iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Apl-004030

Ensembl Protein ID

ENSAPLP00000013987.1

UniProt Accession

U3J3B0; U3J3B0_ANAPL

Genbank Protein ID

ENSAPLP00000013987

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADON01086945

Gene Name

USP25

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAPLG00000014057.1	ENSAPLT00000014755.1	ENSAPLP00000013987.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	1.40e-63	214.9	166	646
UBD/Alpha-Helix/UBA	7.60e-06	25.6	15	51

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle....kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefs 85
           +GlkN+gNtC++ +v+Q+L+n+ e+r+l+l+     + ++l+++++++++ +++++l+ lf+ l+ sk+k+v+p++ +++lk++ ++ +
   Q: 166  VGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNfnppANAQDLPRNQKEHRNLPFMRELRYLFALLVGSKRKYVDPSRAVEILKDAFKS-N 253
           6*******************************9999999999999999999*******************************99997.9 PP
   S: 86   gyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlsl 174
            ++qqD++Ef++ lld le++++                   + +ee++ +k k+++++lF g++    + +  +++ + +e f +++l
   Q: 254  DSQQQDVSEFTHKLLDWLEDAFQ------------------IKAEEERDGEKPKNPMVELFYGRFLAVGVLE--GKKFENTEMFGQYPL 322
           **********************2..................22345678999**************777664..444556899****** PP
   S: 175  pvpgkeetkkeslqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksrekinkkvefpleLdlsp 263
           +v+g +     +l++cLe+ + e e+e+   +++e+  k+    +++++++lP+vL+++L+Rf+f+++ +++eki++k+efp  L l++
   Q: 323  QVNGFK-----DLHECLEAAMIEGEIES---LHSENSAKS---GQEHWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPPILYLDR 400
           ******.....9**************96...899998754...589******************************************* PP
   S: 264  fcts..................................................................................... 267
           ++++                                                                                     
   Q: 401  YMHKnreitrikrdeikrlkeyltvlqqrlerylsygsgpkrfplvdvlqyalefasskpvctspvddlgasapssgtlpaqtspstid 489
           ****8888888888888888888888888888888888888887777777777777777777777777777777777777777766666 PP
   S: 268  ........................peekqke.......................................................... 274
                                   +     +                                                          
   Q: 490  qqgpsssdvpstspvqrsvihkpfT-----Qsrippdlpmhpaprhiteeelsvlegclhrwrtevendtrdlqesisrihrtielmys 573
           6666666665555555555555550.....05555555555555555555555666666666666666666677777777777777777 PP
   S: 275  .....kkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg.....staYvlfYk 336
                ++ Y+L+av+vH+G+++ GHY+ay+++++++ W++++D +Vt++++ee ++++      ++aY+l+Y 
   Q: 574  dktmvQVPYRLHAVLVHEGQANAGHYWAYIYDHHQNrWMKYNDISVTKSTWEELERDSFggyrnASAYCLMYI 646
           77777***************************77667*******************8779************6 PP

UBD/Alpha-Helix/UBA

   S: 4    edkleqlve.MGF.dreealqaLraannnleaAveyL 38
           +  l+ql+e +G+ d +  +qaL ++n+nle Av++L
   Q: 15   QTFLNQLREiTGInDIQVLQQALKDSNGNLELAVAFL 51
           6669*******************************98 PP

Organism

Anas platyrhynchos

Protein Sequence
(Fasta)

KQSKTKAQNS HEHQQTFLNQ LREITGINDI QVLQQALKDS NGNLELAVAF LTAKNAKVPQ 60
QEEATYYQTA LPGNDRYISV GSQADTNVID LTGDDKDDLQ RAIALSLEES NRAFRETGIT 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AAACAGAGCA AAACAAAAGC TCAAAATTCA CATGAAGTGA ATGTAGAAGA GCTGCTTAAC 60
CTCTTTCTCT TTCTAACTAC AAGCATTACT TGAAGCTCAG TCACGGACAC TGATTGATTC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR001394--Peptidase_C19_UCH
IPR009060--UBA-like
IPR003903--UIM_dom
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS50330--UIM
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF00443--UCH

SMART

SM00726--UIM

Gene Ontology

GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:1904293--P:negative regulation of ERAD pathway
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001340	Ailuropoda melanoleuca	85.29	0.00e+00	1879.00
IUUC-Aca-004753	Anolis carolinensis	73.17	0.00e+00	1160.00
IUUC-Ame-010624	Astyanax mexicanus	76.65	0.00e+00	1222.00
IUUC-Bta-013166	Bos taurus	83.66	0.00e+00	1779.00
IUUC-Cel-018346	Caenorhabditis elegans	28.35	2.00e-28	121.00
IUUC-Cja-019150	Callithrix jacchus	81.91	0.00e+00	1845.00
IUUC-Cfa-020649	Canis familiaris	82.82	0.00e+00	1857.00
IUUC-Cpo-021807	Cavia porcellus	85.66	0.00e+00	1939.00
IUUC-Csa-023388	Chlorocebus sabaeus	82.70	0.00e+00	1873.00
IUUC-Cho-024343	Choloepus hoffmanni	70.46	0.00e+00	890.00
IUUC-Cin-025302	Ciona intestinalis	37.61	3.00e-97	348.00
IUUC-Csv-025911	Ciona savignyi	37.32	2.00e-145	509.00
IUUC-Cgl-026575	Colletotrichum gloeosporioides	55.56	1.00e-10	62.00
IUUC-Cme-027167	Cyanidioschyzon merolae	31.34	4.00e-13	70.50
IUUC-Dre-028016	Danio rerio	77.45	0.00e+00	1197.00
IUUC-Dno-029495	Dasypus novemcinctus	80.86	0.00e+00	1855.00
IUUC-Dor-030948	Dipodomys ordii	73.92	0.00e+00	1347.00
IUUC-Fca-035876	Felis catus	83.66	0.00e+00	1809.00
IUUC-Fal-036762	Ficedula albicollis	98.12	0.00e+00	1255.00
IUUC-Fox-037752	Fusarium oxysporum	25.54	1.00e-18	89.00
IUUC-Gmo-039490	Gadus morhua	76.64	0.00e+00	1663.00
IUUC-Gga-040817	Gallus gallus	95.56	0.00e+00	2130.00
IUUC-Gac-042473	Gasterosteus aculeatus	76.81	0.00e+00	1689.00
IUUC-Ggo-044939	Gorilla gorilla	83.03	0.00e+00	1821.00
IUUC-Hsa-046204	Homo sapiens	82.29	0.00e+00	1788.00
IUUC-Lch-049572	Latimeria chalumnae	81.62	0.00e+00	1808.00
IUUC-Loc-052070	Lepisosteus oculatus	79.27	0.00e+00	1742.00
IUUC-Laf-054426	Loxodonta africana	82.36	0.00e+00	1674.00
IUUC-Mcc-055858	Macaca mulatta	82.57	0.00e+00	1877.00
IUUC-Mga-059808	Meleagris gallopavo	95.51	0.00e+00	2058.00
IUUC-Mmr-060987	Microcebus murinus	82.14	0.00e+00	1838.00
IUUC-Mmu-064245	Mus musculus	81.09	0.00e+00	1789.00
IUUC-Mpu-066304	Mustela putorius furo	82.18	0.00e+00	1851.00
IUUC-Mlu-067139	Myotis lucifugus	83.29	0.00e+00	1840.00
IUUC-Nfi-068458	Neosartorya fischeri	25.11	4.00e-15	77.40
IUUC-Nle-069075	Nomascus leucogenys	82.01	0.00e+00	1779.00
IUUC-Ont-072150	Oreochromis niloticus	72.83	0.00e+00	1680.00
IUUC-Oan-073054	Ornithorhynchus anatinus	83.13	0.00e+00	1798.00
IUUC-Ocu-074102	Oryctolagus cuniculus	81.05	0.00e+00	1852.00
IUUC-Ola-086529	Oryzias latipes	73.06	0.00e+00	1622.00
IUUC-Oga-088939	Otolemur garnettii	82.84	0.00e+00	1787.00
IUUC-Oar-090266	Ovis aries	82.70	0.00e+00	1849.00
IUUC-Ptr-090546	Pan troglodytes	82.10	0.00e+00	1785.00
IUUC-Pan-092311	Papio anubis	81.91	0.00e+00	1875.00
IUUC-Psi-093459	Pelodiscus sinensis	95.31	0.00e+00	1239.00
IUUC-Pno-095093	Phaeosphaeria nodorum	40.74	4.00e-12	67.00
IUUC-Pfo-096726	Poecilia formosa	68.57	0.00e+00	1549.00
IUUC-Pab-097608	Pongo abelii	85.54	0.00e+00	1866.00
IUUC-Pca-100718	Procavia capensis	80.00	0.00e+00	1176.00
IUUC-Pva-103150	Pteropus vampyrus	83.39	0.00e+00	1422.00
IUUC-Rno-105727	Rattus norvegicus	80.90	0.00e+00	1758.00
IUUC-Sha-107051	Sarcophilus harrisii	86.95	0.00e+00	1878.00
IUUC-Ssl-108532	Sclerotinia sclerotiorum	35.44	2.00e-09	58.20
IUUC-Sar-113097	Sorex araneus	79.63	0.00e+00	1735.00
IUUC-Ssc-115877	Sus scrofa	80.09	0.00e+00	1769.00
IUUC-Tgu-117473	Taeniopygia guttata	91.18	0.00e+00	1930.00
IUUC-Tru-118135	Takifugu rubripes	68.31	0.00e+00	1444.00
IUUC-Tsy-119471	Tarsius syrichta	81.68	0.00e+00	1693.00
IUUC-Tni-120139	Tetraodon nigroviridis	67.02	0.00e+00	1328.00
IUUC-Tbe-127549	Tupaia belangeri	80.11	0.00e+00	1728.00
IUUC-Ttr-128896	Tursiops truncatus	82.12	0.00e+00	1783.00
IUUC-Vpa-130500	Vicugna pacos	80.78	0.00e+00	1758.00
IUUC-Xtr-132896	Xenopus tropicalis	81.84	0.00e+00	1823.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence