iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Ath-006986

UUCD1 version

UUC-ArT-00136

Ensembl Protein ID

AT4G21070.1

UniProt Accession

Q8RXD4; Q9SUA7; BRCA1_ARATH

Genbank Protein ID

AAL91217.1; CAB45902.1; CAB79107.1; AEE84396.1; AAO39850.1; AAQ65170.1

Protein Name

Protein BREAST CANCER SUSCEPTIBILITY 1 homolog

Genbank Nucleotide ID

AY081328; AL080282; AL161554; CP002687; AF515728; BT010547

Gene Name

BRCA1; At4g21070; T13K14.230

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G21070	AT4G21070.1	AT4G21070.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
Protein-protein Interaction
iRefIndex	PINA	HINT
Protein Expression/Proteomics

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	15644464

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	1.50e-05	26.3	16	54

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           C+iCl+ +    ++l+C+Hvf+  C+ k        +  ++CP+C+
   Q: 16   CPICLSLYNS-AVSLSCNHVFCNACIVKS------MKMDATCPVCK 54
           ********88.999************444......899999****7 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Plays a role in DNA repair and in cell-cycle control. Required for the repair of DNA double-strand breaks (DSBs), both natural and induced by genotoxic stress, by homologous recombination (HR).

Protein Sequence
(Fasta)

MADTSHLERM GRELKCPICL SLYNSAVSLS CNHVFCNACI VKSMKMDATC PVCKIPYHRR 60
EIRGAPHMDS LVSIYKNMED ASGIKLFVSQ NNPSPSDKEK QVRDASVEKA SDKNRQGSRK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CGGGATTGGA AATATTTTGA AGTAGATGAA AATTTGGCGC TTTTTATTTA GTCTGTAAAG 60
CTTTCAAGGG AAGCCTCTTT GAAGGACACG CTTCGTCATC TATCTATCTA TATACCCAAA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0479--Metal-binding
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0677--Repeat
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR031099--BRCA1-associated
IPR001357--BRCT_dom
IPR034732--EPHD
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
IPR017907--Znf_RING_CS

PROSITE

PS50172--BRCT
PS51805--EPHD
PS00518--ZF_RING_1
PS50089--ZF_RING_2

Pfam

PF00533--BRCT
PF16589--BRCT_2

SMART

SM00292--BRCT
SM00184--RING

Gene Ontology

GO:0070531--C:BRCA1-A complex
GO:0031436--C:BRCA1-BARD1 complex
GO:0005634--C:nucleus
GO:0005886--C:plasma membrane
GO:0004842--F:ubiquitin-protein transferase activity
GO:0008270--F:zinc ion binding
GO:0071480--P:cellular response to gamma radiation
GO:0006310--P:DNA recombination
GO:0006281--P:DNA repair
GO:0000724--P:double-strand break repair via homologous recombination
GO:0045717--P:negative regulation of fatty acid biosynthetic process
GO:0035067--P:negative regulation of histone acetylation
GO:0071158--P:positive regulation of cell cycle arrest
GO:0035066--P:positive regulation of histone acetylation
GO:0045944--P:positive regulation of transcription from RNA polymerase II promoter
GO:0042127--P:regulation of cell proliferation
GO:0010332--P:response to gamma radiation

KEGG

ath:AT4G21070

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000225	Aegilops tauschii	51.97	3.00e-120	425.00
IUUC-Aml-002346	Ailuropoda melanoleuca	32.87	3.00e-23	102.00
IUUC-Atr-002625	Amborella trichopoda	45.20	2.00e-102	366.00
IUUC-Apl-004108	Anas platyrhynchos	31.52	1.00e-18	87.80
IUUC-Aca-005387	Anolis carolinensis	33.54	4.00e-20	92.80
IUUC-Acl-008246	Aspergillus clavatus	26.98	1.00e-06	47.00
IUUC-Afu-009052	Aspergillus fumigatus	26.98	8.00e-07	47.80
IUUC-Aor-010037	Aspergillus oryzae	27.40	6.00e-07	48.10
IUUC-Ate-010516	Aspergillus terreus	27.40	2.00e-07	48.50
IUUC-Ame-011720	Astyanax mexicanus	27.56	2.00e-14	74.30
IUUC-Bgr-012178	Blumeria graminis	29.85	3.00e-09	55.10
IUUC-Bta-013417	Bos taurus	32.87	5.00e-23	102.00
IUUC-Bdi-014760	Brachypodium distachyon	52.07	7.00e-119	421.00
IUUC-Bol-016476	Brassica oleracea	69.83	0.00e+00	1236.00
IUUC-Bra-017176	Brassica rapa	70.79	0.00e+00	1225.00
IUUC-Cel-018208	Caenorhabditis elegans	31.82	2.00e-07	50.40
IUUC-Cja-019415	Callithrix jacchus	33.33	7.00e-24	105.00
IUUC-Cfa-020351	Canis familiaris	32.87	1.00e-23	104.00
IUUC-Cpo-021746	Cavia porcellus	38.64	1.00e-24	107.00
IUUC-Cre-022955	Chlamydomonas reinhardtii	29.77	4.00e-12	67.00
IUUC-Csa-023450	Chlorocebus sabaeus	33.33	3.00e-24	106.00
IUUC-Cho-024530	Choloepus hoffmanni	26.32	4.00e-11	63.90
IUUC-Csv-025987	Ciona savignyi	27.13	5.00e-15	75.10
IUUC-Cme-027224	Cyanidioschyzon merolae	37.04	1.00e-09	58.20
IUUC-Dre-028792	Danio rerio	34.44	1.00e-10	60.50
IUUC-Dno-029038	Dasypus novemcinctus	34.26	8.00e-24	105.00
IUUC-Dor-030826	Dipodomys ordii	40.41	2.00e-16	80.90
IUUC-Ete-033061	Echinops telfairi	36.52	4.00e-23	102.00
IUUC-Eca-033446	Equus caballus	27.36	8.00e-16	79.70
IUUC-Eeu-035266	Erinaceus europaeus	36.49	8.00e-09	54.70
IUUC-Fca-035414	Felis catus	39.22	7.00e-23	102.00
IUUC-Fal-037357	Ficedula albicollis	29.67	6.00e-21	95.50
IUUC-Fox-037868	Fusarium oxysporum	28.57	2.00e-08	52.80
IUUC-Fso-038144	Fusarium solani	29.03	4.00e-08	51.60
IUUC-Gmo-038782	Gadus morhua	27.61	3.00e-13	70.50
IUUC-Ggr-039737	Gaeumannomyces graminis	34.48	6.00e-09	54.70
IUUC-Gga-040255	Gallus gallus	32.61	9.00e-20	91.70
IUUC-Gac-042296	Gasterosteus aculeatus	26.92	1.00e-16	81.60
IUUC-Gma-044372	Glycine max	41.95	0.00e+00	644.00
IUUC-Ggo-045300	Gorilla gorilla	37.50	1.00e-23	104.00
IUUC-Hsa-045826	Homo sapiens	33.33	1.00e-23	104.00
IUUC-Itr-048456	Ictidomys tridecemlineatus	33.33	3.00e-22	99.80
IUUC-Lch-050674	Latimeria chalumnae	32.85	4.00e-15	76.30
IUUC-Lpe-050895	Leersia perrieri	49.50	1.00e-117	417.00
IUUC-Loc-051952	Lepisosteus oculatus	27.96	1.00e-17	85.90
IUUC-Laf-054591	Loxodonta africana	37.08	5.00e-24	105.00
IUUC-Mcc-055017	Macaca mulatta	33.33	4.00e-24	105.00
IUUC-Meu-056710	Macropus eugenii	30.86	3.00e-09	55.80
IUUC-Mor-057071	Magnaporthe oryzae	28.32	4.00e-10	58.50
IUUC-Mpo-057628	Magnaporthe poae	36.21	1.00e-09	56.60
IUUC-Mtr-058400	Medicago truncatula	54.81	1.00e-130	460.00
IUUC-Mla-059052	Melampsora laricipopulina	40.48	3.00e-07	47.80
IUUC-Mga-059484	Meleagris gallopavo	34.24	2.00e-20	94.00
IUUC-Mmr-061544	Microcebus murinus	33.49	2.00e-24	107.00
IUUC-Mdo-062408	Monodelphis domestica	28.97	6.00e-18	85.50
IUUC-Mmu-064203	Mus musculus	34.66	7.00e-21	95.10
IUUC-Mac-065131	Musa acuminata	45.41	1.00e-115	410.00
IUUC-Mpu-066899	Mustela putorius furo	32.87	2.00e-23	103.00
IUUC-Mlu-067781	Myotis lucifugus	34.96	1.00e-25	110.00
IUUC-Nfi-068501	Neosartorya fischeri	26.98	7.00e-07	47.80
IUUC-Ncr-068917	Neurospora crassa	32.81	9.00e-10	57.80
IUUC-Nle-069031	Nomascus leucogenys	33.33	3.00e-24	106.00
IUUC-Opr-071057	Ochotona princeps	35.37	8.00e-11	61.20
IUUC-Ont-072380	Oreochromis niloticus	31.08	3.00e-17	84.00
IUUC-Oan-073243	Ornithorhynchus anatinus	37.93	3.00e-11	60.10
IUUC-Ocu-074785	Oryctolagus cuniculus	36.26	6.00e-24	105.00
IUUC-Oba-075676	Oryza barthii	38.69	4.00e-164	571.00
IUUC-Obr-076308	Oryza brachyantha	51.72	4.00e-114	405.00
IUUC-Ogl-077654	Oryza glaberrima	38.69	4.00e-164	571.00
IUUC-Ogu-078659	Oryza glumaepatula	38.63	3.00e-164	572.00
IUUC-Oin-079086	Oryza indica	38.63	3.00e-164	571.00
IUUC-Olo-080264	Oryza longistaminata	37.36	9.00e-161	560.00
IUUC-Ome-081445	Oryza meridionalis	50.50	1.00e-108	387.00
IUUC-Oni-082502	Oryza nivara	38.83	2.00e-164	572.00
IUUC-Opu-083700	Oryza punctata	50.00	7.00e-112	397.00
IUUC-Oru-085093	Oryza rufipogon	38.73	4.00e-165	574.00
IUUC-Osa-086087	Oryza sativa	38.73	2.00e-165	575.00
IUUC-Ola-086863	Oryzias latipes	25.84	4.00e-14	73.60
IUUC-Olu-087771	Ostreococcus lucimarinus	29.41	3.00e-07	48.90
IUUC-Oga-088383	Otolemur garnettii	34.41	5.00e-20	92.40
IUUC-Oar-089357	Ovis aries	32.41	2.00e-22	100.00
IUUC-Ptr-090959	Pan troglodytes	33.80	2.00e-24	107.00
IUUC-Pan-092160	Papio anubis	33.33	2.00e-24	106.00
IUUC-Psi-093036	Pelodiscus sinensis	35.93	3.00e-21	96.30
IUUC-Pfo-096328	Poecilia formosa	27.45	2.00e-16	81.30
IUUC-Pab-098198	Pongo abelii	33.33	1.00e-23	104.00
IUUC-Pop-099956	Populus trichocarpa	42.93	0.00e+00	649.00
IUUC-Pca-100698	Procavia capensis	28.50	8.00e-19	89.70
IUUC-Ppe-101676	Prunus persica	56.75	3.00e-123	436.00
IUUC-Pva-102243	Pteropus vampyrus	34.26	8.00e-21	95.10
IUUC-Pte-104362	Pyrenophora teres	40.43	1.00e-07	50.40
IUUC-Pyt-104823	Pyrenophora triticirepentis	40.43	1.00e-07	50.40
IUUC-Rno-104832	Rattus norvegicus	38.36	3.00e-19	90.10
IUUC-Sit-110609	Setaria italica	52.30	2.00e-120	426.00
IUUC-Sly-111863	Solanum lycopersicum	48.84	4.00e-113	402.00
IUUC-Stu-112154	Solanum tuberosum	47.47	1.00e-115	410.00
IUUC-Sbi-114470	Sorghum bicolor	49.15	2.00e-119	423.00
IUUC-Sre-115123	Sporisorium reilianum	34.48	8.00e-06	44.30
IUUC-Ssc-115611	Sus scrofa	33.33	8.00e-24	105.00
IUUC-Tgu-116812	Taeniopygia guttata	29.67	1.00e-20	94.40
IUUC-Tru-117895	Takifugu rubripes	29.08	9.00e-17	82.40
IUUC-Tsy-119446	Tarsius syrichta	34.81	2.00e-19	90.10
IUUC-Tca-121417	Theobroma cacao	56.63	3.00e-134	472.00
IUUC-Tre-121893	Trichoderma reesei	30.65	7.00e-08	51.20
IUUC-Tvi-122405	Trichoderma virens	29.21	1.00e-08	53.50
IUUC-Tae-124838	Triticum aestivum	52.71	5.00e-126	444.00
IUUC-Tur-126725	Triticum urartu	52.71	1.00e-126	446.00
IUUC-Tbe-127550	Tupaia belangeri	37.28	4.00e-22	99.40
IUUC-Ttr-128364	Tursiops truncatus	33.88	9.00e-16	78.20
IUUC-Vpa-130659	Vicugna pacos	33.33	1.00e-23	103.00
IUUC-Vvi-131586	Vitis vinifera	56.62	2.00e-114	407.00
IUUC-Xtr-131846	Xenopus tropicalis	34.94	2.00e-21	97.10
IUUC-Xma-133651	Xiphophorus maculatus	27.81	1.00e-10	62.40
IUUC-Zma-135107	Zea mays	42.11	1.00e-97	350.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence