iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

iUUCD ID

IUUC-Aml-001795

Ensembl Protein ID

ENSAMEP00000019234.1

UniProt Accession

G1MIP9; G1MIP9_AILME

Genbank Protein ID

ENSAMEP00000019234

Protein Name

Histone-lysine N-methyltransferase

Genbank Nucleotide ID

ACTA01043487

Gene Name

NSD1

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSAMEG00000018192.1	ENSAMET00000020000.1	ENSAMEP00000019234.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/RING/PHD	2.10e-14	53.5	1714	1754

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/PHD

   S: 3    vClvCgeggedekslveCekCrewfHpaClklsveeelpnsekwiCpkCr 52
           +C vC egg+    l++C+ C  +fH +Cl++      p+ + w+C++C+
   Q: 1714 WCFVCSEGGS----LLCCDSCPAAFHRECLNID----IPEGN-WYCNDCK 1754
           8*********....*******************....99996.******8 PP

Organism

Ailuropoda melanoleuca

Protein Sequence
(Fasta)

MDQTCELSRR NCLLPFSNPV NLDAPEDKDS PFGNGQSNFS EPLNGCTMQL STASGTSQNA 60
YGQDSPSCYI PLRRLQDLAS MINVEYLNGS ADGSESFQDP EKSDSRAQSP IVCTSLSPGG 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGATCAGA CCTGTGAACT ATCTAGAAGA AATTGTCTGC TGCCCTTTTC CAATCCAGTG 60
AATTTAGATG CCCCTGAAGA CAAGGACAGC CCTTTCGGTA ATGGTCAATC CAATTTTTCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0479--Metal-binding
KW-0489--Methyltransferase
KW-0539--Nucleus
KW-1185--Reference proteome
KW-0949--S-adenosyl-L-methionine
KW-0808--Transferase
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR006560--AWS_dom
IPR003616--Post-SET_dom
IPR000313--PWWP_dom
IPR001214--SET_dom
IPR019786--Zinc_finger_PHD-type_CS
IPR011011--Znf_FYVE_PHD
IPR001965--Znf_PHD
IPR019787--Znf_PHD-finger
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51215--AWS
PS50868--POST_SET
PS50812--PWWP
PS50280--SET
PS01359--ZF_PHD_1
PS50016--ZF_PHD_2

Pfam

PF00855--PWWP
PF00856--SET

SMART

SM00570--AWS
SM00249--PHD
SM00508--PostSET
SM00293--PWWP
SM00317--SET

Gene Ontology

GO:0005634--C:nucleus
GO:0046975--F:histone methyltransferase activity (H3-K36 specific)
GO:0000979--F:RNA polymerase II core promoter sequence-specific DNA binding
GO:0003712--F:transcription cofactor activity
GO:0008270--F:zinc ion binding
GO:0045893--P:positive regulation of transcription, DNA-templated
GO:0000414--P:regulation of histone H3-K36 methylation
GO:0033135--P:regulation of peptidyl-serine phosphorylation
GO:1903025--P:regulation of RNA polymerase II regulatory region sequence-specific DNA binding

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Ata-000310	Aegilops tauschii	29.53	7.00e-12	65.90
IUUC-Apl-003953	Anas platyrhynchos	56.77	0.00e+00	2246.00
IUUC-Aca-005339	Anolis carolinensis	50.37	0.00e+00	1746.00
IUUC-Bta-012966	Bos taurus	93.75	0.00e+00	4993.00
IUUC-Bdi-014781	Brachypodium distachyon	30.10	6.00e-13	69.70
IUUC-Bol-016001	Brassica oleracea	29.51	2.00e-16	82.40
IUUC-Bra-017864	Brassica rapa	28.96	2.00e-15	78.60
IUUC-Cja-018780	Callithrix jacchus	90.75	0.00e+00	4498.00
IUUC-Cfa-020975	Canis familiaris	96.41	0.00e+00	5077.00
IUUC-Cpo-021331	Cavia porcellus	88.44	0.00e+00	2720.00
IUUC-Csa-024226	Chlorocebus sabaeus	90.89	0.00e+00	4224.00
IUUC-Cho-024464	Choloepus hoffmanni	76.92	0.00e+00	1420.00
IUUC-Dre-028152	Danio rerio	63.23	0.00e+00	1259.00
IUUC-Dno-029230	Dasypus novemcinctus	88.51	0.00e+00	4593.00
IUUC-Dor-031016	Dipodomys ordii	80.82	0.00e+00	1321.00
IUUC-Dme-032193	Drosophila melanogaster	36.70	2.00e-122	434.00
IUUC-Eca-033591	Equus caballus	92.94	0.00e+00	4382.00
IUUC-Fca-035791	Felis catus	96.82	0.00e+00	5233.00
IUUC-Fal-037378	Ficedula albicollis	58.07	0.00e+00	2068.00
IUUC-Gmo-038919	Gadus morhua	71.04	0.00e+00	935.00
IUUC-Gga-040881	Gallus gallus	56.33	0.00e+00	2170.00
IUUC-Gac-041378	Gasterosteus aculeatus	77.54	0.00e+00	1071.00
IUUC-Hsa-046436	Homo sapiens	91.75	0.00e+00	4802.00
IUUC-Itr-048194	Ictidomys tridecemlineatus	89.40	0.00e+00	4275.00
IUUC-Lch-049684	Latimeria chalumnae	47.74	0.00e+00	1706.00
IUUC-Lpe-051661	Leersia perrieri	28.72	5.00e-12	67.00
IUUC-Laf-054046	Loxodonta africana	90.56	0.00e+00	4201.00
IUUC-Mcc-055593	Macaca mulatta	91.45	0.00e+00	4767.00
IUUC-Mga-059756	Meleagris gallopavo	56.56	0.00e+00	2224.00
IUUC-Mmr-061182	Microcebus murinus	90.46	0.00e+00	4821.00
IUUC-Mdo-061984	Monodelphis domestica	68.70	0.00e+00	3083.00
IUUC-Mmu-063605	Mus musculus	83.25	0.00e+00	4355.00
IUUC-Mpu-066446	Mustela putorius furo	97.08	0.00e+00	5174.00
IUUC-Mlu-067261	Myotis lucifugus	92.34	0.00e+00	4858.00
IUUC-Nle-069818	Nomascus leucogenys	91.10	0.00e+00	4264.00
IUUC-Opr-070842	Ochotona princeps	84.36	0.00e+00	2376.00
IUUC-Ont-072448	Oreochromis niloticus	75.37	0.00e+00	1150.00
IUUC-Oan-073496	Ornithorhynchus anatinus	74.89	0.00e+00	1648.00
IUUC-Ocu-074918	Oryctolagus cuniculus	90.64	0.00e+00	4837.00
IUUC-Obr-076753	Oryza brachyantha	54.84	8.00e-08	53.50
IUUC-Ogu-078898	Oryza glumaepatula	28.90	1.00e-09	57.40
IUUC-Oin-079557	Oryza indica	28.90	1.00e-09	57.40
IUUC-Ola-087518	Oryzias latipes	76.38	0.00e+00	1056.00
IUUC-Oga-088743	Otolemur garnettii	88.87	0.00e+00	4101.00
IUUC-Oar-090265	Ovis aries	93.19	0.00e+00	4962.00
IUUC-Ptr-090521	Pan troglodytes	91.97	0.00e+00	4822.00
IUUC-Psi-093245	Pelodiscus sinensis	59.11	0.00e+00	2048.00
IUUC-Pfo-096066	Poecilia formosa	62.59	0.00e+00	1227.00
IUUC-Pab-098644	Pongo abelii	90.81	0.00e+00	4221.00
IUUC-Pva-103094	Pteropus vampyrus	91.09	0.00e+00	2795.00
IUUC-Rno-105803	Rattus norvegicus	82.73	0.00e+00	3840.00
IUUC-Sha-107278	Sarcophilus harrisii	69.96	0.00e+00	3520.00
IUUC-Sar-113402	Sorex araneus	77.39	0.00e+00	2657.00
IUUC-Sbi-114400	Sorghum bicolor	36.54	3.00e-13	67.00
IUUC-Ssc-116193	Sus scrofa	93.19	0.00e+00	4284.00
IUUC-Tgu-116532	Taeniopygia guttata	89.55	0.00e+00	1253.00
IUUC-Tru-117988	Takifugu rubripes	77.71	0.00e+00	1202.00
IUUC-Tsy-118830	Tarsius syrichta	90.12	0.00e+00	3834.00
IUUC-Tca-121456	Theobroma cacao	30.81	5.00e-20	93.20
IUUC-Tae-124687	Triticum aestivum	29.53	9.00e-12	65.50

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence