• HOME
  • BROWSE
  • SEARCH
  • LINK
  • DOWNLOAD
  • USER GUIDE
  • Protein
  • Gene
  • Annotation
  • Details
  • Classification
  • Domain Profile
  • Function
  • Protein Sequence
  • Nucleotide Sequence
  • Keyword
  • GO
  • Orthology
  • TOP

Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Mmu-063674
UUCD1 version UUC-MuM-00433
Ensembl Protein ID ENSMUSP00000143859.1
UniProt Accession O08759; E9QKT1; P97482; Q8CE29; UBE3A_MOUSE
Genbank Protein ID AAB63361.1; AAB47756.1; BAC26314.1; AAI31659.1; AAI31660.1
Protein Name Ubiquitin-protein ligase E3A; HECT-type ubiquitin transferase E3A; Oncogenic protein-associated protein E6-AP
Genbank Nucleotide ID U96636; U82122; AK029133; AC167971; BC131659
Gene Name Ube3a
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSMUSG00000025326.12 ENSMUST00000200758.3 ENSMUSP00000143859.1
ENSMUSG00000025326.12 ENSMUST00000202247.3 ENSMUSP00000144398.1
ENSMUSG00000025326.12 ENSMUST00000202288.1 ENSMUSP00000144645.1
Annotation
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressGXD
DNA & RNA Element
AREsitecircBasemicroRNATRANSFAC
RepTarRAID2
Protein-protein Interaction
IIDiRefIndexHINT
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMUniProt
mUbiSiDa
Protein Expression/Proteomics
GPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/HECT HECT 19645749; 22910419; 24728990
Classification
Family E-value Score Start End
E3 activity/HECT 2.10e-107 360.5 543 869
Active Site
Position(s) Description Evidence
838 Glycyl thioester intermediate {ECO:0000255|PROSITE-ProRule:PRU00104}
Domain Profile

   E3 activity/HECT
   S: 2    ksdlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldl 90
           ++dlkk+l+vef+gE+g+d gGv++ef++l+++e++npd+g+f+y+e  k  ++ np+s+    e +  F+++G++lg+a++++ +ld+
   Q: 543  PADLKKQLYVEFEGEQGVDEGGVSKEFFQLVVEEIFNPDIGMFTYDEATKLFWF-NPSSF----ETEGQFTLIGIVLGLAIYNNCILDV 626
           689******************************************998888776.88888....789********************** PP
   S: 91   plsksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseei.lgetkeeeLkpgGenipVtneNkeeYvklvv 178
           +++ ++y++l+gkk ++ dl + +p ly+slk ++e+ e ++e+  + +tf++s++  +g+   ++Lk++G++ip+tneN++e+v+l+ 
   Q: 627  HFPMVVYRKLMGKKGTFRDLGDSHPVLYQSLKDLLEY-EGSVEDD-MMITFQISQTDlFGNPMMYDLKENGDKIPITNENRKEFVNLYS 713
           *************************************.6677775.999**9665444******************************* PP
   S: 179  eyrlkegikeqveafreGfneviple.llslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLq 266
           +y+l++++++q++afr+Gf+ v +++ l  lF++ee+ellicG++++d+++l+++t+y+ggyt++s +i+ Fwe++++f++e+++ fLq
   Q: 714  DYILNKSVEKQFKAFRRGFHMVTNESpLKYLFRPEEIELLICGSRNLDFQALEETTEYDGGYTRESVVIREFWEIVHSFTDEQKRLFLQ 802
           ***********************99934558********************************************************** PP
   S: 267  FvTgssrlPlgGfaelkprlfvirkdasd.drlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFel 335
           F+Tg++r+P+gG+ +lk   ++i k++ d +rlP+s+TCfn+L LPeYsske+lke+Ll Ai+++kgF++
   Q: 803  FTTGTDRAPVGGLGKLK---MIIAKNGPDtERLPTSHTCFNVLLLPEYSSKEKLKERLLKAITYAKGFGM 869
           *****************...8888866666**************************************97 PP
   
Organism Mus musculus
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo (By similarity). Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).
 E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates. Several substrates have been identified including the RAD23A and RAD23B, MCM7 (which is involved in DNA replication), annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B. Additionally, may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins. Finally, UBE3A also promotes its own degradation in vivo (By similarity). Plays an important role in the regulation of the circadian clock: involved in the ubiquitination of the core clock component ARNTL/BMAL1, leading to its proteasomal degradation (PubMed:24728990).
Protein Sequence
(Fasta)
MATACKRSPG ESQSEDIEAS RMKRAAAKHL IERYYHQLTE GCGNEACTNE FCASCPTFLR 60
MDNNAAAIKA LELYKINAKL CDPHPSKKGA SSAYLENSKG ASNNSEIKMN KKEGKDFKDV 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Mmu-063674|E3,HECT|Mus musculus
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTGTCGGGAT ACTCGGTCCG CCCACCTAGT CCTCTCGTCC AGTGCTGCGT TCGCGAGATC 60
CGTATTTCTC CCAAGATGGT GGCGCTCCTC TTTGGGTGAC TCCAGGAGAC GACAGGGCCT 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Mmu-063674|E3,HECT|Mus musculus
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0025--Alternative splicing
KW-0090--Biological rhythms
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0479--Metal-binding
KW-0539--Nucleus
KW-0597--Phosphoprotein
KW-0647--Proteasome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR032353--AZUL
IPR000569--HECT_dom
IPR017134--UBE3A
PROSITE

PS50237--HECT
Pfam

PF16558--AZUL
PF00632--HECT
SMART

SM00119--HECTc
Gene Ontology

GO:0005829--C:cytosol
GO:0005634--C:nucleus
GO:0000502--C:proteasome complex
GO:0046872--F:metal ion binding
GO:0003713--F:transcription coactivator activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0004842--F:ubiquitin-protein transferase activity
GO:0030521--P:androgen receptor signaling pathway
GO:0001541--P:ovarian follicle development
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0031398--P:positive regulation of protein ubiquitination
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0060736--P:prostate gland growth
GO:0051865--P:protein autoubiquitination
GO:0070936--P:protein K48-linked ubiquitination
GO:0016567--P:protein ubiquitination
GO:0042752--P:regulation of circadian rhythm
GO:2000058--P:regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0035037--P:sperm entry
GO:0006511--P:ubiquitin-dependent protein catabolic process
KEGG mmu:22215
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002214 Ailuropoda melanoleuca 95.32 0.00e+00 1565.00
IUUC-Atr-003144 Amborella trichopoda 47.52 2.00e-95 343.00
IUUC-Apl-003742 Anas platyrhynchos 90.00 0.00e+00 1571.00
IUUC-Aca-004873 Anolis carolinensis 92.19 0.00e+00 1592.00
IUUC-Ame-011166 Astyanax mexicanus 85.31 0.00e+00 1435.00
IUUC-Bta-013286 Bos taurus 94.74 0.00e+00 1559.00
IUUC-Cja-019707 Callithrix jacchus 95.39 0.00e+00 1595.00
IUUC-Cfa-020154 Canis familiaris 94.83 0.00e+00 1573.00
IUUC-Cpo-021292 Cavia porcellus 95.54 0.00e+00 1578.00
IUUC-Cre-022790 Chlamydomonas reinhardtii 48.74 1.00e-81 296.00
IUUC-Csa-023378 Chlorocebus sabaeus 95.65 0.00e+00 1605.00
IUUC-Cho-025059 Choloepus hoffmanni 91.35 0.00e+00 1476.00
IUUC-Cin-025643 Ciona intestinalis 44.56 0.00e+00 704.00
IUUC-Csv-026282 Ciona savignyi 45.22 0.00e+00 674.00
IUUC-Cme-027151 Cyanidioschyzon merolae 44.52 1.00e-101 364.00
IUUC-Dre-027901 Danio rerio 84.60 0.00e+00 1414.00
IUUC-Dno-029320 Dasypus novemcinctus 94.98 0.00e+00 1600.00
IUUC-Dor-030756 Dipodomys ordii 92.86 0.00e+00 728.00
IUUC-Dme-032035 Drosophila melanogaster 42.64 5.00e-164 572.00
IUUC-Eca-033843 Equus caballus 94.73 0.00e+00 1523.00
IUUC-Eeu-035109 Erinaceus europaeus 94.71 0.00e+00 1526.00
IUUC-Fca-036344 Felis catus 93.27 0.00e+00 1584.00
IUUC-Fal-036747 Ficedula albicollis 90.00 0.00e+00 1571.00
IUUC-Gmo-038840 Gadus morhua 63.46 0.00e+00 1103.00
IUUC-Gga-040399 Gallus gallus 89.89 0.00e+00 1570.00
IUUC-Gac-041933 Gasterosteus aculeatus 83.31 0.00e+00 1375.00
IUUC-Ggo-044804 Gorilla gorilla 95.40 0.00e+00 1595.00
IUUC-Hsa-045727 Homo sapiens 95.40 0.00e+00 1595.00
IUUC-Itr-048289 Ictidomys tridecemlineatus 92.61 0.00e+00 1496.00
IUUC-Lch-050197 Latimeria chalumnae 89.21 0.00e+00 1519.00
IUUC-Loc-052743 Lepisosteus oculatus 87.87 0.00e+00 1506.00
IUUC-Lma-053245 Leptosphaeria maculans 33.87 6.00e-57 216.00
IUUC-Laf-053615 Loxodonta africana 93.76 0.00e+00 1568.00
IUUC-Mcc-054934 Macaca mulatta 95.72 0.00e+00 1591.00
IUUC-Meu-056061 Macropus eugenii 88.03 0.00e+00 1395.00
IUUC-Mga-059271 Meleagris gallopavo 90.09 0.00e+00 1530.00
IUUC-Mmr-061288 Microcebus murinus 95.72 0.00e+00 1593.00
IUUC-Mdo-062975 Monodelphis domestica 93.74 0.00e+00 1582.00
IUUC-Mpu-066568 Mustela putorius furo 95.32 0.00e+00 1611.00
IUUC-Mlu-067522 Myotis lucifugus 87.17 0.00e+00 1482.00
IUUC-Nle-069505 Nomascus leucogenys 95.40 0.00e+00 1595.00
IUUC-Opr-070570 Ochotona princeps 87.65 0.00e+00 1435.00
IUUC-Ont-071527 Oreochromis niloticus 83.35 0.00e+00 1440.00
IUUC-Oan-073446 Ornithorhynchus anatinus 88.85 0.00e+00 1033.00
IUUC-Ocu-074922 Oryctolagus cuniculus 93.87 0.00e+00 1613.00
IUUC-Ola-086996 Oryzias latipes 83.82 0.00e+00 1454.00
IUUC-Oga-088261 Otolemur garnettii 95.89 0.00e+00 1571.00
IUUC-Oar-090024 Ovis aries 94.74 0.00e+00 1559.00
IUUC-Ptr-090455 Pan troglodytes 95.40 0.00e+00 1595.00
IUUC-Pan-092509 Papio anubis 93.43 0.00e+00 1423.00
IUUC-Psi-092974 Pelodiscus sinensis 90.10 0.00e+00 1543.00
IUUC-Pma-094643 Petromyzon marinus 71.61 0.00e+00 1256.00
IUUC-Pno-094886 Phaeosphaeria nodorum 35.32 1.00e-57 219.00
IUUC-Pfo-096905 Poecilia formosa 83.31 0.00e+00 1434.00
IUUC-Pab-097840 Pongo abelii 93.66 0.00e+00 1529.00
IUUC-Pca-100869 Procavia capensis 94.26 0.00e+00 1554.00
IUUC-Pva-103040 Pteropus vampyrus 96.43 0.00e+00 666.00
IUUC-Rno-105453 Rattus norvegicus 97.59 0.00e+00 1618.00
IUUC-Sha-107651 Sarcophilus harrisii 93.74 0.00e+00 1583.00
IUUC-Smo-108858 Selaginella moellendorffii 49.43 6.00e-117 414.00
IUUC-Sar-113293 Sorex araneus 95.08 0.00e+00 1561.00
IUUC-Ssc-115979 Sus scrofa 95.08 0.00e+00 1559.00
IUUC-Tgu-116901 Taeniopygia guttata 90.00 0.00e+00 1571.00
IUUC-Tru-118368 Takifugu rubripes 84.95 0.00e+00 1442.00
IUUC-Tsy-119516 Tarsius syrichta 91.66 0.00e+00 1458.00
IUUC-Tni-120143 Tetraodon nigroviridis 82.77 0.00e+00 1434.00
IUUC-Tbe-127484 Tupaia belangeri 89.29 0.00e+00 1063.00
IUUC-Ttr-129078 Tursiops truncatus 94.61 0.00e+00 1531.00
IUUC-Vpa-130312 Vicugna pacos 86.96 0.00e+00 1313.00
IUUC-Xtr-132881 Xenopus tropicalis 89.55 0.00e+00 1522.00
Created Date 25-Jun-2017

https://dev.news.makassarkota.go.id/public/pgsoft-demo/ https://jdih.sumbawabaratkab.go.id/lato/pg-soft-demo/ https://dev.news.makassarkota.go.id/public/slot-gacor/ http://pbb.tanahbumbukab.go.id/-/slot-gacor/ slot gacor https://siakad.unipra.ac.id/sass/slot-gacor-x500/ http://kpm.dinus.ac.id/assets/images/berita/slot/
Copyright © 2004-2017.The CUCKOO Workgroup. All Rights Reserved