iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046883

UUCD1 version

UUC-HoS-00376

Ensembl Protein ID

ENSP00000386830.1

UniProt Accession

Q9H992; A8K9X1; B7Z7P5; D3DPB0; Q53GQ1; Q9BTR9; MARH7_HUMAN

Genbank Protein ID

BAB14340.1; BAF85525.1; BAH13681.1; BAD96600.1; AAY14941.1; EAX11402.1; AAH03404.1; AAH65014.1

Protein Name

E3 ubiquitin-protein ligase MARCH7; Axotrophin; Membrane-associated RING finger protein 7; Membrane-associated RING-CH protein VII; RING finger protein 177; RING-type E3 ubiquitin transferase MARCH7

Genbank Nucleotide ID

AK022973; AK292836; AK302347; AK222880; AC009961; CH471058; BC003404; BC065014

Gene Name

MARCH7; AXOT; RNF177

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000136536.14	ENST00000409175.5	ENSP00000386830.1
ENSG00000136536.14	ENST00000409591.5	ENSP00000387238.1
ENSG00000136536.14	ENST00000539065.5	ENSP00000442992.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	THPA	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
miRTarBase	microRNA	TRANSFAC	RepTar
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	BioGRID
DNA Methylation
TCGA	ICGC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	20962578; 19342884; 19901269

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates.

Protein Sequence
(Fasta)

MESKPSRIPR RISVQPSSSL SARMMSGSRG SSLNDTYHSR DSSFRLDSEY QSTSASASAS 60
PFQSAWYSES EITQGARSRS QNQQRDHDSK RPKLSCTNCT TSAGRNVGNG LNTLSDSSWR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GCGAAGTGGG GGGAGGAGGA GCAGGGAGGG GCACTTAACG GTGGTGGCTG GTTCTGCGCC 60
GGATCCGGGA GAGGGGCGGG CGCCATTGTG CTTCGCTGCC GACTGCATTT CCTCAGTCAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR011016--Znf_RING-CH
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51292--ZF_RING_CH

Pfam

PF12906--RINGv

SMART

SM00744--RINGv

Gene Ontology

GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0042130--P:negative regulation of T cell proliferation
GO:0016567--P:protein ubiquitination
GO:0002643--P:regulation of tolerance induction

KEGG

hsa:64844

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Apl-003999	Anas platyrhynchos	65.46	0.00e+00	631.00
IUUC-Aca-005296	Anolis carolinensis	63.57	1.00e-156	546.00
IUUC-Ame-011193	Astyanax mexicanus	60.34	1.00e-67	251.00
IUUC-Bta-013333	Bos taurus	86.72	0.00e+00	971.00
IUUC-Cja-019610	Callithrix jacchus	96.73	0.00e+00	963.00
IUUC-Cfa-021250	Canis familiaris	90.82	0.00e+00	902.00
IUUC-Cpo-022016	Cavia porcellus	86.39	0.00e+00	759.00
IUUC-Csa-023420	Chlorocebus sabaeus	97.81	0.00e+00	974.00
IUUC-Dre-027865	Danio rerio	62.21	9.00e-63	235.00
IUUC-Dno-030094	Dasypus novemcinctus	89.41	0.00e+00	948.00
IUUC-Dor-030822	Dipodomys ordii	81.07	0.00e+00	859.00
IUUC-Ete-032649	Echinops telfairi	87.98	0.00e+00	931.00
IUUC-Eca-033241	Equus caballus	90.81	0.00e+00	910.00
IUUC-Eeu-035188	Erinaceus europaeus	80.30	0.00e+00	641.00
IUUC-Fca-035415	Felis catus	90.82	0.00e+00	890.00
IUUC-Fal-036666	Ficedula albicollis	64.70	4.00e-176	611.00
IUUC-Gac-041953	Gasterosteus aculeatus	42.54	1.00e-51	197.00
IUUC-Ggo-045544	Gorilla gorilla	99.57	0.00e+00	967.00
IUUC-Itr-047989	Ictidomys tridecemlineatus	91.46	0.00e+00	718.00
IUUC-Loc-051840	Lepisosteus oculatus	67.91	3.00e-76	280.00
IUUC-Laf-054541	Loxodonta africana	88.82	0.00e+00	871.00
IUUC-Mcc-054882	Macaca mulatta	98.72	0.00e+00	939.00
IUUC-Mga-059356	Meleagris gallopavo	63.29	2.00e-172	599.00
IUUC-Mmr-060788	Microcebus murinus	92.93	0.00e+00	937.00
IUUC-Mdo-062794	Monodelphis domestica	78.88	0.00e+00	775.00
IUUC-Mmu-063335	Mus musculus	83.72	0.00e+00	894.00
IUUC-Mpu-066830	Mustela putorius furo	90.25	0.00e+00	898.00
IUUC-Mlu-067138	Myotis lucifugus	87.84	0.00e+00	912.00
IUUC-Nle-069584	Nomascus leucogenys	98.86	0.00e+00	954.00
IUUC-Opr-070434	Ochotona princeps	81.52	6.00e-106	378.00
IUUC-Ont-072653	Oreochromis niloticus	45.91	3.00e-52	200.00
IUUC-Ocu-074137	Oryctolagus cuniculus	91.53	0.00e+00	909.00
IUUC-Oga-088502	Otolemur garnettii	91.51	0.00e+00	911.00
IUUC-Oar-090338	Ovis aries	86.38	0.00e+00	965.00
IUUC-Ptr-090675	Pan troglodytes	99.86	0.00e+00	972.00
IUUC-Pan-092888	Papio anubis	98.72	0.00e+00	941.00
IUUC-Psi-094028	Pelodiscus sinensis	69.27	0.00e+00	647.00
IUUC-Pfo-096417	Poecilia formosa	44.65	1.00e-55	211.00
IUUC-Pab-097652	Pongo abelii	99.29	0.00e+00	966.00
IUUC-Pca-100973	Procavia capensis	71.39	0.00e+00	688.00
IUUC-Pva-103013	Pteropus vampyrus	87.69	0.00e+00	874.00
IUUC-Rno-105410	Rattus norvegicus	86.46	0.00e+00	934.00
IUUC-Sha-107373	Sarcophilus harrisii	75.39	0.00e+00	772.00
IUUC-Sar-113462	Sorex araneus	81.04	0.00e+00	826.00
IUUC-Tgu-116487	Taeniopygia guttata	64.61	0.00e+00	639.00
IUUC-Tru-118111	Takifugu rubripes	59.18	2.00e-50	193.00
IUUC-Tni-120549	Tetraodon nigroviridis	61.31	6.00e-48	185.00
IUUC-Tae-124283	Triticum aestivum	39.34	5.00e-08	51.20
IUUC-Tbe-127282	Tupaia belangeri	90.05	0.00e+00	764.00
IUUC-Ttr-129177	Tursiops truncatus	87.29	0.00e+00	866.00
IUUC-Vpa-130101	Vicugna pacos	88.68	0.00e+00	771.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence