iUUCD 2.0 - integrated annotations for ubiquitin and ubiquitin-like conjugation database

Protein
Gene
Annotation
Classification
Domain Profile
Function
Protein Sequence
Nucleotide Sequence
Keyword
GO
Orthology
TOP

Tag

Content

UUCD2 ID

IUUC-Ggo-045023

UUCD1 version

UUC-GoG-01061

Ensembl Protein ID

ENSGGOP00000006587.2

UniProt Accession

G3QV24; G3QV24_GORGO

Protein Name

Uncharacterized protein

Gene Name

OTUB2

Ensembl Information

Ensembl Gene ID	Ensembl Transcript ID	Ensembl Protein ID
ENSGGOG00000006732.2	ENSGGOT00000006760.2	ENSGGOP00000006587.2

Status

Unreviewed

Classification

Family	E-Value	Score	Start	End
DUB/OTU	1.90e-49	168.0	41	230

Active Site

Position(s)	Description	Evidence
48	N/A	{ECO:0000256\|PIRSR:PIRSR013503-1}
51	Nucleophile	{ECO:0000256\|PIRSR:PIRSR013503-1}
224		{ECO:0000256\|PIRSR:PIRSR013503-1}

Domain Profile

DUB/OTU

   S: 2    lilktkgDGnCLlrAvsqs..........................................................llgvfdddslsd 32
           +i+ktkgDGnC++rA+++s                                                          ll+vf+d+s+sd
   Q: 41   AIRKTKGDGNCFYRALGYSylesllgksreifkfkervlqtpndllaagfeehkfrnffnafysvvelvekdgsvssLLKVFNDQSASD 129
           79*************************************************************************************** PP
   S: 33   alveaLreltseylqkesdffsefieekedekefcqklvepeak.geeihifaLaqiLsrpiivvdvdsleskvggillpllfpeeklk 120
           ++v++Lr+lts+++++++dff++fi+e++d+k+fc+++vep+a+ +++i+i+aL+q+Ls++++v++vd++++    +l++++fpe++ +
   Q: 130  HIVQFLRLLTSAFIRNRADFFRHFIDEEMDIKDFCTHEVEPMATeCDHIQITALSQALSIALQVEYVDEMDT----ALNHHVFPEAA-T 213
           **********************************************************************95....***********.* PP
   S: 121  kpivLlYrsgHYdaLva 137
           ++++LlY+++HY++L+a
   Q: 214  PSVYLLYKTSHYNILYA 230
           ***************97 PP

Organism

Gorilla gorilla

Protein Sequence
(Fasta)

MSATSFNLIS EKCDILSILR DHPENRIYRR KIEELSKRFT AIRKTKGDGN CFYRALGYSY 60
LESLLGKSRE IFKFKERVLQ TPNDLLAAGF EEHKFRNFFN AFYSVVELVE KDGSVSSLLK 120

It may take some time, please wait.

Nucleotide Sequence
(Fasta)

CTTTGGTTTG CGGAGCGGTC GGGTGTATTC TCCGCCGCCC CCACGCCCTC GAGGTCCCCG 60
CCACCGAACC AGCGGCGGAG CCCGCCCGCG CCTCCCGCGG CATTCCCGCA CCGGATCGCT 120

It may take some time, please wait.

Sequence Source

Ensembl

Keyword

KW-0181--Complete proteome
KW-1185--Reference proteome

Interpro

IPR003323--OTU_dom
IPR030299--OTUB2
IPR016615--Otubain
IPR019400--Peptidase_C65_otubain

PROSITE

PS50802--OTU

Pfam

PF10275--Peptidase_C65

Gene Ontology

GO:0005634--C:nucleus
GO:0004843--F:thiol-dependent ubiquitin-specific protease activity
GO:0035871--P:protein K11-linked deubiquitination
GO:0071108--P:protein K48-linked deubiquitination
GO:0070536--P:protein K63-linked deubiquitination

KEGG

ggo:101143810

Orthology

iUUCD ID	Species	Identity	E-value	Score
IUUC-Aml-002059	Ailuropoda melanoleuca	94.83	6.00e-131	459.00
IUUC-Aly-005710	Arabidopsis lyrata	38.67	1.00e-35	143.00
IUUC-Ath-007112	Arabidopsis thaliana	38.05	4.00e-35	141.00
IUUC-Bta-012766	Bos taurus	95.30	1.00e-131	461.00
IUUC-Bol-016100	Brassica oleracea	37.55	2.00e-34	139.00
IUUC-Bra-017705	Brassica rapa	35.77	2.00e-30	125.00
IUUC-Cel-018295	Caenorhabditis elegans	31.14	1.00e-28	119.00
IUUC-Cja-019480	Callithrix jacchus	96.15	2.00e-133	467.00
IUUC-Cfa-021106	Canis familiaris	95.26	1.00e-131	461.00
IUUC-Cpo-022187	Cavia porcellus	93.99	8.00e-130	455.00
IUUC-Cre-022997	Chlamydomonas reinhardtii	34.76	5.00e-30	124.00
IUUC-Csa-023493	Chlorocebus sabaeus	99.57	9.00e-137	478.00
IUUC-Cho-024411	Choloepus hoffmanni	74.63	5.00e-83	300.00
IUUC-Cin-025507	Ciona intestinalis	37.42	2.00e-28	118.00
IUUC-Csv-026273	Ciona savignyi	37.72	1.00e-42	166.00
IUUC-Dno-029346	Dasypus novemcinctus	94.85	3.00e-131	460.00
IUUC-Dor-031012	Dipodomys ordii	94.85	2.00e-131	461.00
IUUC-Ete-032266	Echinops telfairi	85.34	5.00e-117	413.00
IUUC-Eca-033356	Equus caballus	96.12	5.00e-131	459.00
IUUC-Eeu-034775	Erinaceus europaeus	95.26	8.00e-131	459.00
IUUC-Fca-035363	Felis catus	93.53	8.00e-129	452.00
IUUC-Gma-043712	Glycine max	37.12	5.00e-33	134.00
IUUC-Hsa-046984	Homo sapiens	99.57	2.00e-137	481.00
IUUC-Itr-048012	Ictidomys tridecemlineatus	94.87	2.00e-132	464.00
IUUC-Lch-050514	Latimeria chalumnae	60.89	3.00e-83	301.00
IUUC-Loc-052003	Lepisosteus oculatus	49.78	9.00e-64	236.00
IUUC-Laf-054382	Loxodonta africana	94.40	1.00e-130	458.00
IUUC-Mcc-055516	Macaca mulatta	99.57	9.00e-137	478.00
IUUC-Meu-056038	Macropus eugenii	87.83	4.00e-99	353.00
IUUC-Mtr-057712	Medicago truncatula	36.22	2.00e-30	125.00
IUUC-Mvi-060358	Microbotryum violaceum	34.85	2.00e-13	69.30
IUUC-Mmr-060918	Microcebus murinus	95.73	1.00e-132	465.00
IUUC-Mdo-062638	Monodelphis domestica	88.84	1.00e-123	435.00
IUUC-Mmu-063973	Mus musculus	94.42	2.00e-130	458.00
IUUC-Mac-065274	Musa acuminata	31.39	1.00e-24	107.00
IUUC-Mpu-066013	Mustela putorius furo	95.69	7.00e-132	462.00
IUUC-Mlu-067509	Myotis lucifugus	93.53	2.00e-127	447.00
IUUC-Nle-069673	Nomascus leucogenys	99.57	2.00e-137	481.00
IUUC-Opr-070761	Ochotona princeps	86.75	1.00e-80	291.00
IUUC-Oan-072922	Ornithorhynchus anatinus	81.94	2.00e-111	394.00
IUUC-Ocu-074643	Oryctolagus cuniculus	94.02	9.00e-131	458.00
IUUC-Oni-082026	Oryza nivara	28.32	3.00e-16	79.70
IUUC-Oru-084761	Oryza rufipogon	28.32	3.00e-16	79.70
IUUC-Ola-086603	Oryzias latipes	44.91	2.00e-51	195.00
IUUC-Oga-088936	Otolemur garnettii	95.28	1.00e-131	461.00
IUUC-Oar-089460	Ovis aries	95.71	6.00e-131	459.00
IUUC-Ptr-090805	Pan troglodytes	99.15	4.00e-137	479.00
IUUC-Pan-091969	Papio anubis	99.57	2.00e-137	481.00
IUUC-Pab-098476	Pongo abelii	99.14	6.00e-136	476.00
IUUC-Pop-099401	Populus trichocarpa	35.93	2.00e-32	132.00
IUUC-Pca-100252	Procavia capensis	88.12	7.00e-52	196.00
IUUC-Ppe-101977	Prunus persica	38.86	1.00e-34	140.00
IUUC-Pva-102204	Pteropus vampyrus	94.02	2.00e-131	461.00
IUUC-Pgr-103552	Puccinia graminis	75.00	2.50e-02	31.60
IUUC-Rno-105062	Rattus norvegicus	94.44	1.00e-131	461.00
IUUC-Sha-106968	Sarcophilus harrisii	88.65	3.00e-121	427.00
IUUC-Sly-111640	Solanum lycopersicum	37.02	2.00e-34	139.00
IUUC-Sar-113295	Sorex araneus	94.83	9.00e-129	452.00
IUUC-Ssc-115288	Sus scrofa	94.85	6.00e-131	459.00
IUUC-Tni-120440	Tetraodon nigroviridis	38.96	2.00e-42	165.00
IUUC-Tca-121467	Theobroma cacao	36.52	2.00e-33	135.00
IUUC-Tbe-127717	Tupaia belangeri	93.92	2.00e-77	280.00
IUUC-Ttr-128221	Tursiops truncatus	76.39	6.00e-100	356.00
IUUC-Uma-129443	Ustilago maydis	31.74	2.00e-24	106.00
IUUC-Vvi-131389	Vitis vinifera	36.64	1.00e-32	133.00
IUUC-Xtr-131951	Xenopus tropicalis	51.13	5.00e-71	260.00

Created Date

25-Jun-2017

Protein Fasta Sequence

Nucleotide Fasta Sequence