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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-045802
UUCD1 version UUC-HoS-00263
Ensembl Protein ID ENSP00000222033.4
UniProt Accession Q8WWF5; A8K886; O75866; ZNRF4_HUMAN
Genbank Protein ID BAF84940.1; AAC62428.1; EAW69169.1; AAH17592.2
Protein Name E3 ubiquitin-protein ligase ZNRF4; Nixin; RING finger protein 204; RING-type E3 ubiquitin transferase ZNRF4; Zinc/RING finger protein 4
Genbank Nucleotide ID AK292251; AC005764; CH471139; BC017592
Gene Name ZNRF4; RNF204
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000105428.5 ENST00000222033.5 ENSP00000222033.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICHPM
DNA & RNA Element
microRNATRANSFACTargetScanRepTar
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Disease-associated Information
OMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlus
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Reviewed
Details
Family Domain References (PMIDs)
E3 activity/RING/RING RING 21205830
Classification
Family E-value Score Start End
E3 activity/RING/RING 2.60e-08 35.9 309 352
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   E3 activity/RING/RING
   S: 1    CaiCledfkdg..plvlpCgHvfhadClqkwpglknssskefrCPlCr 46
           CaiCl+++++g  +++lpC H++h +C+  w     s+ ++ +CP+C+
   Q: 309  CAICLDEYEEGdqLKILPCSHTYHCKCIDPW----FSQAPRRSCPVCK 352
           ********55555******************....9***********7 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830). Could have a role in spermatogenesis (By similarity).
 E3 ubiquitin-protein ligase which specifically induces ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum (PubMed:21205830). Could have a role in spermatogenesis (By similarity).
Protein Sequence
(Fasta)
MPLCRPEHLM PRASRVPVAA SLPLSHAVIP TQLPSRPGHR PPGRPRRCPK ASCLPPPVGP 60
SSTQTAKRVT MGWPRPGRAL VAVKALLVLS LLQVPAQAVV RAVLEDNSSS VDFADLPALF 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-045802|E3,RING|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
ATCTGCCAGA AAGGCCACCT GCGCCAGCAC CTCCTGAGAC CGGCCTTCAA AGACACGACG 60
CATGCCGCTC TGCCGTCCGG AGCACTTAAT GCCTAGAGCC AGCAGGGTCC CAGTGGCCGC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-045802|E3,RING|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0181--Complete proteome
KW-0256--Endoplasmic reticulum
KW-0325--Glycoprotein
KW-0472--Membrane
KW-0479--Metal-binding
KW-0621--Polymorphism
KW-1185--Reference proteome
KW-0732--Signal
KW-0808--Transferase
KW-0812--Transmembrane
KW-1133--Transmembrane helix
KW-0862--Zinc
KW-0863--Zinc-finger
Interpro

IPR003137--PA_domain
IPR001841--Znf_RING
IPR013083--Znf_RING/FYVE/PHD
PROSITE

PS50089--ZF_RING_2
Pfam

PF02225--PA
PF13639--zf-RING_2
SMART

SM00184--RING
Gene Ontology

GO:0005789--C:endoplasmic reticulum membrane
GO:0016021--C:integral component of membrane
GO:0016740--F:transferase activity
GO:0008270--F:zinc ion binding
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
KEGG hsa:148066
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001654 Ailuropoda melanoleuca 71.67 2.00e-137 482.00
IUUC-Bta-012572 Bos taurus 67.63 3.00e-119 421.00
IUUC-Cja-019445 Callithrix jacchus 79.76 1.00e-154 539.00
IUUC-Cfa-020828 Canis familiaris 73.04 1.00e-125 443.00
IUUC-Csa-023281 Chlorocebus sabaeus 91.14 4.00e-179 620.00
IUUC-Dor-030690 Dipodomys ordii 54.23 8.00e-61 226.00
IUUC-Ete-032610 Echinops telfairi 65.79 3.00e-124 438.00
IUUC-Ggo-045531 Gorilla gorilla 95.09 0.00e+00 699.00
IUUC-Itr-048891 Ictidomys tridecemlineatus 75.50 3.00e-113 401.00
IUUC-Laf-053469 Loxodonta africana 68.94 5.00e-123 434.00
IUUC-Mcc-054662 Macaca mulatta 91.38 1.00e-179 622.00
IUUC-Meu-056499 Macropus eugenii 58.54 6.00e-97 347.00
IUUC-Mdo-062468 Monodelphis domestica 53.99 1.00e-101 362.00
IUUC-Mmu-064409 Mus musculus 50.15 8.00e-64 237.00
IUUC-Mpu-066553 Mustela putorius furo 72.58 2.00e-132 465.00
IUUC-Oan-073710 Ornithorhynchus anatinus 51.74 1.00e-68 253.00
IUUC-Ptr-090842 Pan troglodytes 94.61 0.00e+00 665.00
IUUC-Pan-092278 Papio anubis 91.61 0.00e+00 629.00
IUUC-Ppa-095724 Physcomitrella patens 32.71 9.00e-25 107.00
IUUC-Pab-097537 Pongo abelii 92.74 2.00e-179 621.00
IUUC-Rno-104830 Rattus norvegicus 50.47 8.00e-58 217.00
Created Date 25-Jun-2017

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