iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Aml-001676

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ACTA01112647

Gene Name

HERC5

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000003022.1	ENSAMET00000003336.1	ENSAMEP00000003205.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	2.50e-87	293.5	697	1018

Active Site

Position(s)	Description	Evidence
988	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrll 88
           ++dl+++l+v+f+gE g+d gGv+ ef+++l++e+ +p++g+f+y e+ +++++p + ++    e+ ++F f+G+l+g++l++ ++ 
   Q: 697  NEDLRRELMVSFSGEIGHDSGGVKVEFFHCLFEEMTRPEYGMFTYPEEASYMWFPVRPKF----EKKRYF-FFGVLCGLSLFNFNVA 778
           6899*******************************************************9....567888.99************** PP
   S: 89   dlplsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvk 175
           ++p++ +++k+ll++  sledl+e+ p l ksl+ +++ + +d  e  + + f     +  + ++ +L+p+G+ + V ++Nk++Yv+
   Q: 779  NIPFPLALFKKLLNQTPSLEDLKELSPVLGKSLQTLLDDEGDDFGEV-FYIYFN----VHWDKNDIDLIPNGSCVIVDQTNKRDYVS 860
           *************************************8855555554.666665....666889999******************** PP
   S: 176  lvveyrlkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerk 262
           + v+y+++ ++k  +e+f++Gf++v+++++++ F++eel+ +i G++++d+e+++k++ y++gy +++p+i +Fw++l++++ ee+k
   Q: 861  KCVSYIFNISVKALYEEFQRGFYKVCDKDIIEFFHPEELKDVIIGNTDYDWETFEKNAHYEEGYDNSHPTIVMFWKALHKLTLEEKK 947
           *************************************************************************************** PP
   S: 263  afLqFvTgssrlPlgGfaelkprlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +fL F+Tg++r+ ++G++++k   f+++++ ++++ ++++TC+++L LP+Ys++e ++e L++Ai++++gF+
   Q: 948  KFLVFLTGTDRIQVKGLKNMK-ITFCCPENVNEKDPIRAQTCISVLYLPKYSTMERVEEALQVAINNSRGFG 1018
           *********************.77999999****************************************96 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MEQRPRRRAR GGVRPVSGPV PPSRPXWLFP SAAGLRRALS QRMEATRQMC CTRGRLVVLE 60
RGGAGVEVHQ LMVARTGSRT VQCVKLGKKM KIHSVDQGAE HMLILSSDGK PFEYNYSIEH 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGAGCAGA GGCCGCGAAG GAGAGCTCGG GGCGGCGTGC GCCCGGTGTC CGGGCCGGTC 60
CCCCCGTCGC GACCGCCNNN NNNNNNNNNN NNNNNNNNNN NNNNTTGGCT CTTCCCCAGC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR009091--RCC1/BLIP-II
IPR000408--Reg_chr_condens

PROSITE

PS50237--HECT
PS00626--RCC1_2
PS50012--RCC1_3

Pfam

PF00632--HECT
PF00415--RCC1

PRINTS

PR00633--RCCNDNSATION

SMART

SM00119--HECTc

Gene Ontology

GO:0042296--F:ISG15 transferase activity
GO:0003723--F:RNA binding
GO:0004842--F:ubiquitin-protein transferase activity
GO:0032020--P:ISG15-protein conjugation
GO:0050688--P:regulation of defense response to virus

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bta-012422	Bos taurus	82.45	0.00e+00	907.00
IUUC-Cja-018751	Callithrix jacchus	74.95	0.00e+00	1547.00
IUUC-Cfa-020247	Canis familiaris	94.09	0.00e+00	1835.00
IUUC-Csa-023204	Chlorocebus sabaeus	77.18	0.00e+00	1397.00
IUUC-Cho-025101	Choloepus hoffmanni	66.40	0.00e+00	672.00
IUUC-Dno-029795	Dasypus novemcinctus	73.28	0.00e+00	1197.00
IUUC-Dor-030862	Dipodomys ordii	68.95	0.00e+00	1345.00
IUUC-Ete-032585	Echinops telfairi	61.34	0.00e+00	874.00
IUUC-Eca-034358	Equus caballus	82.54	0.00e+00	1640.00
IUUC-Eeu-035282	Erinaceus europaeus	72.65	0.00e+00	833.00
IUUC-Fca-036505	Felis catus	91.41	0.00e+00	1863.00
IUUC-Ggo-045445	Gorilla gorilla	74.15	0.00e+00	1442.00
IUUC-Hsa-046342	Homo sapiens	76.85	0.00e+00	1526.00
IUUC-Itr-049004	Ictidomys tridecemlineatus	74.28	0.00e+00	1508.00
IUUC-Laf-053921	Loxodonta africana	75.58	0.00e+00	1538.00
IUUC-Mcc-054850	Macaca mulatta	76.96	0.00e+00	1399.00
IUUC-Mmr-060783	Microcebus murinus	66.84	0.00e+00	1232.00
IUUC-Mpu-066123	Mustela putorius furo	91.44	0.00e+00	1895.00
IUUC-Mlu-067914	Myotis lucifugus	82.28	0.00e+00	1549.00
IUUC-Nle-069986	Nomascus leucogenys	76.33	0.00e+00	1540.00
IUUC-Opr-070513	Ochotona princeps	71.68	0.00e+00	1083.00
IUUC-Ocu-074305	Oryctolagus cuniculus	74.87	0.00e+00	1464.00
IUUC-Oar-089456	Ovis aries	84.38	0.00e+00	1671.00
IUUC-Ptr-091216	Pan troglodytes	77.04	0.00e+00	1347.00
IUUC-Pan-091706	Papio anubis	74.88	0.00e+00	1468.00
IUUC-Pca-100320	Procavia capensis	68.58	0.00e+00	1381.00
IUUC-Pva-102646	Pteropus vampyrus	86.67	0.00e+00	1782.00
IUUC-Sar-113605	Sorex araneus	80.24	4.00e-162	565.00
IUUC-Ssc-116076	Sus scrofa	83.75	0.00e+00	644.00
IUUC-Tsy-119240	Tarsius syrichta	65.45	0.00e+00	1238.00
IUUC-Tbe-127787	Tupaia belangeri	72.94	0.00e+00	1397.00
IUUC-Ttr-128191	Tursiops truncatus	81.05	0.00e+00	1625.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence