iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Nle-069558

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ADFV01081824

Gene Name

FBXW8

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSNLEG00000000280.2	ENSNLET00000000351.2	ENSNLEP00000000327.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/DCX/DWD	1.40e-13	50.5	474	507
UBD/Beta-Prp	7.30e-46	156.7	204	506

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/DCX/DWD

   S: 2    HtdsvtclafsdtllvsGsdDgtikvWDlrtgvl 35
           H+ +v++++ +d+ +vsG+  g + vWD+rt+ +
   Q: 474  HQLRVCAVQMDDWKIVSGGEEGLVSVWDYRTNQK 507
           777899999966*****************99865 PP

UBD/Beta-Prp

   S: 4    tlkghhksvitcvkfspdksllatgsrdgtikvwdvttgkllrslsgheae.........vtavkfspdgkilvtgseDrtikvwdlst 83
           +l++ ++ v+++v+   ++ ++++g+++g ++vwd++t+++++ + + e+e         v+ v+++++  + v + eD+++++wdl+t
   Q: 204  ELEHVPDVVLCDVHS--HDGVVIAGYTSGDVRVWDTRTWDYVAPFLESEDEedepgmqpnVSFVRINSS--LAVAAYEDGFLNIWDLRT 288
           566777888887777..9***********************9999777777789999999*********..9***************** PP
   S: 84   gkcvhtlkghedsvlslsfspsgdklvsGshdrtirvwdletgqcleetlsghdgvvncvvvhpdg.nllvsGslDrtvrlWdlktgkl 171
           gk+ ++  +h++++ +l++s+++ +++++s+ +++++   e+g++  + + +  ++v+++++ p++ ++ v+ ++ + ++ + lk ++ 
   Q: 289  GKYPVHRFEHDARIQALALSQDDATVATASAFDVVMLSPNEEGYWQIAAEFEVPKLVQYLEIVPETrRYPVAVAAAGDLM-YLLKAEDS 376
           ***999999**********************************************************************8.******** PP
   S: 172  lrtltgghtdsvyslsfdsng.....kelvsgsldgtvklwdlqtgecvrtlnghtdnvksvrfs.pnderlvsgssDgsiriWdlrsg 254
            rtl  +h ++v++l+++ n+     + l ++ + +++ +++l++g+c+ +l +  + +++v++s +  +++vsg++Dg +ri+dlrsg
   Q: 377  ARTLLYAHGPPVTCLDVSANQvafgvQGLGWVYEGSKILVYSLEAGRCLLKLGNVLRDFTCVNLSdSPANLMVSGNMDGRVRIHDLRSG 465
           *****************************************************************8899******************** PP
   S: 255  dllktlqlhnssvisvavlsfgdnvlvlgsedskvniwklkkne 298
           ++  +l+ h+ +v +v++   +d+++v+g+e++ v +w++++n+
   Q: 466  NIALSLSAHQLRVCAVQM---DDWKIVSGGEEGLVSVWDYRTNQ 506
           **********99999999...*******************9987 PP

Organism

Nomascus leucogenys

Protein Sequence
(Fasta)

MDDYSLDEFR RRWQEELAQA QAPRKRRRPE AAERRARRPE VGSGCGEQAS GDPALAQGLL 60
EGAGRTPAAR ATRAEGQDVA SRSRSPLARE GARGGEQLVD QLIRDLNEMN DVPFFDIQLP 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGACGACT ACAGCCTGGA TGAGTTCCGT CGGCGCTGGC AGGAGGAGCT GGCGCAGGCC 60
CAGGCGCCGA GGAAGCGGCG ACGGCCCGAG GCTGCCGAGA GGCGGGCTCG GCGGCCGGAG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0853--WD repeat

Interpro

IPR001810--F-box_dom
IPR011047--Quinoprotein_ADH-like_supfam
IPR015943--WD40/YVTN_repeat-like_dom
IPR001680--WD40_repeat
IPR019775--WD40_repeat_CS
IPR017986--WD40_repeat_dom

PROSITE

PS50181--FBOX
PS00678--WD_REPEATS_1
PS50082--WD_REPEATS_2
PS50294--WD_REPEATS_REGION

Pfam

PF12937--F-box-like

SMART

SM00256--FBOX
SM00320--WD40

Gene Ontology

GO:1990393--C:3M complex
GO:0031467--C:Cul7-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008283--P:cell proliferation
GO:0007030--P:Golgi organization
GO:0050775--P:positive regulation of dendrite morphogenesis

KEGG

nle:100595548

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001274	Ailuropoda melanoleuca	87.73	0.00e+00	900.00
IUUC-Apl-003239	Anas platyrhynchos	61.57	0.00e+00	640.00
IUUC-Aca-004756	Anolis carolinensis	58.82	4.00e-119	421.00
IUUC-Ame-011198	Astyanax mexicanus	54.30	2.00e-57	215.00
IUUC-Bta-012430	Bos taurus	59.69	2.00e-144	505.00
IUUC-Cja-019131	Callithrix jacchus	88.66	0.00e+00	962.00
IUUC-Cfa-021022	Canis familiaris	78.10	0.00e+00	876.00
IUUC-Cpo-021898	Cavia porcellus	77.34	0.00e+00	855.00
IUUC-Csa-023452	Chlorocebus sabaeus	95.29	0.00e+00	1054.00
IUUC-Cho-024759	Choloepus hoffmanni	74.69	0.00e+00	779.00
IUUC-Dre-028123	Danio rerio	46.12	2.00e-135	476.00
IUUC-Dno-029045	Dasypus novemcinctus	86.81	0.00e+00	781.00
IUUC-Dor-030433	Dipodomys ordii	76.91	0.00e+00	762.00
IUUC-Ete-032465	Echinops telfairi	79.84	0.00e+00	742.00
IUUC-Eca-034134	Equus caballus	87.15	0.00e+00	850.00
IUUC-Eeu-035047	Erinaceus europaeus	76.66	0.00e+00	729.00
IUUC-Fca-036574	Felis catus	87.15	0.00e+00	842.00
IUUC-Fal-037665	Ficedula albicollis	59.45	4.00e-161	561.00
IUUC-Gmo-039137	Gadus morhua	39.79	1.00e-68	253.00
IUUC-Gga-040711	Gallus gallus	58.35	5.00e-180	624.00
IUUC-Gac-041675	Gasterosteus aculeatus	51.90	5.00e-42	163.00
IUUC-Ggo-045331	Gorilla gorilla	97.64	0.00e+00	946.00
IUUC-Hsa-046240	Homo sapiens	97.38	0.00e+00	1065.00
IUUC-Itr-048412	Ictidomys tridecemlineatus	88.22	0.00e+00	833.00
IUUC-Loc-052631	Lepisosteus oculatus	53.22	4.00e-154	538.00
IUUC-Laf-054127	Loxodonta africana	70.34	3.00e-42	163.00
IUUC-Mcc-055083	Macaca mulatta	96.16	0.00e+00	1042.00
IUUC-Mga-060113	Meleagris gallopavo	62.13	2.00e-175	608.00
IUUC-Mmr-061780	Microcebus murinus	86.59	0.00e+00	879.00
IUUC-Mdo-063066	Monodelphis domestica	61.38	0.00e+00	667.00
IUUC-Mmu-063524	Mus musculus	76.79	0.00e+00	798.00
IUUC-Mpu-066913	Mustela putorius furo	87.73	0.00e+00	880.00
IUUC-Mlu-067924	Myotis lucifugus	84.49	0.00e+00	892.00
IUUC-Opr-070506	Ochotona princeps	82.20	0.00e+00	858.00
IUUC-Ont-071514	Oreochromis niloticus	48.64	6.00e-136	478.00
IUUC-Ocu-074477	Oryctolagus cuniculus	85.16	0.00e+00	822.00
IUUC-Ola-087416	Oryzias latipes	44.52	6.00e-137	481.00
IUUC-Oga-088643	Otolemur garnettii	85.86	0.00e+00	885.00
IUUC-Oar-090172	Ovis aries	85.87	0.00e+00	838.00
IUUC-Ptr-090870	Pan troglodytes	97.38	0.00e+00	1061.00
IUUC-Pan-092017	Papio anubis	94.94	0.00e+00	1052.00
IUUC-Psi-093794	Pelodiscus sinensis	64.36	5.00e-178	617.00
IUUC-Pfo-096192	Poecilia formosa	50.94	5.00e-138	484.00
IUUC-Pab-097882	Pongo abelii	96.51	0.00e+00	1047.00
IUUC-Pca-100902	Procavia capensis	82.56	2.00e-153	535.00
IUUC-Pva-103139	Pteropus vampyrus	82.93	0.00e+00	896.00
IUUC-Rno-105798	Rattus norvegicus	80.75	0.00e+00	808.00
IUUC-Sha-106576	Sarcophilus harrisii	65.23	0.00e+00	630.00
IUUC-Ssc-115923	Sus scrofa	76.04	0.00e+00	871.00
IUUC-Tgu-116667	Taeniopygia guttata	53.14	6.00e-100	357.00
IUUC-Tru-118323	Takifugu rubripes	44.02	6.00e-129	454.00
IUUC-Tsy-118818	Tarsius syrichta	68.12	2.00e-82	299.00
IUUC-Tni-120438	Tetraodon nigroviridis	42.91	3.00e-126	445.00
IUUC-Tbe-127784	Tupaia belangeri	83.01	8.00e-97	347.00
IUUC-Ttr-128288	Tursiops truncatus	77.70	0.00e+00	763.00
IUUC-Vpa-130307	Vicugna pacos	83.67	0.00e+00	800.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence