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Basic Information Integrated Annotations
Tag Content
iUUCD ID IUUC-Hsa-046258
Ensembl Protein ID ENSP00000369981.4
UniProt Accession Q99962; B2R618; Q9NQK5; SH3G2_HUMAN
Genbank Protein ID CAA67971.1; AAC04764.1; CAG46883.1; CAG46899.1; AAV38488.1; BAG35315.1; CAB92765.2; CAB92765.2; CAH70742.1; CAH70742.1; EAW58661.1
Protein Name Endophilin-A1; EEN-B1; Endophilin-1; SH3 domain protein 2A; SH3 domain-containing GRB2-like protein 2
Genbank Nucleotide ID X99657; AF036268; CR542086; CR542102; BT019682; AK312400; AL139115; AL133214; AL133214; AL139115; CH471071
Gene Name SH3GL2; CNSA2; SH3D2A
Ensembl Information
Ensembl Gene ID Ensembl Transcript ID Ensembl Protein ID
ENSG00000107295.9 ENST00000380607.4 ENSP00000369981.4
Annotation
Cancer Mutation
TCGAICGCCOSMICCGAP
IntOGen
Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEOArrayExpressTCGAICGC
COSMICTHPAHPM
DNA & RNA Element
UTRdbAREsitecircBaseCircNet
miRTarBasemicroRNATRANSFACmiRWalk
TargetScanRepTarmiRNAMapSomamiR
miRcodeRAID2
Protein-protein Interaction
IIDiRefIndexPINAHINT
MenthaInWeb_IM
Protein 3D Structure
PDBMMDB
Disease-associated Variation
GWASdbOMIM
Post-translational Modifications (PTMs)
dbPAFPhosphositePlusdbPTMHPRD
Phospho.ELMPHOSIDABioGRID
DNA Methylation
TCGAICGCCOSMIC
Protein Expression/Proteomics
THPAHPMGPMDB
Status Unreviewed
Classification
Family E-Value Score Start End
UBD/SH3 1.40e-14 55.4 294 345
Active Site
Position(s) Description Evidence
N/A N/A N/A
Domain Profile

   UBD/SH3
   S: 5    kvqvlydyeaqnddeLtlkkGdvvlviekeeqdegWlkgvkelegkrGlfPenFve 60
            +++lyd+e++n++eL +k+Gd++++   ++ de+W +g   l+g +G+fP n+ve
   Q: 294  CCRALYDFEPENEGELGFKEGDIITLT--NQIDENWYEG--MLHGHSGFFPINYVE 345
           699***********************7..99********..8*************8 PP
   
Organism Homo sapiens
Functional Description
(View)

Functional Description


     Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
 Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes.
Protein Sequence
(Fasta)
MSVAGLKKQF HKATQKVSEK VGGAEGTKLD DDFKEMERKV DVTSRAVMEI MTKTIEYLQP 60
NPASRAKLSM INTMSKIRGQ EKGPGYPQAE ALLAEAMLKF GRELGDDCNF GPALGEVGEA 120
It may take some time, please wait.

Protein Fasta Sequence


>IUUC-Hsa-046258|UBD,SH3|Homo sapiens
Please wait for a moment...
Nucleotide Sequence
(Fasta)
GCAAGAGCCC GTGTCCCGCT AGGCTCCGCG CCCTCGCGCC CATAGCCCCG GCGGCGGCAC 60
GACCAGAGGC GGCCAGGGGA GCGCGCCGCC CCGCTCGGCC CTCCAGTCCC CCTCCGCCTC 120
It may take some time, please wait.

Nucleotide Fasta Sequence


>IUUC-Hsa-046258|UBD,SH3|Homo sapiens
Please wait for a moment...
Sequence Source Ensembl
Keyword

KW-0002--3D-structure
KW-0175--Coiled coil
KW-0181--Complete proteome
KW-0963--Cytoplasm
KW-0254--Endocytosis
KW-0967--Endosome
KW-0446--Lipid-binding
KW-0472--Membrane
KW-0597--Phosphoprotein
KW-1185--Reference proteome
KW-0728--SH3 domain
Interpro

IPR027267--AH/BAR-dom
IPR004148--BAR_dom
IPR011511--SH3_2
IPR001452--SH3_domain
IPR013315--Spectrin_alpha_SH3
PROSITE

PS51021--BAR
PS50002--SH3
Pfam

PF03114--BAR
PF07653--SH3_2
PRINTS

PR00452--SH3DOMAIN
PR01887--SPECTRNALPHA
SMART

SM00721--BAR
SM00326--SH3
Gene Ontology

GO:0030669--C:clathrin-coated endocytic vesicle membrane
GO:0005829--C:cytosol
GO:0005769--C:early endosome
GO:0070062--C:extracellular exosome
GO:0000139--C:Golgi membrane
GO:0005886--C:plasma membrane
GO:0045202--C:synapse
GO:0042802--F:identical protein binding
GO:0008289--F:lipid binding
GO:0019886--P:antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:1990416--P:cellular response to brain-derived neurotrophic factor stimulus
GO:0007417--P:central nervous system development
GO:0097484--P:dendrite extension
GO:0061024--P:membrane organization
GO:0007018--P:microtubule-based movement
GO:0042059--P:negative regulation of epidermal growth factor receptor signaling pathway
GO:0031175--P:neuron projection development
GO:0002090--P:regulation of receptor internalization
GO:0007165--P:signal transduction
GO:0016191--P:synaptic vesicle uncoating
KEGG hsa:6456
Orthology
iUUCD ID Species Identity E-value Score
IUUC-Aml-001915 Ailuropoda melanoleuca 98.22 0.00e+00 684.00
IUUC-Apl-003760 Anas platyrhynchos 83.51 0.00e+00 638.00
IUUC-Aca-004816 Anolis carolinensis 89.46 0.00e+00 654.00
IUUC-Ame-011714 Astyanax mexicanus 77.56 4.00e-166 577.00
IUUC-Bta-012465 Bos taurus 98.30 0.00e+00 715.00
IUUC-Cja-019054 Callithrix jacchus 100.00 0.00e+00 727.00
IUUC-Cfa-020276 Canis familiaris 98.11 0.00e+00 645.00
IUUC-Cpo-021492 Cavia porcellus 97.93 0.00e+00 686.00
IUUC-Csa-023432 Chlorocebus sabaeus 99.37 0.00e+00 656.00
IUUC-Cho-024348 Choloepus hoffmanni 96.31 0.00e+00 704.00
IUUC-Dre-028301 Danio rerio 75.00 3.00e-155 540.00
IUUC-Dno-029915 Dasypus novemcinctus 97.68 1.00e-177 615.00
IUUC-Dor-030855 Dipodomys ordii 89.02 4.00e-177 613.00
IUUC-Ete-032686 Echinops telfairi 89.32 2.00e-177 614.00
IUUC-Eca-033814 Equus caballus 98.52 0.00e+00 689.00
IUUC-Eeu-034924 Erinaceus europaeus 97.16 0.00e+00 705.00
IUUC-Fca-035895 Felis catus 98.22 0.00e+00 685.00
IUUC-Fal-037607 Ficedula albicollis 92.05 0.00e+00 677.00
IUUC-Gga-041254 Gallus gallus 90.37 0.00e+00 667.00
IUUC-Gac-041419 Gasterosteus aculeatus 76.63 3.00e-151 527.00
IUUC-Ggo-045606 Gorilla gorilla 100.00 0.00e+00 727.00
IUUC-Lch-049520 Latimeria chalumnae 76.66 2.00e-137 481.00
IUUC-Loc-052760 Lepisosteus oculatus 80.12 2.00e-156 544.00
IUUC-Mcc-055545 Macaca mulatta 99.41 0.00e+00 697.00
IUUC-Meu-056119 Macropus eugenii 95.74 0.00e+00 700.00
IUUC-Mmr-061111 Microcebus murinus 96.54 0.00e+00 686.00
IUUC-Mdo-062217 Monodelphis domestica 95.74 0.00e+00 699.00
IUUC-Mmu-063284 Mus musculus 98.86 0.00e+00 718.00
IUUC-Mpu-066706 Mustela putorius furo 97.45 0.00e+00 638.00
IUUC-Mlu-067212 Myotis lucifugus 89.43 0.00e+00 673.00
IUUC-Ont-072622 Oreochromis niloticus 79.60 6.00e-169 586.00
IUUC-Oan-073674 Ornithorhynchus anatinus 94.67 0.00e+00 663.00
IUUC-Ocu-074005 Oryctolagus cuniculus 98.30 0.00e+00 716.00
IUUC-Ola-086840 Oryzias latipes 74.65 2.00e-151 528.00
IUUC-Oga-089025 Otolemur garnettii 95.14 0.00e+00 685.00
IUUC-Oar-089614 Ovis aries 98.22 0.00e+00 686.00
IUUC-Ptr-090943 Pan troglodytes 100.00 0.00e+00 727.00
IUUC-Pan-091990 Papio anubis 99.41 0.00e+00 697.00
IUUC-Psi-093052 Pelodiscus sinensis 90.91 0.00e+00 672.00
IUUC-Pva-102745 Pteropus vampyrus 97.44 0.00e+00 713.00
IUUC-Rno-105095 Rattus norvegicus 98.58 0.00e+00 718.00
IUUC-Sha-106694 Sarcophilus harrisii 93.45 0.00e+00 679.00
IUUC-Sar-113540 Sorex araneus 92.58 0.00e+00 643.00
IUUC-Ssc-116180 Sus scrofa 89.19 2.00e-173 601.00
IUUC-Tgu-117366 Taeniopygia guttata 91.76 0.00e+00 676.00
IUUC-Tru-118509 Takifugu rubripes 78.19 2.00e-166 578.00
IUUC-Vpa-130032 Vicugna pacos 84.03 2.00e-152 531.00
IUUC-Xtr-131877 Xenopus tropicalis 79.02 2.00e-161 561.00
Created Date 25-Jun-2017

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