iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Loc-052743

Ensembl Protein ID

ENSLOCP00000010189.1

UniProt Accession

W5MP80; W5MP80_LEPOC

Genbank Protein ID

ENSLOCP00000010189

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AHAT01003405

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSLOCG00000008388.1	ENSLOCT00000010201.1	ENSLOCP00000010189.1
ENSLOCG00000008388.1	ENSLOCT00000010218.1	ENSLOCP00000010205.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	5.90e-105	351.5	572	898

Active Site

Position(s)	Description	Evidence
867	Glycyl thioester intermediate	{ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e+ k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 572  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDETTKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 655
           689*******************************************99888877.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl++ +p l++slke++e+ e ++ee ++ +tf++s++  +g+   ++L ++G++ipVtneN++++v +++
   Q: 656  HFPMVVYRKLMGKKGTFRDLADSHPVLFQSLKELLEY-EGSVEE-DMMITFQISQTDlFGNPLMYDLRENGDKIPVTNENRKDFVTQYA 742
           *************************************.556665.59999996554449****************************** PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           ey+l++ +++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggy++ds+ i+ Fw+++++f +e+++ fLq
   Q: 743  EYILNKAVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYNRDSRIIKDFWDIVHAFGEEQKRLFLQ 831
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d drlP+s+TCfn+L LPeY++ke+lke+Ll Ai+++kgF++
   Q: 832  FTTGTDRAPVGGLGKLK---MIIAKNGPDtDRLPTSHTCFNVLLLPEYTTKEKLKERLLKAITYAKGFGM 898
           *****************...8888866666**************************************97 PP

Organism

Lepisosteus oculatus

Protein Sequence
(Fasta)

MNSDEKQDCE CAPPQAEPAP TGGSDRSPGE PDIENPEASR MKRAAAKHLI ERYYHQLTEG 60
CGNEACTNEF CASCPSFHRM DNNAAAVKAL ELYKINAKLC DPHPSKKGTS SAYLENSAKG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGAATTCCG ACGAGAAGCA GGACTGTGAG TGTGCGCCAC CACAGGCCGA GCCAGCCCCT 60
ACAGGAGGAT CCGACAGGTC GGTACGGGGC TGGGGAAAGG GCCGGGGATT CCGGTCGCGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A

PROSITE

PS50237--HECT

Pfam

PF16558--AZUL
PF00632--HECT

SMART

SM00119--HECTc

Gene Ontology

GO:0061630--F:ubiquitin protein ligase activity
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002214	Ailuropoda melanoleuca	90.33	0.00e+00	1514.00
IUUC-Atr-003144	Amborella trichopoda	44.77	5.00e-94	338.00
IUUC-Apl-003742	Anas platyrhynchos	90.97	0.00e+00	1563.00
IUUC-Aca-004873	Anolis carolinensis	90.58	0.00e+00	1565.00
IUUC-Ame-011166	Astyanax mexicanus	88.72	0.00e+00	1486.00
IUUC-Bta-013286	Bos taurus	88.22	0.00e+00	1488.00
IUUC-Cja-019707	Callithrix jacchus	88.56	0.00e+00	1524.00
IUUC-Cfa-020154	Canis familiaris	89.13	0.00e+00	1524.00
IUUC-Cpo-021292	Cavia porcellus	89.28	0.00e+00	1490.00
IUUC-Cre-022790	Chlamydomonas reinhardtii	49.37	7.00e-82	296.00
IUUC-Csa-023378	Chlorocebus sabaeus	88.10	0.00e+00	1516.00
IUUC-Cho-025059	Choloepus hoffmanni	86.03	0.00e+00	1428.00
IUUC-Cin-025643	Ciona intestinalis	43.91	0.00e+00	698.00
IUUC-Csv-026282	Ciona savignyi	43.44	0.00e+00	654.00
IUUC-Cme-027151	Cyanidioschyzon merolae	43.12	2.00e-98	354.00
IUUC-Dre-027901	Danio rerio	86.98	0.00e+00	1456.00
IUUC-Dno-029320	Dasypus novemcinctus	89.13	0.00e+00	1528.00
IUUC-Dor-030756	Dipodomys ordii	84.81	0.00e+00	675.00
IUUC-Dme-032035	Drosophila melanogaster	43.25	9.00e-165	574.00
IUUC-Eca-033843	Equus caballus	89.16	0.00e+00	1483.00
IUUC-Eeu-035109	Erinaceus europaeus	88.81	0.00e+00	1466.00
IUUC-Fca-036344	Felis catus	89.13	0.00e+00	1527.00
IUUC-Fal-036747	Ficedula albicollis	90.86	0.00e+00	1562.00
IUUC-Gmo-038840	Gadus morhua	63.30	0.00e+00	1105.00
IUUC-Gga-040399	Gallus gallus	90.86	0.00e+00	1562.00
IUUC-Gac-041933	Gasterosteus aculeatus	88.05	0.00e+00	1443.00
IUUC-Ggo-044804	Gorilla gorilla	88.63	0.00e+00	1519.00
IUUC-Hsa-045727	Homo sapiens	88.63	0.00e+00	1519.00
IUUC-Itr-048289	Ictidomys tridecemlineatus	86.25	0.00e+00	1414.00
IUUC-Lch-050197	Latimeria chalumnae	88.67	0.00e+00	1553.00
IUUC-Lma-053245	Leptosphaeria maculans	34.31	1.00e-55	212.00
IUUC-Laf-053615	Loxodonta africana	88.88	0.00e+00	1510.00
IUUC-Mcc-054934	Macaca mulatta	88.14	0.00e+00	1514.00
IUUC-Meu-056061	Macropus eugenii	85.66	0.00e+00	1375.00
IUUC-Mga-059271	Meleagris gallopavo	91.15	0.00e+00	1535.00
IUUC-Mmr-061288	Microcebus murinus	88.66	0.00e+00	1528.00
IUUC-Mdo-062975	Monodelphis domestica	91.42	0.00e+00	1574.00
IUUC-Mmu-063674	Mus musculus	87.87	0.00e+00	1484.00
IUUC-Mpu-066568	Mustela putorius furo	89.93	0.00e+00	1540.00
IUUC-Mlu-067522	Myotis lucifugus	84.77	0.00e+00	1433.00
IUUC-Nle-069505	Nomascus leucogenys	88.63	0.00e+00	1519.00
IUUC-Opr-070570	Ochotona princeps	82.93	0.00e+00	1372.00
IUUC-Ont-071527	Oreochromis niloticus	84.72	0.00e+00	1539.00
IUUC-Oan-073446	Ornithorhynchus anatinus	88.96	0.00e+00	1020.00
IUUC-Ocu-074922	Oryctolagus cuniculus	88.40	0.00e+00	1521.00
IUUC-Ola-086996	Oryzias latipes	86.66	0.00e+00	1504.00
IUUC-Oga-088261	Otolemur garnettii	89.74	0.00e+00	1507.00
IUUC-Oar-090024	Ovis aries	88.22	0.00e+00	1488.00
IUUC-Ptr-090455	Pan troglodytes	88.63	0.00e+00	1519.00
IUUC-Pan-092509	Papio anubis	86.90	0.00e+00	1358.00
IUUC-Psi-092974	Pelodiscus sinensis	91.08	0.00e+00	1549.00
IUUC-Pma-094643	Petromyzon marinus	70.99	0.00e+00	1250.00
IUUC-Pno-094886	Phaeosphaeria nodorum	35.84	3.00e-58	221.00
IUUC-Pfo-096905	Poecilia formosa	86.65	0.00e+00	1546.00
IUUC-Pab-097840	Pongo abelii	88.36	0.00e+00	1463.00
IUUC-Pca-100869	Procavia capensis	88.59	0.00e+00	1494.00
IUUC-Pva-103040	Pteropus vampyrus	91.07	0.00e+00	635.00
IUUC-Rno-105453	Rattus norvegicus	87.07	0.00e+00	1478.00
IUUC-Sha-107651	Sarcophilus harrisii	91.42	0.00e+00	1575.00
IUUC-Smo-108858	Selaginella moellendorffii	48.46	4.00e-113	402.00
IUUC-Sar-113293	Sorex araneus	90.34	0.00e+00	1512.00
IUUC-Ssc-115979	Sus scrofa	90.21	0.00e+00	1510.00
IUUC-Tgu-116901	Taeniopygia guttata	90.86	0.00e+00	1561.00
IUUC-Tru-118368	Takifugu rubripes	87.93	0.00e+00	1520.00
IUUC-Tsy-119516	Tarsius syrichta	85.90	0.00e+00	1397.00
IUUC-Tni-120143	Tetraodon nigroviridis	87.82	0.00e+00	1516.00
IUUC-Tbe-127484	Tupaia belangeri	85.92	0.00e+00	1043.00
IUUC-Ttr-129078	Tursiops truncatus	88.59	0.00e+00	1484.00
IUUC-Vpa-130312	Vicugna pacos	81.17	0.00e+00	1266.00
IUUC-Xtr-132881	Xenopus tropicalis	88.18	0.00e+00	1543.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence