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Tag Content
iUUCD ID IUUC-Dre-027978
Ensembl Protein ID ENSDARP00000009659.6
UniProt Accession A1A5H8; Q6EWH1; Q8AXW6; YES_DANRE
Genbank Protein ID CAF06180.1; CAN88236.1; AAI28658.1; AAN73265.1
Protein Name Tyrosine-protein kinase yes; p61-Yes
Genbank Nucleotide ID AJ620749; BX927088; BC128657; AY157872
Gene Name yes1; yes
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSDARG00000005941.7 ENSDART00000027090.6 ENSDARP00000009659.6
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 9.90e-15 55.2 99 154
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 6    vqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFvekle 63
           + +lydyea ++d+L++ kGd  ++i  ++++++W+++ +  +g++G +P+n+v+ ++
   Q: 99   FVALYDYEARTSDDLSFSKGDRFQII--NNTEGDWWEARSINTGQKGYIPSNYVAPAD 154
           679***********************..8999**********************9875 PP
   
Organism Danio rerio
Functional Description
(View)

Functional Description


     Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis (By similarity). Required for convergent extension cell movements during gastrulation, acting with fyna via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling. During embryonic development, phosphorylates ptk2.1/fak.
 Non-receptor protein tyrosine kinase that is involved in the regulation of cell growth and survival, apoptosis, cell-cell adhesion, cytoskeleton remodeling, differentiation, G2/M progression and cytokinesis (By similarity). Required for convergent extension cell movements during gastrulation, acting with fyna via rhoa. May be required for epiboly to occur, possibly through its effects in calcium signaling. During embryonic development, phosphorylates ptk2.1/fak.
Protein Sequence
(Fasta)
MGCVKSKEDK GPTQKYRPDP TNPTPGSHMG LYGPDPTQMG QSPALKGPTN NYNSRSSGLT 60
PFGGSSSVIT PFGGASSSFS TVAVNNPFPG VVTGGVTFFV ALYDYEARTS DDLSFSKGDR 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Dre-027978|UBD,SH3|Danio rerio
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GACACAACAA AGGAAGGAGC CCTAACATAT GACAGGGGGA CCTCCTATAT ATGCATAAGC 60
AACTGGGTGT GATCATGTGA CTGGATGCCA GACTGTGACA GGCACGGGCC CCAGGTGTGA 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Dre-027978|UBD,SH3|Danio rerio
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0067--ATP-binding
KW-1003--Cell membrane
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0206--Cytoskeleton
KW-0217--Developmental protein
KW-0418--Kinase
KW-0449--Lipoprotein
KW-0472--Membrane
KW-0519--Myristate
KW-0547--Nucleotide-binding
KW-0564--Palmitate
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0727--SH2 domain
KW-0728--SH3 domain
KW-0808--Transferase
KW-0829--Tyrosine-protein kinase
Interpro

IPR011009--Kinase-like_dom
IPR000719--Prot_kinase_dom
IPR017441--Protein_kinase_ATP_BS
IPR001245--Ser-Thr/Tyr_kinase_cat_dom
IPR000980--SH2
IPR001452--SH3_domain
IPR008266--Tyr_kinase_AS
IPR020635--Tyr_kinase_cat_dom
PROSITE

PS00107--PROTEIN_KINASE_ATP
PS50011--PROTEIN_KINASE_DOM
PS00109--PROTEIN_KINASE_TYR
PS50001--SH2
PS50002--SH3
Pfam

PF07714--Pkinase_Tyr
PF00017--SH2
PF00018--SH3_1
PRINTS

PR00401--SH2DOMAIN
PR00452--SH3DOMAIN
PR00109--TYRKINASE
SMART

SM00252--SH2
SM00326--SH3
SM00219--TyrKc
Gene Ontology

GO:0005829--C:cytosol
GO:0031234--C:extrinsic component of cytoplasmic side of plasma membrane
GO:0005815--C:microtubule organizing center
GO:0005524--F:ATP binding
GO:0004715--F:non-membrane spanning protein tyrosine kinase activity
GO:0004713--F:protein tyrosine kinase activity
GO:0005102--F:receptor binding
GO:0034334--P:adherens junction maintenance
GO:0030154--P:cell differentiation
GO:0016477--P:cell migration
GO:0060027--P:convergent extension involved in gastrulation
GO:0045087--P:innate immune response
GO:0038083--P:peptidyl-tyrosine autophosphorylation
GO:0046777--P:protein autophosphorylation
GO:0042127--P:regulation of cell proliferation
GO:0045859--P:regulation of protein kinase activity
GO:0007169--P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG dre:407620
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-002374 Ailuropoda melanoleuca 86.29 0.00e+00 946.00
IUUC-Apl-004032 Anas platyrhynchos 88.28 0.00e+00 983.00
IUUC-Aca-004255 Anolis carolinensis 87.43 0.00e+00 989.00
IUUC-Ame-010954 Astyanax mexicanus 95.61 0.00e+00 1090.00
IUUC-Bta-013503 Bos taurus 85.71 0.00e+00 933.00
IUUC-Bdi-014324 Brachypodium distachyon 35.58 3.00e-23 103.00
IUUC-Cja-019694 Callithrix jacchus 85.43 0.00e+00 930.00
IUUC-Cfa-020402 Canis familiaris 86.26 0.00e+00 949.00
IUUC-Cpo-022506 Cavia porcellus 85.90 0.00e+00 942.00
IUUC-Csa-023713 Chlorocebus sabaeus 85.90 0.00e+00 936.00
IUUC-Dno-029897 Dasypus novemcinctus 84.17 0.00e+00 833.00
IUUC-Dor-030202 Dipodomys ordii 92.92 0.00e+00 889.00
IUUC-Eca-034157 Equus caballus 85.71 0.00e+00 942.00
IUUC-Eeu-034950 Erinaceus europaeus 72.56 7.00e-156 543.00
IUUC-Fca-036233 Felis catus 86.26 0.00e+00 978.00
IUUC-Fal-037461 Ficedula albicollis 87.36 0.00e+00 988.00
IUUC-Gmo-038929 Gadus morhua 91.44 0.00e+00 974.00
IUUC-Gga-041107 Gallus gallus 88.10 0.00e+00 981.00
IUUC-Gac-042321 Gasterosteus aculeatus 91.07 0.00e+00 1021.00
IUUC-Gma-043938 Glycine max 33.84 2.00e-22 101.00
IUUC-Hsa-047010 Homo sapiens 85.90 0.00e+00 946.00
IUUC-Lch-050239 Latimeria chalumnae 88.10 0.00e+00 1001.00
IUUC-Lpe-051166 Leersia perrieri 35.35 5.00e-23 103.00
IUUC-Loc-052314 Lepisosteus oculatus 91.97 0.00e+00 992.00
IUUC-Laf-053517 Loxodonta africana 83.88 0.00e+00 923.00
IUUC-Mcc-055626 Macaca mulatta 85.90 0.00e+00 936.00
IUUC-Meu-056155 Macropus eugenii 76.50 0.00e+00 725.00
IUUC-Mga-059310 Meleagris gallopavo 88.10 0.00e+00 981.00
IUUC-Mmr-061652 Microcebus murinus 84.25 0.00e+00 937.00
IUUC-Mdo-062963 Monodelphis domestica 84.98 0.00e+00 949.00
IUUC-Mmu-064128 Mus musculus 85.45 0.00e+00 953.00
IUUC-Mpu-065906 Mustela putorius furo 86.45 0.00e+00 948.00
IUUC-Mlu-067035 Myotis lucifugus 85.43 0.00e+00 936.00
IUUC-Nle-069041 Nomascus leucogenys 81.87 0.00e+00 887.00
IUUC-Opr-070299 Ochotona princeps 77.47 0.00e+00 822.00
IUUC-Ont-072337 Oreochromis niloticus 90.86 0.00e+00 1035.00
IUUC-Oan-072997 Ornithorhynchus anatinus 92.47 0.00e+00 904.00
IUUC-Ocu-074171 Oryctolagus cuniculus 84.62 0.00e+00 947.00
IUUC-Ola-086619 Oryzias latipes 86.96 0.00e+00 993.00
IUUC-Oga-087957 Otolemur garnettii 84.25 0.00e+00 935.00
IUUC-Oar-089670 Ovis aries 84.43 0.00e+00 946.00
IUUC-Ptr-091352 Pan troglodytes 85.90 0.00e+00 946.00
IUUC-Pan-092202 Papio anubis 85.90 0.00e+00 936.00
IUUC-Psi-093310 Pelodiscus sinensis 87.91 0.00e+00 998.00
IUUC-Pma-094232 Petromyzon marinus 85.84 0.00e+00 862.00
IUUC-Pfo-097076 Poecilia formosa 87.96 0.00e+00 1013.00
IUUC-Pab-098301 Pongo abelii 91.80 0.00e+00 907.00
IUUC-Ppe-102072 Prunus persica 38.00 1.00e-25 112.00
IUUC-Pva-102592 Pteropus vampyrus 80.59 0.00e+00 894.00
IUUC-Rno-105544 Rattus norvegicus 84.46 0.00e+00 938.00
IUUC-Sar-113364 Sorex araneus 79.45 0.00e+00 883.00
IUUC-Tgu-117380 Taeniopygia guttata 87.36 0.00e+00 988.00
IUUC-Tru-117784 Takifugu rubripes 89.40 0.00e+00 1011.00
IUUC-Tni-120433 Tetraodon nigroviridis 86.64 0.00e+00 980.00
IUUC-Ttr-128893 Tursiops truncatus 85.53 0.00e+00 941.00
IUUC-Vpa-130060 Vicugna pacos 84.43 0.00e+00 939.00
IUUC-Xtr-132322 Xenopus tropicalis 88.64 0.00e+00 994.00
Created Date 25-Jun-2017

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