iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ptr-090709

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AACZ03094825

Gene Name

SOCS4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPTRG00000006368.4	ENSPTRT00000011665.3	ENSPTRP00000010802.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box	4.20e-17	61.7	378	425

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/ECS/SOCS_VHL_BC-box

   S: 3    klwllrseprSLqhLCRlaIrrclgsqrlkaidkLPLPksLkdYLlyedyq 53
           +++l+r+ p+SLqh+CR +I++c++++++   d+LP+P+s+k YL++++y+
   Q: 378  STPLIRTFPFSLQHICRTVICNCTTYDGI---DALPIPSSMKLYLKEYHYK 425
           678899***********************...****************985 PP

Organism

Pan troglodytes

Protein Sequence
(Fasta)

MAENNENISK NVDVRPKTSR SRSADRKDGY VWSGKKLSWS KKSESYSDAE TVNGIEKTEV 60
SLRNQERKHS CSSIELDLDH SCGHRFLGRS LKQKLQDAVG QCFPIKNCSS RHSSGLPSKR 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AGCGCAGGTC CCGACAGAGG TCGCCGGGTG GTGGCGTCAG CTGCGGCGCC CTCCGCGTGG 60
AAATTAGCCG GTTGCCCGGG CAAGTGAGGG AGGAAGGGAG GGAGCTGAAT ACGGAAGTGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR000980--SH2
IPR028416--SOCS4
IPR022252--SOCS4/SOCS5_dom
IPR001496--SOCS_box

PROSITE

PS50001--SH2
PS50225--SOCS

Pfam

PF00017--SH2
PF12610--SOCS
PF07525--SOCS_box

SMART

SM00252--SH2
SM00253--SOCS
SM00969--SOCS_box

Gene Ontology

GO:0005737--C:cytoplasm
GO:0004860--F:protein kinase inhibitor activity
GO:0019221--P:cytokine-mediated signaling pathway
GO:0035556--P:intracellular signal transduction
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0007175--P:negative regulation of epidermal growth factor-activated receptor activity
GO:0046426--P:negative regulation of JAK-STAT cascade
GO:0006469--P:negative regulation of protein kinase activity
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0016567--P:protein ubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001789	Ailuropoda melanoleuca	93.62	0.00e+00	788.00
IUUC-Apl-003839	Anas platyrhynchos	79.27	0.00e+00	636.00
IUUC-Aca-004840	Anolis carolinensis	80.41	0.00e+00	702.00
IUUC-Bta-012503	Bos taurus	93.20	0.00e+00	784.00
IUUC-Cja-019284	Callithrix jacchus	97.95	0.00e+00	829.00
IUUC-Cfa-020890	Canis familiaris	93.64	0.00e+00	800.00
IUUC-Cpo-022081	Cavia porcellus	78.57	0.00e+00	670.00
IUUC-Csa-023076	Chlorocebus sabaeus	99.09	0.00e+00	836.00
IUUC-Cho-024700	Choloepus hoffmanni	93.65	0.00e+00	832.00
IUUC-Dno-029961	Dasypus novemcinctus	94.33	0.00e+00	830.00
IUUC-Dor-030273	Dipodomys ordii	92.97	0.00e+00	797.00
IUUC-Ete-032972	Echinops telfairi	92.31	2.00e-169	587.00
IUUC-Eca-034289	Equus caballus	94.10	0.00e+00	796.00
IUUC-Eeu-035208	Erinaceus europaeus	89.98	0.00e+00	748.00
IUUC-Fal-036829	Ficedula albicollis	79.50	0.00e+00	634.00
IUUC-Gga-040725	Gallus gallus	78.82	0.00e+00	664.00
IUUC-Ggo-044886	Gorilla gorilla	100.00	0.00e+00	847.00
IUUC-Hsa-046322	Homo sapiens	99.77	0.00e+00	845.00
IUUC-Itr-048585	Ictidomys tridecemlineatus	93.79	0.00e+00	793.00
IUUC-Lch-049459	Latimeria chalumnae	57.31	9.00e-138	483.00
IUUC-Laf-053484	Loxodonta africana	94.71	0.00e+00	788.00
IUUC-Mcc-054890	Macaca mulatta	98.86	0.00e+00	835.00
IUUC-Meu-056532	Macropus eugenii	84.30	0.00e+00	640.00
IUUC-Mtr-057670	Medicago truncatula	36.67	2.20e+00	26.60
IUUC-Mvi-060418	Microbotryum violaceum	32.10	1.30e-02	33.10
IUUC-Mmr-061714	Microcebus murinus	96.15	0.00e+00	806.00
IUUC-Mmu-063161	Mus musculus	87.02	0.00e+00	742.00
IUUC-Mac-064598	Musa acuminata	27.94	2.00e-02	32.00
IUUC-Mpu-066499	Mustela putorius furo	94.09	0.00e+00	823.00
IUUC-Mlu-066945	Myotis lucifugus	92.97	0.00e+00	783.00
IUUC-Nle-069976	Nomascus leucogenys	99.55	0.00e+00	843.00
IUUC-Opr-070255	Ochotona princeps	87.53	0.00e+00	749.00
IUUC-Ocu-074764	Oryctolagus cuniculus	92.97	0.00e+00	788.00
IUUC-Oga-088910	Otolemur garnettii	88.46	0.00e+00	771.00
IUUC-Oar-090330	Ovis aries	93.20	0.00e+00	781.00
IUUC-Pan-092540	Papio anubis	99.09	0.00e+00	836.00
IUUC-Psi-093678	Pelodiscus sinensis	81.09	0.00e+00	717.00
IUUC-Pfo-097139	Poecilia formosa	80.81	5.00e-87	315.00
IUUC-Pab-097970	Pongo abelii	98.93	0.00e+00	702.00
IUUC-Pop-098820	Populus trichocarpa	41.18	1.10e-01	31.20
IUUC-Pca-100211	Procavia capensis	82.54	0.00e+00	665.00
IUUC-Rno-106014	Rattus norvegicus	85.19	0.00e+00	734.00
IUUC-Sha-106822	Sarcophilus harrisii	84.28	0.00e+00	721.00
IUUC-Ssc-115821	Sus scrofa	93.42	0.00e+00	789.00
IUUC-Tgu-117117	Taeniopygia guttata	79.95	0.00e+00	637.00
IUUC-Tsy-118979	Tarsius syrichta	97.47	5.00e-129	452.00
IUUC-Tca-121131	Theobroma cacao	30.77	3.00e-03	36.20
IUUC-Vpa-130626	Vicugna pacos	93.20	0.00e+00	791.00
IUUC-Vvi-131327	Vitis vinifera	43.75	9.20e-02	31.20

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence