iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045462

UUCD1 version

UUC-GoG-00612

Ensembl Protein ID

ENSGGOP00000015258.2

UniProt Accession

G3RHX8; G3RHX8_GORGO

Protein Name

Uncharacterized protein

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000015628.2	ENSGGOT00000015693.2	ENSGGOP00000015258.2
ENSGGOG00000015628.2	ENSGGOT00000023581.1	ENSGGOP00000024293.1

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
E3 activity/HECT	4.70e-99	332.4	822	964

Active Site

Position(s)	Description	Evidence
934	Glycyl thioester intermediate	{ECO:0000256\|PIRSR:PIRSR001569-1, ECO:0000256\|PROSITE-ProRule:PRU00104}

Domain Profile

E3 activity/HECT

   S: 196  GfneviplellslFteeelellicGeeeidvedlkketkykggytedspaiqwFwevleefsseerkafLqFvTgssrlPlgGfaelk. 283
           Gf e+ip++l+++F+e+elell+cG  ++dv+d++++tkyk+gy++++++iqwFw+++ +++se+r ++LqFvTg+sr+P++Gfael  
   Q: 822  GFFELIPQDLIKIFDENELELLMCGLGDVDVNDWREHTKYKNGYSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYg 910
           9**************************************************************************************** PP
   S: 284  ...prlfvirkdasddrlPssnTCfnyLkLPeYsskeilkekLlyAieetkgFe 334
              p++f++++++++++lP+++TCfn+L+LP+Y+s e+l +kL++Aie+t+gF+
   Q: 911  sngPQSFTVEQWGTPEKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 964
           *****************************************************8 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MAQSLRLHFA ARRSNTYPLS ETSGDDLDSH VHMCFKRPTR ISTSNVVQMK LTPRQTALAP 60
LIKENIQSQE RSSVPSSENV NKKSSCLQIS LQPTRYSGYL QSSNVLADSD DASFTCILKD 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

ATGGCACAAA GCTTACGATT GCACTTTGCA GCCAGAAGAA GCAATACTTA CCCTTTGTCA 60
GAAACCTCCG GAGATGACTT GGATAGCCAT GTTCACATGT GCTTCAAAAG ACCAACACGG 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome
KW-0808--Transferase
KW-0833--Ubl conjugation pathway

Interpro

IPR000569--HECT_dom
IPR001202--WW_dom

PROSITE

PS50237--HECT
PS01159--WW_DOMAIN_1
PS50020--WW_DOMAIN_2

Pfam

PF00632--HECT
PF00397--WW

SMART

SM00119--HECTc
SM00456--WW

Gene Ontology

GO:0005938--C:cell cortex
GO:0000785--C:chromatin
GO:0070062--C:extracellular exosome
GO:0005794--C:Golgi apparatus
GO:0048471--C:perinuclear region of cytoplasm
GO:0005886--C:plasma membrane
GO:0019871--F:sodium channel inhibitor activity
GO:0061630--F:ubiquitin protein ligase activity
GO:0044111--P:development involved in symbiotic interaction
GO:0042921--P:glucocorticoid receptor signaling pathway
GO:2000650--P:negative regulation of sodium ion transmembrane transporter activity
GO:0010768--P:negative regulation of transcription from RNA polymerase II promoter in response to UV-induced DNA damage
GO:0031175--P:neuron projection development
GO:0046824--P:positive regulation of nucleocytoplasmic transport
GO:0014068--P:positive regulation of phosphatidylinositol 3-kinase signaling
GO:0045732--P:positive regulation of protein catabolic process
GO:0050847--P:progesterone receptor signaling pathway
GO:0006622--P:protein targeting to lysosome
GO:0042787--P:protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0032801--P:receptor catabolic process
GO:0031623--P:receptor internalization
GO:0042391--P:regulation of membrane potential
GO:1901016--P:regulation of potassium ion transmembrane transporter activity
GO:0019089--P:transmission of virus
GO:0043162--P:ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Cja-019034	Callithrix jacchus	92.82	0.00e+00	999.00
IUUC-Cho-024672	Choloepus hoffmanni	83.53	0.00e+00	721.00
IUUC-Opr-070443	Ochotona princeps	75.69	0.00e+00	744.00
IUUC-Ptr-091629	Pan troglodytes	98.60	0.00e+00	1038.00
IUUC-Pva-102303	Pteropus vampyrus	83.74	0.00e+00	876.00
IUUC-Stu-112501	Solanum tuberosum	40.77	9.00e-22	97.80
IUUC-Sar-113715	Sorex araneus	97.01	1.00e-119	424.00
IUUC-Tsy-118806	Tarsius syrichta	89.51	0.00e+00	926.00
IUUC-Ttr-128437	Tursiops truncatus	86.06	0.00e+00	860.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence