iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Dre-027845

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitin carboxyl-terminal hydrolase 12A; Deubiquitinating enzyme 12A; Ubiquitin thioesterase 12A; Ubiquitin-specific-processing protease 12A

Genbank Nucleotide ID

BC115286

Gene Name

usp12a; usp12

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSDARG00000078109.2	ENSDART00000112670.2	ENSDARP00000103890.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.80e-97	327.5	39	369

Active Site

Position(s)	Description	Evidence
48	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
318	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelw..kskkkavsprellkalkkeaeefsgy 87
           +Gl N+gNtCY+NSvLQ+L++++++re +l  ++++      + +k++ll++l++lf+++   k+k +++ p+++++ l+ke+e f++y
   Q: 39   FGLVNFGNTCYCNSVLQALYFCRPFREKILA-YRSQ------PRRKENLLTCLADLFHSIAnqKRKVGVIPPKKFITRLRKENELFDNY 120
           6******************************.4443......456789************976777779******************** PP
   S: 88   eqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpv 176
           +qqDa+Efl++ll+++ + l++  + ++++++++  + + d+++++ +  ++++++++Fqg+l+++++cl+c+++ss++e+fldls++v
   Q: 121  MQQDAHEFLNYLLNTIADLLQE--ERKQDKQNGKLANGTLDSQNNNSTPPSTTWVHEIFQGTLTNETRCLTCETISSKDEDFLDLSVDV 207
           ********************44..5555556666666778888899999999************************************* PP
   S: 177  pgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlspfc 265
           ++++     s+++cL+ f+++e+l++e kyyce+c++kqea k++++kklP +L lhLkRf++ e+ ++ +k++ +v fpleL l  f+
   Q: 208  EQNT-----SITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMRVKKLPMILALHLKRFKYMEQLQRYTKLSYRVVFPLELRL--FN 289
           ****.....9**********************************************************************66665..77 PP
   S: 266  tspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetg.........staYvlfYkr 337
           ts + + + ++ Y+L+avvvH G +++ GHY+a+vk+ ++ WllfdD+ V++++ + ++e+ g         +++Y+lfY++
   Q: 290  TSGDAT-NPERLYDLVAVVVHCGsGPNRGHYIAIVKS-HDFWLLFDDDIVEKIDAQAIEEFYGltseisknsESGYILFYQS 369
           774444.469***************************.555*******************999*****************97 PP

Organism

Danio rerio

Functional Description
(View)

Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with wdr48 to have a high activity.

Protein Sequence
(Fasta)

MEILMTVSKF ASFCTMGANA SALEKEIGSE QFPVNEHYFG LVNFGNTCYC NSVLQALYFC 60
RPFREKILAY RSQPRRKENL LTCLADLFHS IANQKRKVGV IPPKKFITRL RKENELFDNY 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTCACGGGGA CTCCTCTTCG CCTCCGCGCG GTGATTGGGT GGAAGATGGC GCTGGGCGAA 60
TGGAAATCCT AATGACAGTT TCCAAATTTG CCTCTTTTTG TACCATGGTG AGTAAATATC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

Gene Ontology

GO:0004197--F:cysteine-type endopeptidase activity
GO:0046872--F:metal ion binding
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

dre:565736

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000193	Aegilops tauschii	59.18	6.00e-126	444.00
IUUC-Aml-001964	Ailuropoda melanoleuca	91.37	0.00e+00	718.00
IUUC-Apl-003411	Anas platyrhynchos	91.97	0.00e+00	708.00
IUUC-Aca-005212	Anolis carolinensis	92.45	0.00e+00	725.00
IUUC-Aly-005830	Arabidopsis lyrata	59.08	1.00e-122	432.00
IUUC-Ath-007280	Arabidopsis thaliana	59.08	1.00e-122	432.00
IUUC-Acl-008239	Aspergillus clavatus	49.34	1.00e-79	291.00
IUUC-Afl-008602	Aspergillus flavus	50.84	1.00e-81	297.00
IUUC-Afu-008816	Aspergillus fumigatus	51.17	7.00e-80	291.00
IUUC-Ani-009137	Aspergillus nidulans	50.17	1.00e-77	284.00
IUUC-Ang-009703	Aspergillus niger	49.83	6.00e-81	295.00
IUUC-Aor-009901	Aspergillus oryzae	50.84	9.00e-82	298.00
IUUC-Ate-010431	Aspergillus terreus	50.17	4.00e-79	289.00
IUUC-Ame-011015	Astyanax mexicanus	98.92	0.00e+00	771.00
IUUC-Bgr-012071	Blumeria graminis	44.37	1.00e-75	278.00
IUUC-Bta-012981	Bos taurus	92.45	0.00e+00	727.00
IUUC-Bci-013837	Botrytis cinerea	42.72	1.00e-73	271.00
IUUC-Bol-015138	Brassica oleracea	60.38	1.00e-124	439.00
IUUC-Bra-016956	Brassica rapa	59.08	6.00e-125	440.00
IUUC-Cja-018831	Callithrix jacchus	93.26	0.00e+00	733.00
IUUC-Cfa-020534	Canis familiaris	93.53	0.00e+00	734.00
IUUC-Cpo-021703	Cavia porcellus	93.24	0.00e+00	701.00
IUUC-Cre-022711	Chlamydomonas reinhardtii	54.62	8.00e-100	357.00
IUUC-Cho-024902	Choloepus hoffmanni	77.18	2.00e-161	561.00
IUUC-Cin-025659	Ciona intestinalis	57.55	3.00e-134	471.00
IUUC-Cgl-026611	Colletotrichum gloeosporioides	43.23	1.00e-75	278.00
IUUC-Dno-029460	Dasypus novemcinctus	93.52	0.00e+00	703.00
IUUC-Dor-030972	Dipodomys ordii	93.75	6.00e-145	506.00
IUUC-Dse-031470	Dothistroma septosporum	48.54	1.00e-77	284.00
IUUC-Ete-033125	Echinops telfairi	72.88	7.00e-123	433.00
IUUC-Eca-033439	Equus caballus	93.80	0.00e+00	705.00
IUUC-Fca-035524	Felis catus	93.54	0.00e+00	707.00
IUUC-Fal-036833	Ficedula albicollis	90.24	0.00e+00	706.00
IUUC-Fox-037682	Fusarium oxysporum	43.05	2.00e-73	270.00
IUUC-Fso-038299	Fusarium solani	44.37	6.00e-74	272.00
IUUC-Gmo-038763	Gadus morhua	97.31	0.00e+00	756.00
IUUC-Gga-041151	Gallus gallus	92.45	0.00e+00	729.00
IUUC-Gac-041967	Gasterosteus aculeatus	98.12	0.00e+00	761.00
IUUC-Hsa-045700	Homo sapiens	93.26	0.00e+00	733.00
IUUC-Hvu-047692	Hordeum vulgare	59.45	8.00e-124	436.00
IUUC-Itr-049082	Ictidomys tridecemlineatus	93.82	0.00e+00	707.00
IUUC-Lpe-051368	Leersia perrieri	58.36	2.00e-122	432.00
IUUC-Loc-051968	Lepisosteus oculatus	94.61	0.00e+00	740.00
IUUC-Laf-053887	Loxodonta africana	93.80	0.00e+00	736.00
IUUC-Mcc-055701	Macaca mulatta	92.99	0.00e+00	731.00
IUUC-Mor-057072	Magnaporthe oryzae	43.65	9.00e-77	281.00
IUUC-Mga-059195	Meleagris gallopavo	90.27	0.00e+00	711.00
IUUC-Mmr-060751	Microcebus murinus	93.80	0.00e+00	736.00
IUUC-Mdo-062735	Monodelphis domestica	91.69	0.00e+00	718.00
IUUC-Mmu-063263	Mus musculus	92.99	0.00e+00	731.00
IUUC-Mlu-068128	Myotis lucifugus	93.80	0.00e+00	705.00
IUUC-Nfi-068611	Neosartorya fischeri	51.17	9.00e-80	291.00
IUUC-Ncr-068699	Neurospora crassa	44.88	1.00e-75	278.00
IUUC-Nle-069767	Nomascus leucogenys	93.26	0.00e+00	704.00
IUUC-Ont-072658	Oreochromis niloticus	97.85	0.00e+00	759.00
IUUC-Oan-073372	Ornithorhynchus anatinus	93.24	0.00e+00	702.00
IUUC-Ocu-074322	Oryctolagus cuniculus	90.84	0.00e+00	709.00
IUUC-Obr-076088	Oryza brachyantha	57.81	1.00e-119	422.00
IUUC-Ola-087418	Oryzias latipes	97.85	0.00e+00	759.00
IUUC-Olu-087809	Ostreococcus lucimarinus	47.86	2.00e-80	293.00
IUUC-Oga-088298	Otolemur garnettii	91.40	0.00e+00	713.00
IUUC-Oar-090269	Ovis aries	90.93	0.00e+00	702.00
IUUC-Ptr-090467	Pan troglodytes	93.26	0.00e+00	733.00
IUUC-Pan-092437	Papio anubis	90.51	0.00e+00	702.00
IUUC-Psi-092993	Pelodiscus sinensis	91.23	0.00e+00	705.00
IUUC-Ppa-095415	Physcomitrella patens	59.89	2.00e-125	442.00
IUUC-Pfo-097052	Poecilia formosa	97.85	0.00e+00	759.00
IUUC-Pab-097797	Pongo abelii	93.26	0.00e+00	733.00
IUUC-Pop-099016	Populus trichocarpa	59.84	2.00e-125	442.00
IUUC-Pca-100835	Procavia capensis	84.15	6.00e-165	573.00
IUUC-Ppe-101474	Prunus persica	59.84	1.00e-126	446.00
IUUC-Pgr-103306	Puccinia graminis	54.30	6.00e-97	349.00
IUUC-Pte-104356	Pyrenophora teres	49.34	7.00e-79	288.00
IUUC-Pyt-104709	Pyrenophora triticirepentis	49.01	6.00e-79	288.00
IUUC-Rno-104918	Rattus norvegicus	90.54	0.00e+00	700.00
IUUC-Sce-106196	Saccharomyces cerevisiae	38.21	1.00e-55	211.00
IUUC-Sha-107087	Sarcophilus harrisii	93.80	0.00e+00	736.00
IUUC-Sja-107684	Schizosaccharomyces japonicus	45.42	1.00e-65	244.00
IUUC-Spo-108095	Schizosaccharomyces pombe	46.58	2.00e-75	277.00
IUUC-Smo-109064	Selaginella moellendorffii	59.68	3.00e-119	421.00
IUUC-Sit-110819	Setaria italica	59.18	3.00e-123	434.00
IUUC-Sly-111165	Solanum lycopersicum	58.52	3.00e-125	441.00
IUUC-Stu-112398	Solanum tuberosum	59.07	1.00e-125	442.00
IUUC-Sar-113216	Sorex araneus	92.96	0.00e+00	694.00
IUUC-Sbi-114724	Sorghum bicolor	59.45	1.00e-124	439.00
IUUC-Sre-115197	Sporisorium reilianum	51.24	5.00e-82	299.00
IUUC-Ssc-116321	Sus scrofa	91.41	0.00e+00	699.00
IUUC-Tgu-117482	Taeniopygia guttata	89.43	0.00e+00	687.00
IUUC-Tru-118613	Takifugu rubripes	97.58	0.00e+00	758.00
IUUC-Tsy-119520	Tarsius syrichta	82.81	5.00e-123	433.00
IUUC-Tni-120293	Tetraodon nigroviridis	97.58	0.00e+00	758.00
IUUC-Tca-121329	Theobroma cacao	59.56	2.00e-125	442.00
IUUC-Tre-122226	Trichoderma reesei	45.36	9.00e-76	278.00
IUUC-Tvi-122330	Trichoderma virens	45.70	2.00e-75	277.00
IUUC-Tae-124807	Triticum aestivum	59.45	1.00e-126	446.00
IUUC-Tur-126563	Triticum urartu	59.45	1.00e-126	446.00
IUUC-Tme-126890	Tuber melanosporum	46.15	2.00e-91	330.00
IUUC-Tbe-127783	Tupaia belangeri	93.24	0.00e+00	690.00
IUUC-Ttr-129083	Tursiops truncatus	93.53	0.00e+00	734.00
IUUC-Uma-129409	Ustilago maydis	50.35	3.00e-82	300.00
IUUC-Vda-129736	Verticillium dahliae	39.09	2.00e-59	224.00
IUUC-Vpa-130391	Vicugna pacos	88.45	0.00e+00	659.00
IUUC-Vvi-131371	Vitis vinifera	59.29	2.00e-125	442.00
IUUC-Xma-133475	Xiphophorus maculatus	97.85	0.00e+00	759.00
IUUC-Zma-134951	Zea mays	58.90	7.00e-124	436.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence