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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046273
Ensembl Protein ID ENSP00000356506.1
UniProt Accession P19878; B2R6Q1; B4DKQ7; B4DQA7; E9PHJ2; E9PHX3; Q2PP06; Q8NFC7; Q9BV51; NCF2_HUMAN
Genbank Protein ID AAA36379.1; AAB60320.1; AAB60320.1; AAB60320.1; AAB60320.1; AAB60320.1; AAB60320.1; AAB60320.1; AAB60320.1; AAB60320.1; AAB60320.1; AAB60320.1; AAB60320.1; AAB60320.1; AAM89263.1; AAP36107.1; BAG59269.1; BAG60869.1; BAG35548.1; ABC40738.1; CAC19686.1; EAW91160.1; AAH01606.1
Protein Name Neutrophil cytosol factor 2; 67 kDa neutrophil oxidase factor; NADPH oxidase activator 2; Neutrophil NADPH oxidase factor 2; p67-phox
Genbank Nucleotide ID M32011; U00788; U00776; U00777; U00778; U00779; U00780; U00781; U00782; U00783; U00784; U00785; U00786; U00787; AF527950; BT007439; AK296672; AK298713; AK312666; DQ314879; AL137800; CH471067; BC001606
Gene Name NCF2; NOXA2; P67PHOX
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000116701.14 ENST00000367536.5 ENSP00000356506.1
ENSG00000116701.14 ENST00000418089.5 ENSP00000407217.1
ENSG00000116701.14 ENST00000413720.5 ENSP00000399294.1
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarSomamiRmiRcode
RAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
ClinVarGWAS CentralOMIM
Drug and target
DrugBankPDTD
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
BioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 3.70e-25 89.3 460 513
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 4    ekvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvek 61
            +v++l++yea++ ++L++++Gd++lv+   + +e+Wl+g  e +gk G+fP+ Fve 
   Q: 460  SQVEALFSYEATQPEDLEFQEGDIILVL--SKVNEEWLEG--ECKGKVGIFPKVFVED 513
           689*************************..999*******..9*************86 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
 NCF2, NCF1, and a membrane bound cytochrome b558 are required for activation of the latent NADPH oxidase (necessary for superoxide production).
Protein Sequence
(Fasta)
MSLVEAISLW NEGVLAADKK DWKGALDAFS AVQDPHSRIC FNIGCMYTIL KNMTEAEKAF 60
TRSINRDKHL AVAYFQRGML YYQTEKYDLA IKDLKEALIQ LRGNQLIDYK ILGLQFKLFA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046273|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
CTAGTCTTTC AGCCTTCAGG CTGTTTTTGG CTTGAAGGTG GGGTTTCACC AGGGACCTGC 60
CCCTATCTGC CTAGGCATTT GGCTGCCTCC TGTCATTATC ACCAGGGAGG TGCCTCTACC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046273|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0025--Alternative splicing
KW-0161--Chronic granulomatous disease
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0225--Disease mutation
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0728--SH3 domain
KW-0802--TPR repeat
Interpro

IPR000270--PB1_dom
IPR001452--SH3_domain
IPR013026--TPR-contain_dom
IPR011990--TPR-like_helical_dom
IPR019734--TPR_repeat
PROSITE

PS51745--PB1
PS50002--SH3
PS50005--TPR
PS50293--TPR_REGION
Pfam

PF00564--PB1
PF00018--SH3_1
PF13181--TPR_8
PRINTS

PR00452--SH3DOMAIN
SMART

SM00666--PB1
SM00326--SH3
SM00028--TPR
Gene Ontology

GO:0001669--C:acrosomal vesicle
GO:0005829--C:cytosol
GO:0043020--C:NADPH oxidase complex
GO:0005730--C:nucleolus
GO:0032010--C:phagolysosome
GO:0009055--F:electron carrier activity
GO:0008022--F:protein C-terminus binding
GO:0016175--F:superoxide-generating NADPH oxidase activity
GO:0002479--P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0045454--P:cell redox homeostasis
GO:0006968--P:cellular defense response
GO:0045087--P:innate immune response
GO:0045730--P:respiratory burst
GO:0000302--P:response to reactive oxygen species
GO:0042554--P:superoxide anion generation
GO:0006801--P:superoxide metabolic process
GO:0048010--P:vascular endothelial growth factor receptor signaling pathway
KEGG hsa:4688
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001888 Ailuropoda melanoleuca 88.80 0.00e+00 862.00
IUUC-Apl-003924 Anas platyrhynchos 61.44 0.00e+00 631.00
IUUC-Aca-005068 Anolis carolinensis 60.12 7.00e-178 617.00
IUUC-Ame-011744 Astyanax mexicanus 45.03 5.00e-122 431.00
IUUC-Bta-012540 Bos taurus 89.10 0.00e+00 879.00
IUUC-Cja-018958 Callithrix jacchus 83.19 0.00e+00 863.00
IUUC-Cfa-020476 Canis familiaris 86.55 0.00e+00 808.00
IUUC-Cpo-021978 Cavia porcellus 89.28 0.00e+00 800.00
IUUC-Csa-023697 Chlorocebus sabaeus 97.91 0.00e+00 966.00
IUUC-Dre-028554 Danio rerio 45.44 8.00e-119 420.00
IUUC-Dno-029212 Dasypus novemcinctus 92.29 0.00e+00 867.00
IUUC-Dor-030205 Dipodomys ordii 79.83 0.00e+00 687.00
IUUC-Ete-032956 Echinops telfairi 82.96 8.00e-106 377.00
IUUC-Eca-033281 Equus caballus 88.97 0.00e+00 852.00
IUUC-Eeu-035239 Erinaceus europaeus 35.82 2.00e-30 126.00
IUUC-Fca-036178 Felis catus 89.35 0.00e+00 872.00
IUUC-Fal-037379 Ficedula albicollis 61.54 1.00e-176 612.00
IUUC-Gmo-039472 Gadus morhua 43.52 9.00e-114 404.00
IUUC-Gga-040921 Gallus gallus 61.38 0.00e+00 628.00
IUUC-Gac-042198 Gasterosteus aculeatus 43.98 3.00e-115 409.00
IUUC-Ggo-045435 Gorilla gorilla 88.95 0.00e+00 957.00
IUUC-Itr-048611 Ictidomys tridecemlineatus 90.30 0.00e+00 853.00
IUUC-Lch-049997 Latimeria chalumnae 49.38 5.00e-138 484.00
IUUC-Loc-052742 Lepisosteus oculatus 49.71 9.00e-142 496.00
IUUC-Laf-053863 Loxodonta africana 90.31 0.00e+00 853.00
IUUC-Mcc-054727 Macaca mulatta 97.72 0.00e+00 964.00
IUUC-Meu-056768 Macropus eugenii 63.92 0.00e+00 632.00
IUUC-Mga-059583 Meleagris gallopavo 62.64 3.00e-177 614.00
IUUC-Mvi-060542 Microbotryum violaceum 48.98 6.00e-11 60.80
IUUC-Mmr-060852 Microcebus murinus 85.88 0.00e+00 833.00
IUUC-Mdo-062806 Monodelphis domestica 78.39 0.00e+00 816.00
IUUC-Mmu-064124 Mus musculus 84.60 0.00e+00 844.00
IUUC-Mpu-066159 Mustela putorius furo 88.59 0.00e+00 826.00
IUUC-Mlu-067637 Myotis lucifugus 77.82 0.00e+00 813.00
IUUC-Nle-068999 Nomascus leucogenys 97.53 0.00e+00 957.00
IUUC-Opr-070374 Ochotona princeps 73.18 2.00e-112 399.00
IUUC-Ont-072616 Oreochromis niloticus 41.83 4.00e-112 398.00
IUUC-Oan-072977 Ornithorhynchus anatinus 62.71 5.00e-97 348.00
IUUC-Ocu-073762 Oryctolagus cuniculus 78.35 0.00e+00 753.00
IUUC-Ola-086389 Oryzias latipes 44.02 9.00e-118 417.00
IUUC-Oga-088801 Otolemur garnettii 90.11 0.00e+00 904.00
IUUC-Oar-090317 Ovis aries 88.43 0.00e+00 869.00
IUUC-Ptr-091639 Pan troglodytes 98.48 0.00e+00 971.00
IUUC-Pan-092699 Papio anubis 97.53 0.00e+00 962.00
IUUC-Psi-093682 Pelodiscus sinensis 65.15 0.00e+00 659.00
IUUC-Pfo-097064 Poecilia formosa 42.69 3.00e-113 402.00
IUUC-Pab-098199 Pongo abelii 98.29 0.00e+00 970.00
IUUC-Pca-100910 Procavia capensis 62.46 0.00e+00 651.00
IUUC-Pva-102487 Pteropus vampyrus 80.39 0.00e+00 840.00
IUUC-Rno-105888 Rattus norvegicus 31.60 1.00e-50 194.00
IUUC-Sha-106930 Sarcophilus harrisii 77.37 0.00e+00 805.00
IUUC-Ssc-115647 Sus scrofa 88.70 0.00e+00 855.00
IUUC-Tgu-116783 Taeniopygia guttata 60.97 9.00e-176 610.00
IUUC-Tru-118473 Takifugu rubripes 42.91 5.00e-113 401.00
IUUC-Tsy-119120 Tarsius syrichta 63.29 1.00e-71 263.00
IUUC-Tni-119900 Tetraodon nigroviridis 41.65 3.00e-111 395.00
IUUC-Tbe-127725 Tupaia belangeri 70.91 6.00e-153 533.00
IUUC-Ttr-128426 Tursiops truncatus 76.81 0.00e+00 778.00
IUUC-Xtr-132656 Xenopus tropicalis 53.00 1.00e-147 516.00
IUUC-Xma-134150 Xiphophorus maculatus 43.79 7.00e-115 407.00
Created Date 25-Jun-2017

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