iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Fca-035363

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

AANG02192230

Gene Name

OTUB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSFCAG00000010228.2	ENSFCAT00000010231.2	ENSFCAP00000009494.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	3.30e-47	160.4	41	230

Active Site

Position(s)	Description	Evidence
48	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
51	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
224		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
            i+ktkgDGnC++rA+++s                                                          ll+vf+d+ +sd
   Q: 41   EIRKTKGDGNCFYRALGYSylesllgksrdilrfkervlqtpndllaagfeehkfrnffnafysvvelvekdgsvssLLKVFNDQGTSD 129
           699************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
            +v++Lr+lts+++++++dff++fi+e++d+ +fc+++vep+a  +++i+i+aL+q+L+++++v++vd++++    +l++++fpe++ +
   Q: 130  RIVQFLRLLTSAFIKNRADFFRHFIDEEMDIEDFCTHEVEPMAMeCDHIQITALSQALNIALQVEYVDEMDT----ALNHHVFPEAA-T 213
           **********************************************************************95....***********.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlY+++HY++L+a
   Q: 214  PSVYLLYKTSHYNILYA 230
           ***************97 PP

Organism

Felis catus

Protein Sequence
(Fasta)

QSETSFDLIS EKCDILSILR DHPENRIYQR KIQELSKRFT EIRKTKGDGN CFYRALGYSY 60
LESLLGKSRD ILRFKERVLQ TPNDLLAAGF EEHKFRNFFN AFYSVVELVE KDGSVSSLLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CAGAGTGAAA CATCTTTCGA CCTAATATCA GAAAAATGTG ACATTCTGTC AATTCTTCGG 60
GATCATCCTG AAAACAGGAT TTACCAGAGG AAAATCCAGG TGAGGCAGAG GTTCAGGAGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	95.28	1.00e-132	464.00
IUUC-Bta-012766	Bos taurus	95.26	5.00e-131	459.00
IUUC-Cja-019480	Callithrix jacchus	93.94	8.00e-129	452.00
IUUC-Cfa-021106	Canis familiaris	96.14	2.00e-133	467.00
IUUC-Cpo-022187	Cavia porcellus	93.99	1.00e-130	457.00
IUUC-Csa-023493	Chlorocebus sabaeus	93.99	5.00e-130	456.00
IUUC-Cho-024411	Choloepus hoffmanni	76.59	2.00e-85	307.00
IUUC-Dno-029346	Dasypus novemcinctus	96.55	6.00e-133	466.00
IUUC-Dor-031012	Dipodomys ordii	95.69	2.00e-132	464.00
IUUC-Ete-032266	Echinops telfairi	87.50	1.00e-119	421.00
IUUC-Eca-033356	Equus caballus	95.71	4.00e-132	463.00
IUUC-Eeu-034775	Erinaceus europaeus	94.40	8.00e-131	459.00
IUUC-Ggo-045023	Gorilla gorilla	93.53	8.00e-129	452.00
IUUC-Hsa-046984	Homo sapiens	93.97	2.00e-129	454.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	94.83	3.00e-131	460.00
IUUC-Lch-050514	Latimeria chalumnae	60.27	1.00e-81	296.00
IUUC-Loc-052003	Lepisosteus oculatus	50.90	2.00e-64	238.00
IUUC-Laf-054382	Loxodonta africana	96.14	5.00e-133	466.00
IUUC-Mcc-055516	Macaca mulatta	93.56	2.00e-129	454.00
IUUC-Meu-056038	Macropus eugenii	87.83	1.00e-98	352.00
IUUC-Mmr-060918	Microcebus murinus	96.98	2.00e-133	467.00
IUUC-Mdo-062638	Monodelphis domestica	89.66	8.00e-124	435.00
IUUC-Mmu-063973	Mus musculus	94.85	7.00e-132	462.00
IUUC-Mpu-066013	Mustela putorius furo	95.69	2.00e-132	464.00
IUUC-Mlu-067509	Myotis lucifugus	92.70	9.00e-128	448.00
IUUC-Nle-069673	Nomascus leucogenys	93.97	2.00e-129	454.00
IUUC-Opr-070761	Ochotona princeps	87.27	2.00e-80	290.00
IUUC-Oan-072922	Ornithorhynchus anatinus	82.10	2.00e-112	397.00
IUUC-Ocu-074643	Oryctolagus cuniculus	96.12	1.00e-132	464.00
IUUC-Oni-082026	Oryza nivara	28.76	3.00e-16	80.10
IUUC-Oru-084761	Oryza rufipogon	28.76	3.00e-16	80.10
IUUC-Ola-086603	Oryzias latipes	45.83	3.00e-52	197.00
IUUC-Oga-088936	Otolemur garnettii	95.28	3.00e-132	463.00
IUUC-Oar-089460	Ovis aries	95.71	1.00e-131	462.00
IUUC-Ptr-090805	Pan troglodytes	93.53	6.00e-129	452.00
IUUC-Pan-091969	Papio anubis	93.97	2.00e-129	454.00
IUUC-Pab-098476	Pongo abelii	93.56	2.00e-129	454.00
IUUC-Pca-100252	Procavia capensis	91.00	2.00e-52	198.00
IUUC-Pva-102204	Pteropus vampyrus	93.53	2.00e-130	457.00
IUUC-Pgr-103552	Puccinia graminis	75.00	2.60e-02	31.20
IUUC-Rno-105062	Rattus norvegicus	94.83	2.00e-131	461.00
IUUC-Sha-106968	Sarcophilus harrisii	89.57	6.00e-123	432.00
IUUC-Sar-113295	Sorex araneus	95.69	1.00e-130	457.00
IUUC-Ssc-115288	Sus scrofa	95.26	3.00e-131	460.00
IUUC-Tni-120440	Tetraodon nigroviridis	39.39	4.00e-43	167.00
IUUC-Tbe-127717	Tupaia belangeri	93.24	3.00e-77	280.00
IUUC-Ttr-128221	Tursiops truncatus	76.29	4.00e-99	353.00
IUUC-Uma-129443	Ustilago maydis	33.65	3.00e-24	105.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence