iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Bta-012766

UUCD1 version

Ensembl Protein ID

UniProt Accession

Genbank Protein ID

Protein Name

Uncharacterized protein

Genbank Nucleotide ID

DAAA02053048

Gene Name

OTUB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSBTAG00000014981.3	ENSBTAT00000019943.3	ENSBTAP00000019943.3

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	7.20e-48	162.6	41	230

Active Site

Position(s)	Description	Evidence
48	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
51	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
224		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+ktkgDGnC++rA+++s                                                          ll+vf+d+s sd
   Q: 41   AIRKTKGDGNCFYRALGYSylesllgksreilkfkervlqtpndllvagfeehtfrnffnafysvvelvekdgsvssLLKVFNDQSFSD 129
           79*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
            +v++Lr+lts+++++++dff++fi+e++d+k+fc ++vep+a  +++i+i+aL+q+L+++++v++vd++++    +l++++fpe++ +
   Q: 130  RIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCAHEVEPMAMeCDHIQITALSQALNIALQVEYVDEMDT----ALNHHVFPEAA-T 213
           **********************************************************************95....***********.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlY+++HY++L+a
   Q: 214  PSVYLLYKTSHYNILYA 230
           ***************97 PP

Organism

Bos taurus

Protein Sequence
(Fasta)

MSETSFNLIS EKCDILSILR DHPENRIYQR KIQELSKRFT AIRKTKGDGN CFYRALGYSY 60
LESLLGKSRE ILKFKERVLQ TPNDLLVAGF EEHTFRNFFN AFYSVVELVE KDGSVSSLLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

TCCTCGCTGG GGCGGGACCT GGCCCGACGG CTCCGGTCAC TATGGTCAGT GGTCTAAGGG 60
GGAAGCGGGG AAGGAGGGGT GGGAAGGGGG CGCGGTAGGC GGGGTCGGCC CCCGGGCGCA 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0019784--F:NEDD8-specific protease activity
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0043130--F:ubiquitin binding
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	96.12	3.00e-132	463.00
IUUC-Cja-019480	Callithrix jacchus	94.02	3.00e-130	457.00
IUUC-Cfa-021106	Canis familiaris	96.55	8.00e-133	465.00
IUUC-Cpo-022187	Cavia porcellus	96.14	3.00e-133	467.00
IUUC-Csa-023493	Chlorocebus sabaeus	95.71	2.00e-131	461.00
IUUC-Cho-024411	Choloepus hoffmanni	77.07	2.00e-85	307.00
IUUC-Dno-029346	Dasypus novemcinctus	97.42	3.00e-134	470.00
IUUC-Dor-031012	Dipodomys ordii	96.57	1.00e-133	468.00
IUUC-Ete-032266	Echinops telfairi	87.50	1.00e-119	421.00
IUUC-Eca-033356	Equus caballus	97.41	6.00e-133	466.00
IUUC-Eeu-034775	Erinaceus europaeus	96.12	8.00e-132	462.00
IUUC-Fca-035363	Felis catus	95.26	6.00e-131	459.00
IUUC-Ggo-045023	Gorilla gorilla	95.30	2.00e-131	461.00
IUUC-Hsa-046984	Homo sapiens	95.73	3.00e-132	463.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	95.73	8.00e-133	465.00
IUUC-Lch-050514	Latimeria chalumnae	61.78	2.00e-83	301.00
IUUC-Loc-052003	Lepisosteus oculatus	50.66	2.00e-64	238.00
IUUC-Laf-054382	Loxodonta africana	96.12	3.00e-132	463.00
IUUC-Mcc-055516	Macaca mulatta	95.71	1.00e-131	461.00
IUUC-Meu-056038	Macropus eugenii	88.89	2.00e-100	357.00
IUUC-Mmr-060918	Microcebus murinus	97.86	1.00e-135	474.00
IUUC-Mdo-062638	Monodelphis domestica	90.99	1.00e-126	445.00
IUUC-Mmu-063973	Mus musculus	96.14	1.00e-132	465.00
IUUC-Mpu-066013	Mustela putorius furo	96.55	5.00e-133	466.00
IUUC-Mlu-067509	Myotis lucifugus	94.40	1.00e-128	451.00
IUUC-Nle-069673	Nomascus leucogenys	95.73	3.00e-132	463.00
IUUC-Opr-070761	Ochotona princeps	87.95	3.00e-81	293.00
IUUC-Oan-072922	Ornithorhynchus anatinus	82.97	8.00e-114	402.00
IUUC-Ocu-074643	Oryctolagus cuniculus	95.73	6.00e-133	466.00
IUUC-Oni-082026	Oryza nivara	28.32	2.00e-15	77.00
IUUC-Oru-084761	Oryza rufipogon	28.32	2.00e-15	77.00
IUUC-Ola-086603	Oryzias latipes	45.83	1.00e-52	199.00
IUUC-Oga-088936	Otolemur garnettii	96.14	8.00e-133	465.00
IUUC-Oar-089460	Ovis aries	99.57	6.00e-137	479.00
IUUC-Ptr-090805	Pan troglodytes	95.30	1.00e-131	462.00
IUUC-Pan-091969	Papio anubis	95.73	3.00e-132	463.00
IUUC-Pab-098476	Pongo abelii	95.28	7.00e-131	459.00
IUUC-Pca-100252	Procavia capensis	91.09	5.00e-53	200.00
IUUC-Pva-102204	Pteropus vampyrus	95.30	6.00e-133	466.00
IUUC-Pgr-103552	Puccinia graminis	75.00	2.70e-02	31.20
IUUC-Rno-105062	Rattus norvegicus	96.15	1.00e-133	468.00
IUUC-Sha-106968	Sarcophilus harrisii	90.83	2.00e-124	437.00
IUUC-Sar-113295	Sorex araneus	96.55	8.00e-131	459.00
IUUC-Ssc-115288	Sus scrofa	96.57	6.00e-133	466.00
IUUC-Tni-120440	Tetraodon nigroviridis	39.83	1.00e-44	172.00
IUUC-Tbe-127717	Tupaia belangeri	96.62	9.00e-79	285.00
IUUC-Ttr-128221	Tursiops truncatus	76.39	2.00e-99	354.00
IUUC-Uma-129443	Ustilago maydis	33.65	3.00e-24	105.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence