iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Basic Information

Integrated Annotations

Tag

Content

UUCD2 ID

IUUC-Ath-007288

UUCD1 version

UUC-ArT-01704

Ensembl Protein ID

AT4G10570.1

UniProt Accession

Q9ZSB5; Q9T0B6; UBP10_ARATH

Genbank Protein ID

AAD03433.1; CAB40023.1; CAB78180.1; AEE82900.1; AT4G10570.1

Protein Name

Ubiquitin carboxyl-terminal hydrolase 10; Deubiquitinating enzyme 10; Ubiquitin thioesterase 10; Ubiquitin-specific-processing protease 10

Genbank Nucleotide ID

AF118222; AL049523; AL161517; CP002687; BT004132

Gene Name

UBP10; At4g10570; F3H7.5; T4F9.30

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
AT4G10570	AT4G10570.1	AT4G10570.1

Annotation

Single Nucleotide Polymorphisms (SNP)
dbSNP
mRNA Expression
GEO
DNA & RNA Element
TRANSFAC
Protein Expression/Proteomics
GPMDB

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/USP	3.30e-110	369.3	305	894

Active Site

Position(s)	Description	Evidence
313	Nucleophile	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}
853	Proton acceptor	ECO:0000255\|PROSITE-ProRule:PRU10092, ECO:0000255\|PROSITE-ProRule:PRU10093}

Domain Profile

DUB/USP

   S: 2    GlkNlgNtCYmNSvLQcLsnipelrelllekkkeklneenpkepkgellkslqklfeelwkskkkavsprellkalkkeaeefsgyeqqDaqEflafl 99
           Gl+NlgNtC+mNS+LQcL+++p++ e++l+ ++ ++n++np ++ gel+ ++ +l+++lw+s ++av+pr+++++l+++a++fsgy+q+D+qE+lafl
   Q: 305  GLSNLGNTCFMNSALQCLAHTPPIVEYFLQDYSDDINRDNPLGMCGELAIAFGDLLKKLWSSGRNAVAPRAFKTKLARFAPQFSGYNQHDSQELLAFL 402
           9************************************************************************************************* PP
   S: 100  ldqleeelkkeknkpkeeeeeedkselsde...aeekkkkknkslisdlFqgqlksqikclecdnvssreepfldlslpvpgkeetkke......... 185
           ld+l+e+l+k k+kp+ e++++d++  ++     ++ +k +n+s+i+d+ qgq+ks+++c+ c+++s +++pf++ls+p+p+  +++++         
   Q: 403  LDGLHEDLNKVKRKPYIELKDSDSRPDDEVaeeLWNYHKARNDSVIVDVCQGQYKSTLVCPVCGKISITFDPFMYLSVPLPSTLTRSMTitvfycdgs 500
           *********************996655544666899*********************************************99999888********* PP
   S: 186  .................................................................................................. 185
                                                                                                             
   Q: 501  rlpmpytvivpkqgsirdlitalgtacclaedeslllaevydhkifryfeipldslsaikddehivayrlnqipkgsrkakleilhggqeravldsvr 598
           ************************************************************************************************** PP
   S: 186  .................................................................................................. 185
                                                                                                             
   Q: 599  gsdvklfgtpfvtyvnteplsgtdidavisgflsplhkvhapskihngsdnghladatvdqasgilsspdteidnasdrelsfrifltderglnikpl 696
           ************************************************************************************************** PP
   S: 186  ....................................................slqdcLesftkeeelegenkyycekckkkqeaekklklkklPevLi 231
                                                               sl +cLe+f +ee l  +++++c++ck++++a+kkl+l+klP++L+
   Q: 697  qsessispgtvtrvlvewnegeherydssylsdlpevhktsfsakktrqesiSLFSCLEAFLAEEPLGPDDMWFCPSCKEHRQANKKLDLWKLPDILV 794
           ************************************************************************************************** PP
   S: 232  lhLkRfsfseeqksrekinkkvefple.LdlspfctspeekqkekkkYeLiavvvHsGslssGHYvayvknekgk.WllfdDskVtevkeeevleetg 327
           +hLkRf++s+  + ++ki++ v+fp + Ldls+++ +++ +   ++ YeL+av +H+G+l++GHY+ay+k  +++ W++fdDs+V++v+e+e+ +   
   Q: 795  FHLKRFTYSR--YLKNKIDTFVNFPVHdLDLSKYVKNKNGQ---SYLYELYAVSNHYGGLGGGHYTAYAKLIDDNkWYHFDDSHVSSVNESEIRN--- 884
           ******9987..6999**********99*******996654...8*************************955555*******************... PP
   S: 328  staYvlfYkr 337
           s aYvlfY+r
   Q: 885  SAAYVLFYRR 894
           ********98 PP

Organism

Arabidopsis thaliana

Functional Description
(View)

Recognizes and hydrolyzes the peptide bond at the C-terminal Gly of ubiquitin. Involved in the processing of poly-ubiquitin precursors as well as that of ubiquitinated proteins (By similarity).

Protein Sequence
(Fasta)

MTIPNSDFML ENGVCDLPFT PEEEKRIVSE LTSESEDNLK QGNLYFVISK RWYTSWQEYV 60
ENSANECSTG ESSEAPRPGP IDNHDIIESD SDINDPQLRR LLVEGEDYVL VPKQVWKRLV 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CATGGTTGCC TGGTTGGTAG CAAAAAAACA CAGATATAAT TACGTTAAGG CTATCATTAA 60
ACAAAGAGGG TCTCGCAATT AAAACTACAC TAATTCATTG TTTACAAGAA AAGAAATTGT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-0378--Hydrolase
KW-0645--Protease
KW-1185--Reference proteome
KW-0788--Thiol protease
KW-0833--Ubl conjugation pathway

Interpro

IPR006615--Pept_C19_DUSP
IPR001394--Peptidase_C19_UCH
IPR018200--USP_CS
IPR028889--USP_dom

PROSITE

PS51283--DUSP
PS00972--USP_1
PS00973--USP_2
PS50235--USP_3

Pfam

PF06337--DUSP
PF00443--UCH

SMART

SM00695--DUSP

Gene Ontology

GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0016579--P:protein deubiquitination
GO:0006511--P:ubiquitin-dependent protein catabolic process

KEGG

ath:AT4G10570

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Bdi-014013	Brachypodium distachyon	53.48	0.00e+00	950.00
IUUC-Bol-015244	Brassica oleracea	85.76	0.00e+00	1575.00
IUUC-Bra-016885	Brassica rapa	85.23	0.00e+00	1581.00
IUUC-Cel-018203	Caenorhabditis elegans	35.95	8.00e-91	328.00
IUUC-Cho-024595	Choloepus hoffmanni	38.37	1.00e-109	390.00
IUUC-Dor-030384	Dipodomys ordii	40.87	1.00e-120	427.00
IUUC-Eeu-034488	Erinaceus europaeus	34.22	5.00e-93	335.00
IUUC-Gma-043077	Glycine max	62.51	0.00e+00	1146.00
IUUC-Hsa-045669	Homo sapiens	36.13	6.00e-145	507.00
IUUC-Lpe-051424	Leersia perrieri	52.98	0.00e+00	937.00
IUUC-Mcc-055556	Macaca mulatta	42.23	1.00e-129	456.00
IUUC-Mtr-058138	Medicago truncatula	62.38	0.00e+00	1130.00
IUUC-Mmr-061400	Microcebus murinus	35.56	3.00e-140	492.00
IUUC-Nle-070010	Nomascus leucogenys	36.18	1.00e-144	506.00
IUUC-Oba-075427	Oryza barthii	48.77	0.00e+00	807.00
IUUC-Obr-076902	Oryza brachyantha	53.33	0.00e+00	936.00
IUUC-Ogu-078422	Oryza glumaepatula	48.77	0.00e+00	813.00
IUUC-Olo-080315	Oryza longistaminata	53.27	0.00e+00	881.00
IUUC-Ome-081271	Oryza meridionalis	52.83	0.00e+00	929.00
IUUC-Oni-082834	Oryza nivara	48.77	0.00e+00	813.00
IUUC-Opu-083691	Oryza punctata	51.09	0.00e+00	911.00
IUUC-Oru-084820	Oryza rufipogon	48.77	0.00e+00	813.00
IUUC-Osa-086139	Oryza sativa	52.51	0.00e+00	920.00
IUUC-Ola-086553	Oryzias latipes	36.71	3.00e-154	538.00
IUUC-Oga-088424	Otolemur garnettii	35.75	3.00e-139	488.00
IUUC-Ptr-090801	Pan troglodytes	35.96	3.00e-145	508.00
IUUC-Pan-092717	Papio anubis	42.23	2.00e-129	456.00
IUUC-Pop-099801	Populus trichocarpa	60.66	0.00e+00	1090.00
IUUC-Pva-103244	Pteropus vampyrus	35.21	3.00e-134	472.00
IUUC-Smo-108686	Selaginella moellendorffii	53.53	2.00e-170	591.00
IUUC-Sit-109948	Setaria italica	54.96	0.00e+00	934.00
IUUC-Sly-111746	Solanum lycopersicum	61.32	0.00e+00	1102.00
IUUC-Ssc-115637	Sus scrofa	42.07	7.00e-128	451.00
IUUC-Tsy-119414	Tarsius syrichta	48.98	2.00e-80	293.00
IUUC-Tca-121001	Theobroma cacao	63.41	0.00e+00	1182.00
IUUC-Tae-125295	Triticum aestivum	55.53	0.00e+00	961.00
IUUC-Tbe-127672	Tupaia belangeri	38.20	1.00e-98	353.00
IUUC-Vda-129781	Verticillium dahliae	30.60	2.00e-64	241.00

Created Date

25-Jun-2017

Functional Description

Protein Fasta Sequence

Nucleotide Fasta Sequence