iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Sha-107429

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Ubiquitinyl hydrolase 1

Genbank Nucleotide ID

AEFK01007693

Gene Name

USP3

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSSHAG00000017829.1	ENSSHAT00000021196.1	ENSSHAP00000021026.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	2.10e-100	336.4	137	488
UBD/ZnF/ZnF_UBP	4.40e-25	87.9	9	82

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

DUB/USP

   S: 1    tGlkNlgNtCYmNSvLQcLsnipelrellle...........kkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalk 78
           tGl+NlgNtC+mN++LQ+Lsni+++ ++++e             +++ + +++ +++ +l+++++k + +lw+++++a+sp++l+ +++
   Q: 137  TGLRNLGNTCFMNAILQSLSNIQQFCCYFKElpavelrngktAGRRTYHTRSQGDNNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVW 225
           7******************************888888777765555555555688889******************************* PP
   S: 79   keaeefsgyeqqDaqEflaflldqleeelkkeknkpkeeeeeedkselsdeaeekkkkknkslisdlFqgqlksqikclecdnvssree 167
           k+ ++f+gy+qqDa+Ef+++lld+l+ el+   n    +   +++s+l + +++   +  +++++ +F+g l++++ cl c+++s +++
   Q: 226  KIMPNFRGYQQQDAHEFMRYLLDHLHLELQGGFNGVSRSVILQENSSL-SASNKCCINGASTVVTAIFGGILQNEVNCLICGTESRKFD 313
           *****************************7644444444444443344.445688899999**************************** PP
   S: 168  pfldlslpvpgkeetkke.........slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLilhLkRfsfseeqksre 247
           pfldlsl++p++  +k +         sl+dcL+sft  eel++ + y c kckkkq+++kk++++klP+vL+lhLkRf+++   + r+
   Q: 314  PFLDLSLDIPSQFRNKRSknqengplcSLRDCLRSFTDLEELDETELYMCHKCKKKQKSTKKFWIQKLPKVLCLHLKRFHWTA--YLRN 400
           **********66655444667899999****************************************************7755..799* PP
   S: 248  kinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsG.slssGHYvayvknekgkWllfdDskVtevkeeevleetgstaYvlf 334
           k++++vefpl+ Ld++ ++ +pe++  e++ Y+L avvvH+G +++sGHY+ay+ + +g+W++f+Ds+Vt ++ee+v++   ++aY+lf
   Q: 401  KVDTYVEFPLRgLDMKCYLLEPENSGPESCLYDLAAVVVHHGsGVGSGHYTAYATH-EGRWFHFNDSTVTLTDEETVVK---AKAYILF 485
           ********************************************************.9*********************...******* PP
   S: 335  Ykr 337
           Y +
   Q: 486  YVE 488
           *76 PP

UBD/ZnF/ZnF_UBP

   S: 5    vcdktenlWlcLtcgsvgCGRyvegHalkHyeetqhpl................vlslstlsvycYacddyvhr 62
           vc++++++W+cLtc+sv+CGRyv+gHa+kHye++q pl                ++++s++s+ycY+cdd+v++
   Q: 9    VCRSNKSPWVCLTCSSVHCGRYVNGHAKKHYEDAQIPLtnhkktekqekvqhtvCMDCSSYSTYCYRCDDFVVN 82
           7***********************************************************************85 PP

Organism

Sarcophilus harrisii

Protein Sequence
(Fasta)

FLEPPHWVVC RSNKSPWVCL TCSSVHCGRY VNGHAKKHYE DAQIPLTNHK KTEKQEKVQH 60
TVCMDCSSYS TYCYRCDDFV VNDTKLGLVQ KVREHLQNLE NSAFTADRHR KRKLLENSSL 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TTTCTAGAGC CCCCACACTG GGGTGATTAA AATACACCGT TCTAGTGGAG AAGTGATGAG 60
GTAGAACTCC TGAGGATAGT GGGAAAATGA AGTCCGTTTA TTTCAAGGAC TTTCCCCTTT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0479--Metal-binding
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom
IPR013083--Znf_RING/FYVE/PHD
IPR001607--Znf_UBP

PROSITE

PS00972--USP_1
PS00973--USP_2
PS50235--USP_3
PS50271--ZF_UBP

Pfam

PF00443--UCH
PF02148--zf-UBP

SMART

SM00290--ZnF_UBP

Gene Ontology

GO:0070938--C:contractile ring
GO:0000790--C:nuclear chromatin
GO:0005654--C:nucleoplasm
GO:0036459--F:thiol-dependent ubiquitinyl hydrolase activity
GO:0008270--F:zinc ion binding
GO:0006281--P:DNA repair
GO:0016578--P:histone deubiquitination
GO:0000278--P:mitotic cell cycle
GO:0031647--P:regulation of protein stability
GO:0006511--P:ubiquitin-dependent protein catabolic process

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001537	Ailuropoda melanoleuca	95.77	0.00e+00	885.00
IUUC-Apl-003358	Anas platyrhynchos	97.56	0.00e+00	915.00
IUUC-Aca-004454	Anolis carolinensis	93.98	0.00e+00	813.00
IUUC-Acl-008124	Aspergillus clavatus	29.80	3.00e-43	169.00
IUUC-Afl-008464	Aspergillus flavus	30.70	9.00e-35	140.00
IUUC-Afu-008912	Aspergillus fumigatus	29.40	7.00e-38	151.00
IUUC-Ani-009168	Aspergillus nidulans	30.08	2.00e-40	159.00
IUUC-Ang-009694	Aspergillus niger	29.07	3.00e-41	162.00
IUUC-Aor-010035	Aspergillus oryzae	35.55	2.00e-31	129.00
IUUC-Ate-010382	Aspergillus terreus	30.79	4.00e-36	145.00
IUUC-Ame-011544	Astyanax mexicanus	76.32	0.00e+00	687.00
IUUC-Bgr-012150	Blumeria graminis	26.30	4.00e-28	119.00
IUUC-Bta-012738	Bos taurus	95.78	0.00e+00	871.00
IUUC-Bci-013604	Botrytis cinerea	28.26	7.00e-34	138.00
IUUC-Bdi-014171	Brachypodium distachyon	30.83	3.00e-40	159.00
IUUC-Cel-018186	Caenorhabditis elegans	37.08	2.00e-55	209.00
IUUC-Cja-018893	Callithrix jacchus	95.37	0.00e+00	877.00
IUUC-Cfa-020607	Canis familiaris	95.98	0.00e+00	869.00
IUUC-Cpo-021828	Cavia porcellus	94.16	0.00e+00	850.00
IUUC-Csa-023884	Chlorocebus sabaeus	97.65	0.00e+00	773.00
IUUC-Cho-024863	Choloepus hoffmanni	85.71	0.00e+00	745.00
IUUC-Cgl-026457	Colletotrichum gloeosporioides	27.11	1.00e-35	144.00
IUUC-Dre-028452	Danio rerio	73.45	0.00e+00	701.00
IUUC-Dno-029531	Dasypus novemcinctus	96.13	0.00e+00	867.00
IUUC-Dor-030913	Dipodomys ordii	88.02	5.00e-176	610.00
IUUC-Dse-031415	Dothistroma septosporum	29.42	3.00e-38	152.00
IUUC-Ete-032611	Echinops telfairi	89.94	0.00e+00	813.00
IUUC-Eca-033622	Equus caballus	96.74	0.00e+00	870.00
IUUC-Eeu-035268	Erinaceus europaeus	92.64	0.00e+00	801.00
IUUC-Fca-035801	Felis catus	96.33	0.00e+00	901.00
IUUC-Fal-036749	Ficedula albicollis	96.73	0.00e+00	865.00
IUUC-Fox-038046	Fusarium oxysporum	28.28	4.00e-35	142.00
IUUC-Fso-038321	Fusarium solani	28.08	5.00e-33	135.00
IUUC-Gmo-039598	Gadus morhua	77.25	0.00e+00	726.00
IUUC-Ggr-040044	Gaeumannomyces graminis	29.51	1.00e-33	137.00
IUUC-Gga-040883	Gallus gallus	97.76	0.00e+00	880.00
IUUC-Gac-042235	Gasterosteus aculeatus	76.71	0.00e+00	701.00
IUUC-Ggo-044767	Gorilla gorilla	91.24	0.00e+00	833.00
IUUC-Hsa-046581	Homo sapiens	95.98	0.00e+00	906.00
IUUC-Itr-047898	Ictidomys tridecemlineatus	95.98	0.00e+00	869.00
IUUC-Lch-049732	Latimeria chalumnae	90.74	0.00e+00	862.00
IUUC-Lpe-050969	Leersia perrieri	29.09	1.00e-37	150.00
IUUC-Loc-052371	Lepisosteus oculatus	88.93	0.00e+00	846.00
IUUC-Lma-053105	Leptosphaeria maculans	30.30	2.00e-36	146.00
IUUC-Laf-054565	Loxodonta africana	95.57	0.00e+00	868.00
IUUC-Mcc-055522	Macaca mulatta	96.18	0.00e+00	907.00
IUUC-Meu-056754	Macropus eugenii	87.43	2.00e-162	565.00
IUUC-Mor-057103	Magnaporthe oryzae	29.55	2.00e-33	137.00
IUUC-Mpo-057621	Magnaporthe poae	29.63	7.00e-33	134.00
IUUC-Mtr-057769	Medicago truncatula	26.92	4.00e-40	159.00
IUUC-Mga-060095	Meleagris gallopavo	97.33	0.00e+00	651.00
IUUC-Mmr-060839	Microcebus murinus	96.18	0.00e+00	870.00
IUUC-Mdo-062339	Monodelphis domestica	100.00	0.00e+00	772.00
IUUC-Mmu-063638	Mus musculus	95.17	0.00e+00	842.00
IUUC-Mpu-066647	Mustela putorius furo	97.47	0.00e+00	758.00
IUUC-Mlu-067921	Myotis lucifugus	95.52	0.00e+00	885.00
IUUC-Nfi-068423	Neosartorya fischeri	29.81	9.00e-38	151.00
IUUC-Ncr-068809	Neurospora crassa	29.06	3.00e-32	133.00
IUUC-Nle-069752	Nomascus leucogenys	96.38	0.00e+00	909.00
IUUC-Opr-070636	Ochotona princeps	85.28	0.00e+00	721.00
IUUC-Ont-071638	Oreochromis niloticus	76.63	0.00e+00	699.00
IUUC-Oan-073417	Ornithorhynchus anatinus	91.15	0.00e+00	844.00
IUUC-Ocu-074620	Oryctolagus cuniculus	94.77	0.00e+00	860.00
IUUC-Oba-075688	Oryza barthii	30.41	6.00e-40	158.00
IUUC-Obr-076652	Oryza brachyantha	30.15	5.00e-40	158.00
IUUC-Ogl-077910	Oryza glaberrima	30.41	5.00e-40	159.00
IUUC-Ogu-078479	Oryza glumaepatula	30.41	4.00e-40	159.00
IUUC-Oin-079697	Oryza indica	30.41	6.00e-40	158.00
IUUC-Ome-081706	Oryza meridionalis	30.41	3.00e-39	156.00
IUUC-Oni-083070	Oryza nivara	30.41	4.00e-40	159.00
IUUC-Oru-084522	Oryza rufipogon	30.41	5.00e-40	159.00
IUUC-Osa-085351	Oryza sativa	30.41	5.00e-40	158.00
IUUC-Ola-087281	Oryzias latipes	79.03	0.00e+00	628.00
IUUC-Olu-087697	Ostreococcus lucimarinus	40.33	8.00e-49	187.00
IUUC-Oga-088448	Otolemur garnettii	95.17	0.00e+00	896.00
IUUC-Oar-090132	Ovis aries	95.98	0.00e+00	868.00
IUUC-Ptr-090696	Pan troglodytes	96.36	0.00e+00	910.00
IUUC-Pan-092124	Papio anubis	95.77	0.00e+00	902.00
IUUC-Psi-093801	Pelodiscus sinensis	97.70	0.00e+00	758.00
IUUC-Pma-094472	Petromyzon marinus	73.68	3.00e-95	340.00
IUUC-Pno-095141	Phaeosphaeria nodorum	31.12	7.00e-31	128.00
IUUC-Ppa-095413	Physcomitrella patens	29.05	4.00e-39	156.00
IUUC-Pfo-096330	Poecilia formosa	79.23	0.00e+00	733.00
IUUC-Pab-098191	Pongo abelii	96.18	0.00e+00	908.00
IUUC-Pop-099893	Populus trichocarpa	28.66	3.00e-39	156.00
IUUC-Pca-100341	Procavia capensis	94.50	0.00e+00	659.00
IUUC-Pva-103177	Pteropus vampyrus	95.37	0.00e+00	856.00
IUUC-Pte-104340	Pyrenophora teres	28.64	2.00e-31	130.00
IUUC-Pyt-104782	Pyrenophora triticirepentis	30.00	1.00e-35	144.00
IUUC-Rno-105048	Rattus norvegicus	93.39	0.00e+00	823.00
IUUC-Sja-107656	Schizosaccharomyces japonicus	27.77	4.00e-37	148.00
IUUC-Spo-108226	Schizosaccharomyces pombe	28.28	5.00e-41	161.00
IUUC-Ssl-108531	Sclerotinia sclerotiorum	27.99	2.00e-32	133.00
IUUC-Sar-113024	Sorex araneus	94.88	0.00e+00	810.00
IUUC-Ssc-115749	Sus scrofa	95.73	8.00e-151	525.00
IUUC-Tgu-117277	Taeniopygia guttata	96.73	0.00e+00	902.00
IUUC-Tru-117844	Takifugu rubripes	77.71	0.00e+00	728.00
IUUC-Tsy-119456	Tarsius syrichta	93.87	0.00e+00	858.00
IUUC-Tni-120251	Tetraodon nigroviridis	74.55	0.00e+00	746.00
IUUC-Tca-121154	Theobroma cacao	28.88	5.00e-44	172.00
IUUC-Tre-122139	Trichoderma reesei	28.11	6.00e-33	134.00
IUUC-Tvi-122599	Trichoderma virens	28.72	2.00e-33	137.00
IUUC-Tae-125608	Triticum aestivum	31.62	3.00e-43	169.00
IUUC-Tme-127115	Tuber melanosporum	31.05	1.00e-46	180.00
IUUC-Tbe-127423	Tupaia belangeri	89.74	0.00e+00	786.00
IUUC-Ttr-128401	Tursiops truncatus	90.39	0.00e+00	788.00
IUUC-Vda-129829	Verticillium dahliae	30.58	4.00e-28	117.00
IUUC-Vpa-130549	Vicugna pacos	86.83	5.00e-163	566.00
IUUC-Xtr-131892	Xenopus tropicalis	83.60	0.00e+00	756.00
IUUC-Xma-133369	Xiphophorus maculatus	79.43	0.00e+00	726.00
IUUC-Yli-134357	Yarrowia lipolytica	31.09	2.00e-37	150.00
IUUC-Zma-134945	Zea mays	31.70	2.00e-37	150.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence