--C:spindle
GO:0008017--F:microtubule binding
GO:0015631--F:tubulin binding
GO:0031115--P:negative regulation of microtubule polymerization
GO:0010968--P:regulation of microtubule nucleation
GO:0007605--P:sensory perception of sound
GO:0007601--P:visual perception
KEGG hsa:24139
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002155 Ailuropoda melanoleuca 95.86 0.00e+00 1482.00
IUUC-Aca-005316 Anolis carolinensis 76.91 0.00e+00 1170.00
IUUC-Ame-011647 Astyanax mexicanus 66.88 0.00e+00 1042.00
IUUC-Bta-013267 Bos taurus 96.20 0.00e+00 1525.00
IUUC-Cja-019146 Callithrix jacchus 92.30 0.00e+00 1242.00
IUUC-Cfa-020267 Canis familiaris 97.06 0.00e+00 1540.00
IUUC-Csv-026305 Ciona savignyi 49.62 0.00e+00 754.00
IUUC-Dno-028961 Dasypus novemcinctus 94.35 0.00e+00 1467.00
IUUC-Eca-033785 Equus caballus 95.33 0.00e+00 1501.00
IUUC-Eeu-035302 Erinaceus europaeus 95.38 0.00e+00 726.00
IUUC-Fca-036170 Felis catus 92.96 0.00e+00 1436.00
IUUC-Gac-042643 Gasterosteus aculeatus 64.04 0.00e+00 1004.00
IUUC-Ggo-044669 Gorilla gorilla 95.03 0.00e+00 1454.00
IUUC-Itr-048788 Ictidomys tridecemlineatus 95.35 0.00e+00 1506.00
IUUC-Loc-052518 Lepisosteus oculatus 67.89 0.00e+00 1070.00
IUUC-Laf-054137 Loxodonta africana 90.74 0.00e+00 1185.00
IUUC-Mcc-055780 Macaca mulatta 98.51 0.00e+00 1228.00
IUUC-Meu-056664 Macropus eugenii 84.14 0.00e+00 1130.00
IUUC-Mmr-060853 Microcebus murinus 96.42 0.00e+00 1521.00
IUUC-Mdo-062224 Monodelphis domestica 86.20 0.00e+00 1193.00
IUUC-Mmu-063860 Mus musculus 95.67 0.00e+00 1512.00
IUUC-Mpu-066043 Mustela putorius furo 95.41 0.00e+00 1533.00
IUUC-Mlu-067125 Myotis lucifugus 75.00 0.00e+00 1061.00
IUUC-Nle-069618 Nomascus leucogenys 90.44 0.00e+00 1347.00
IUUC-Opr-070228 Ochotona princeps 86.31 0.00e+00 1132.00
IUUC-Ont-071258 Oreochromis niloticus 64.50 0.00e+00 1029.00
IUUC-Ocu-074087 Oryctolagus cuniculus 83.04 0.00e+00 864.00
IUUC-Oga-088048 Otolemur garnettii 93.25 0.00e+00 1466.00
IUUC-Oar-089907 Ovis aries 96.01 0.00e+00 1248.00
IUUC-Pan-092082 Papio anubis 96.36 0.00e+00 1568.00
IUUC-Pab-097619 Pongo abelii 99.69 0.00e+00 1323.00
IUUC-Pca-101070 Procavia capensis 84.91 0.00e+00 1100.00
IUUC-Pva-102957 Pteropus vampyrus 91.43 0.00e+00 1204.00
IUUC-Rno-105074 Rattus norvegicus 93.66 0.00e+00 1243.00
IUUC-Sha-106692 Sarcophilus harrisii 83.17 0.00e+00 1242.00
IUUC-Tru-117809 Takifugu rubripes 62.64 0.00e+00 1064.00
IUUC-Tni-120815 Tetraodon nigroviridis 63.45 0.00e+00 1070.00
Created Date 25-Jun-2017

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