iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSCJAG00000015591.2	ENSCJAT00000030360.2	ENSCJAP00000028732.2
ENSCJAG00000015591.2	ENSCJAT00000052362.1	ENSCJAP00000046278.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/RING	1.90e-08	35.6	16	55
E3 activity/RING/U-box	1.10e-09	39.1	12	75

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl++f + p++  CgH f+++C+  +       ++   CP+Cr
   Q: 16   CPICLDPFVE-PVSIECGHSFCQECISEV-----GRNGGGVCPVCR 55
           **********.***************999.....7889999****8 PP

E3 activity/RING/U-box

   S: 4    eeflCpIslelMrdPvvlpsGitydrssIekwlasggktcPvtrqplteedlvPnltlrrliqa 67
           ee  CpI l+++ +Pv +++G+++ +++I +  ++gg  cPv+rq++  ++l Pn  l +++++
   Q: 12   EEVTCPICLDPFVEPVSIECGHSFCQECISEVGRNGGGVCPVCRQRFLLKNLRPNRQLANMVDN 75
           6889***************************9999999*******************9999875 PP

Organism

Callithrix jacchus

Protein Sequence
(Fasta)

MASAARLTMM WEEVTCPICL DPFVEPVSIE CGHSFCQECI SEVGRNGGGV CPVCRQRFLL 60
KNLRPNRQLA NMVDNLREIS QDTKEGTQGE RCAVHGERLH LFCEKDGKAL CWVCAQSRKH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCCTCTGAGC GGAAACTGAA AGTGAAATAG GGAGCTGGCT ACCCGCGTTG AGTCCCCTGT 60
AAAGGTGAGT GAACCTCACT AAATCAAGGA ACCCCTGCCC TCCTAGTGGA CCTCTCCCCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0436--Ligase
KW-0479--Metal-binding
KW-1185--Reference proteome
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001870--B30.2/SPRY
IPR003879--Butyrophylin
IPR013320--ConA-like_dom
IPR006574--PRY
IPR003877--SPRY_dom
IPR003613--Ubox_domain
IPR000315--Znf_B-box
IPR020457--Znf_B-box_chordata
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50188--B302_SPRY
PS50119--ZF_BBOX
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF13765--PRY
PF00622--SPRY
PF00643--zf-B_box

PRINTS

PR01406--BBOXZNFINGER
PR01407--BUTYPHLNCDUF

SMART

SM00336--BBOX
SM00589--PRY
SM00184--RING
SM00449--SPRY
SM00504--Ubox

Gene Ontology

GO:0005737--C:cytoplasm
GO:0005654--C:nucleoplasm
GO:0019005--C:SCF ubiquitin ligase complex
GO:0016874--F:ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0032088--P:negative regulation of NF-kappaB transcription factor activity
GO:0090086--P:negative regulation of protein deubiquitination
GO:1902187--P:negative regulation of viral release from host cell
GO:0032897--P:negative regulation of viral transcription
GO:0010508--P:positive regulation of autophagy
GO:0045787--P:positive regulation of cell cycle
GO:0051091--P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046598--P:positive regulation of viral entry into host cell
GO:0051865--P:protein autoubiquitination
GO:0031648--P:protein destabilization
GO:0006513--P:protein monoubiquitination
GO:0000209--P:protein polyubiquitination
GO:0070206--P:protein trimerization
GO:0034341--P:response to interferon-gamma

KEGG

cjc:100387049

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001896	Ailuropoda melanoleuca	78.21	0.00e+00	769.00
IUUC-Bta-013083	Bos taurus	73.20	0.00e+00	684.00
IUUC-Cfa-020415	Canis familiaris	75.27	0.00e+00	736.00
IUUC-Cpo-021948	Cavia porcellus	72.32	0.00e+00	689.00
IUUC-Csa-023135	Chlorocebus sabaeus	92.42	0.00e+00	820.00
IUUC-Cho-024493	Choloepus hoffmanni	68.18	1.00e-102	365.00
IUUC-Dre-028064	Danio rerio	31.73	2.00e-64	240.00
IUUC-Dno-030061	Dasypus novemcinctus	72.20	0.00e+00	716.00
IUUC-Ete-033168	Echinops telfairi	68.89	9.00e-168	582.00
IUUC-Eca-033578	Equus caballus	80.65	0.00e+00	762.00
IUUC-Eeu-034749	Erinaceus europaeus	57.20	9.00e-132	463.00
IUUC-Fca-035468	Felis catus	74.29	0.00e+00	720.00
IUUC-Gac-042446	Gasterosteus aculeatus	38.57	1.00e-75	277.00
IUUC-Ggo-045190	Gorilla gorilla	91.79	0.00e+00	852.00
IUUC-Hsa-046583	Homo sapiens	92.42	0.00e+00	858.00
IUUC-Itr-048632	Ictidomys tridecemlineatus	77.99	0.00e+00	731.00
IUUC-Laf-053455	Loxodonta africana	76.23	0.00e+00	686.00
IUUC-Mcc-054609	Macaca mulatta	92.21	0.00e+00	815.00
IUUC-Mtr-058638	Medicago truncatula	44.90	5.00e-09	54.70
IUUC-Mmr-061369	Microcebus murinus	77.47	0.00e+00	667.00
IUUC-Mmu-063166	Mus musculus	71.24	0.00e+00	664.00
IUUC-Mpu-066889	Mustela putorius furo	75.85	0.00e+00	748.00
IUUC-Mlu-067647	Myotis lucifugus	79.35	0.00e+00	704.00
IUUC-Nle-069567	Nomascus leucogenys	92.00	0.00e+00	853.00
IUUC-Opr-071178	Ochotona princeps	64.21	8.00e-172	596.00
IUUC-Oar-090413	Ovis aries	78.06	0.00e+00	715.00
IUUC-Ptr-091187	Pan troglodytes	92.42	0.00e+00	858.00
IUUC-Pan-092231	Papio anubis	92.52	0.00e+00	805.00
IUUC-Pma-094734	Petromyzon marinus	26.59	7.00e-24	105.00
IUUC-Pfo-096972	Poecilia formosa	34.62	1.00e-68	254.00
IUUC-Pab-098079	Pongo abelii	88.95	3.00e-174	603.00
IUUC-Pca-100639	Procavia capensis	72.98	6.00e-149	520.00
IUUC-Pva-102476	Pteropus vampyrus	77.26	0.00e+00	739.00
IUUC-Rno-105054	Rattus norvegicus	71.67	5.00e-176	610.00
IUUC-Sar-113204	Sorex araneus	75.05	0.00e+00	665.00
IUUC-Ssc-116291	Sus scrofa	76.50	0.00e+00	717.00
IUUC-Tsy-118803	Tarsius syrichta	78.70	1.00e-144	506.00
IUUC-Tbe-127337	Tupaia belangeri	62.94	6.00e-112	396.00
IUUC-Ttr-128914	Tursiops truncatus	76.50	0.00e+00	661.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence