iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress
DNA & RNA Element
microRNA	TRANSFAC	miRNAMap	RAID2
Post-translational Modifications (PTMs)
CPLM
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB	1.40e-16	61.0	77	147
E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box	2.40e-10	39.5	181	211

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 adaptor/Cullin RING/BCR/BTB_3-box: BTB

   S: 1    aDvilvv.....ggeeffahkivLaasSsvFyalflmeleesksklmveikdvqpevfrallkFlYtgklde 67
           +Dv+l+v        +f ahk+vLa+sS+vF+a+f+++l+e+   + v i+++ p+v++ l++F Yt +++ 
   Q: 77   CDVTLQVkyediPAAQFMAHKVVLASSSPVFKAMFTNGLREQG-MEVVSIEGIHPKVMERLIEFAYTASISV 147
           89*****655444999*************************98.***********************98875 PP

E3 adaptor/Cullin RING/BCR/BTB_3-box: 3-box

   S: 1    leNclgilrfAdlydcpdLkdaaldfilkhF 31
           ++N++gi  fA++ +c++L+++a+++i  hF
   Q: 181  PSNAIGIANFAEQIGCTELHQRAREYIYMHF 211
           89****************************9 PP

Organism

Rattus norvegicus

Protein Sequence
(Fasta)

MQPEPKPSGA PRSSQFLPLW SKCPEGAGDA VMYASTECKA EVTPSQDGNR TFSYTLEDHT 60
KQAFGIMNEL RLSQQLCDVT LQVKYEDIPA AQFMAHKVVL ASSSPVFKAM FTNGLREQGM 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

AACCCGGAGG CAGGCTCCTA GGGCCGCCCT GACCCACGCC CTGCTCCCTC CGCCCGGCAC 60
CTGCAGGAAG GGCTGGAACC GCCTCTGCGT GCCCGCCGCC TGTTTCCGCC CTCCCGCTCC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0880--Kelch repeat
KW-1267--Proteomics identification
KW-1185--Reference proteome
KW-0677--Repeat

Interpro

IPR011705--BACK
IPR017096--BTB-kelch_protein
IPR000210--BTB/POZ_dom
IPR015916--Gal_Oxidase_b-propeller
IPR030563--KEAP1
IPR015915--Kelch-typ_b-propeller
IPR006652--Kelch_1
IPR011333--SKP1/BTB/POZ

PROSITE

PS50097--BTB

Pfam

PF07707--BACK
PF00651--BTB
PF01344--Kelch_1

SMART

SM00875--BACK
SM00225--BTB
SM00612--Kelch

Gene Ontology

GO:0005884--C:actin filament
GO:0031463--C:Cul3-RING ubiquitin ligase complex
GO:0005829--C:cytosol
GO:0005783--C:endoplasmic reticulum
GO:0005815--C:microtubule organizing center
GO:0030496--C:midbody
GO:0005654--C:nucleoplasm
GO:0071353--P:cellular response to interleukin-4
GO:0001701--P:in utero embryonic development
GO:0010499--P:proteasomal ubiquitin-independent protein catabolic process
GO:0016567--P:protein ubiquitination
GO:0045604--P:regulation of epidermal cell differentiation
GO:0006355--P:regulation of transcription, DNA-templated

KEGG

rno:117519

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001377	Ailuropoda melanoleuca	93.43	0.00e+00	1226.00
IUUC-Aca-005389	Anolis carolinensis	83.64	0.00e+00	1052.00
IUUC-Ame-010749	Astyanax mexicanus	77.38	0.00e+00	955.00
IUUC-Bta-013505	Bos taurus	94.07	0.00e+00	1233.00
IUUC-Cja-018823	Callithrix jacchus	93.43	0.00e+00	1225.00
IUUC-Cfa-021202	Canis familiaris	93.75	0.00e+00	1227.00
IUUC-Cpo-021830	Cavia porcellus	93.87	0.00e+00	815.00
IUUC-Csa-023728	Chlorocebus sabaeus	93.43	0.00e+00	1223.00
IUUC-Cin-025195	Ciona intestinalis	54.14	0.00e+00	664.00
IUUC-Csv-026155	Ciona savignyi	53.06	8.00e-180	623.00
IUUC-Dre-027388	Danio rerio	75.89	0.00e+00	932.00
IUUC-Dno-029066	Dasypus novemcinctus	82.24	0.00e+00	1042.00
IUUC-Dor-030674	Dipodomys ordii	92.16	0.00e+00	806.00
IUUC-Dme-032165	Drosophila melanogaster	49.02	6.00e-156	544.00
IUUC-Ete-032255	Echinops telfairi	91.76	1.00e-96	346.00
IUUC-Eca-034381	Equus caballus	92.61	0.00e+00	1184.00
IUUC-Eeu-034791	Erinaceus europaeus	89.58	0.00e+00	790.00
IUUC-Fca-036067	Felis catus	94.23	0.00e+00	1233.00
IUUC-Gmo-039691	Gadus morhua	76.02	0.00e+00	933.00
IUUC-Gga-040266	Gallus gallus	78.86	0.00e+00	976.00
IUUC-Gac-041866	Gasterosteus aculeatus	75.59	0.00e+00	933.00
IUUC-Ggo-044719	Gorilla gorilla	93.59	0.00e+00	1226.00
IUUC-Hsa-046255	Homo sapiens	93.59	0.00e+00	1226.00
IUUC-Itr-048457	Ictidomys tridecemlineatus	93.27	0.00e+00	1221.00
IUUC-Lch-049646	Latimeria chalumnae	80.34	0.00e+00	1008.00
IUUC-Loc-052296	Lepisosteus oculatus	56.62	0.00e+00	631.00
IUUC-Laf-054579	Loxodonta africana	93.11	0.00e+00	1221.00
IUUC-Mcc-055315	Macaca mulatta	93.43	0.00e+00	1223.00
IUUC-Meu-056288	Macropus eugenii	84.78	0.00e+00	1081.00
IUUC-Mmr-061639	Microcebus murinus	93.43	0.00e+00	1230.00
IUUC-Mdo-062072	Monodelphis domestica	90.06	0.00e+00	1172.00
IUUC-Mmu-063622	Mus musculus	97.60	0.00e+00	1277.00
IUUC-Mpu-066737	Mustela putorius furo	90.71	0.00e+00	1181.00
IUUC-Mlu-068173	Myotis lucifugus	92.79	0.00e+00	1215.00
IUUC-Nle-069336	Nomascus leucogenys	61.61	0.00e+00	692.00
IUUC-Opr-070432	Ochotona princeps	93.32	0.00e+00	1181.00
IUUC-Ont-072160	Oreochromis niloticus	75.97	0.00e+00	935.00
IUUC-Oan-072691	Ornithorhynchus anatinus	78.82	0.00e+00	957.00
IUUC-Ocu-073798	Oryctolagus cuniculus	92.79	0.00e+00	1221.00
IUUC-Ola-086367	Oryzias latipes	74.03	0.00e+00	912.00
IUUC-Oga-088231	Otolemur garnettii	93.59	0.00e+00	1228.00
IUUC-Oar-089227	Ovis aries	92.79	0.00e+00	1207.00
IUUC-Ptr-091460	Pan troglodytes	93.59	0.00e+00	1226.00
IUUC-Pan-092713	Papio anubis	93.43	0.00e+00	1223.00
IUUC-Pfo-096468	Poecilia formosa	77.42	0.00e+00	940.00
IUUC-Pab-098357	Pongo abelii	93.75	0.00e+00	1230.00
IUUC-Pca-100837	Procavia capensis	92.31	0.00e+00	1207.00
IUUC-Pva-103249	Pteropus vampyrus	90.54	0.00e+00	1155.00
IUUC-Sha-107245	Sarcophilus harrisii	89.90	0.00e+00	1171.00
IUUC-Sar-112985	Sorex araneus	91.67	0.00e+00	1207.00
IUUC-Ssc-115756	Sus scrofa	94.07	0.00e+00	1232.00
IUUC-Tgu-116838	Taeniopygia guttata	53.95	9.00e-115	406.00
IUUC-Tru-117644	Takifugu rubripes	76.81	0.00e+00	956.00
IUUC-Tni-120245	Tetraodon nigroviridis	76.66	0.00e+00	943.00
IUUC-Tbe-127472	Tupaia belangeri	96.33	4.00e-146	511.00
IUUC-Ttr-128953	Tursiops truncatus	90.78	0.00e+00	667.00
IUUC-Vpa-130683	Vicugna pacos	90.51	0.00e+00	1058.00
IUUC-Xtr-132827	Xenopus tropicalis	74.57	0.00e+00	930.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence