iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Pab-098394

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

ABGA01126189

Gene Name

NEDD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSPPYG00000006501.2	ENSPPYT00000007674.2	ENSPPYP00000007372.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	1.50e-135	452.1	605	934

Active Site

Position(s)	Description	Evidence
904	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 4    dlkkrlevefvgEegldlgGvtreflallskelqnpdlglflysendketlqpnpdsglknpehlklFeflGrllgkalqdgrlldlpl 92
            lk+rl++ef gE+gld+gGv+re+++l+ske++np++glf+ys++d++tlq+np+sgl+n++hl++F+f+Gr+ g+a+++g+lld ++
   Q: 605  FLKARLWIEFDGEKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPNSGLCNEDHLSYFKFIGRVAGMAVYHGKLLDGFF 693
           5899************************************************************************************* PP
   S: 93   sksfyklllgkklsledleevdpelykslkeikenaesdieelgldltfsvseeilgetkeeeLkpgGenipVtneNkeeYvklvveyr 181
            ++fyk++l+k+++l+d+e+vd+e+y+sl +i+en   d +e  ldl+f ++ee++g+t+++eLk gG++i Vtn+Nk+eY+ lv+++r
   Q: 694  IRPFYKMMLHKPITLHDMESVDSEYYNSLRWILEN---DPTE--LDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQWR 777
           *********************************99...6666..7******************************************** PP
   S: 182  lkegikeqveafreGfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTg 270
           + ++i++q++af+eGf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy++++++iqwFw+++ +++se+r ++LqFvTg
   Q: 778  FVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTG 866
           ***************************************************************************************** PP
   S: 271  ssrlPlgGfaelk....prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
           +sr+P++Gfael     p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 867  TSRVPMNGFAELYgsngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 934
           *******************************************************************8 PP

Organism

Pongo abelii

Protein Sequence
(Fasta)

TVPAAALPTP RAPPRAPPPS PRSARHRPFP AALPGAASAR SPGEALLSLE RLENSRIVRV 60
KVIAGIGLAK KDILGASDPY VRVTLYDPMN GVLTSVQTKT IKKSLNPKWN EEILFRVHPQ 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ACGGTCCCCG CCGCGCGCCC TCCCCACCCC CCGAGCCCCG CCACGCGCGC CCCCGCCCAG 60
CCCCAGGAGC GCGCGCCACC GGCCTTTTCC CGCCGCGCTG CCGGGTGCCG CTAGTGCCCG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000008--C2_dom
IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50004--C2
PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00168--C2
PF00632--HECT
PF00397--WW

SMART

SM00239--C2
SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0005829--C:cytosol
GO:0043197--C:dendritic spine
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0000151--C:ubiquitin ligase complex
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0002250--P:adaptive immune response
GO:0048514--P:blood vessel morphogenesis
GO:0044111--P:development involved in symbiotic interaction
GO:0003197--P:endocardial cushion development
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0030948--P:negative regulation of vascular endothelial growth factor receptor signaling pathway
GO:0007528--P:neuromuscular junction development
GO:0031175--P:neuron projection development
GO:0003151--P:outflow tract morphogenesis
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006513--P:protein monoubiquitination
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0048814--P:regulation of dendrite morphogenesis
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0050807--P:regulation of synapse organization
GO:0042110--P:T cell activation
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001201	Ailuropoda melanoleuca	95.27	0.00e+00	1545.00
IUUC-Apl-003886	Anas platyrhynchos	75.50	0.00e+00	1398.00
IUUC-Ame-011138	Astyanax mexicanus	83.54	0.00e+00	842.00
IUUC-Bta-012453	Bos taurus	91.84	0.00e+00	1462.00
IUUC-Cja-019034	Callithrix jacchus	95.99	0.00e+00	1425.00
IUUC-Cfa-020258	Canis familiaris	95.02	0.00e+00	1472.00
IUUC-Cpo-021648	Cavia porcellus	91.42	0.00e+00	1622.00
IUUC-Csa-023334	Chlorocebus sabaeus	97.44	0.00e+00	1674.00
IUUC-Cin-025157	Ciona intestinalis	55.94	0.00e+00	974.00
IUUC-Dre-027924	Danio rerio	68.33	0.00e+00	1035.00
IUUC-Dno-029159	Dasypus novemcinctus	89.81	0.00e+00	1316.00
IUUC-Ete-032409	Echinops telfairi	86.22	0.00e+00	1181.00
IUUC-Eca-033441	Equus caballus	94.81	0.00e+00	1588.00
IUUC-Eeu-034546	Erinaceus europaeus	74.81	0.00e+00	1177.00
IUUC-Fca-036384	Felis catus	94.29	0.00e+00	1513.00
IUUC-Fal-037547	Ficedula albicollis	80.97	0.00e+00	1438.00
IUUC-Gmo-039679	Gadus morhua	68.30	0.00e+00	1217.00
IUUC-Gga-040524	Gallus gallus	81.26	0.00e+00	1441.00
IUUC-Gac-042607	Gasterosteus aculeatus	67.06	0.00e+00	1219.00
IUUC-Hsa-046479	Homo sapiens	99.13	0.00e+00	1565.00
IUUC-Itr-048383	Ictidomys tridecemlineatus	83.40	0.00e+00	1209.00
IUUC-Lch-050445	Latimeria chalumnae	71.97	0.00e+00	1190.00
IUUC-Loc-052645	Lepisosteus oculatus	73.75	0.00e+00	1324.00
IUUC-Laf-053638	Loxodonta africana	83.94	0.00e+00	1353.00
IUUC-Mcc-055585	Macaca mulatta	98.63	0.00e+00	1526.00
IUUC-Meu-056897	Macropus eugenii	95.47	2.00e-170	593.00
IUUC-Mga-059362	Meleagris gallopavo	75.79	0.00e+00	1408.00
IUUC-Mmr-061061	Microcebus murinus	94.40	0.00e+00	1541.00
IUUC-Mmu-063318	Mus musculus	80.68	0.00e+00	1414.00
IUUC-Mpu-066567	Mustela putorius furo	94.83	0.00e+00	1679.00
IUUC-Mlu-068148	Myotis lucifugus	94.03	0.00e+00	1490.00
IUUC-Nle-069225	Nomascus leucogenys	98.88	0.00e+00	1576.00
IUUC-Ont-071664	Oreochromis niloticus	67.31	0.00e+00	1187.00
IUUC-Oan-073019	Ornithorhynchus anatinus	84.80	0.00e+00	1462.00
IUUC-Ocu-074409	Oryctolagus cuniculus	93.03	0.00e+00	1503.00
IUUC-Oga-088241	Otolemur garnettii	86.85	0.00e+00	1341.00
IUUC-Oar-089797	Ovis aries	94.82	0.00e+00	1590.00
IUUC-Ptr-091629	Pan troglodytes	97.46	0.00e+00	1402.00
IUUC-Pan-092285	Papio anubis	96.78	0.00e+00	1155.00
IUUC-Psi-093618	Pelodiscus sinensis	82.48	0.00e+00	1306.00
IUUC-Pfo-097145	Poecilia formosa	69.68	0.00e+00	1195.00
IUUC-Pca-100568	Procavia capensis	78.31	0.00e+00	1137.00
IUUC-Rno-106095	Rattus norvegicus	80.90	0.00e+00	1419.00
IUUC-Sha-107370	Sarcophilus harrisii	79.13	0.00e+00	1333.00
IUUC-Sja-107786	Schizosaccharomyces japonicus	50.81	7.00e-156	544.00
IUUC-Tgu-117474	Taeniopygia guttata	80.88	0.00e+00	1454.00
IUUC-Tru-117675	Takifugu rubripes	64.89	0.00e+00	1187.00
IUUC-Tni-119993	Tetraodon nigroviridis	64.51	0.00e+00	1165.00
IUUC-Tbe-127408	Tupaia belangeri	86.23	0.00e+00	1154.00
IUUC-Ttr-128437	Tursiops truncatus	84.84	0.00e+00	1184.00
IUUC-Vpa-130503	Vicugna pacos	88.48	0.00e+00	1295.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence