iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Mga-060194

Ensembl Protein ID

ENSMGAP00000007465.1

UniProt Accession

G1N615; G1N615_MELGA

Protein Name

Tyrosine-protein kinase

Gene Name

HCK

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSMGAG00000007338.1	ENSMGAT00000008239.1	ENSMGAP00000007465.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/SH3	1.00e-16	60.3	5	62

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/SH3

   S: 3    kekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           +++v +lydyea ++++L+++kG++++v+   eq ++W+++ +  +g++G++P+nFv++++
   Q: 5    DNVVLALYDYEAMHSGDLSFQKGEQLQVL---EQLGEWWQARSLVTGRKGFIPSNFVARAN 62
           57899************************...**************************987 PP

Organism

Meleagris gallopavo

Protein Sequence
(Fasta)

AGSGDNVVLA LYDYEAMHSG DLSFQKGEQL QVLEQLGEWW QARSLVTGRK GFIPSNFVAR 60
ANSLEAEEWF FKGISRKDAE RQLLSPGNTL GSFMIRDSET TKGCYSLSVR DGDGLHGGSI 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCAGGCTCAG GGGACAACGT GGTGCTGGCA CTGTATGACT ATGAGGCGAT GCACTCTGGG 60
GACCTGAGCT TCCAGAAAGG GGAACAGCTG CAGGTCCTGG AGCAGTACGT GTCCCCTGCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0418--Kinase
KW-0547--Nucleotide-binding
KW-1185--Reference proteome
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase

Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom

PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3

Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1

PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE

SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc

Gene Ontology

GO:0005654--C:nucleoplasm
GO:0005886--C:plasma membrane
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001284	Ailuropoda melanoleuca	80.89	0.00e+00	763.00
IUUC-Apl-003285	Anas platyrhynchos	87.67	0.00e+00	835.00
IUUC-Aca-004724	Anolis carolinensis	78.81	0.00e+00	736.00
IUUC-Ame-011954	Astyanax mexicanus	76.12	0.00e+00	705.00
IUUC-Bta-013060	Bos taurus	80.62	0.00e+00	764.00
IUUC-Cja-019817	Callithrix jacchus	80.67	0.00e+00	762.00
IUUC-Cfa-020511	Canis familiaris	81.29	0.00e+00	767.00
IUUC-Cpo-022538	Cavia porcellus	78.89	0.00e+00	756.00
IUUC-Csa-024143	Chlorocebus sabaeus	81.29	0.00e+00	765.00
IUUC-Dre-028157	Danio rerio	76.84	0.00e+00	735.00
IUUC-Dno-029761	Dasypus novemcinctus	80.00	0.00e+00	765.00
IUUC-Eca-034090	Equus caballus	79.51	0.00e+00	745.00
IUUC-Fca-035937	Felis catus	80.40	0.00e+00	743.00
IUUC-Fal-036624	Ficedula albicollis	85.56	0.00e+00	816.00
IUUC-Gmo-039009	Gadus morhua	73.32	0.00e+00	704.00
IUUC-Gga-040296	Gallus gallus	94.03	0.00e+00	886.00
IUUC-Gac-042362	Gasterosteus aculeatus	76.06	0.00e+00	734.00
IUUC-Ggo-044570	Gorilla gorilla	80.67	0.00e+00	768.00
IUUC-Hsa-046378	Homo sapiens	80.89	0.00e+00	769.00
IUUC-Itr-048695	Ictidomys tridecemlineatus	80.89	0.00e+00	767.00
IUUC-Lch-049991	Latimeria chalumnae	71.43	0.00e+00	673.00
IUUC-Loc-052904	Lepisosteus oculatus	78.79	0.00e+00	756.00
IUUC-Laf-053654	Loxodonta africana	81.78	0.00e+00	776.00
IUUC-Mcc-055317	Macaca mulatta	81.51	0.00e+00	772.00
IUUC-Mmr-061510	Microcebus murinus	79.56	0.00e+00	759.00
IUUC-Mdo-062035	Monodelphis domestica	79.19	0.00e+00	754.00
IUUC-Mmu-064037	Mus musculus	81.07	0.00e+00	773.00
IUUC-Mpu-066874	Mustela putorius furo	80.89	0.00e+00	766.00
IUUC-Mlu-068202	Myotis lucifugus	77.01	0.00e+00	729.00
IUUC-Nle-069222	Nomascus leucogenys	80.85	0.00e+00	768.00
IUUC-Opr-070705	Ochotona princeps	78.44	0.00e+00	750.00
IUUC-Ont-072347	Oreochromis niloticus	76.73	0.00e+00	715.00
IUUC-Ocu-074490	Oryctolagus cuniculus	79.96	0.00e+00	760.00
IUUC-Ola-086521	Oryzias latipes	76.56	0.00e+00	728.00
IUUC-Oga-088153	Otolemur garnettii	80.44	0.00e+00	763.00
IUUC-Oar-090184	Ovis aries	79.87	0.00e+00	759.00
IUUC-Ptr-090505	Pan troglodytes	76.67	0.00e+00	717.00
IUUC-Pan-092260	Papio anubis	81.51	0.00e+00	772.00
IUUC-Psi-093685	Pelodiscus sinensis	71.21	0.00e+00	688.00
IUUC-Pfo-096566	Poecilia formosa	75.83	0.00e+00	733.00
IUUC-Pab-098601	Pongo abelii	71.08	0.00e+00	691.00
IUUC-Pva-103021	Pteropus vampyrus	81.29	0.00e+00	768.00
IUUC-Rno-105309	Rattus norvegicus	80.85	0.00e+00	773.00
IUUC-Sha-107099	Sarcophilus harrisii	79.19	0.00e+00	752.00
IUUC-Sbi-114009	Sorghum bicolor	30.71	2.00e-20	94.40
IUUC-Tgu-116912	Taeniopygia guttata	84.89	0.00e+00	808.00
IUUC-Tru-118449	Takifugu rubripes	76.68	0.00e+00	717.00
IUUC-Tsy-119440	Tarsius syrichta	71.52	0.00e+00	686.00
IUUC-Tae-125706	Triticum aestivum	29.18	2.00e-19	90.50
IUUC-Tur-126322	Triticum urartu	28.83	8.00e-19	88.20
IUUC-Tbe-128144	Tupaia belangeri	72.38	0.00e+00	666.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence