iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Ocu-074837

Ensembl Protein ID

ENSOCUP00000011052.2

UniProt Accession

G1T469; G1T469_RABIT

Protein Name

Uncharacterized protein

Gene Name

NOD2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSOCUG00000012840.2	ENSOCUT00000012844.2	ENSOCUP00000011052.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
UBD/CARD	1.40e-18	67.3	148	204

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

UBD/CARD

   S: 3    eeyrlllstlqdrvrklLdvtdvldkylseflleeekelilaaaetkgnmqaaelLLk 60
           +e+rl+++t ++r+r+lLd+++v++++l++fll+++++l++    + ++++++ + ++
   Q: 148  DEIRLPIFTSSQRARRLLDLATVKANGLAAFLLQHVQKLPVSLSLPFEAAACK-KYMS 204
           8*******************************************999999999.5554 PP

Organism

Oryctolagus cuniculus

Protein Sequence
(Fasta)

TLSPGCEMCS QEAFQAQRSQ LVGLLVSGSL EGFESILDLL LSWEVLSWED YEGLRLVGQP 60
LSHLARRLLD TVWNKGTWGC QKLIAAVQEA QDSSQCPELH GCWDPHSLHP AQDLQSHRPA 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACTCTCTCCC CAGGTTGTGA AATGTGCTCT CAAGAGGCTT TCCAGGCACA GAGGAGCCAG 60
CTGGTGGGGC TGCTGGTTTC GGGGTCCCTG GAGGGCTTCG AGAGCATCCT GGACTTGCTG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0002--3D-structure
KW-0067--ATP-binding
KW-0181--Complete proteome
KW-0547--Nucleotide-binding
KW-1185--Reference proteome

Interpro

IPR007109--Brix
IPR001315--CARD
IPR011029--DEATH-like_dom
IPR001611--Leu-rich_rpt
IPR007111--NACHT_NTPase
IPR027417--P-loop_NTPase

PROSITE

PS50209--CARD
PS51450--LRR
PS50837--NACHT

Pfam

PF00619--CARD
PF13516--LRR_6

Gene Ontology

GO:0016323--C:basolateral plasma membrane
GO:0009986--C:cell surface
GO:0008180--C:COP9 signalosome
GO:0005856--C:cytoskeleton
GO:0005829--C:cytosol
GO:0005794--C:Golgi apparatus
GO:0031982--C:vesicle
GO:0005524--F:ATP binding
GO:0032500--F:muramyl dipeptide binding
GO:0042834--F:peptidoglycan binding
GO:0071225--P:cellular response to muramyl dipeptide
GO:0002374--P:cytokine secretion involved in immune response
GO:0042742--P:defense response to bacterium
GO:0016045--P:detection of bacterium
GO:0032498--P:detection of muramyl dipeptide
GO:0045087--P:innate immune response
GO:0030277--P:maintenance of gastrointestinal epithelium
GO:0070431--P:nucleotide-binding oligomerization domain containing 2 signaling pathway
GO:0050871--P:positive regulation of B cell activation
GO:1900017--P:positive regulation of cytokine production involved in inflammatory response
GO:0043123--P:positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050718--P:positive regulation of interleukin-1 beta secretion
GO:0032740--P:positive regulation of interleukin-17 production
GO:0032755--P:positive regulation of interleukin-6 production
GO:0032757--P:positive regulation of interleukin-8 production
GO:0046330--P:positive regulation of JNK cascade
GO:0051092--P:positive regulation of NF-kappaB transcription factor activity
GO:1901224--P:positive regulation of NIK/NF-kappaB signaling
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0032760--P:positive regulation of tumor necrosis factor production
GO:0002830--P:positive regulation of type 2 immune response
GO:0042981--P:regulation of apoptotic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001822	Ailuropoda melanoleuca	81.43	0.00e+00	1490.00
IUUC-Ame-011021	Astyanax mexicanus	47.33	0.00e+00	902.00
IUUC-Bta-013241	Bos taurus	81.84	0.00e+00	1624.00
IUUC-Cja-019633	Callithrix jacchus	83.12	0.00e+00	1258.00
IUUC-Cfa-020039	Canis familiaris	84.01	0.00e+00	1630.00
IUUC-Cpo-022337	Cavia porcellus	81.62	0.00e+00	1564.00
IUUC-Csa-023906	Chlorocebus sabaeus	86.42	0.00e+00	1712.00
IUUC-Dre-027568	Danio rerio	48.67	0.00e+00	858.00
IUUC-Dno-029098	Dasypus novemcinctus	81.32	0.00e+00	1500.00
IUUC-Dor-031102	Dipodomys ordii	76.53	0.00e+00	714.00
IUUC-Ete-032943	Echinops telfairi	77.91	0.00e+00	1135.00
IUUC-Eca-034310	Equus caballus	85.46	0.00e+00	1640.00
IUUC-Eeu-034589	Erinaceus europaeus	82.88	2.00e-162	566.00
IUUC-Fca-036252	Felis catus	82.27	0.00e+00	820.00
IUUC-Gac-041442	Gasterosteus aculeatus	46.93	0.00e+00	831.00
IUUC-Ggo-044861	Gorilla gorilla	86.44	0.00e+00	1652.00
IUUC-Hsa-046093	Homo sapiens	86.44	0.00e+00	1654.00
IUUC-Itr-048543	Ictidomys tridecemlineatus	83.28	0.00e+00	1514.00
IUUC-Lch-049454	Latimeria chalumnae	53.65	0.00e+00	922.00
IUUC-Laf-053553	Loxodonta africana	83.89	0.00e+00	1519.00
IUUC-Mcc-055772	Macaca mulatta	86.54	0.00e+00	1687.00
IUUC-Meu-056785	Macropus eugenii	51.19	1.00e-117	417.00
IUUC-Mmr-060596	Microcebus murinus	84.43	0.00e+00	1600.00
IUUC-Mdo-062983	Monodelphis domestica	67.56	0.00e+00	1114.00
IUUC-Mmu-063951	Mus musculus	77.68	0.00e+00	1516.00
IUUC-Mpu-066412	Mustela putorius furo	82.72	0.00e+00	1613.00
IUUC-Mlu-067601	Myotis lucifugus	80.04	0.00e+00	1449.00
IUUC-Nle-069913	Nomascus leucogenys	86.33	0.00e+00	1385.00
IUUC-Opr-070999	Ochotona princeps	89.25	0.00e+00	1070.00
IUUC-Ont-072512	Oreochromis niloticus	47.33	0.00e+00	891.00
IUUC-Oan-073564	Ornithorhynchus anatinus	61.82	0.00e+00	1115.00
IUUC-Ola-086555	Oryzias latipes	46.12	0.00e+00	833.00
IUUC-Oga-088909	Otolemur garnettii	84.09	0.00e+00	1612.00
IUUC-Oar-089315	Ovis aries	80.97	0.00e+00	1557.00
IUUC-Ptr-090542	Pan troglodytes	86.35	0.00e+00	1650.00
IUUC-Pan-092545	Papio anubis	86.32	0.00e+00	1674.00
IUUC-Pma-094167	Petromyzon marinus	33.70	1.00e-63	237.00
IUUC-Ppa-095344	Physcomitrella patens	23.66	5.00e-05	43.50
IUUC-Pfo-096976	Poecilia formosa	44.97	0.00e+00	842.00
IUUC-Pab-098481	Pongo abelii	86.05	0.00e+00	1639.00
IUUC-Pca-100135	Procavia capensis	77.26	0.00e+00	1324.00
IUUC-Pva-102127	Pteropus vampyrus	81.42	0.00e+00	1452.00
IUUC-Rno-105783	Rattus norvegicus	80.40	0.00e+00	1516.00
IUUC-Sce-106163	Saccharomyces cerevisiae	26.92	7.90e-02	33.50
IUUC-Sar-113448	Sorex araneus	75.25	0.00e+00	943.00
IUUC-Tru-118708	Takifugu rubripes	45.18	0.00e+00	791.00
IUUC-Tni-120172	Tetraodon nigroviridis	36.30	9.00e-32	130.00
IUUC-Tbe-127661	Tupaia belangeri	83.93	0.00e+00	821.00
IUUC-Ttr-128318	Tursiops truncatus	76.65	0.00e+00	1403.00
IUUC-Vpa-130502	Vicugna pacos	75.26	1.00e-160	560.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence