iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Details
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

iUUCD ID

IUUC-Hsa-046364

UUCD1 version

UUC-HoS-00260

Ensembl Protein ID

ENSP00000261593.3

UniProt Accession

Q8WVD3; B2RE17; Q9H8K2; Q9UF87; Q9UKI6; RN138_HUMAN

Genbank Protein ID

AAD46623.2; BAB14614.1; BAG38114.1; AAP35524.1; CAG33431.1; EAX01280.1; AAH18107.1; CAB63712.1

Protein Name

E3 ubiquitin-protein ligase RNF138; Nemo-like kinase-associated RING finger protein; RING finger protein 138; RING-type E3 ubiquitin transferase RNF138

Genbank Nucleotide ID

AF162680; AK023579; AK315761; BT006878; CR457150; CH471088; BC018107; AL133557

Gene Name

RNF138; NARF; HSD-4; HSD4

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSG00000134758.13	ENST00000261593.7	ENSP00000261593.3
ENSG00000134758.13	ENST00000257190.9	ENSP00000257190.5
ENSG00000134758.13	ENST00000580499.1	ENSP00000463153.1
ENSG00000134758.13	ENST00000577999.1	ENSP00000463659.1

Annotation

Cancer Mutation
TCGA	ICGC	COSMIC	CGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO	ArrayExpress	TCGA	ICGC
COSMIC	HPM
DNA & RNA Element
UTRdb	AREsite	circBase	circRNADb
CircNet	miRTarBase	microRNA	TRANSFAC
TargetScan	miRecords	RepTar	miRNAMap
SomamiR	miRcode	RAID2
Protein-protein Interaction
IID	iRefIndex	PINA	HINT
Mentha	InWeb_IM
Disease-associated Information
GWASdb	OMIM
Post-translational Modifications (PTMs)
CPLM	dbPAF	PhosphositePlus	dbPTM
HPRD	Phospho.ELM	UniProt	mUbiSiDa
DNA Methylation
TCGA	ICGC	COSMIC
Protein Expression/Proteomics
THPA	HPM	GPMDB

Status

Reviewed

Details

Family	Domain	References (PMIDs)
E3 activity/RING/RING	RING	16714285

Classification

Family	E-value	Score	Start	End
E3 activity/RING/RING	2.20e-07	32.9	18	58

Active Site

Position(s)	Description	Evidence
N/A	N/A	N/A

Domain Profile

E3 activity/RING/RING

   S: 1    CaiCledfkdgplvlpCgHvfhadCl.qkwpglknssskefrCPlCr 46
           C++C+e +k++++++ C+Hvf+++C+  ++          ++CPlCr
   Q: 18   CPVCQEVLKTPVRTTACQHVFCRKCFlTAM------RESGAHCPLCR 58
           *************************95666......999999****8 PP

Organism

Homo sapiens

Functional Description
(View)

E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057). Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057). Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055). According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057). Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285). Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285). May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).

Protein Sequence
(Fasta)

MAEDLSAATS YTEDDFYCPV CQEVLKTPVR TTACQHVFCR KCFLTAMRES GAHCPLCRGN 60
VTRRERACPE RALDLENIMR KFSGSCRCCA KQIKFYRMRH HYKSCKKYQD EYGVSSIIPN 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

GTCACAACCC GCGGAAGGCG CCGTGCGCCG GTTGCTATAC AGGCCGCACT TCACACCCCG 60
TGCCTCCCCG CCTCTCCTGG CTCCTCCGCC CAGATCCCCG GCGCTCCCGC GTTCGGTGAC 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0007--Acetylation
KW-0025--Alternative splicing
KW-0158--Chromosome
KW-0181--Complete proteome
KW-0227--DNA damage
KW-0234--DNA repair
KW-0238--DNA-binding
KW-0479--Metal-binding
KW-0597--Phosphoprotein
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0677--Repeat
KW-0808--Transferase
KW-0832--Ubl conjugation
KW-0833--Ubl conjugation pathway
KW-0879--Wnt signaling pathway
KW-0862--Zinc
KW-0863--Zinc-finger

Interpro

IPR008598--Di19_Zn_binding_dom
IPR034734--ZF_C2HC_RNF
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD

PROSITE

PS51803--ZF_C2HC_RNF
PS50089--ZF_RING_2

Pfam

PF05605--zf-Di19

SMART

SM00184--RING

Gene Ontology

GO:0005634--C:nucleus
GO:0035861--C:site of double-strand break
GO:0019901--F:protein kinase binding
GO:0003697--F:single-stranded DNA binding
GO:0031624--F:ubiquitin conjugating enzyme binding
GO:0061630--F:ubiquitin protein ligase activity
GO:0008270--F:zinc ion binding
GO:0010792--P:DNA double-strand break processing involved in repair via single-strand annealing
GO:0000724--P:double-strand break repair via homologous recombination
GO:0032436--P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0000209--P:protein polyubiquitination
GO:0016567--P:protein ubiquitination
GO:0016055--P:Wnt signaling pathway

KEGG

hsa:51444

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-001267	Ailuropoda melanoleuca	98.37	8.00e-145	505.00
IUUC-Apl-003941	Anas platyrhynchos	67.61	2.00e-90	325.00
IUUC-Aca-005233	Anolis carolinensis	68.33	5.00e-101	360.00
IUUC-Bgr-011969	Blumeria graminis	48.98	2.00e-08	53.50
IUUC-Bta-012999	Bos taurus	97.14	6.00e-144	503.00
IUUC-Cja-019489	Callithrix jacchus	98.37	2.00e-145	508.00
IUUC-Cfa-020567	Canis familiaris	98.99	3.00e-116	410.00
IUUC-Cpo-022165	Cavia porcellus	97.14	2.00e-143	501.00
IUUC-Csa-024096	Chlorocebus sabaeus	99.59	8.00e-147	512.00
IUUC-Cho-024686	Choloepus hoffmanni	88.94	2.00e-105	374.00
IUUC-Cgl-026426	Colletotrichum gloeosporioides	39.71	4.00e-09	56.20
IUUC-Dno-029625	Dasypus novemcinctus	97.55	2.00e-143	501.00
IUUC-Dor-030983	Dipodomys ordii	83.67	1.00e-115	409.00
IUUC-Ete-032453	Echinops telfairi	72.24	1.00e-98	352.00
IUUC-Eca-034367	Equus caballus	98.56	1.00e-122	431.00
IUUC-Eeu-034722	Erinaceus europaeus	77.88	8.00e-89	319.00
IUUC-Fca-036590	Felis catus	98.78	1.00e-145	508.00
IUUC-Fal-037287	Ficedula albicollis	71.60	3.00e-106	377.00
IUUC-Fox-037926	Fusarium oxysporum	40.58	1.00e-09	57.00
IUUC-Gga-041055	Gallus gallus	70.71	2.00e-102	365.00
IUUC-Ggo-045324	Gorilla gorilla	100.00	3.00e-147	513.00
IUUC-Itr-048181	Ictidomys tridecemlineatus	97.55	1.00e-142	498.00
IUUC-Loc-052428	Lepisosteus oculatus	37.72	4.00e-45	174.00
IUUC-Laf-054506	Loxodonta africana	98.37	3.00e-145	507.00
IUUC-Mcc-054595	Macaca mulatta	100.00	3.00e-124	437.00
IUUC-Mpo-057316	Magnaporthe poae	44.64	3.00e-08	53.50
IUUC-Mga-060068	Meleagris gallopavo	70.95	7.00e-102	363.00
IUUC-Mmr-061516	Microcebus murinus	95.97	9.00e-141	492.00
IUUC-Mdo-062243	Monodelphis domestica	86.99	8.00e-129	452.00
IUUC-Mmu-063719	Mus musculus	93.88	4.00e-140	490.00
IUUC-Mpu-065869	Mustela putorius furo	98.78	1.00e-145	508.00
IUUC-Mlu-068157	Myotis lucifugus	97.60	2.00e-121	427.00
IUUC-Nle-069538	Nomascus leucogenys	84.08	4.00e-115	406.00
IUUC-Opr-070640	Ochotona princeps	95.10	3.00e-141	494.00
IUUC-Oan-072919	Ornithorhynchus anatinus	88.44	7.00e-97	346.00
IUUC-Ocu-074897	Oryctolagus cuniculus	98.37	4.00e-145	506.00
IUUC-Oga-088165	Otolemur garnettii	97.14	5.00e-144	503.00
IUUC-Oar-090364	Ovis aries	97.49	2.00e-116	410.00
IUUC-Ptr-090784	Pan troglodytes	100.00	3.00e-147	513.00
IUUC-Pan-091874	Papio anubis	99.59	8.00e-147	512.00
IUUC-Psi-093531	Pelodiscus sinensis	76.80	2.00e-105	374.00
IUUC-Pab-098013	Pongo abelii	100.00	3.00e-147	513.00
IUUC-Pca-100822	Procavia capensis	91.03	2.00e-119	421.00
IUUC-Pva-102936	Pteropus vampyrus	97.55	7.00e-145	506.00
IUUC-Rno-106110	Rattus norvegicus	57.26	3.00e-72	264.00
IUUC-Sha-107403	Sarcophilus harrisii	93.97	8.00e-113	399.00
IUUC-Sja-107830	Schizosaccharomyces japonicus	46.67	5.00e-07	49.30
IUUC-Sar-113678	Sorex araneus	96.39	4.00e-45	174.00
IUUC-Ssc-116192	Sus scrofa	98.78	1.00e-145	508.00
IUUC-Tgu-116820	Taeniopygia guttata	70.64	1.00e-97	348.00
IUUC-Tsy-119211	Tarsius syrichta	81.25	2.00e-94	338.00
IUUC-Tre-121992	Trichoderma reesei	40.00	1.00e-07	51.60
IUUC-Tbe-127480	Tupaia belangeri	60.00	3.00e-75	274.00
IUUC-Ttr-128859	Tursiops truncatus	97.55	7.00e-145	506.00
IUUC-Vda-129783	Verticillium dahliae	36.67	1.00e-09	57.80
IUUC-Vpa-130682	Vicugna pacos	93.06	4.00e-132	463.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence